Download or read book Characterization and Functional Comparison of the Latency associated Nuclear Antigen 1 LANA 1 of Kaposi s Sarcoma associated Herpesvirus KSHV and Its Homologues in Other Rhadinoviruses written by Emrah Kati and published by . This book was released on 2006 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Functional Characterisation of Intracellular Interaction Partners of the KSHV Kaposi s Sarcoma associated Herpesvirus Latency associated Nuclear Antigen LANA 1 Protein written by Eva Brüning and published by . This book was released on 2006 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book HIV AIDS Associated Viral Oncogenesis written by Craig Meyers and published by Springer. This book was released on 2018-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.
Download or read book Kaposi Sarcoma Herpesvirus written by Department of Business Management C Boshoff and published by Springer. This book was released on 2016-04-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of the DNA Binding Domain of the Latency associated Nuclear Antigen Protein of Kaposi s Sarcoma associated Herpesvirus microform written by Charles Khoury and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2005 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latency associated nuclear antigen (LANA) protein of Kaposi's sarcoma associated herpesvirus (KSHV) plays several roles in KSHV latent infection including viral genome replication and segregation. Central to these roles is LANA's ability to self-associate and bind specific DNA sequences in the KSHV genome. The goal of this thesis was to characterize the LANA DNA binding and oligomerization domain. The C-terminal region of LANA (LANA-C), containing amino acids 941--1162, was cloned, expressed and purified and shown to possess sequence-specific DNA binding activity. DNA binding activity was further localized to the 1008--1162 amino acid fragment, while the 1021--1162 fragment had reduced DNA binding activity. For each of these LANA fragments, the addition of 0.5 M guanidine hydrochloride was found to greatly enhance purification. Each of the LANA fragments formed large oligmers, and gel filtration and glycerol gradient analyses of LANA-C indicated that the oligmeric state was an octamer.
Download or read book Functional Analysis of the Latency associated Nuclear Antigen of Kaposi s Sarcoma associated Herpes Virus written by Alexander Charles Garber and published by . This book was released on 2002 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research on Kaposi s sarcoma associated herpesvirus past present and future written by Keiji Ueda and published by Frontiers E-books. This book was released on with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been 16 years since Kaposi's sarcoma-associated herpesvirus (KSHV) was found from Kaposi's sarcoma. Very extensive studies on KSHV have been performed and we now know well that KSHV is actually the very etiologic agent to cause Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease and this virus is an oncogenic DNA virus in such sense. Though a lot of reports have been published, there are lots of enigmas on its epidemiology, entry, lytic replication/induction, viral particle assembly/egress, latency, oncogenesis and so on. At this time point, it is better for us to review what we learned from the studies of this virus and consider what we have to clarify about this virus nature for future by comparing the virus with the other virus research.
Download or read book Purification and Characterization of a Kaposi s Sarcoma associated Herpesvirus Latency associated Nuclear Antigen DNA binding Domain Mutant written by Carlie Sunga Mendoza and published by . This book was released on 2018 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi's sarcoma-associated herpesvirus (KSHV) infection is associated with three human malignancies: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman’s disease (MCD). Latency-associated nuclear antigen (LANA) is one of the few viral proteins expressed during latent KSHV infection. It acts as the master regulator of KSHV latency and is essential for viral replication and episome maintenance. Previous studies have shown that these functions are promoted by oligomerization of LANA, which is a process mediated by the DNA-binding domain (DBD). The structure of the wild-type LANADBD forms higher-order oligomers upon crystallization, which poses a challenge to characterizing the DBD. Mutations within the dimer-dimer interface of LANA, specifically at residues F1037 and F1041, disrupt higher-order oligomerization. Crystallization of lower-order oligomers could improve resolution of the DBD. Given this, we sought to purify and crystallize the LANA DBD F1037A/F1041A double mutant (LANA,DBD,AA). Bacterial expression of LANADBD,AA was optimized by varying IPTG concentration, the duration of IPTG induction, and the induction temperature. Multiple methods of protein purification were utilized, including batch affinity purification, affinity column chromatography and ion-exchange column chromatography. Purified LANA,DBD,AA was subjected to a variety of crystallization conditions. These conditions included attempts to optimize buffer pH, %PEG, and molecular weight of PEG. Future directions will focus on determining the structure of LANA,DBD,AA, as well as the structures of the single mutants F1037A (LANA,DBD,AF) and F1041 (LANA,DBD,FA). These mutant structures will aid in the design and development of a small molecule that inhibits LANA-DNA binding.
Download or read book Characterization and Functional Assessment of the Kaposi s Sarcoma Herpesvirus Latency associated Nuclear Antigen C terminal Chromosome Binding Domain written by Brenna Kelley-Clarke and published by . This book was released on 2006 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Latency Strategies of Herpesviruses written by Janos Minarovits and published by Springer Science & Business Media. This book was released on 2006-12-13 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of the latency strategies developed during the estimated 200,000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.
Download or read book Epigenetics of Infectious Diseases written by Walter Doerfler and published by Springer. This book was released on 2017-05-26 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.
Download or read book DNA Tumor Viruses written by Blossom Damania and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Download or read book Rare Genitourinary Tumors written by Lance Pagliaro and published by Springer. This book was released on 2016-06-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.
Download or read book Functional Targets of the Latent Nuclear Antigen LANA1 of Kaposi s Sarcoma associated Herpesvirus KSHV written by and published by . This book was released on 2004 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kaposi Sarcoma associated Herpesvirus Latency Associated Nuclear Antigen LANA Protein Complexes written by David Andrés Nivia Torres and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New and Evolving Infections of the 21st Century written by I.W. Fong and published by Springer Science & Business Media. This book was released on 2006-12-13 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides guidance and answers to frequently asked questions in infectious diseases, thus facilitating improved patient care, prudent and cost effective management and investigation of these disorders. Other more complicated but less common conditions are also reviewed. Uniquely, this volume directly discusses several controversies regarding infectious diseases from the 21st century.
