Download or read book Cellular and Molecular Regulation of Testicular Cells written by Claude Desjardins and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptual advances in the biological sciences are marked by the applica tion of new techniques and experimental strategies. Nowhere has this ge neric principle been more apparent than in the study of testicular cells, as judged by the evolution of themes presented at the Testis Workshop over the past 23 years. Like its predecessors, the 1995 Testis Workshop was structured to offer fresh insights and approaches for understanding the mechanisms of spermatogenesis and steroidogenesis. The chapters pre sented in this book emphasize three aspects of testicular cell function: first, the molecular analysis of the cell cycle; second, examination of the cell cycle, including the function and identification of specific macromolecules that direct the proliferation and differentiation of germ cells; and third, the development of Leydig cells and the role of specific macromolecules in the formation of testicular steroids. Each chapter is based on a lecture presented at the XIIIth Testis Work shop held on March 30 to April 1, 1995, at the Radisson Plaza Hotel in Raleigh, North Carolina. The selection of topics reflects the recommenda tions of the workshop'S organizing committee. Sincere thanks are due to the speakers who agreed to lecture and prepare chapters.
Download or read book Cell and Molecular Biology of the Testis written by Claude Desjardins and published by Oxford University Press, USA. This book was released on 1993 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive, multi-authored work on the structure and function of the mammalian testis. The approach emphasizes gene expression, translation and production of specific gene products and the cellular and molecular regulation of these fundamental processes. Rather than provide a global survey of all aspects of male reproduction, this book stresses specific mechanisms that underscore the structure and function of the testis. It explains old and new concepts from a cellular and molecular perspective. This novel approach allows the authors to forge links between cell and molecular biology and well-established aspects of spermatogenesis and steroidogenesis. The result is a well-focused, comprehensive, and synthetic analysis of testicular biology.
Download or read book Sertoli Cell Biology written by Michael D. Griswold and published by Academic Press. This book was released on 2014-11-19 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro. Fully revised Written by experts in the field Summarizes 10 years of research Contains clear explanations and summaries Provides a summary of references over the last 10 years
Download or read book Comparative Cellular and Molecular Biology of Testis in Vertebrates written by Sardul S. Guraya and published by . This book was released on 2001 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comparative review of advances in the structure, biochemistry, function and intercellular communication at the molecular level in the testis of different groups of non-mammalian vertebrates and mammals, including ruminants and humans.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms in Spermatogenesis written by C.Y. Cheng and published by Springer Science & Business Media. This book was released on 2009-10-24 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.
Download or read book Testicular Function From Gene Expression to Genetic Manipulation written by Mario Stefanini and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the text of the plenary lectures given by internationally recognized experts in the field of gametogenesis and endocrinology at the 10th European Workshop on Molecular and Cellular Endocrinology of the Testis. Topics include spermatogonial transplantation, germ stem cell biology, regulation of meiosis and spermiogenesis, growth factors, cell signaling and transduction, steriodogenesis, androgen-regulated genes, sperm activation and sperm factors active at fertilization. The present volume pays particular attention to the use of genetically manipulated animal models in the study of the regulation of spermatogenesis and testicular functions.
Download or read book Molecular and Cellular Endocrinology of the Testis written by G. Verhoeven and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Workshops on Molecular and Cellular Endocrinology of the Testis have become by now a well-established tradition. Thanks to their special format, the quality of the main lectures and miniposters, and the vivid discussions, they enjoy the ever-increasing interest and active participation of all European scientists working in the field. Moreover, since the very beginning they have attracted investigators from all over the world. The most recent "Testis Workshop" was held in De Panne, Belgium, from 27-3\ March, 1994. As always, the frame work of the workshop was provided by a series of lectures delivered by a panel of internationally recognized authorities. These lectures are ga thered in the present volume of the Ernst Schering Foundation Work shop series. Together with the Miniposter book they constitute an excel lent written account of the Proceedings of the 8th European Testis Workshop. The testis undoubtedly represents one of the most complex and in triguing tissues in the body. Both its endocrine function, the secretion of male sex hormones, and its exocrine role, the production of mature spermatozoa, continue to raise startling questions to clinicians, physi ologists, endocrinologists, and scientists involved in fundamental re search. Few organs maintain and support a differentiation process as complicated as spermatogenesis; few tissues continually display both mitotic and meiotic cell cyles in such a stringently controlled fashion or a comparable need for coordinated endocrine and local control.
Download or read book Molecular Biology of the Male Reproductive System written by David de Kretser and published by Elsevier. This book was released on 2012-12-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. - Provides up-to-date reviews of the molecular and cellular biology of male reproduction - Includes chapters on the developmental biology of the testes - Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes
Download or read book The Sertoli Cell written by Lonnie Dee Russell and published by . This book was released on 1993 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Testicular Tangrams written by Focko Rommerts and published by Springer Science & Business Media. This book was released on 2002-04-03 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past two decades research on the testis has created a vast number of publications. New techniques, such as cell and gene clon ing, germ cell manipulation and transplantation, as well as gene ex pression, have surpassed the classical approaches that involved studies on receptor activation and endocrine, paracrine and autocrine regula tory mechanisms. Due to the expansion of this field of research it has become increasingly difficult to integrate the large number of observa tions and relate them to the physiology and pathophysiology of the tes tis. More emphasis must, therefore, be put on the integration of isolated findings and the construction of the total picture. In order to stimulate this specific mental activity we have named this book Testicular Tan gram. We hope that the chapters in this book will be used as pieces of the testicular puzzle and that the reader enjoys composing new shapes. The chapters of this book are representative of the plenary lectures presented at the I ih European Workshop on Molecular and Cellular Endocrinology of the Testis held in Doorwerth The Netherlands, from April 6 - I 0, 2002. Publication of this book has been made possible by the generous support of the Ernst Schering Research Foundation. We would also like to thank the distinguished scientists, who have pro vided us with their excellent manuscripts well before the start of the Workshop. We acknowledge the help of Dr. U. -F. Habenicht, Dr. M.
Download or read book Testis Epididymis and Technologies in the Year 2000 written by B. Jegou and published by Springer Science & Business Media. This book was released on 2000-05-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of chapters present the most novel research on testicular and epididymal functions or on more general fields of hormone action and molecular cell biology as it is now a tradition. However, exceptionally, the book also contains several chapters dealing with the "Approaches and Tools in the Third Millenium". The unusual inclusion of technologies as such in the 2000 edition of the workshop was an absolute necessity, as these technologies are revolutionizing the fields of biology and medicine and, in many instances, how to do research. This volume gives the scientific community essential information about the very latest technical developments and their potential for future progress.
Download or read book Regulation of Testicular Cell Junction Dynamics written by Xu Zhang and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Regulation of Testicular Cell Junction Dynamics" by Xu, Zhang, 张栩, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Spermatogenesis is an important cellular process in which mature haploid spermatozoa are produced from diploid spermatogonia and finally released from the seminiferous epithelium into the tubular lumen. This process involves extensive and timely restructuring of cell junctions at the Sertoli-Sertoli cell interface where the blood-testis barrier (BTB) and basal ectoplasmic specialization (ES) are located and at the Sertoli-germ cell interface where apical ES is present. The restructuring of cell junctions is involved in facilitating the translocation of spermatocytes across the BTB into adluminal compartment of the seminiferous epithelium as well as the detachment of mature elongated spermatids from the epithelium for release. Turnover of the BTB and Sertoli-mature spermatid contact (apical ES) can be interrupted by environmental toxicant such as cadmium (Cd) and is tightly regulated by cytokines such as transforming growth factor betas (TGF-βs). However, the molecular mechanisms involved in the regulation of testicular cell junction dynamics have not been completely explored. This dissertation focused on examining the mechanisms on how Cd and TGF-β3 regulate junction proteins, nectin-2 and JAM-B respectively. Nectin-2 is found at the basal and apical ES for the formation of the BTB and Sertoli-spermatid adhesion. Results of this study have demonstrated that CdCl2 reduces nectin-2 mRNA and protein levels and causes the loss of nectin-2 at the cell-cell interface. Inhibitor and shRNA knockdown have shown that CdCl2 speeds up nectin-2 protein degradation through clathrin-mediated endocytosis. Immunofluorescence staining and endocytosis assays further confirmed that nectin-2 internalization is promoted upon Cd treatment. In addition, Cd causes nectin-2 gene repression by reducing the bioavailability of endogenous transcription factors as well as impeding the binding of positive regulators to the promoter region. Collectively, these results have unraveled a novel and direct regulatory mechanism of Cd-mediated male reproductive dysfunction and explain why testis is more susceptible to Cd toxicity than other tissues. Junctional adhesion molecule-B (JAM-B) is found between Sertoli cells at the BTB as well as between Sertoli and germ cells at the apical ES in the testis. It was found that TGF-β3 downregulates JAM-B mRNA and protein levels, and reduces the bioavailability of JAM-B at the site of cell-cell contact. TGF-β3 promotes JAM-B protein degradation via ubiquitin-proteasome pathway with the activation of Smad signaling cascade. Besides, TGF-β3 destabilizes JAM-B mRNA transcript via ERK1/2 and p54 JNK activation. These results have unraveled the mechanisms by which TGF-β3 exerts negative regulatory effects on JAM-B expression that is crucial for the BTB integrity and Sertoli-germ cell interaction. Taken together, the findings reported herein demonstrate that testicular cell junction proteins are regulated by environmental toxicant and cytokine at the transcriptional, post-transcriptional and post-translational levels. Data presented herein strengthen the understanding on how testicular cell junction dynamic is regulated and shed new insights for prevention of Cd-induced male infertility. DOI: 10.5353/th_b5312329 Subjects: Spermatogenesis Cell interaction
Download or read book The Testis written by Henry G. Burger and published by . This book was released on 1981 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Sertoli Cell and Germ Cell Differentiation written by R. Brehm and published by Springer Science & Business Media. This book was released on 2005-12-12 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.
Download or read book Signal Transduction in Testicular Cells written by Vidar Hansson and published by . This book was released on 1996 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Signaling in Spermatogenesis and Male Infertility written by Rajender Singh and published by CRC Press. This book was released on 2019-11-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis
