Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Download or read book Cell Language Theory The Connecting Mind And Matter written by Sungchul Ji and published by World Scientific. This book was released on 2017-11-24 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the results of 45 years of research on a wide range of topics, including atomic physics, single-molecule enzymology, whole-cell metabolism, physiology, pharmacology, linguistics, semiotics, and cosmology. It describes the first comprehensive molecular theory of the genotype-phenotype coupling based on two key theoretical concepts: (i) the conformon, the conformational wave packet in biopolymers carrying both the free energy and genetic information; and (ii) the intracellular dissipative structures, the chemical concentration waves inside the cell that serve as the immediate drivers of all cell functions. Conformons provide the driving forces for all molecular machines in the cell, and intracellular dissipative structures coordinate intra- and intercellular processes such as gene expression and cell-cell communications.One of the predictions made by the cell language theory (CLT) is that there are two forms of genetic information — the Watson-Crick genes transmitting information in time (identified with DNA), and the Prigoginian genes transmitting information in space (identified with RNA expression profiles). The former is analogous to sheet music or written language and the latter is akin to audio music or spoken language, both being coupled by conformons acting as the analog of the pianist. The new theory of DNA structure and function constructed on the basis of CLT can rationally account for most of the puzzling findings recently unearthed by the ENCODE (Encyclopedia of DNA Elements) project.The Cell Language Theory has important applications in biomedical sciences including drug discovery research and personalized medicine on the one hand and in the mind-body research and consciousness studies on the other.

Download or read book hack CELL Volume 1 written by Ryo Suzukaze and published by TokyoPop. This book was released on 2010-03-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hospital patient Midori Shinomura learns that she is mysteriously bound to another Midori, a warrior in The World, an on-line computer game, and in order to save them both, the Midori in the game must solve the mysteries of her own past.

Download or read book The Lives of a Cell written by Lewis Thomas and published by Penguin. This book was released on 1978-02-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things. Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine. Lewis Thomas writes, "Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us."

Download or read book Dynamics of the Il 2 Cytokine Network and T cell Proliferation written by Dorothea Busse and published by Logos Verlag Berlin GmbH. This book was released on 2010 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.

Download or read book Cell Polarity 2 written by Klaus Ebnet and published by Springer. This book was released on 2015-02-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or several aspects of cell polarity are impaired, and in which a loss of cell polarity possibly contributes to disease (e.g. epithelial-to-mesenchymal transition in cancer, role of polarity proteins in cancer). Both volumes are intended for professors, group leaders and researchers in cell biology as well as for medical professionals working in anatomy, cell biology, physiology, pathology and tumor biology.

Download or read book Cell Biology Genetics Molecular Biology Evolution and Ecology Volume 2 written by Dr. Sonali Santosh Kadam and published by AG Publishing House. This book was released on with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: First stated as a method for understanding the basis of biological events, molecular biology seeks to understand how organisms work by delving into the structure and function of individual molecules and how these molecules interact with one another and with the larger environment. According to this book understanding how the chemicals that make up cells impact the behavior of living things is a central goal of molecular biology and genetics. To understand how these molecules work in the dynamic environment of a live cell, biologists use a wide range of molecular and genetic techniques.These methods are being used by groups in our department to investigate a broad range of issues, including as the basic mechanisms governing transcription and translation as well as pathways involved in signal transduction. Among them are the role of the senses of sight and smell and how genetic diversity in wild populations influences evolution. Although the systems being studied include a variety of model species, including bacteria, the yeast, slime molds, worms, the fruit flies, zebrafish, and mice, the findings from these research have some direct or indirect relevance to human health. This book covers the key topics in cell biology, genetics, molecular biology, evolution, and ecology, such as the structure and function of nucleic acids, a general review of cells, and DNA replication with knowledge of genetics and their evolutionary histories.

Download or read book Cell Biology and Translational Medicine Volume 2 written by Kursad Turksen and published by Springer. This book was released on 2018-11-28 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This online first book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the second volume of a continuing series.

Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Download or read book Thomas Hematopoietic Cell Transplantation 2 Volume Set written by Stephen J. Forman and published by John Wiley & Sons. This book was released on 2016-12-27 with total page 1789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Download or read book The nature of activatory and tolerogenic dendritic cell derived signal 2 written by Francesca Granucci and published by Frontiers E-books. This book was released on 2014-07-08 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most interesting issues in immunology is how the innate and adaptive branches of the immune system cooperate in vertebrate organisms to respond and destroy invading microorganisms without destroying self-tissues. More than 20 years ago, Charles Janeway proposed the innate immune recognition theory [1]. He hypothesized the existence of innate receptors (Pattern recognition receptors, PRRs) that, by recognizing molecular structures associated to pathogens (PAMPs) and being expressed by antigen presenting cells (APCs) and epithelial cells, could alert the immune system to the presence of a pathogen, making it possible to mount an immediate inflammatory response. Moreover, by transducing the alert signal in professional APCs and inducing the expression of costimulatory molecules, these receptors could control the activation of lymphocytes bearing clonal antigen-specific receptors, thereby promoting appropriate adaptive immune responses. Since adaptive immunity can be activated also following sterile inflammatory conditions, it was subsequently proposed by Polly Matzinger that the innate immune system could be also activated by endogenous danger signals, generically called danger associated molecular patterns (DAMPs)[2]. The first prediction has been amply confirmed by the discovery of Toll-like receptors [3; 4; 5] and cytoplasmic PRRs such as RIG-like receptors [6]. Other PRR families such as the NOD-like receptors and C-type lectins exert immunogenic or tolerogenic signals [7; 8; 9] and may recognize not strictly pathogens but also endogenous danger signals that may lead to inflammasome activation [10; 11] . Dendritic cells (DCs) have been identified as the cells of the innate immune system that, by sensing PAMPs or DAMPs transduce signals to the nucleus. This leads to a transcriptional reprogramming of DCs with the consequent expression of three signals, namely signal 1 (MHC+peptide), signal 2 (surface costimulatory molecules) and signal 3 (cytokines) necessary for the priming of antigen-specific naïve T cell responses (signal 1 and 2) and T cell polarization (signal 3). The reason why DCs are superior with respect to other professional APCs in naïve T cell activation has not been unequivocally defined but in vivo may mainly result from their migration capacity to secondary lymphoid organs. It has not been established whether DCs can provide a special “signal 2” or simply very high levels, compared with other APCs, of commonly expressed signals 1 and 2, so that a naïve T cell could reach the threshold of activation. A second aspect of DC biology needs also to be taken into account. Concerning the question of how self-tissues are not destroyed following the initiation of adaptive immune responses, different mechanisms of central and peripheral auto-reactive T cell tolerization have been proposed [12]. In particular, it has been defined that high affinity T cells are deleted in the thymus, while low affinity auto-reactive T cells or T cells specific for tissue-sequestered antigens that do not have access to the thymus are controlled in the periphery. In a simplified vision of how peripheral T cell tolerance could be induced and maintained, it was thought that, in resting conditions, immature DCs, expressing low levels of signal 1 and low or no levels of signal 2, were able to induce T cell unresponsiveness. Nevertheless, it is now clear that a fundamental contribution to the peripheral tolerance is due to the conversion of naïve T cells into peripheral regulatory T cells (pTreg cells) and it is also clear that DCs need to receive a specific conditioning to become able to induce pTreg cell differentiation. Even more intriguing is that also DCs activated through PRRs, with particular Toll like receptor (TLR) agonists, are capable of generating pTreg cell conversion if these agonists induce the production of the appropriate cytokines.

Download or read book Deciphering the T Cell Response in SARS CoV 2 Infection written by Alessio Mazzoni and published by Frontiers Media SA. This book was released on 2024-07-22 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: COVID-19 is a recently emerged infectious disease caused by the novel coronavirus SARS-CoV-2. The immune system has a primary role in pathogen elimination and a rapid and effective response can limit disease severity. In this context, T cells play the major role in cell mediated adaptive immune response. The protective role of CD4+ and CD8+ T cells has been inferred from studies on patients who recovered from SARS and MERS and accumulating data are now showing their relevance in SARS-CoV-2 infection. Moreover, memory T cells induced by previous pathogens can shape the susceptibility to, and the clinical severity of other infections, but the complete picture has yet to be elucidated. If the virus is not rapidly eliminated, COVID-19 may progress towards a secondary inflammatory phase that is directly responsible for a worsening in clinical symptoms and immune system impairment. Besides marked lymphopenia, COVID-19 patients’ T cell compartment displays several alterations involving different subpopulations of T cells in terms of phenotype, metabolic profile and functionality.

Download or read book Evaluation of mixed cell types and 5 Iodo 2 Deoxyuridine treatment upon plaque assay titers of human enteric viruses written by William H. Benton and published by . This book was released on 1986 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Desperation written by Stephen King and published by Simon and Schuster. This book was released on 2016-04-26 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several cross-country travelers--including a writer, a family on vacation, and a professor and his wife--end up in the little mining town of Desperation, where a crazy policeman and evil forces compel them to fight for their lives.

Download or read book Physical Biology of the Cell written by Rob Phillips and published by Garland Science. This book was released on 2012-10-29 with total page 1089 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that

Download or read book Molecular Biology of the Cell 6E The Problems Book written by John Wilson and published by Garland Science. This book was released on 2014-11-21 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Problems Book helps students appreciate the ways in which experiments and simple calculations can lead to an understanding of how cells work by introducing the experimental foundation of cell and molecular biology. Each chapter reviews key terms, tests for understanding basic concepts, and poses research-based problems. The Problems Book has be