Download or read book Cellular Biological Approaches to Treating Peripheral Nerve Injuries written by P. J. Kingham and published by . This book was released on 2015-05-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional recovery after peripheral nerve injury is poor, and it has become clear that surgical reconstruction should be combined with novel therapies which address the problems of the limited rate and quantity of axonal regeneration, neuronal cell death and target organ atrophy. There is significant scope for the application of cellular and biological approaches towards peripheral nerve repair. This special topics issue begins with an introduction to the importance of Schwann cell-axon interactions which is followed by a series of papers highlighting the exciting therapeutic potential of various cell types including skin, adipose, bone marrow and hair follicle-derived adult stem cells, induced pluripotent stem cells and olfactory ensheathing cells. Another biological approach, the use of chondroitinase to overcome nerve scarring, is also described. Finally, noninvasive imaging methods, which will be necessary to determine the efficacy of these novel treatments, are reviewed. The publication will be of interest to a large number of interdisciplinary scientists including cell biologists, biomaterials scientists and chemists as well as surgeons who are involved in translational research aimed at improving the treatment of peripheral nerve injury.
Download or read book Peripheral Nerve Injury An Anatomical and Physiological Approach for Physical Therapy Intervention written by Stephen Carp and published by F.A. Davis. This book was released on 2015-04-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here’s everything you need to know about peripheral nerve injuries and how to recognize and treat acute and chronic injuries and conditions across the lifespan. In-depth discussions, organized in a streamlined format, ensure you understand the identification, pathophysiology, assessment, and procedural interventions associated with peripheral nerve injuries. Build the knowledge base you need to evaluate the most common to complex injuries, make a diagnosis, and implement a plan of care with this one-of-a-kind resource.
Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scaffolds for Peripheral Nerve Regeneration the Importance of In Vitro and In Vivo Studies for the Development of Cell Based Therapies and Biomaterials State of the Art written by Sílvia Santos Pedrosa and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.
Download or read book Cell Therapy for the Treatment and Repair of Nervous System Damage written by Azizi and published by Wiley-Blackwell. This book was released on 2015-03-13 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Complications in Neuroanesthesia written by Hemanshu Prabhakar and published by Academic Press. This book was released on 2016-02-11 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complications in Neuroanesthesia focuses on complications that may arise related to neuroanesthesia practice and discusses its various causes. Each complication is written as a separate chapter, and the pathophysiology and mechanisms of each complication, as well as measures for diagnosis, treatment and prevention are discussed. Towards the end of the book, several case scenarios are provided to the readers that challenge readers to diagnose the possible complication for each case. Chapters include brain and spinal cord problems, cardiovascular and hematological problems, and nerve and muscle problems. Written in a standard format, Complications in Neuroanesthesia provides quick and easy access to understanding problems in neuroanesthesia. It provides insight into all possible complications occurring during perioperative management of neurosurgical and neurologic patients. It is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, and neurology by providing an understanding of preventable mishaps that may occur in neurosurgical or neurologic patients. - Quick and easy reference for understanding problems in neuroanesthesia - Provides comprehensive insights into all possible complications occurring during perioperative management of neurosurgical and neurologic patients - Includes useful section with clinical case studies of complications in neuroanesthesia
Download or read book Cell Engineering and Regeneration written by Heinz Redl and published by Springer. This book was released on 2017-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Download or read book Musculoskeletal Disorders and the Workplace written by Institute of Medicine and published by National Academies Press. This book was released on 2001-05-24 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.
Download or read book Indwelling Neural Implants written by William M. Reichert and published by CRC Press. This book was released on 2007-12-17 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Download or read book Neural Crest Stem Cells written by Maya Sieber-Blum and published by World Scientific. This book was released on 2012 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.
Download or read book Peripheral Nerve Regeneration written by Ana Colette Maurício and published by BoD – Books on Demand. This book was released on 2017-05-31 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
Download or read book Axon Degeneration written by Elisabetta Babetto and published by Humana. This book was released on 2020-06-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of classical as well as innovative methods used to investigate axon degeneration with a particular focus on addressing the common challenges encountered while performing these procedures. Particular attention is devoted to the study of axon loss in several model organisms, as each poses unique challenges and provides powerful advantages. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Axon Degeneration: Methods and Protocols is an ideal guide for facilitating the application and further development of these protocols, which will help the scientific community tackle important questions regarding axon degeneration. Chapters 2, 3, and 20 are available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Neuropathic Pain written by Jianguo Cheng and published by Oxford University Press. This book was released on 2019-01-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathic pain is one of the most common, most debilitating, most costly, and most difficult to treat categories of chronic pain conditions that are characterized by a lesion or disease of the somatosensory nervous system. Managing neuropathic pain is challenging and requires skillful assessment and comprehensive and integrated treatment strategies that are mechanism-guided, evidence-based, and individualized. However, these critical and integral elements are very fragmented in the current literature. The mechanistic understanding of neuropathic pain is typically found in basic research articles. Clinical research evidence is presented in forms of clinical trials with emphasis on minimizing biases such as those from patient selection and assessment. Individualized considerations for each patient are usually presented in case reports and problem-based learning discussions. This book overcomes these barriers and integrates all the critical elements around individual patient care into a coherent management strategy that is practical and applicable to daily clinical practice. Rather than compiling what have been published in the literature, this work emphasizes on identifying and highlighting the key points or findings that guide decision-making in clinical practice. It integrates the key points around a typical case scenario that not only represents the core of the diagnostic and therapeutic processes but also allows introduction and differentiation of painful conditions that bare similarities with the case in hand. The overarching goal is to improve clinical outcomes through better understanding of the mechanisms, more accurate diagnosis, and wiser and more comprehensive treatment strategies.
Download or read book Management of Peripheral Nerve Problems written by George E. Omer and published by . This book was released on 1998 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here's a completely expanded and restructured edition of the classic work on nerve problems outside the brain and spine! Coverage ranges from surgical anatomy, and diagnostic and basic techniques...through trauma, compression syndromes, and limb reconstruction. Current and comprehensive, this text is the result of contributions from experts in hand surgery, orthopedics, plastic surgery, neurosurgery, and rehabilitation.
Download or read book Surgical Disorders of the Peripheral Nerves written by Rolfe Birch and published by Springer Science & Business Media. This book was released on 2011-01-21 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the highly praised first edition of Surgical Disorders of the Peripheral Nerves was published in 1998, greater understanding of the the molecular and cellular events which underlie the response of nerves to injury, regeneration and neuropathic pain has been achieved. This second edition has been fully updated in line with new clinical knowledge, and also incorporates the extensive study of thousands of surgical case studies spanning repairs of the supraclavicular plexus in the adult, the birth lesion of the brachial plexus,compound nerve injury and iatrogenous injury. Beginning with the fundamentals of the anatomy and function of the peripheral nervous system, and working its way through various types of injury, operative methods, the regeneration and recovery of nerves, surgical reconstruction, pain, and rehabilitation, this eloquently written work provides the reader with the solid understanding required to successfully perform surgery on the peripheral nervous system. Dr Shelagh Smith, joined by Dr Ravi Knight, has rewritten the chapter Electrodiagnosis. Professor Tara Renton has written a new chapter on injuries to the trigeminal nerve in maxilla-facial and dental work. The drawings, by Mr Philip Wilson, are new. Most of the 700 illustrations are also new. This thorough and authoritative look at the surgical treatment of the peripheral nerves is fully illustrated throughout with exquisite line diagrams and clear, instructive photographs.
Download or read book Hypnosis for Chronic Pain Management Workbook written by Harborview Medical Center Mark P. Jensen Professor and Vice Chair for Research Department of Rehabilitation Medicine and published by Oxford University Press, USA. This book was released on 2011-04-02 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you suffer from chronic pain, whether as a result of an injury, illness, or accident, you know it can interfere with every aspect of your life. You may also know the medical treatments currently available are limited and, for many, ineffective. Current research has shown hypnosis to be an effective treatment for managing chronic pain, and almost all patients who learn self-hypnosis skills benefit from this approach. The hypnosis treatment found in this workbook has been scientifically tested and proven effective for reducing the intensity of chronic pain, including migraines, back pain, and tension headaches, among others. This workbook explains how to use these techniques to manage your chronic pain and take back control of your life and your health. Used in combination with the program described in the corresponding therapist guide, this workbook teaches you self-hypnosis skills for lessening your pain, enhancing your sleep, and improving your mood. The first chapters will help you understand how hypnosis works by changing how your brain deals with information it receives from the body. The complete hypnosis treatment described in this book, alongside the treatment you receive from your clinician, will ultimately teach you skills for pain management that you can use at any time, and for the rest of your life. "An excellent blueprint to understanding pain and the fundamentals of how hypnosis combined with CBT can offer pain amelioration. Perfect, even for uninitiated practitioners who wish to use empirically based scripts."--Jeffrey Zeig, Ph.D., The Milton Erickson Foundation "Pain can too easily enslave people, holding them captive in many different ways. It is a liberating theme of empowerment that echoes throughout Dr. Jensen's work: he empowers clinicians to work more knowledgeably and skillfully with people who suffer painful conditions using his therapist guide, and he encourages the suffering individual to break free from pain's grip with the practical pain management skills taught in his workbook. Dr. Jensen's vision for the many ways hypnosis can help reduce the debilitating effects of painful conditions is fresh, inspiring and should be regularly integrated into every pain management program."--Michael D. Yapko, Ph.D., Clinical Psychologist and author of Trancework: An Introduction to the Practice of Clinical Hypnosis (Third Edition) and Treating Depression with Hypnosis
Download or read book Examination of Peripheral Nerve Injuries written by Stephen Russell and published by Thieme. This book was released on 2011-01-01 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly Commended in Neurology by the British Medical Association, 2007 This book is an anatomically based guide to locating and diagnosing peripheral nerve entrapment and injuries, complete with all the fundamental science concepts and diagnostic techniques the clinician needs to address injuries in the upper and lower extremities of the body. Full-color photographs and easy-to-digest schematic illustrations aid the comprehension of complex anatomy and its variations, and help the reader learn the examination techniques described in the book.Highlights: Step-by-step descriptions supplemented by 150 full color illustrations and photographs guide the reader through the examination techniques Thorough review of the anatomy of each peripheral nerve helps the reader gain a firm understanding of normal structure essential for recognizing and diagnosing injury Emphasis on the most common anatomical variations in the peripheral nervous system prepares the reader for the full range of clinical scenarios Descriptions of the brachial and lumbosacral plexi in the context of their major branches allows the reader to fully grasp complicated structures Examination of Peripheral Nerve Injuries addresses the needs of residents, fellows, trainees, and students in a range of specialties including neurology, orthopedics, neurosurgery, rehabilitation medicine, plastic surgery, hand surgery, peripheral nerve surgery, physical therapy, pain management and primary care. Residents seeking an excellent board review in this area will appreciate the concise format and the wealth of information contained in this book.
