Download or read book Cartilage Defect Repair by Osteochondral Allografts written by Andrea L. Pallante and published by . This book was released on 2012 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Articular cartilage exhibits limited intrinsic healing, and when defects are left untreated, they can increase in size and cartilage degeneration may progress to end-stage joint failure. Osteochondral allografting has been widely used in the clinic to treat large or multiple focal defects, or as a salvage procedure to avoid total joint replacement, and aims to restore mature, hyaline cartilage in a biologically, structurally, and functionally appropriate manner. Repair outcomes may be influenced by the presence of viable chondrocytes within graft cartilage and the integration of the graft bone to surrounding host tissue. Thus, the overall motivation of this dissertation work was to develop an integrative and multi-scale approach to cartilage defect repair analysis by osteochondral allografts in order to expand the current understanding of in vivo cartilage and bone remodeling. A novel approach for analyzing in vivo cartilage defect repair by osteochondral allografts was developed using interdisciplinary and multi-scale analysis methods in the goat model. Maintenance of cartilage load-bearing function in allografts in vivo was associated with zonal maintenance of cartilage cellularity and matrix content. Reduced cellularity at the articular surface, resulting from 4°C storage, was associated with variable long-term outcomes, while allograft failure was accompanied with cartilage softening, loss of cells/matrix, and/or graft subsidence. Production of the lubricant, proteoglycan-4 (PRG4), from allografts was a useful marker of biological performance. 37°C storage supports long-term chondrocyte viability, especially at the vulnerable articular surface. Bone structure in allografts was altered in vivo compared to non-operated bone, with allografts displaying bone cysts, and bone surface channels with or without roughening at the bone-cartilage interface. This work has further elucidated the interrelationship between biological and structural aspects of cartilage and bone remodeling in vivo after osteochondral allografting. Such analysis has established the inferiority of 4°C stored allografts versus fresh allografts, identified potential biomarkers of allograft performance and alternative storage protocols, and provided insight into the pathogenesis of subchondral bone cysts during cartilage defect repair. Analyzing cartilage and bone biology, structure, and function in an integrative manner identified properties of the osteochondral tissue that are critical to repair efficacy and potential mechanisms of graft success/failure.
Download or read book Cartilage Restoration written by Jack Farr and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempting to bridge the gap between the science and art of cartilage restoration, Cartilage Restoration: Practical Clinical Applications combines an overview of clinical research and methodologies with clinical cases to help guide the orthopedic treatment and care of patients presenting with cartilage issues. With chapters written by internationally-renowned orthopedic surgeons, topics include an overview of current surgical options, debridement and marrow stimulation, autograft plug transfer, allografts, cell therapy, and meniscal issues. Cartilage Restoration is a valuable resource for orthopedic surgeons, residents, and fellows.
Download or read book The Illustrative Book of Cartilage Repair written by Deepak Rajkumar Goyal and published by Springer Nature. This book was released on 2020-10-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book employs a wealth of high-quality illustrations to provide the reader with a detailed understanding of the anatomy and the histology of the cartilage, the etiology and the classification of the cartilage lesions, and the numerous techniques employed for cartilage repair. Detailed attention is devoted to healthy cartilage, to each stage in the degenerative process, and to the response of the cartilage to the treatment. Imaging of the damaged and the repaired cartilage, as well as the information on the biomechanics are provided in great detail. The chapters on the techniques cover a wide range of approaches: marrow stimulation techniques, osteochondral cylinder transfer techniques, first, second and third generation autologous chondrocyte implantation techniques, allografts, cell-based therapies, orthobiologic approaches, and the role of 3D printing. The chapters closes with a consideration of the success of rehabilitation devices and the long-term results of cartilage repair.The book will be invaluable for all general orthopaedic and arthroscopic surgeons seeking a deeper knowledge of cartilage science and will help to dispel the confusion that still surrounds the reparative treatment. The authors are recognized experts in the fields of cartilage histology, assessment, classification, and repair.
Download or read book Osteochondral Allografts written by American Association of Tissue Banks and published by Little, Brown Medical Division. This book was released on 1983 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cartilage Restoration written by Jack Farr and published by Springer. This book was released on 2018-06-12 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a revised and expanded second edition, this practical text utilizes the most current evidence and knowledge of articular cartilage as the basis for clinical interventions for cartilage repair and restoration, combining an overview of clinical research and methodologies with clinical cases to help guide the orthopedic treatment and care of patients presenting with cartilage issues. Carefully updated chapters discuss the state-of-the-art in cartilage anatomy, defects and imaging, current tibiofemoral and patellofemoral surgical options, debridement and marrow stimulation, osteochondral autografts and allografts, osteotomies, cell therapy, and meniscal transplantation. New chapters explore new surgical treatment strategies and revision for failed cartilage repair, case vignettes presenting real-life treatment decisions and outcomes, and rehabilitation protocols following cartilage repair. Written and edited by experts in the field and bringing the most recent literature and research to bear, Cartilage Restoration remains a valuable resource on joint preservation for orthopedic surgeons, residents, and fellows, sports medicine specialists and rheumatologists.
Download or read book Articular Cartilage Injury of the Knee Basic Science to Surgical Repair written by James P. Stannard and published by Thieme. This book was released on 2013-04-15 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: A contemporary guide on articular cartilage injury of the knee Articular Cartilage Injury of the Knee is a comprehensive reference that combines the basic scientific knowledge of articular cartilage as it relates to patient health and disease with patient-focused diagnosis and treatment options. This book emphasizes the importance of bridging the divide between basic science and clinical applications in order to select the best possible treatment when injuries occur. Key Features: Provides clinically-relevant information on each topic that can easily be applied in practice Showcases the latest techniques in transplantation and scaffolds for cartilage repair Includes a focused chapter on assessment outcomes after cartilage repair of the knee Written and edited by leading orthopedic surgeons and basic science experts who represent the most current philosophy of effective management of articular cartilage injury of the knee Orthopedic surgeons specializing in the lower extremity will find this book to be an excellent resource that they can consult to guide them in the treatment of patients with articular cartilage injury of the knee.
Download or read book Cartilage Repair and Regeneration written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2018-02-14 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is the result of a partnership that began in 2011, when I received for the first time the invitation to be the scientific editor of a book on bone grafting, by the still little publisher known as InTech. Now six years later, InTech has grown and thrived. My respect and warm approval for the quality of the publisher's work only increased. The hyaline cartilage is a tissue that challenges tissue engineering and regenerative medicine because of its avascular nature. In the 11 chapters of this book, the reader will find texts written by researchers working on advanced topics related to basic laboratory research, as well as excellent reviews on the clinical use of currently available therapies.
Download or read book Developing Insights in Cartilage Repair written by Pieter J. Emans and published by Springer Science & Business Media. This book was released on 2013-10-16 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book discusses cartilage repair and all its aspects. These aspects vary from basic insights in cartilage biology and regeneration via MRI, to results of existing cartilage repair techniques and upcoming novel approaches. Fundamental cartilage biology is the topic covered within the first chapters of the book. These chapters not only provide an insight in healthy, damaged and regenerative cartilage but also describe developments in gene therapy and methods to enhance chondrogenesis of stemcells and prevent hypertophic differentiation. There is a huge progress in the possibilities of MR imaging of both healthy, damaged and regenerative cartilage. These developments not only enable better monitoring of cartilage repair but may also unravel the pathophysiology of the development of cartilage defects. Different cartilage repair techniques (e.g. allografts, autologous chondrocytes transplantation [ACT], microfracture), there technical aspects (e.g. developments towards an total arthroscopic approach), pitfalls, and outcomes are reported in the following chapters. In these chapters factors important for the results of cartilage repair such as meniscal repair, patient factors are described. Finally, an overview of novel cartilage repair techniques such as minced cartilage, denovo cartilage and more areas are discussed in this comprehensive addition to the literature.
Download or read book Techniques in Cartilage Repair Surgery written by A. Ananthram Shetty and published by Springer Science & Business Media. This book was released on 2014-04-11 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cartilage defects are common. Cartilage repair surgery is not only fascinating but also surgically challenging. There are books dealing with basic science and some surgical aspect. This book fills a gap in surgical techniques for cartilage repair. All of the surgical chapters are logically organised, covering patient selection, patient setup/positioning, surgical approach, potential complications and troubleshooting. An attempt is made to compare with various surgical techniques. This book also covers anaesthesia, postoperative follow-up, pain management and rehabilitation. Both the editors and the authors are renowned experts in the field. This book will be invaluable for orthopaedic and sports medicine surgeons (consultants and training doctors) and is also of potential interest to physiotherapists, medical students, general practitioners, physical medicine and rehabilitation specialists and rheumatology specialists.
Download or read book Cartilage Repair and Joint Preservation of the Knee written by Tom Minas and published by Elsevier Health Sciences. This book was released on 2021-10-01 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated with recent technologies, current scientific knowledge, and the latest techniques, A Primer in Cartilage Repair and Joint Preservation of the Knee, 2nd Edition, presents the full range of treatment options for a changing, increasingly younger patient population. Using an easy-to-follow, step-by-step approach, Dr. Thomas Minas clearly teaches how to meet the new challenges of cartilage repair by utilizing the latest techniques and technologies, including advances in orthobiologics. Surgical photographs, abundant illustrations, and procedural videos provide detailed visual guidance. Details the systematic approach to diagnosis, patient management, surgical techniques, and rehabilitation for a variety of problems. Covers current scientific knowledge of cartilage properties, the etiology of damage and the intrinsic repair and regeneration processes. Helps you select the best treatment course for each patient through extensive coverage of options from non-surgical to mini-incision total knee arthroplasty. Discusses the latest evidence, research and challenges associated with new techniques such as MACI, ACI, HTO, DFO, and more. Features new and expanded coverage of the latest advances in orthobiologics including platelet-rich plasma, bone marrow stem cells, fat stem cells, scaffolds and much more. Includes key topics such as printed 3-D cartilage structures and the management of secondary cartilage lesions. Contains high-quality illustrations and surgical photos, as well as new videos that provide clear instructions on how to perform key procedures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Download or read book Osteochondral Allograft Preservation in a Serum free Chemically defined Media written by Joseph Thomas Garrity and published by . This book was released on 2011 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Articular cartilage has a very limited capacity as compared to other biological tissues to repair and regenerate because of its avascular nature. Chronic degradation of articular cartilage may result in osteoarthritis, the most common debilitating disease worldwide. In order to alleviate severe pain symptoms and dysfunction associated with osteoarthritis, treatment strategies to replace rather than repair the tissue have been developed. Osteochondral allografts (OCAs) allow the transplantation of whole cartilage tissue into a defect with viable cells, or chondrocytes that will maintain the cartilage matrix. Fresh OCAs have demonstrated greater than 75% clinical success in the treatment of articular cartilage lesions. Currently allografts are stored at 4°C and used within 28 days, however, FDA-mandated disease testing requires 14 days of screening which decreases the effective window for implantation to 14 days. The purpose of this study was to evaluate OCAs stored up to 56 days in a Control (DMEM supplemented with ITS, Sodium Pyruvate, L-ascorbic acid, and MEM Non-essential amino acids) and Test (DMEM) supplemented ITS+, Sodium Pyruvate, L-ascorbic acid, MEM Non-Essential amino acids, dexamethasone, boron, and TGF-[beta]3) media preparation at 4°C and 37°C. Media was changed and collected every 7 days. At Days 0, 28, and 56, full thickness cartilage was evaluated for cell viability, GAG and HP content, and histologic evaluation. Media was collected at Days 7, 14, 21, 28, 35, 42, 49, and 56 for GAG content of the media, a measure of GAG release from tissue. Media collected on Days 7, 28, and 56 was also evaluated for NO, PGE2, MMP, and cytokine content. Cell viability as well as tissue GAG and HP content were maintained at Day 0 levels up to Day 56 in the 37°C Control media. GAG release of tissues at 37°C indicated active metabolism in the tissue. The profile of cytokines released during storage by OCAs stored in the 37°C Control media may be a preliminary step towards a screening protocol for testing OCA viability during storage. Our work showed that storage in a serum-free chemically-defined media at 37°C can maintain OCAs \ better than the current tissue banking protocol for storage.
Download or read book Cartilage Repair Strategies written by Riley J. Williams and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this book is to create a comprehensive analysis of cartilage injury and repair strategies. Twenty chapters cover proven and emerging procedures and methodologies. Readers will be able to understand the clinical problem, appropriate diagnosis, and repair strategies relevant to first line and secondary cartilage repair procedures.
Download or read book Cartilage Injury of the Knee written by Aaron J. Krych and published by Springer Nature. This book was released on 2021-08-31 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cartilage injuries of the knee are common, and diagnosis and treatment options have continued to evolve. This book focuses on current non-operative and surgical treatment strategies for articular cartilage injuries, highlighting the controversies and different approaches from an international perspective. This book includes information on the basic science of cartilage structure and function, expert perspectives on imaging and diagnosing, as well as work-up of athletes and patients presenting with acute or chronic cartilage injury. It also provides an evidence base for current cutting-edge cartilage repair and restoration. Written by leading experts in the field, the book, published in collaboration with ISAKOS and ICRS, is vital reading for orthopaedic and sports medicine surgeons, fellows and residents. It is also of interest to sports trainers, physiotherapists, medical students, postgraduate students, and physical medicine and rehabilitation specialists.
Download or read book Custom Surgical Guides for Articular Cartilage Repair written by Alexander Fredric Szewczyk and published by . This book was released on 2018 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteochondral lesions are injuries which affect the bone and articular cartilage of knee joints. Osteochondral allografts procedures are commonly used to repair damaged articular cartilage. Due to inconsistent cut angles of the recipient and donor sites, surface incongruities after an allograft procedure can lead to poor outcomes. The purpose of this project was to develop a process that would produce surface-matching surgical guides from CT scans, which would ensure that allograft cutting tools were normal (perpendicular) to the articular cartilage when performing the procedure, therefore reducing surface incongruities. In order to achieve this, image processing software was developed to automatically orient CT scans of femurs in a standard way, additional software was developed to produce surface normal vectors from a defect site, and CAD models of surgical guides were created, prototyped, and tested for edge displacement improvements compared with unguided procedures.
Download or read book Current Issues in Treatment of Osteochondral Defects An Issue of Foot and Ankle Clinics written by Mark S. Myerson and published by Elsevier Health Sciences. This book was released on 2013-03-28 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue will provide a comprehensive overview of OCD, from the perspective of the Foot and Ankle surgeon. Topics to be covered include basic biology, advances in synthetic cartilage technology, surgical approaches, pediatric care, allografts, and the use of other surgical revision technology.
Download or read book The Knee Joint written by Michel Bonnin and published by Springer Science & Business Media. This book was released on 2013-07-04 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pushed by the progress of biology, technology and biomechanics, knee surgery has dramatically evolved in the last decades. This book is a "state of the art" concerning all aspects of knee surgery from ligament reconstruction to Total Knee Arthroplasty. An international panel of renowned authors have worked on this didactic fully illustrated book. It will help young surgeons to understand basic sciences and modern sugical techniques. The experienced surgeon will find help to deal with difficult cases and clarifications in recent technologic advances such as cartilage surgery, navigation and mini invasive surgery.
Download or read book Articular Cartilage Lesions written by Brian J. Cole and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Cole and Malek, recognized leaders in the field, wrote this cutting-edge text to fill the void in the literature regarding the management of articular cartilage disease and meniscal deficiency. The book enables orthopedic surgeons to develop an evidence-based decision-making framework that guides the management of articular cartilage lesions. Carefully chosen contributors provide readers with a practical background in articular lesions, patient assessment, and management strategies. Subsequent chapters address the gamut of current surgical techniques, from arthroscopy and debridement to unicondylar arthroplasty, in a step-by-step manner. More than 500 detailed illustrations, many in color, help readers understand and master treatments. Case studies, which include preoperative planning and postoperative outcomes, reinforce the decision-making process. Nearly every permutation and treatment option is covered, making this text a prime resource for surgeons committed to exercising sound judgement.
