Download or read book CARMA Proteins Playing a Hand of Four CARDs written by Frédéric Bornancin and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.
Download or read book Stiehm s Immune Deficiencies written by Kathleen E. Sullivan and published by Academic Press. This book was released on 2020-05-23 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stiehm's Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. - Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians - Fills an increasingly deep gap in the information available to clinicians - Presents both clinical management and scientific advances for immune deficiencies - Provides a primary resource for physicians in the field of immunodeficiencies - Includes website access to a range of videos relevant to the topics discussed
Download or read book Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2012-09-25 with total page 1071 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
Download or read book Contact Cards written by Kim Carlsberg and published by Bear. This book was released on 1996 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Divination systems are tools for accessing knowledge that is beyond our ordinary sensory ability. Contact Cards are the specific conduit for extraterrestrial information, initiating the exploration of intergalactic energies, stars, crop circles, and spaceships. For you voyagers seeking universal understanding during your earthly sojourns, playing with Contact Cards expands awareness of inner, as well as outer, space."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Download or read book Archetype Cards written by Caroline Myss and published by National Geographic Books. This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Archetypes are ancient, universal patterns of behavior that are embedded in what Carl Jung called the “collective unconscious.” Caroline Myss has created a unique set of 80 Archetype Cards, each individually designed to provide the basic Light and Shadow Attributes of a different Archetype. The deck also contains six blank cards on which you can create your own Archetypes. The deck comes with an instruction booklet explaining how to use the cards to help determine which Archetypes are most active in your psyche, and how they can lead you to achieve greater insights into your life. The deck is suitable to be used by itself, in conjunction with Caroline's book Sacred Contracts, or with any of her workshops and seminars.
Download or read book The 4 Hour Body written by Timothy Ferriss and published by Random House. This book was released on 2011-02-03 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will redefine how you approach losing weight. Based on over 15 years of research and with personal stories, amazing before and after photos, recipes and sidebars, The 4-Hour Body, from international bestselling author Tim Ferriss, will give unbelievable results and change the way you look forever. 'Mr. Ferriss makes difficult things seem very easy' -- NY Times 'The Superman of Silicon Valley' - Wired 'This book has changed my life' -- ***** Reader review 'An uncommon genius' -- ***** Reader review 'This book is awesome' -- ***** Reader review 'Educational and mind blowing' -- ***** Reader review ***************************************************************** Whatever your physical goal, The 4-Hour Body eclipses every other health manual by sharing the best kept secrets in the latest science and research to provide new strategies for redesigning the human body. And you don't need to exhaust yourself. International bestselling author, Timothy Ferriss, helps you reach your true genetic potential in 3-6 months with a commitment of less than four hours per week. You can pick and choose from a menu of options, from simple to extreme, for dramatic body changes. Packed full of personal case studies, before and after photos, recipes and top tips, this book will help you achieve your body goals in record time.
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 2084 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Academic Press. This book was released on 2014-12-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Download or read book History of Tofu and Tofu Products 965 CE to 2013 written by William Shurtleff and published by Soyinfo Center. This book was released on 2013-05 with total page 4016 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Yoga Journal written by and published by . This book was released on 1991-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 30 years, Yoga Journal has been helping readers achieve the balance and well-being they seek in their everyday lives. With every issue,Yoga Journal strives to inform and empower readers to make lifestyle choices that are healthy for their bodies and minds. We are dedicated to providing in-depth, thoughtful editorial on topics such as yoga, food, nutrition, fitness, wellness, travel, and fashion and beauty.
Download or read book Pediatric Allergy Principles and Practice E Book written by Donald Y. M. Leung and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
Download or read book This is Your Brain on Music written by Daniel Levitin and published by Penguin UK. This book was released on 2019-07-04 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the author of The Changing Mind and The Organized Mind comes a New York Times bestseller that unravels the mystery of our perennial love affair with music ***** 'What do the music of Bach, Depeche Mode and John Cage fundamentally have in common?' Music is an obsession at the heart of human nature, even more fundamental to our species than language. From Mozart to the Beatles, neuroscientist, psychologist and internationally-bestselling author Daniel Levitin reveals the role of music in human evolution, shows how our musical preferences begin to form even before we are born and explains why music can offer such an emotional experience. In This Is Your Brain On Music Levitin offers nothing less than a new way to understand music, and what it can teach us about ourselves. ***** 'Music seems to have an almost wilful, evasive quality, defying simple explanation, so that the more we find out, the more there is to know . . . Daniel Levitin's book is an eloquent and poetic exploration of this paradox' Sting 'You'll never hear music in the same way again' Classic FM magazine 'Music, Levitin argues, is not a decadent modern diversion but something of fundamental importance to the history of human development' Literary Review
Download or read book Out Of Control written by Kevin Kelly and published by Basic Books. This book was released on 2009-04-30 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Out of Control chronicles the dawn of a new era in which the machines and systems that drive our economy are so complex and autonomous as to be indistinguishable from living things.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Glory in the Heavens written by Hârun Yahya and published by GLOBAL YAYINCILIK. This book was released on 2004 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second book in this series brings to life the wonders of the universe and explains how it all began in a simple yet engaging way. The reader is taken on a fascinating scientific journey from planet earth, through the atmosphere into the solar system and the stars and galaxies beyond. In full colour and recommended for ages 10 and over.
Download or read book The World of Animals written by Harun Yahya and published by GLOBAL YAYINCILIK. This book was released on 2002 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Let s Learn Our Islam written by Harun Yahya and published by GLOBAL YAYINCILIK. This book was released on 2002 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
