Download or read book Treatment of Neurodevelopmental Disorders written by Randi Jenssen Hagerman and published by Oxford University Press, USA. This book was released on 2014 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.

Download or read book Modeling the Psychopathological Dimensions of Schizophrenia written by Mikhail Pletnikov and published by Academic Press. This book was released on 2015-11-05 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader's understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. - Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models - Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia - Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Download or read book The Neurobiology of Schizophrenia written by Ted Abel and published by Academic Press. This book was released on 2016-07-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. - Provides a comprehensive overview of neurobiological aspects of schizophrenia - Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels - Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance - Elucidates connections between the various systems depicted, when possible

Download or read book Neurotoxin Modeling of Brain Disorders Life long Outcomes in Behavioral Teratology written by Richard M. Kostrzewa and published by Springer. This book was released on 2016-07-13 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

Download or read book Neurodevelopmental Mechanisms in Psychopathology written by Dante Cicchetti and published by Cambridge University Press. This book was released on 2003-08-04 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents a burgeoning perspective on the origins of psychopathology, one that focuses on the development of the human central nervous system. The contemporary neurodevelopmental perspective assumes that mental disorders result from etiologic factors that alter the normal course of brain development. Defined here in its broadest sense, neurodevelopment is a process that begins at conception and extends throughout the life span. We now know that it is a complex process, and that its course can be altered by a host of factors, ranging from inherited genetic liabilities to psychosocial stressors. This book features the very best thinking in the converging fields of developmental neuroscience and developmental psychopathology. The developmental window represented is broad, extending from the prenatal period through adulthood, and the authors cover a broad range of etiologic factors and a spectrum of clinical disorders. Moreover, the contributors did not hesitate to use the opportunity to hypothesize about underlying mechanisms and to speculate on research directions.

Download or read book Neurodevelopment and Adult Psychopathology written by Matcheri S. Keshavan and published by Cambridge University Press. This book was released on 1997-09-11 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this important 1997 book on the role of neurodevelopmental factors in the pathogenesis of the major psychiatric disorders, the fields of developmental neurobiology, clinical psychiatry and behavioural neuroscience are reviewed by an international group of experts, including many of those responsible for the ideas that have come to dominate current thinking. The first section, 'The Developing Brain', reviews neurodevelopment from the molecular to the behavioural level. Section Two, 'Development and Psychopathology', covers clinical applications of the basic principles of developmental neurobiology. The third and final section, 'Integrative Models', presents approaches toward a synthesis of neurodevelopmental and clinical findings in psychiatric disorder. For students, scientists and clinicians in psychiatry, psychology, and neurodevelopment, this is an essential reference.

Download or read book Schizophrenia written by Steven R. Hirsch and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is one of the most complex and puzzling diseases toaffect mankind. It is the most common of the severe mentalillnesses (psychoses) with an estimated prevalence of 0.5 - 1% inthe general population and accounts for a very large portion of theday to day workload of the average psychiatrist. 50% of long-termpsychiatric patients in mental hospitals are schizophrenic. There is a great deal of controversy about the causes, diagnosisand treatment of schizophrenia with the consequence that a hugeamount of research is carried out in the field by psychiatrists,psychologists, neuroscientists and pharmacologists. For the averagepractising psychiatrist seeing schizophrenics on a regular basis,making sense of the vast body of information on the subject andfiltering out what is of clinical relevance can be very difficult.There is a constant stream of new drugs emerging and the newergeneration of drugs (the so-called atypicals) is very effective,but often expensive. The Editors (one American and one British) are both highlyrespected clinical psychiatrists who are probably the leadingexperts on schizophrenia from their respective countries andjointly have published almost 150 papers on the subject. They have brought together a strong group of contributors from theUSA, UK and Europe to produce what will be an essential referencefor the trainee and practising psychiatrist. The book consists of four sections; descriptive aspects,causative aspects, physical treatments andpsychological/behavioural/social treatments. There will bediscussion of the theoretical controversies over symptomatology,classification and aetiology, the relationship of schizophrenia tothe other psychoses, the significance of positive and negativesymptoms and pre-morbid personality. There will be chapters onorganic models of schiziophrenia, neurodevelopmental, genetic andstructural studies and the role of high-expressed emotion. Thefinal section will cover social and environmental treatment, therole of the families of schizophrenics and the psychoanalyticaltherapies. There is a new chapter on the patient's perspectivewritten by a former patient.

Download or read book Advances in Psychobiology written by Francesco Chiappelli and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Broadly defined psychobiology is a wide field of scientific endeavor, which bridges the artificial divide imposed by the Cartesian philosophy of things of the mind and things of the body. Starting in the early decades of the 20th century, mind-body research developed new avenues of understanding in Western science. It became increasingly clear that processes attributed to the psyche, including emotions, cognitions, memories, and personalities, had important effects upon physiological events, could disrupt homeostasis, determined and controlled allostasis, and arose, in fact, from biological phenomena driven by cell biology, biochemistry, genomics and, in a larger sense, interactomics. In brief, psychobiology reunited, at last, the sciences of psychology and physiology. Current advanced research in psychobiology proffers a new perspective on human and animal behavior, with cognitions, emotions, and traits describing the interaction between biological systems and behavior. Today, novel frontiers in psychobiology research encompass how cognition (what we are thinking) and mood (how we are feeling) combine with, determine and are engendered by biological events. The superb chapters that compose this book are written by the premier internationally and most renowned psychobiologists in the world at this time. They examine several of the most important domains of psychobiology research today: from a novel conceptualization of stress in the context of the person-environment fit model, to the modulation of immune surveillance by perceived stress, the alterations of cognition by pharmaceutical use and over-use, as well as from athletic training or ionization poisoning to, ultimately, the brain-gut interaction. The role of functional MRS in the study of advanced research questions in psychobiology is also discussed in depth. Taken together, this collection of chapters make this book on advanced psychobiology both timely and critical. Expectations are that future research development in psychobiology, as the field continues to advance, will continue to strive to understand how psychological and biological connections shape the human experience. Psychobiology will increasingly provide a uniquely new perspective in psychology on the one hand, and on the other hand, in biology along several of the dimensions proffered in this book.

Download or read book Neuroprotection in Autism Schizophrenia and Alzheimer s disease written by Illana Gozes and published by Academic Press. This book was released on 2019-10-16 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer's disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. - Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders - Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders - Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry

Download or read book Behavioral Neurobiology of Schizophrenia and Its Treatment written by Neal R. Swerdlow and published by Springer Science & Business Media. This book was released on 2010-08-19 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state-of-the-art of treatment of schizophrenia and reflects its development in 22 chapters written by leading authorities in the field

Download or read book Developmental Psychopathology Volume 2 written by Dante Cicchetti and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Psychopathology, Second Edition, contains in three volumes the most complete and current research on every aspect of developmental psychopathology. This seminal reference work features contributions from national and international expert researchers and clinicians who bring together an array of interdisciplinary work to ascertain how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns and the pathways by which the same developmental outcomes may be achieved. This volume addresses theoretical perspectives and methodological.

Download or read book Neurodevelopment and Schizophrenia written by Matcheri S. Keshavan and published by Cambridge University Press. This book was released on 2004-11-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Download or read book Cognitive and Brain Plasticity Induced by Physical Exercise Cognitive Training Video Games and Combined Interventions written by Soledad Ballesteros and published by Frontiers Media SA. This book was released on 2018-07-05 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: The premise of neuroplasticity on enhancing cognitive functioning among healthy as well as cognitively impaired individuals across the lifespan, and the potential of harnessing these processes to prevent cognitive decline attract substantial scientific and public interest. Indeed, the systematic evidence base for cognitive training, video games, physical exercise and other forms of brain stimulation such as entrain brain activity is growing rapidly. This Research Topic (RT) focused on recent research conducted in the field of cognitive and brain plasticity induced by physical activity, different types of cognitive training, including computerized interventions, learning therapy, video games, and combined intervention approaches as well as other forms of brain stimulation that target brain activity, including electroencephalography and neurofeedback. It contains 49 contributions to the topic, including Original Research articles (37), Clinical Trials (2), Reviews (5), Mini Reviews (2), Hypothesis and Theory (1), and Corrections (2).

Download or read book Neurogenesis in the Adult Brain II written by Tatsunori Seki and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Download or read book Factors Affecting Neurodevelopment written by Colin R Martin and published by Academic Press. This book was released on 2021-05-29 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems. - Provides the most comprehensive coverage of a broad range of topics relating to the neuroscience of development - Features sections on the genetics of developmental conditions and accompanying behavior - Contains an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding in each chapter - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables

Download or read book Schizophrenia written by Daniel R. Weinberger and published by John Wiley & Sons. This book was released on 2011-07-13 with total page 1139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia is one of the most complex and disabling diseases to affect mankind. Relatively little is known about its nature and its origins, and available treatments are inadequate for most patients. As a result, there are inevitable controversies about what causes it, how to diagnose it, and how best to treat it. However, in the past decade, there has been an explosion of new research, with dramatic discoveries involving genetic etiology and epidemiological risk factors. There has also been a catalog of new drugs coming to market, and controversy about the relative advantages and disadvantages of newer compared with older therapies. In addition, developing technologies in genomics, molecular biology and neuroimaging provide streams of new information. This book represents a definitive, essential, and up-to-date reference text on schizophrenia. It extensively and critically digests and clarifies recent advances and places them within a clinical context. The Editors (one American and one British), highly respected clinical psychiatrists and researchers and acknowledged experts on schizophrenia, have again assembled an outstanding group of contributors from the USA, UK, Europe and Australia, It will be of value to practising psychiatrists and to trainees, as well as to clinical and neuroscience researchers interested in keeping up with this field or coming into it. The book consists of four sections: descriptive aspects, biological aspects, physical treatments, and psychological and social aspects. It reviews the theoretical controversies over symptomatology, classification and aetiology (particularly pertinent as DSM-V is being developed), the relationship of schizophrenia to the other psychoses, the significance of positive and negative symptoms and pre-morbid personality. It describes a variety of approaches to integrating the vast research data about schizophrenia, including neurodevelopmental, genetic, pharmacological, brain imaging and psychological findings. The biological treatment section reviews the comparative efficacy of various drugs, the management of drug-resistant patients and both neurological and metabolic complications. The final section looks at psychological therapies, social outcomes, and the economics of schizophrenia. Highly Commended in the Psychiatry section of the 2012 BMA Book Awards.