Download or read book RIA Federal Tax Handbook written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Checkpoint written by David Albahari and published by Restless Books. This book was released on 2018-09-11 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the award-winning Serbian author David Albahari comes a devastating and Kafkaesque war fable about an army unit sent to guard a military checkpoint with no idea where they are or who the enemy might be. Atop a hill, deep in the forest, an army unit is dropped off to guard a checkpoint. The commander doesn’t know where they are, what border they’re protecting, or why. Their map is useless. The radio crackles with a language no one can recognize. A soldier is found dead in a latrine and the unit vows vengeance—but the killer, like the enemy, is unknown. Amid orgies and massacres, the commander struggles to maintain order and keep his soldiers alive, but he can’t be sure whether they’re fighting a war or caught in some bizarre military experiment. Equal parts Waiting for Godot and Catch-22, David Albahari’s Checkpoint is a haunting and hysterical confrontation with the absurdity of war. Praise for Checkpoint: "A satirical take on war in the vein of Catch-22 and Slaughterhouse Five, Serbian author David Albahari’s Checkpointis shocking and comic in equal turns, skillfully pulled together by the force of Albahari’s wit.... Visceral, wild, and often hilarious, Checkpoint is a dark delight." —Ho Lin, Foreword Reviews, Starred Review “A worthy descendant of The Good Soldier Svejk and Catch-22.” —Kirkus Reviews “Checkpoint is a tornado of a book. David Albahari, a noted Serbian author who lives in Canada, muscles this Kafkaesque short novel into the war-is-absurd literary tradition in one tremendous 183-page paragraph…. Stylistically, JP Donleavy and Gary Shteyngart come to mind at times, while imagistically one might think of Goya, Picasso, or the Surrealists. But Albahari has a distinctive voice, and it comes through vividly in Ellen Elias-Bursać’s able translation from the Serbian.” —Jon Sobel, Blogcritics “Between adventure and apocalypse... Kafka and Kubrick...combining in grotesque-comical manner all the ridiculousness, beauty, horror, subtlety and extravagance that literature can hold.“ —Neue Zürcher Zeitung

Download or read book Checkpoint Watch written by Judith Keshet and published by Zed Books Ltd.. This book was released on 2013-07-04 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a critical exploration of Israel's curfew-closure policy in the Occupied Palestinian Territories through the eyes of CheckpointWatch, an organization of Israeli women monitoring human rights abuses. The book combines observers' daily reports from the checkpoints and along the Separation Wall, with analysis of the bureaucracy that supports the ongoing occupation. Keshet demonstrates the link between Israeli bureaucracy and the closure system as integral to a wider project of ethnic cleansing. As co-founder of the group, Keshet critically reviews the organisation's transformation from a feminist, radical protest movement to one both reclaimed by, and reclaiming, the consensus. Illustrating the nature of Israeli mainstream discourse as both anodyne and cruel, the book also analyses Israeli media representation of Checkpoint Watch and human rights activism in general. Keshet contends that the dilemmas of these Israeli women, torn between opposition to the Occupation and their loyalty to the state, reflects political divisions within Israel society as a whole.

Download or read book Checkpoint Charlie written by Iain MacGregor and published by Simon and Schuster. This book was released on 2019-11-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A “constantly captivating…well-researched and often moving” (The Wall Street Journal) history of Checkpoint Charlie, the famous military gate on the border of East and West Berlin where the United States confronted the USSR during the Cold War. In the early 1960s, East Germany committed a billion dollars to the creation of the Berlin Wall, an eleven-foot-high barrier that consisted of seventy-nine miles of fencing, 300 watchtowers, 250 guard dog runs, twenty bunkers, and was operated around the clock by guards who shot to kill. Over the next twenty-eight years, at least five thousand people attempt to smash through it, swim across it, tunnel under it, or fly over it. In 1989, the East German leadership buckled in the face of a civil revolt that culminated in half a million East Berliners demanding an end to the ban on free movement. The world’s media flocked to capture the moment which, perhaps more than any other, signaled the end of the Cold War. Checkpoint Charlie had been the epicenter of global conflict for nearly three decades. Now, “in capturing the essence of the old Cold War [MacGregor] may just have helped us to understand a bit more about the new one” (The Times, London)—the mistrust, oppression, paranoia, and fear that gripped the world throughout this period. Checkpoint Charlie is about the nerve-wracking confrontation between the West and USSR, highlighting such important global figures as Eisenhower, Stalin, JFK, Nikita Khrushchev, Mao Zedung, Nixon, Reagan, and other politicians of the period. He also includes never-before-heard interviews with the men who built and dismantled the Wall; children who crossed it; relatives and friends who lost loved ones trying to escape over it; military policemen and soldiers who guarded the checkpoints; CIA, MI6, and Stasi operatives who oversaw operations across its borders; politicians whose ambitions shaped it; journalists who recorded its story; and many more whose living memories contributed to the full story of Checkpoint Charlie.

Download or read book Checkpoints written by Brian Mills and published by Tyndale House. This book was released on 2014-02-27 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Society today rejects the idea of absolute truth and is openly hostile toward God. For boys who want to be more like Christ, going through adolescence in this culture is like crossing a minefield without a map. They need parents and youth workers to engage with them early and equip them with the skills needed to thrive. Checkpoints plots a course through this enemy territory that not only steers young men toward godliness but also explains how to avoid potential pitfalls. Checkpoints honestly talks about the core issues boys face, opening a vital dialogue between fathers and sons, pastors and students. Key takeaways: Created by student pastors with 20+ years in ministry 8 lessons Written in a devotional style Guys spend just 15 minutes each day to prepare them for their small group time.

Download or read book Cambridge Checkpoint English Coursebook 8 written by Marian Cox and published by Cambridge University Press. This book was released on 2013-07-18 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cambridge Checkpoint English suite provides a comprehensive, structured resource which covers the Secondary 1 framework for English and seamlessly progresses into the next key stage (covered by our Cambridge IGCSE® First Language English series). This lively stage 8 Coursebook contains 12 themed units providing comprehensive coverage of the revised Cambridge Secondary 1 syllabus. As the core component in this suite, this title includes coverage of the five content areas (Phonics, Spelling and Vocabulary, Grammar and Punctuation, Reading, Writing, and Speaking and Listening). Additional features include rigorous language practice and teaching of key concepts, engaging activities to develop reading and writing skills, integrated speaking and listening tasks and a wide range of fiction and non-fiction texts from around the world. A skill-building, write-in workbook and a Teacher's Resource CD-ROM are available separately.

Download or read book Checkpoint Controls and Targets in Cancer Therapy written by Zahid H. Siddik and published by Springer Science & Business Media. This book was released on 2010-03-12 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal cells, checkpoint pathways are activated when genetic or cellular homeostasis is compromised, and signals are then transduced to re-stabilize homeostasis, and, failing this, to activate the apoptotic machinery to induce a cellular suicidal response. This implies that both survival and cell death pathways are induced following checkpoint activation, and that the final decision is dependant on the net result of integrating the two sets of signals. It is intriguing that checkpoint pathways are also critical in cancer therapy to provide an apoptotic stimulus when cellular damage induced by the therapeutic agent is detected by the sensor system. Therefore, it is not surprising that failure in pro-survival checkpoint response will render tumor cells hypersensitive to cytotoxics and, conversely, failure in pro-apoptotic checkpoint response will induce genetic instability and/or therapeutic resistance. Understanding the intricacies of checkpoint response is, therefore, central to the design of therapeutic regimen that will enhance antitumor effects. Although early versions of this design entail combination of cytotoxic agents with cell cycle or checkpoint inhibitors, a greater understanding of the concepts could make such combinations clinically more effective. The contributions in this book will consolidate the current state of knowledge on checkpoint responses that may lay the foundation for hypothesis-driven rational approaches in advancing the management of cancer. The immediate attraction of the book to the scientific community is that it represents a timely opportunity to build upon existing concepts of checkpoints to expand our understanding of the inner workings of the critical checkpoint machinery. The present understanding has provided ample appreciation that response to checkpoint activation is manifested through coordinated inhibition of cyclin-dependent kinase (CDK) complexes in G1, S and/or the G2 phase in order to arrest the cell cycle. Kinase inhibition can occur through several mechanisms, including inhibitory phosphorylation of CDK, destruction of the cognate cyclins, and recruitment of CDK inhibitors from the INK and WAF1/CIP1 families. However, the wealth of information from recent discoveries needs to be examined critically to consolidate our conceptual knowledge of checkpoints. At the same time, there is acute awareness in the diversity of checkpoint response between cytotoxic agents, and this serves as a reminder of the magnitude of complexity that is inherent in checkpoint regulation. This volume is intended to bring the cancer research community closer toward an improved understanding of this regulation, how checkpoint abnormalities can impact negatively on cancer therapy, and emerging strategies to target checkpoint response as a therapeutic end-point.

Download or read book Immune Checkpoint Biology in Health and Disease written by and published by Elsevier. This book was released on 2024-01-15 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Checkpoint Biology in Health and Disease, Volume 382 provides in-depth reviews on the latest progress concerning research on immune-checkpoint biology and its immunotherapeutic implications, especially in cancer. Topics connected to immune-checkpoint biology covered in this volume include Novel technologies for applying immune checkpoint blockers, Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment, Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer, Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients, and much more. Other sections cover Recent advancements in tumor microenvironment landscaping for target selection and response prediction in immune checkpoint therapies achieved through spatial protein multiplexing analysis, Immune Modulation During Anti-Cancer Radio(immuno)therapy, and Preconditioning with immunogenic cell death-inducing treatments for subsequent immunotherapy. Provides comprehensive reviews from frontline experts on the topic of Immune-checkpoints Presents useful schematic material and cutting-edge discussions Covers the latest insights and future perspectives on the covered topics and their implications for immunology and immunotherapy, as well as clinical perspectives

Download or read book Checkpoint Controls and Cancer written by Axel H. Schönthal and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.

Download or read book Checkpoint Responses in Cancer Therapy written by Wei Dai and published by Springer Science & Business Media. This book was released on 2008-05-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.

Download or read book Checkpoint Charlie written by Iain MacGregor and published by Scribner. This book was released on 2020-11-10 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A “constantly captivating…well-researched and often moving” (The Wall Street Journal) history of Checkpoint Charlie, the famous military gate on the border of East and West Berlin where the United States confronted the USSR during the Cold War. In the early 1960s, East Germany committed a billion dollars to the creation of the Berlin Wall, an eleven-foot-high barrier that consisted of seventy-nine miles of fencing, 300 watchtowers, 250 guard dog runs, twenty bunkers, and was operated around the clock by guards who shot to kill. Over the next twenty-eight years, at least five thousand people attempt to smash through it, swim across it, tunnel under it, or fly over it. In 1989, the East German leadership buckled in the face of a civil revolt that culminated in half a million East Berliners demanding an end to the ban on free movement. The world’s media flocked to capture the moment which, perhaps more than any other, signaled the end of the Cold War. Checkpoint Charlie had been the epicenter of global conflict for nearly three decades. Now, “in capturing the essence of the old Cold War [MacGregor] may just have helped us to understand a bit more about the new one” (The Times, London)—the mistrust, oppression, paranoia, and fear that gripped the world throughout this period. Checkpoint Charlie is about the nerve-wracking confrontation between the West and USSR, highlighting such important global figures as Eisenhower, Stalin, JFK, Nikita Khrushchev, Mao Zedung, Nixon, Reagan, and other politicians of the period. He also includes never-before-heard interviews with the men who built and dismantled the Wall; children who crossed it; relatives and friends who lost loved ones trying to escape over it; military policemen and soldiers who guarded the checkpoints; CIA, MI6, and Stasi operatives who oversaw operations across its borders; politicians whose ambitions shaped it; journalists who recorded its story; and many more whose living memories contributed to the full story of Checkpoint Charlie.

Download or read book Multidisciplinary Management of Cancer Patients with Immune Related Adverse Events from Checkpoint Inhibitors written by Mar Riveiro Barciela and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell Cycle Checkpoint Control Protocols written by Howard B. Lieberman and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cell cycle regulation is based on the observation that the life cycle of a cell progresses through several distinct phases, G1, M, S, and G2, occurring in a well-defined temporal order. Details of the mechanisms involved are rapidly emerging and appear extraordinarily complex. Furthermore, not only is the order of the phases important, but in normal eukaryotic cells one phase will not begin unless the prior phase is completed successfully. Che- point control mechanisms are essentially surveillance systems that monitor the events in each phase, and assure that the cell does not progress prematurely to the next phase. If conditions are such that the cell is not ready to progress—for example, because of incomplete DNA replication in S or DNA damage that may interfere with chromosome segregation in M—a transient delay in cell cycle progression will occur. Once the inducing event is properly handled— for example, DNA replication is no longer blocked or damaged DNA is repaired—cell cycle progression continues. Checkpoint controls have recently been the focus of intense study by investigators interested in mechanisms that regulate the cell cycle. Furthermore, the relationship between checkpoint c- trol and carcinogenesis has additionally enhanced interest in these cell cycle regulatory pathways. It is clear that cancer cells often lack these checkpoints and exhibit genomic instability as a result. Moreover, several tumor suppressor genes participate in checkpoint control, and alterations in these genes are as- ciated with genomic instability as well as the development of cancer.

Download or read book Cambridge Checkpoint Mathematics Practice Book 9 written by Greg Byrd and published by Cambridge University Press. This book was released on 2013-06-06 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by well-respected authors, the Cambridge Checkpoint Mathematics suite provides a comprehensive structured resource which covers the full Cambridge Secondary 1 Mathematics framework in three stages. This Practice Book for Stage 9 contains further exercise questions for practice in the classroom or at home. It provides coverage of the Problem Solving section of the framework, with questions relating to these framework statements highlighted.

Download or read book Factors Determining Long Term Anti Tumor Responses to Immune Checkpoint Blockade Therapy written by Alison Taylor and published by Frontiers Media SA. This book was released on 2023-01-31 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Immunotherapy with checkpoint inhibitors for non small cell lung cancer colon cancer and esophageal cancer written by Xuelei Ma and published by Frontiers Media SA. This book was released on 2022-12-16 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cambridge Checkpoint Lower Secondary World English Student s Book 8 written by Fiona Macgregor and published by Hachette UK. This book was released on 2021-04-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Checkpoint World English Stage 8 has been endorsed by Cambridge Assessment International Education. This series offers full coverage of the learning objectives for the Cambridge Lower Secondary English as a Second language curriculum framework (0876) and is mapped to the Common European Framework of Reference. - Stimulate learners with model texts and a range of activities to develop skills, knowledge and comprehension. - Revisit previous knowledge with the 'Do you remember?' feature to recap topics and activate schema, along with practice tasks, exercises and 'Challenge yourself' activities to consolidate learning. - Clearly address the key objectives: reading, writing, speaking, listening and use of English. - Support activities and knowledge covered in the Student's Book with the accompanying Workbook and Teacher's Guide with Boost subscription. - Audio files are available free at https://www.hoddereducation.co.uk/cambridgeextras