Download or read book Chemistry of NI II Complexes of Relevance to Acireductone Dioxygenase written by Ewa Szajna-Fuller and published by . This book was released on 2006 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Nickel Complexes with Relevance to Nickel Acireductone Dioxygenase and Nickel Superoxide Dismutase written by Margo Nicole Montgomery and published by . This book was released on 2012 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research presents an investigation of synthetic model complexes with relevance to the active site of Ni(II) acireductone dioxygenase (Ni-ARD) and Ni(II) superoxide dismutase (Ni-SOD). Acireductone dioxygenases (ARDs) are a unique set of enzymes found in the methionine salvage pathway that catalyze the oxidation reaction of acireductone (1, 2-dihydroxy-3-oxo-5-(methylthio)pent-1-ene). These enzymes share a common polypeptide sequence but bind different metal ions, Ni 2+ or Fe2+, at the active site. The Ni-ARD enzyme is responsible for the off pathway shunt in the pathway. Using the tridentate nitrogen donor ligands hydrotris(3,5-dimethyl-1-pyrazolyl)borate (Tp*) and the newly developed tris(1, 2-dimethyl-4-imadozyl)carbinol, (4-TIC Me, Me) several reactions involving the acireductone analog 2-hydroxy-1, 3-diphenylpropan-1, 3-dione and O2 were investigated for similarities to the Ni-ARD active site. Superoxide dismutases (SODs) play a key role in protecting cells against oxidative damage by regulating the cellular concentration of the superoxide radical (O2.- ) which is an unwanted byproduct of cellular metabolism. This process is accomplished by converting the superoxide radicals to hydrogen peroxide and molecular oxygen. Several small-molecule complexes were synthesized and characterized in an effort to model the reduced state of the Ni-SOD using the Tp* ligand. The structures for these complexes have been determined using X-Ray Crystallography.

Download or read book Ligand and Metal Effects on the Co release Reactivity of Metal Acireductone and Flavonolate Complexes written by Katarzyna Grubel and published by . This book was released on 2011 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research reported herein involves synthetic metal complexes of relevance to dioxygenase enzymes (Ni(II)-containing acireductone dioxygenase (Ni(II)-ARD) and quercentinase (2,4-flavonol dioxygenase) that promote oxidative carbon-carbon bond cleavage and CO release. The experiments focus on the elucidation of structure-reactivity relationships and evaluation of the conditions under which CO is generated. It had been proposed that hydrogen bond donors in the secondary environment of the active site metal center in Ni(II)-ARD influence the coordination of the acireductone substrate on the nickel center. To evaluate this proposal, we investigated the Ni(II) coordination chemistry of an acireductone-type enolate anion using a supporting chelate ligand having two internal hydrogen bond-donors. The resulting complex exhibited differences in terms of the organic product distribution in a CO release reaction resulting from oxidative C-C bond cleavage of the enolate ligand relative to this reported for the hydrophobic, 6-Ph2TPA-supported (6-Ph2TPA = N, N-bis((6-phenyl-2-pyridyl)methyl)-N-((2-pyridyl)methyl)amine) analogue. In another study, we found that changes in the supporting chelate ligand or metal center influenced the coordination chemistry of the acireductone-type enolate anion. This chemistry highlighted the propensity of the enolate to undergo isomerization without CO release in the presence of water. Rigorously excluding water enabled the isolation of a Ni(II) enolate complex of the 6-PhTPA ligand and examination of its oxidative CO release chemistry, as well as the spectroscopic characterization of the first Co(II) complex of an acireductone-type enolate. To elucidate factors influencing the CO-release reactivity of metal-flavonoid complexes, some of which have relevance to quercentinase enzymes, we synthesized and characterized the first series of structurally-related metal-flavonolate complexes [(6-Ph2TPA)M(3-Hfl)]X (M = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II); X = OTfor ClO4 - ). Exposure of these complexes to UV light initiated photooxidative carboncarbon bond cleavage and CO release in a metal-dependent manner, with closed-shell d10 metals giving rise to the highest rate of CO release. These studies suggest that metal flavonolate species may be useful as a new type of photo-induced CO release molecules (CORMs). Such species are of current interest for possible therapeutic applications.

Download or read book Comprehensive Inorganic Chemistry II written by and published by Newnes. This book was released on 2013-07-23 with total page 7694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Chemistry, to form a trio of works covering the whole of modern inorganic chemistry. Chapters are designed to provide a valuable, long-standing scientific resource for both advanced students new to an area and researchers who need further background or answers to a particular problem on the elements, their compounds, or applications. Chapters are written by teams of leading experts, under the guidance of the Volume Editors and the Editors-in-Chief. The articles are written at a level that allows undergraduate students to understand the material, while providing active researchers with a ready reference resource for information in the field. The chapters will not provide basic data on the elements, which is available from many sources (and the original work), but instead concentrate on applications of the elements and their compounds. Provides a comprehensive review which serves to put many advances in perspective and allows the reader to make connections to related fields, such as: biological inorganic chemistry, materials chemistry, solid state chemistry and nanoscience Inorganic chemistry is rapidly developing, which brings about the need for a reference resource such as this that summarise recent developments and simultaneously provide background information Forms the new definitive source for researchers interested in elements and their applications; completely replacing the highly cited first edition, which published in 1973

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book On Biomimetics written by Lilyana Pramatarova and published by BoD – Books on Demand. This book was released on 2011-08-29 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-mimicry is fundamental idea "How to mimic the Nature" by various methodologies as well as new ideas or suggestions on the creation of novel materials and functions. This book comprises seven sections on various perspectives of bio-mimicry in our life; Section 1 gives an overview of modeling of biomimetic materials; Section 2 presents a processing and design of biomaterials; Section 3 presents various aspects of design and application of biomimetic polymers and composites are discussed; Section 4 presents a general characterization of biomaterials; Section 5 proposes new examples for biomimetic systems; Section 6 summarizes chapters, concerning cells behavior through mimicry; Section 7 presents various applications of biomimetic materials are presented. Aimed at physicists, chemists and biologists interested in biomineralization, biochemistry, kinetics, solution chemistry. This book is also relevant to engineers and doctors interested in research and construction of biomimetic systems.

Download or read book Applied Chemistry and Chemical Engineering Volume 4 written by A. K. Haghi and published by CRC Press. This book was released on 2017-12-22 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Chemistry and Chemical Engineering, Volume 4: Experimental Techniques and Methodical Developments provides a detailed yet easy-to-follow treatment of various techniques useful for characterizing the structure and properties of engineering materials. This timely volume provides an overview of new methods and presents experimental research in applied chemistry using modern approaches. Each chapter describes the principle of the respective method as well as the detailed procedures of experiments with examples of actual applications and then goes on to demonstrate the advantage and disadvantages of each physical technique. Thus, readers will be able to apply the concepts as described in the book to their own experiments. The book is broken into several subsections: Polymer Chemistry and Technology Computational Approaches Clinical Chemistry and Bioinformatics Special Topics This volume presents research and reviews and information on implementing and sustaining interdisciplinary studies in science, technology, engineering, and mathematics.

Download or read book Bioinorganic Chemistry of Nickel written by Michael J. Maroney and published by MDPI. This book was released on 2020-06-16 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology.

Download or read book Applied Chemistry and Chemical Engineering Volume 1 written by A. K. Haghi and published by CRC Press. This book was released on 2017-12-22 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book brings together innovative research, new concepts, and novel developments in the application of informatics tools for applied chemistry and computer science. It presents a modern approach to modeling and calculation and also looks at experimental design in applied chemistry and chemical engineering. The volume discusses the developments of advanced chemical products and respective tools to characterize and predict the chemical material properties and behavior. Providing numerous comparisons of different methods with one another and with different experiments, not only does this book summarize the classical theories, but it also exhibits their engineering applications in response to the current key issues. Recent trends in several areas of chemistry and chemical engineering science, which have important application to practice, are discussed. Applied Chemistry and Chemical Engineering: Volume 1: Mathematical and Analytical Techniques provides valuable information for chemical engineers and researchers as well as for graduate students. It demonstrates the progress and promise for developing chemical materials that seem capable of moving this field from laboratory-scale prototypes to actual industrial applications. Volume 2 will focus principles and methodologies in applied chemistry and chemical engineering.

Download or read book Development of Nickel II Complexes of Oxime Containing Ligands for the Activation of Dioxygen written by Michael Joseph Goldcamp and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ligands containing two oxime donor groups with a variable third group in a tripodal amine motif have been designed and synthesized. Their Ni(II) complexes, and some Zn(II), Cu(II), and Fe(III) complexes, have been structurally and spectroscopically characterized. Deprotonation of the oxime groups gives Ni(II)--Polyoximate complexes that form bis(N-O) oximate bridged dimers with significantly low oxidation potentials for Ni(II). These Ni(II)-polyoximate complexes react with dioxygen, consuming multiple equivalents. This is unusual chemistry for Ni(II), especially in the absence of ligand oxidation. The Ni(II) / O 2 reaction system promotes oxidation of triphenyl phosphine, with oxygen atom transfer, benzyl alcohol, and 3,5-di-tert-butylcatechol. Reaction of the Ni(II)-polyoximate complexes with o-quinones causes the formation of high-valent nickel complexes of the reduced dioxolenes, semiquinones and catecholates.

Download or read book Bioscience Methodologies in Physical Chemistry written by Alberto D'Amore and published by CRC Press. This book was released on 2013-07-29 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of bioscience methodologies in physical chemistry stands at the intersection of the power and generality of classical and quantum physics with the minute molecular complexity of chemistry and biology. This book provides an application of physical principles in explaining and rationalizing chemical and biological phenomena. It does not stick to the classical topics that are conventionally considered as part of physical chemistry; instead it presents principles deciphered from a modern point of view, which is the strength of this book.

Download or read book Synthetic Complexes of Relevance to Ni II containing Enzymes written by Katarzyna Rudzka and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Biological Chemistry of Nickel written by Deborah Zamble and published by Royal Society of Chemistry. This book was released on 2017-03-24 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Download or read book Engineering Technology and Industrial Chemistry with Applications written by Reza K. Haghi and published by CRC Press. This book was released on 2018-09-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, Engineering Technology and Industrial Chemistry with Applications, brings together innovative research, new concepts, and novel developments in the application of new tools for chemical and materials engineers. It provides a collection of innovative chapters on new scientific and industrial research from chemists and chemical engineers at several prestigious institutions. It looks at recent significant research and reports on new methodologies and important applications in the fields of chemical engineering as well as provides coverage of chemical databases, bringing together theory and practical applications. Highlighting theoretical foundations, real-world cases, and future directions, this authoritative reference source will be a valuable addition for researchers, practitioners, professionals, and students of chemistry material and chemical engineering.

Download or read book Synthesis Characterization and Reactivity of Ni II Complexes Stabilized by an Intramolecular Hydrogen Bonding Network written by Darla A. Powell-Jia and published by . This book was released on 2010 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloenzymes are able to perform a wide variety of difficult chemical transformations in a highly selective and efficient manner. The ability of metal complexes to perform a particular chemical reaction is dependant on the properties of the primary and secondary coordination environments. Development of transition metal complexes that catalyze the formation of organic compounds in a selective and highly efficient manner is of interest to synthetic chemists. Advancement in this area of research requires studies aimed at developing ligands that will give desirable properties upon binding to a metal ion. Using interactions present in biological systems, the ligands in this study have been developed to investigate the effects of the primary coordination sphere as well as hydrogen bonding interactions on complex formation as well as reactivity. Chapter 2 discusses the synthesis of terminal monomeric NiII-OH complexes with H41R. The hydroxo ligand is stabilized by two intramolecular hydrogen bonding interactions and the source of the hydroxo ligand was confirmed to be water. Attempts to deprotonate the NiII-OH complex to form a NiII-oxo complex were unsuccessful. Treating the NiII-OH complexes with KOtBu afforded the alkoxide substituted product. NiII-siloxide complexes were isolated upon reaction of NiII-OH with K[N(TMS)2]. Chapter 3 features the synthesis of a series of Ni(II) complexes with H2pmb, which contains two carboxyamido units appended from pyridine rings. Four Ni(II) complexes were synthesized and structurally characterized. It was determined that the carboxyamido groups either provided intramolecular H-bonds or the carbonyl oxygen can bind directly to the metal center. Chapter 4 explores the electrochemistry of the Ni(II) complexes characterized in Chapter 3. Based upon the observed reduction potentials, the reduction chemistry of [NiIIH2pmb(Cl)2] was explored. Further reactivity of the reduced species was also explored with dioxygen. Preliminary reactivity studies will also be discussed.

Download or read book Modern Tendencies in Organic and Bioorganic Chemistry written by Gennadiĭ Efremovich Zaikov and published by Nova Publishers. This book was released on 2008 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes the following analyses: factors regarding thermal and thermooxidative degradation of polyolefine nanocomposites, modelling of catalytic complexes in the oxidation reactions, modelling the kinetics of moisture adsorption by natural and synthetic polymers, new trends, achievements and developments on the effects of beam radiation, structural behaviour of composite materials, comparative evaluation of antioxidant properties, synthesis, properties and application of polymeric composites and nanocomposites, photodegradation and light stabilisation of polymers, wear resistant composite polymeric materials, some macrokinetic phenomena, transport phenomena in polymer matrixes, liquid crystals, flammability of polymeric materials and new flame retardants.

Download or read book Physical Chemistry Research for Engineering and Applied Sciences Three Volume Set written by Eli M. Pearce and published by CRC Press. This book was released on 2015-06-24 with total page 971 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 3-volume set covers new research and applications on physical chemical for engineering and applied sciences. Volume 1 discusses the principles and technological implications of industrial chemistry and biochemical physics. Volume 2 presents some fascinating phenomena associated with the remarkable features of high performance polymers and also