Download or read book Chagas disease novel drug targets and treatments written by Vilma G. Duschak and published by Frontiers Media SA. This book was released on 2023-06-22 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Discovery and Development of Drugs for Neglected Diseases Chagas Disease Human African Trypanosomiasis and Leishmaniasis written by Gildardo Rivera and published by Frontiers Media SA. This book was released on 2021-12-20 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investing to Overcome the Global Impact of Neglected Tropical Diseases written by World Health Organization and published by World Health Organization. This book was released on 2015-08-05 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.
Download or read book Chagas Disease written by Veeranoot Nissapatorn and published by BoD – Books on Demand. This book was released on 2018-09-12 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 11 chapters of significant and updated materials on what we know and what we lack and need in better understanding of Trypanosoma cruzi - a parasite that never dies - and the consequences of Chagas disease as one of the most important neglected parasitic diseases threatening the global health and wellbeing. This book is intended to increase the readers' enthusiasm to explore the four sections of the contents: Section 1 begins with biochemistry, pathophysiology, histo-immunological study, and findings to assist in the diagnosis; Section 2 further investigates the role of vector in propagation of the parasite, the intensity on epidemiology, and the severity on clinical aspects, which help us to be well perceived on the course of disease; Section 3 is seeking beyond modern medicine and what lays in the nature that helps fight against this parasite; and the last section, Section 4, deals with the impacts of public health problem and the control strategies on Chagas disease.
Download or read book American Trypanosomiasis written by Jenny Telleria and published by Elsevier. This book was released on 2010-09-03 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: - The host: human and mammalian reservoirs - The insect vectors: domestic and sylvatic vectors - The causative parasite: Trypanosoma cruzi - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts
Download or read book Repurposing of Human Tyrosine Kinase Inhibitors for Neglected Diseases written by Uma Swaminathan and published by . This book was released on 2014 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: *Chapter 1: Neglected tropical disease, Chagas disease and target repurposing approach* The term "Neglected Tropical Diseases" (NTDs) most commonly refers to a group of parasitic and bacterial infectious disease affecting more than one billion people globally. There are 13 core diseases in the NTD group that are widespread across the countries from sub-Saharan Africa, Asia and to Latin America. These diseases primarily occur in rural areas, urban slums or conflict zones and affect 2.7 billion people who live on less than $2 per day, causing considerable morbidity and mortality. NTDs cause severe impact on physical and cognitive development, long-term illness, impaired childhood growth and development, adverse outcomes of pregnancy and trap the poor population in a cycle of poverty and disease. Many of these diseases are neglected at the global and local level by the government and private sector owing to the poor return of drug discovery research costs. Also, the emerging resistance to the current therapies can add more burdens to the poor nations The focus of this thesis is upon finding new leads for targeting protozoan parasite "Trypanosoma cruzi", responsible for Chagas disease (CD) by using Target repurposing approach. CD affects nearly 8 million people in Latin America and increasing number of cases reported across Europe and United States. Only two FDA approved drugs are currently available for treating CD. Target repurposing approach is a viable strategy to reduce the time and expense of discovering new therapeutic molecules. In this approach a molecular target in the parasites are matched with homologous human targets that has been previously pursued for drug discovery. We can utilize this knowledge of "druggable" targets in one organism to pursue new potential drug targets in the parasites. *Chapters 2 & 3: Scaffold replacements and head group truncation using in silico models* Our lab has applied target repurposing approach to identify several novel leads against protozoan parasites responsible for causing CD, human African sleeping sickness, leishmaniasis and malaria. Kinases are an extensively pursued class of drug targets to treat several diseases like cancer, immunological and neurological disorders, inflammation and infectious diseases. Lapatinib, an FDA approved dual tyrosine kinase inhibitor (EGFR/HER2) drug for treating breast cancer was repurposed for its anti-trypanosomal properties. Extensive SAR studies of lapatinib analogs led to sub-micromolar potent compound 1.25 (Figure 1.9) against the parasite "T. brucei". Hypothesizing that other parasites express similar kinase pathways, these libraries of compound were screened against other related parasites, which resulted in several lead compounds of micromolar potency. Encouraged by these results, we advanced our work to a scaffold replacement strategy. This resulted in the discovery of a potent lead 2.25b (Figure 2.6) with 0.09 μM activity against "T. cruzi". Despite having a good efficacy, the lead compound failed in the in vivo animal studies due to poor physicochemical properties. In an attempt to improve the physicochemical properties, we adopted a head group replacement strategy for the lead compound based on molecular modelling and virtual screening tools. The concept of ligand efficiency (LE) and lipophilic ligand efficiency (LLE/LiPE) were introduced with an aim to identify new leads. Finally, an attempt was made to establish a possible structure activity relationship (SAR) from the screening data of all the library series. *Chapter 4: Future directions* Final chapter summarizes the results of this thesis and provides the futuristic plan for the advancement of the current work to identify potent leads for Chagas disease.
Download or read book Chagas Disease written by María-Jesús Pinazo Delgado and published by Springer Nature. This book was released on 2020-07-20 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive resource on various aspects of the parasite Trypanosoma cruzi and the neglected tropical disease Chagas disease (American trypanosomiasis), the disorder resulting from infection with the parasite. Topics include the biological description and taxonomy of the parasite, epidemiology and transmission routes, laboratory techniques in use when working with the parasite, as well as diagnostic measures and treatment of Chagas disease. Furthermore, a chapter with life stories of people in contact with the disease in endemic as well as non-endemic countries is included. The book is therefore a valuable source for individuals engaged in basic research as well as patient care and health management related to American trypanosomiasis.
Download or read book Drug Targets in Kinetoplastid Parasites written by Hemanta K. Majumder and published by Springer. This book was released on 2011-01-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.
Download or read book Drug Discovery for Leishmaniasis written by Luis Rivas and published by Royal Society of Chemistry. This book was released on 2017-10-26 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.
Download or read book Antiprotozoal Drug Discovery A Challenge That Remains written by Norma Rivera and published by Bentham Science Publishers. This book was released on 2016-09-06 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protozoan infections that are endemic in countries with limited economic resources pose a significant public health challenge to affected communities and some of these diseases are categorized as neglected tropical diseases by the World Health Organization. At the moment, there is an urgent need to identify and develop new antiprotozoal drugs. Antiprotozoal Drug Discovery: A Challenge That Remains brings together research from all scientists (including parasitologists, chemists, biologists among others) involved in the field of antiprotozoal experimental pharmacology, drug design and natural product research. The monograph is a compilation of review chapters written by experts on medical parasitology and pharmacology that covers a wide range of topics such as general characteristics of protozoan diseases (malaria, toxoplasmosis, Chagas’ disease, leishmaniasis, trichomoniasis) prophylaxis, treatments, natural products and rational drug design. The contents of this book are useful to medical microbiologists and pharmaceutical scientists seeking to update their knowledge about antiprotozoal drug design.
Download or read book Natural Remedies in the Fight Against Parasites written by Hanem Khater and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book emphasizes past and current research efforts about principles of natural control of major parasites affecting humans, animals, and crops. Each chapter is a complete and integrated subject that presents a problem and confers on the safe alternatives to chemicals. This book discusses and updates information about three major topics of natural remedies. The first topic is represented in a chapter outlining important information on biological control of parasites, the second topic is represented in three chapters dealing with botanicals as promising antiparasitic agents, and the last four chapters deal with miscellaneous control strategies against parasites. This easily readable book is designed precisely for students as well as professors linked with the field of parasitic control. We enhanced words with breathing areas in the form of graphical abstracts, figures, photographs, and tables.
Download or read book Neglected Tropical Diseases written by David C. Swinney and published by John Wiley & Sons. This book was released on 2019-07-25 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.
Download or read book American Trypanosomiasis written by Kevin M. Tyler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite, Trypanosoma cruzi. Sixteen to eighteen million people are currently infected with this organism, and 45,000 deaths are attributed to the disease each year. Infection with T. cruzi is life-long, and 10-30% of persons who harbor the parasite chronically develop cardiac and gastrointestinal problems associated with the parasitosis. Although major progress has been made in recent years in reducing vector-borne and transfusion-associated transmission of T. cruzi, the burden of disability and death in persons chronically infected with the organism continues to be enormous. Eight to ten million persons born in countries in which Chagas disease is endemic currently reside in the United States, and epidemiologic and census data suggest that 50,000-100,000 are chronically infected with T. cruzi. The presence of these infected persons poses a risk of transmission of the parasite in the USA through blood transfusion and organ transplantation and several such cases have now been documented. American Trypanosomiasis, volume seven of World Class Parasites is written for students of tropical medicine, parasitology and public health, for researchers and practitioners alike who wish to bring themselves abreast of the status quo with respect to this disease. It is intended to supplement formal textbooks, in order to broaden and illuminate current areas of scientific and public health concern. Uniquely for T. cruzi, this book addresses parasite, vector and host biology, the pathogenesis of Chagas disease and current and prospective therapeutics and control strategies in a single volume.
Download or read book Forgotten People Forgotten Diseases written by Peter J. Hotez and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forgotten People, Forgotten Diseases Second Edition The neglected tropical diseases (NTDs) are the most common infections of the world's poor, but few people know about these diseases and why they are so important. This second edition of Forgotten People, Forgotten Diseases provides an overview of the NTDs and how they devastate the poor, essentially trapping them in a vicious cycle of extreme poverty by preventing them from working or attaining their full intellectual and cognitive development. Author Peter J. Hotez highlights a new opportunity to control and perhaps eliminate these ancient scourges, through alliances between nongovernmental development organizations and private-public partnerships to create a successful environment for mass drug administration and product development activities. Forgotten People, Forgotten Diseases also Addresses the myriad changes that have occurred in the field since the previous edition. Describes how NTDs have affected impoverished populations for centuries, changing world history. Considers the future impact of alliances between nongovernmental development organizations and private-public partnerships. Forgotten People, Forgotten Diseases is an essential resource for anyone seeking a roadmap to coordinate global advocacy and mobilization of resources to combat NTDs.
Download or read book The Kissing Bug written by Daisy Hernandez and published by National Geographic Books. This book was released on 2021-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing up in a New Jersey factory town in the 1980s, Daisy Hernández believed that her aunt had become deathly ill from eating an apple. No one in her family, in either the United States or Colombia, spoke of infectious diseases. Even into her thirties, she only knew that her aunt had died of Chagas, a rare and devastating illness that affects the heart and digestive system. But as Hernández dug deeper, she discovered that Chagas—or the kissing bug disease—is more prevalent in the United States than the Zika virus. After her aunt’s death, Hernández began searching for answers. Crisscrossing the country, she interviewed patients, doctors, epidemiologists, and even veterinarians with the Department of Defense. She learned that in the United States more than three hundred thousand people in the Latinx community have Chagas, and that outside of Latin America, this is the only country with the native insects—the “kissing bugs”—that carry the Chagas parasite. Through unsparing, gripping, and humane portraits, Hernández chronicles a story vast in scope and urgent in its implications, exposing how poverty, racism, and public policies have conspired to keep this disease hidden. A riveting and nuanced investigation into racial politics and for-profit healthcare in the United States, The Kissing Bug reveals the intimate history of a marginalized disease and connects us to the lives at the center of it all.
Download or read book Antiprotozoal Drug Development and Delivery written by Alane Beatriz Vermelho and published by Springer Nature. This book was released on 2022-06-24 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.
Download or read book Evidence Based Cardiology written by Salim Yusuf and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second editionis a ground-breaking clinical text with a strong emphasis on rigorous evidence. Leaders in the field discuss best practice in the light of systematic reviews and randomised control trials, and how best to treat where the information is less clear. Case histories provide intriguing discussions on how to apply the evidence in real life situations. Evidence-based Cardiology also includes free access to the latest evidence, which is automatically posted on a companion website.
