Download or read book Cellular and Molecular Mechanisms of Immunologic Tolerance written by Tomáš Hraba and published by . This book was released on 1981 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Dendritic Cell Mediated Immune Tolerance and Autoimmunity written by Fang Zhou and published by Frontiers Media SA. This book was released on 2024-04-09 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.
Download or read book Cellular and Molecular Mechanisms of Immune Tolerance Induction in Hemophilia A written by Mirjam Meißner and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular and Molecular Mechanisms in Immune Tolerance to Renal Cancer written by Xavier Frigola Baró and published by . This book was released on 2009 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Immunological Self Recognition written by Frederick Alt and published by Academic Press. This book was released on 2014-06-28 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.
Download or read book Immunological Tolerance written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunological Tolerance written by David H. Katz and published by Academic Press. This book was released on 2014-06-28 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.
Download or read book Cellular and Molecular Mechanisms of Immunological Tolerance written by and published by . This book was released on 1980 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Oral Tolerance written by Olivier Morteau and published by Springer Science & Business Media. This book was released on 2004-08-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral tolerance is a major immunological property of the gastrointestinal mucosa. It plays a critical role in immune defence by preventing inflammatory and allergic responses to dietary and non pathogenic microbial antigens. The interest in oral tolerance has been renewed in the recent years, due to novel insights on its cellular mechanisms and potential clinical applications in the treatment of autoimmune diseases. Oral Tolerance: Cellular and Molecular Basis, Clinical Aspects, and Therapeutic Potential, has been designed as a concise yet comprehensive overview of the newest fundamental and clinical advances in the field. Based on the outstanding contribution of world experts, this book will be helpful to students, clinicians, and researchers working in mucosal immunology and gastroenterology. The first part of this volume describes the structure and functions of the gastrointestinal mucosa and the fundamental features and mechanisms of oral tolerance, including the role of T cells, cytokines, IgA antibodies, and bacterial antigens. The second part explores the clinical implications of the disruption of oral tolerance in Inflammatory Bowel Diseases, food and milk allergies, and coeliac disease in particular. The final chapter focuses on the clinical potential of oral tolerance as a promising therapeutic tool.
Download or read book Cellular and Molecular Mechanisms Underlying Immune Tolerance Against Type 1 Diabetes written by Weirong Chen and published by . This book was released on 2016 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing [beta]-cells are selectively destroyed by self-reactive T cells. In prior studies, we incorporated mimotope p79 into an Ig molecule and the resulting Ig-p79 chimera was able to prevent the adoptive transfer of T1D by diabetogenic BDC2.5 T cells. Further analysis has shown that these T cells are retained in the spleen and cannot migrate to the pancreas due to diminished expression of the transcription factor T-bet and downregulation of the chemokine receptor CXCR3. Investigation of the molecular mechanisms underlying this form of T cell tolerance indicates that expression of mammalian target of rapamycin (mTOR), a conserved serine/threonine kinase, is inhibited and its function is impaired. In contrast, overexpression of mTOR or its positive regulator, AKT, in BDC2.5 T cells restores the expression of T-bet and CXCR3, reestablishes the pancreatic infiltration of those T cells and consequently, nullifies antigen-induced tolerance. These findings suggest that PI3K-AKT-mTOR pathway, via modulating CXCR3, determines the trafficking ability of self-reactive T cells. Ig-p79-mediated T cell tolerance is associated with the upregulation of programmed deathligand 1 (PD-L1) on antigen presenting cells (APCs). Blockade of PD-L1 restores mTORC1 signaling and CXCR3 expression, reestablishes T cell infiltration in the pancreas and consequently, abolishes Ig-p79-induced tolerance. Moreover, binding of programmed death-1 (PD-1) on T cells to PD-L1 on APCs leads to recruitment of SHP-2 phosphatase to the cytoplasmic tail of PD-1, SHP-2 then induces dephosphorylation of phosphatidylinositol-3-kinase protein (PI3K), leading to defective function of the mTORC1 pathway, diminished CXCR3 expression and suppression of T1D development. Thus, this study not only delineates the molecular mechanisms underlying antigen-induced T cell tolerance but also provides a useful target for modulation of pathogenic T cells and treatment of type 1 diabetes.
Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Download or read book The Molecular Mechanisms of Regulatory T cell Immunosuppression written by Kendall A. Smith and published by Frontiers E-books. This book was released on with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 production and action, and the production of suppressive cytokines such as IL-10 and Tumor Growth Factor-beta, to list a few. However, the field has thus far failed to come to a consensus, such that some investigators have now asserted that many molecular mechanisms may be operative, in fact that perhaps all of the described mechanisms may account for the suppressive effects of these cells, acting either simultaneously or sequentially. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for T-Reg immunosuppression.
Download or read book Immunological Tolerance written by Ashleigh S. Boyd and published by Humana Press. This book was released on 2019-01-17 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition provides a detailed, up-to-date overview of methods used in the field of immune tolerance. Chapters guide readers through tolerogenic cell types, isolating tolerogenic cell populations for study and therapeutic utility, multiple methods to study the mechanisms underpinning tolerance, methods to induce tolerance through thymus progenitors, and methods to assess the breakdown of immune tolerance in specific pathological conditions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Immunological Tolerance: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Download or read book Mechanisms of Immunological Self tolerance written by Guido Kroemer and published by R. G. Landes. This book was released on 1994 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the multiple mechanisms that are involved in maintaining immunological self-tolerance. It presents an overall organigram of immune homeostasis, revealing the strategema of the immune system to take advantage of several tolerance-inducing mechanisms that are interconnected in series. The molecular mechanisms governing each individual tolerance-inducing event are explored extensively.
Download or read book The Molecular Mechanisms Supporting Peripheral T Cell Tolerance Potential Therapeutic Approaches to Autoimmunity and Allograft Rejection written by D.L. Mueller and published by . This book was released on 2007 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
