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Book Capstone Design Courses  Part Two

Download or read book Capstone Design Courses Part Two written by Jay Goldberg and published by Morgan & Claypool Publishers. This book was released on 2012-09-01 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years, develop their communication, teamwork, project management, and design skills, and learn about the product development process. It prepares students for professional practice and serves as a preview of what it will be like to work as a biomedical engineer. The capstone design experience can change the way engineering students think about technology, themselves, society, and the world around them. It can make them aware of their potential to make a positive contribution to healthcare throughout the world and generate excitement for, and pride in, the engineering profession. Ideas for how to organize, structure, and manage a senior capstone design course for biomedical and other engineering students are presented here. These ideas will be helpful to faculty who are creating a new design course, expanding a current design program, or just looking for some ideas for improving an existing course. The better we can make these courses, the more "industry ready" our students will be, and the better prepared they will be for meaningful, successful careers in biomedical engineering. This book is the second part of a series covering Capstone Design Courses for biomedical engineers. Part I is available online here and in print (ISBN 9781598292923) and covers the following topics: Purpose, Goals, and Benefits; Designing a Course to Meet Student Needs; Enhancing the Capstone Design Courses; Meeting the Changing Needs of Future Engineers. Table of Contents: The Myth of the "Industry-Ready" Engineer / Recent Trends and the Current State of Capstone Design / Preparing Students for Capstone Design / Helping Students Recognize the Value of Capstone Design Courses / Developing Teamwork Skills / Incorporating Design Controls / Learning to Identify Problems, Unmet Needs, and New Product Opportunities / Design Verification and Validation / Liability Issues with Assistive Technology Projects / Standards in Capstone Design Courses and the Engineering Curriculum / Design Transfer and Design for Manufacturability / Learning from other Engineering Disciplines: Capstone Design Conferences / Maintaining a Relevant, Up-to-Date Capstone Design Course / Active Learning in Capstone Design Courses / Showcasing Student Projects: National Student Design Competitions / Managing Student Expectations of the "Real World" / Career Management and Professional Development / Conclusion

Book Capstone Design Courses  Part II

Download or read book Capstone Design Courses Part II written by Jay Goldberg and published by Springer Nature. This book was released on 2022-05-31 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years, develop their communication, teamwork, project management, and design skills, and learn about the product development process. It prepares students for professional practice and serves as a preview of what it will be like to work as a biomedical engineer. The capstone design experience can change the way engineering students think about technology, themselves, society, and the world around them. It can make them aware of their potential to make a positive contribution to healthcare throughout the world and generate excitement for, and pride in, the engineering profession. Ideas for how to organize, structure, and manage a senior capstone design course for biomedical and other engineering students are presented here. These ideas will be helpful to faculty who are creating a new design course, expanding a current design program, or just looking for some ideas for improving an existing course. The better we can make these courses, the more "industry ready" our students will be, and the better prepared they will be for meaningful, successful careers in biomedical engineering. This book is the second part of a series covering Capstone Design Courses for biomedical engineers. Part I is available online here and in print (ISBN 9781598292923) and covers the following topics: Purpose, Goals, and Benefits; Designing a Course to Meet Student Needs; Enhancing the Capstone Design Courses; Meeting the Changing Needs of Future Engineers. Table of Contents: The Myth of the "Industry-Ready" Engineer / Recent Trends and the Current State of Capstone Design / Preparing Students for Capstone Design / Helping Students Recognize the Value of Capstone Design Courses / Developing Teamwork Skills / Incorporating Design Controls / Learning to Identify Problems, Unmet Needs, and New Product Opportunities / Design Verification and Validation / Liability Issues with Assistive Technology Projects / Standards in Capstone Design Courses and the Engineering Curriculum / Design Transfer and Design for Manufacturability / Learning from other Engineering Disciplines: Capstone Design Conferences / Maintaining a Relevant, Up-to-Date Capstone Design Course / Active Learning in Capstone Design Courses / Showcasing Student Projects: National Student Design Competitions / Managing Student Expectations of the "Real World" / Career Management and Professional Development / Conclusion

Book Capstone Design Courses  Part Two

Download or read book Capstone Design Courses Part Two written by Jay R. Goldberg and published by Morgan & Claypool Publishers. This book was released on 2012 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years, develop their communication, teamwork, project management, and design skills, and learn about the product development process. It prepares students for professional practice and serves as a preview of what it will be like to work as a biomedical engineer. The capstone design experience can change the way engineering students think about technology, themselves, society, and the world around them. It can make them aware of their potential to make a positive contribution to healthcare throughout the world and generate excitement for, and pride in, the engineering profession.Ideas for how to organize, structure, and manage a senior capstone design course for biomedical and other engineering students are presented here. These ideas will be helpful to faculty who are creating a new design course, expanding a current design program, or just looking for some ideas for improving an existing course. The better we can make these courses, the more "industry ready" our students will be, and the better prepared they will be for meaningful, successful careers in biomedical engineering.This book is the second part of a series covering Capstone Design Courses for biomedical engineers. Part I is available online and in print (ISBN 9781598292923) and covers the following topics: Purpose, Goals, and Benefits; Designing a Course to Meet Student Needs; Enhancing the Capstone Design Courses; Meeting the Changing Needs of Future Engineers.Table of Contents: The Myth of the "Industry-Ready" Engineer / Recent Trends and the Current State of Capstone Design / Preparing Students for Capstone Design / Helping Students Recognize the Value of Capstone Design Courses / Developing Teamwork Skills / Incorporating Design Controls / Learning to Identify Problems, Unmet Needs, and New Product Opportunities / Design Verification and Validation / Liability Issues with Assistive Technology Projects / Standards in Capstone Design Courses and the Engineering Curriculum / Design Transfer and Design for Manufacturability / Learning from other Engineering Disciplines: Capstone Design Conferences / Maintaining a Relevant, Up-to-Date Capstone Design Course / Active Learning in Capstone Design Courses / Showcasing Student Projects: National Student Design Competitions / Managing Student Expectations of the "Real World" / Career Management and Professional Development / Conclusion

Book Engineering Capstone Design

Download or read book Engineering Capstone Design written by Bahram Nassersharif and published by CRC Press. This book was released on 2022-06-27 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structured with a practical approach, Engineering Capstone Design guides engineering students to successfully manage capstone design projects. The book addresses the challenge of open-ended design projects, often in a team-based format, discussing team member roles, communication, and cooperation. It incorporates accreditation requirements and provides a modern framework for working with industry, reinforced by the inclusion of case studies. Offers a structured process for capstone design, responsive to ABET accreditation requirements Explains how to manage design projects under critical timelines and budgets Covers essential topics and steps in a capstone design sequence, including defining, conceiving, presenting, prototyping, building, testing, and redesigning Considers industry perspectives, as well as design competitions Includes case studies for a look into industry experience In addition to guiding engineering students conducting capstone design projects, this book will also interest industry professionals who are engaged in product development or design problem-solving.

Book Practical Concepts for Capstone Design Engineering

Download or read book Practical Concepts for Capstone Design Engineering written by Frederick Bloetscher and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Concepts for Capstone Design Engineering is the first and only comprehensive senior-level college textbook that provides the essential information needed to complete a successful capstone project in civil or construction engineering. Students will gain valuable insight and preparation for civil and construction engineering professional practice, and will learn how to smoothly transition from strictly academic work to solving real-world problems in the context of their capstone projects. The authors provide professional quality work examples, case studies, helpful hints, and assignments at the end of each chapter that further enhance comprehension. In addition to providing students with the key skills necessary to successfully enter the profession, they will also be well prepared for the Fundamentals of Engineering Exam upon graduation. Key Features: Replicates the steps used by practicing engineers to complete design projects from site selection, investigation, and site planning, through the preliminary design calculations and drawing preparation. Offers an approach for integrating students, faculty, design professionals, clients, consultants and regulators bridging the gap between the classroom and the profession with astounding results Provides faculty with a framework for developing an effective capstone course, including examples of grading and rubric sheets for student presentations Appropriate for adoption as primary or supplemental reading in other engineering and construction courses as well

Book Designing and Teaching Undergraduate Capstone Courses

Download or read book Designing and Teaching Undergraduate Capstone Courses written by Robert C. Hauhart and published by John Wiley & Sons. This book was released on 2015-01-12 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enrich your students and the institution with a high-impact practice Designing and Teaching Undergraduate Capstone Courses is a practical, research-backed guide to creating a course that is valuable for both the student and the school. The book covers the design, administration, and teaching of capstone courses throughout the undergraduate curriculum, guiding departments seeking to add a capstone course, and allowing those who have one to compare it to others in the discipline. The ideas presented in the book are supported by regional and national surveys that help the reader understand what's common, what's exceptional, what works, and what doesn't within capstone courses. The authors also provide additional information specific to different departments across the curriculum, including STEM, social sciences, humanities, fine arts, education, and professional programs. Identified as a high-impact practice by the National Survey of Student Engagement (NSSE) and the Association of American Colleges and Universities' LEAP initiative, capstone courses culminate a student's final college years in a project that integrates and applies what they've learned. The project takes the form of a research paper, a performance, a portfolio, or an exhibit, and is intended to showcase the student's very best work as a graduating senior. This book is a guide to creating for your school or department a capstone course that ties together undergraduate learning in a way that enriches the student and adds value to the college experience. Understand what makes capstone courses valuable for graduating students Discover the factors that make a capstone course effective, and compare existing programs, both within academic disciplines and across institutions Learn administrative and pedagogical techniques that increase the course's success Examine discipline-specific considerations for design, administration, and instruction Capstones are generally offered in departmental programs, but are becoming increasingly common in general education as well. Faculty and administrators looking to add a capstone course or revive an existing one need to understand what constitutes an effective program. Designing and Teaching Undergraduate Capstone Courses provides an easily digested summary of existing research, and offers expert guidance on making your capstone course successful.

Book Design Education Today

Download or read book Design Education Today written by Dirk Schaefer and published by Springer. This book was released on 2019-05-16 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides extensive information on the key technical design disciplines, education programs, international best practices and modes of delivery that are aimed at preparing a trans-disciplinary design workforce for the future. It also presents a comprehensive overview of the scope of, and state of the art in, design education. The book highlights signature design education programs from around the globe and across all levels, in both traditional and distance learning settings. Additionally, it discusses professional societies for designers and design educators, as well as the current standards for professional registration, and program accreditation. Reflecting recent advances and emerging trends, it offers a valuable handbook for design practitioners and managers, curriculum designers and program leaders alike. It will also be of interest to students and academics looking to develop a career related to the more technical aspects of design.

Book Capstone Design Courses

Download or read book Capstone Design Courses written by Jay Richard Goldberg and published by Morgan & Claypool Publishers. This book was released on 2007 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years; develop their communication (written, oral, and graphical), interpersonal (teamwork, conflict management, and negotiation), project management, and design skills; and learn about the product development process. It also provides students with an understanding of the economic, financial, legal, and regulatory aspects of the design, development, and commercialization of medical technology. The capstone design experience can change the way engineering students think about technology, society, themselves, and the world around them. It gives them a short preview of what it will be like to work as an engineer. It can make them aware of their potential to make a positive contribution to health care throughout the world and generate excitement for and pride in the engineering profession. Working on teams helps students develop an appreciation for the many ways team members, with different educational, political, ethnic, social, cultural, and religious backgrounds, look at problems. They learn to value diversity and become more willing to listen to different opinions and perspectives. Finally, they learn to value the contributions of nontechnical members of multidisciplinary project teams. Ideas for how to organize, structure, and manage a senior capstone design course for biomedical and other engineering students are presented here. These ideas will be helpful to faculty who are creating a new design course, expanding a current design program to more than the senior year, or just looking for some ideas for improving an existing course.

Book Health Care Engineering Part II

Download or read book Health Care Engineering Part II written by Monique Frize and published by Springer Nature. This book was released on 2022-06-01 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part II of Health Care Engineering begins with statistics on the occurrence of medical errors and adverse events, and includes some technological solutions. A chapter on electronic medical records follows. The knowledge management process divided into four steps is described; this includes a discussion on data acquisition, storage, and retrieval. The next two chapters discuss the other three steps of the knowledge management process (knowledge discovery, knowledge translation, knowledge integration and sharing). The last chapter briefly discusses usability studies and clinical trials. This two-part book consolidates material that supports courses on technology development and management issues in health care institutions. It can be useful for anyone involved in design, development, or research, whether in industry, hospitals, or government.

Book Capstone Design Courses  Part II

Download or read book Capstone Design Courses Part II written by Jay Goldberg and published by Springer. This book was released on 2012-09-25 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years, develop their communication, teamwork, project management, and design skills, and learn about the product development process. It prepares students for professional practice and serves as a preview of what it will be like to work as a biomedical engineer. The capstone design experience can change the way engineering students think about technology, themselves, society, and the world around them. It can make them aware of their potential to make a positive contribution to healthcare throughout the world and generate excitement for, and pride in, the engineering profession. Ideas for how to organize, structure, and manage a senior capstone design course for biomedical and other engineering students are presented here. These ideas will be helpful to faculty who are creating a new design course, expanding a current design program, or just looking for some ideas for improving an existing course. The better we can make these courses, the more "industry ready" our students will be, and the better prepared they will be for meaningful, successful careers in biomedical engineering. This book is the second part of a series covering Capstone Design Courses for biomedical engineers. Part I is available online here and in print (ISBN 9781598292923) and covers the following topics: Purpose, Goals, and Benefits; Designing a Course to Meet Student Needs; Enhancing the Capstone Design Courses; Meeting the Changing Needs of Future Engineers. Table of Contents: The Myth of the "Industry-Ready" Engineer / Recent Trends and the Current State of Capstone Design / Preparing Students for Capstone Design / Helping Students Recognize the Value of Capstone Design Courses / Developing Teamwork Skills / Incorporating Design Controls / Learning to Identify Problems, Unmet Needs, and New Product Opportunities / Design Verification and Validation / Liability Issues with Assistive Technology Projects / Standards in Capstone Design Courses and the Engineering Curriculum / Design Transfer and Design for Manufacturability / Learning from other Engineering Disciplines: Capstone Design Conferences / Maintaining a Relevant, Up-to-Date Capstone Design Course / Active Learning in Capstone Design Courses / Showcasing Student Projects: National Student Design Competitions / Managing Student Expectations of the "Real World" / Career Management and Professional Development / Conclusion

Book Senior Design Experience

Download or read book Senior Design Experience written by Mansour Eslami and published by Agile Press. This book was released on 2008 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook mainly geared toward seniors in engineering, and aiming to meet the requirements for ABET (Accreditation Board for Engineering & Technology (U.S.))

Book Capstone Design Courses

Download or read book Capstone Design Courses written by Jay Goldberg and published by Springer Nature. This book was released on 2022-06-01 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years; develop their communication (written, oral, and graphical), interpersonal (teamwork, conflict management, and negotiation), project management, and design skills; and learn about the product development process. It also provides students with an understanding of the economic, financial, legal, and regulatory aspects of the design, development, and commercialization of medical technology. The capstone design experience can change the way engineering students think about technology, society, themselves, and the world around them. It gives them a short preview of what it will be like to work as an engineer. It can make them aware of their potential to make a positive contribution to health care throughout the world and generate excitement for and pride in the engineering profession. Working on teams helps students develop an appreciation for the many ways team members, with different educational, political, ethnic, social, cultural, and religious backgrounds, look at problems. They learn to value diversity and become more willing to listen to different opinions and perspectives. Finally, they learn to value the contributions of nontechnical members of multidisciplinary project teams. Ideas for how to organize, structure, and manage a senior capstone design course for biomedical and other engineering students are presented here. These ideas will be helpful to faculty who are creating a new design course, expanding a current design program to more than the senior year, or just looking for some ideas for improving an existing course. Contents: I. Purpose, Goals, and Benefits / Why Our Students Need a Senior Capstone Design Course / Desired Learning Outcomes / Changing Student Attitudes, Perceptions, and Awarenesss / Senior Capstone Design Courses and Accreditation Board for Engineering and Technology Outcomes / II. Designing a Course to Meet Student Needs / Course Management and Required Deliverables / Projects and Project Teams / Lecture Topics / Intellectual Property Confidentiality Issues in Design Projects / III. Enhancing the Capstone Design Experience / Industry Involvement in Capstone Design Courses / Developing Business and Entrepreneurial Literacy / Providing Students with a Clinical Perspective / Service Learning Opportunities / Collaboration with Industrial Design Students / National Student Design Competitions / Organizational Support for Senior Capstone Design Courses / IV. Meeting the Changing Needs of Future Engineers / Capstone Design Courses and the Engineer of 2020

Book Development of Capstone Design Courses for Engineering Processes

Download or read book Development of Capstone Design Courses for Engineering Processes written by J. Lewis Dorrity and published by . This book was released on 1990 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Models of Horizontal Eye Movements  Part II

Download or read book Models of Horizontal Eye Movements Part II written by John Enderle and published by Springer Nature. This book was released on 2022-06-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The control of saccades is initiated by the superior colliculus and terminated by the cerebellar fastigial nucleus, and involves a complex neural circuit in the mid brain. This book is the second part of a book series on models of horizontal eye movements. Table of Contents: 2009 Linear Homeomorphic Saccadic Eye Movement Model and Post-Saccade Behavior: Dynamic and Glissadic Overshoot / Neural Network for the Saccade Controller

Book Models of Horizontal Eye Movements

Download or read book Models of Horizontal Eye Movements written by Alireza Ghahari and published by Springer Nature. This book was released on 2022-06-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book series is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. In Part 1, early models of saccades and smooth pursuit are presented. A number of oculomotor plant models are described here beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th order oculomotor plant model. In Part 2, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. Part 3 describes a model of the saccade system, focusing on the neural network. It presents a neural network model of biophysical neurons in the midbrain for controlling oculomotor muscles during horizontal human saccades. In this book, a multiscale model of the saccade system is presented, focusing on a multiscale neural network and muscle fiber model. Chapter 1 presents a comprehensive model for the control of horizontal saccades using a muscle fiber model for the lateral and medial rectus muscles. The importance of this model is that each muscle fiber has a separate neural input. This model is robust and accounts for the neural activity for both large and small saccades. The muscle fiber model consists of serial sequences of muscle fibers in parallel with other serial sequences of muscle fibers. Each muscle fiber is described by a parallel combination of a linear length tension element, viscous element, and active-state tension generator. Chapter 2 presents a biophysically realistic neural network model in the midbrain to drive a muscle fiber oculomotor plant during horizontal monkey saccades. Neural circuitry, including omnipause neuron, premotor excitatory and inhibitory burst neurons, long lead burst neuron, tonic neuron, interneuron, abducens nucleus, and oculomotor nucleus, is developed to examine saccade dynamics. The time-optimal control mechanism demonstrates how the neural commands are encoded in the downstream saccadic pathway by realization of agonist and antagonist controller models. Consequently, each agonist muscle fiber is stimulated by an agonist neuron, while an antagonist muscle fiber is unstimulated by a pause and step from the antagonist neuron. It is concluded that the neural network is constrained by a minimum duration of the agonist pulse, and that the most dominant factor in determining the saccade magnitude is the number of active neurons for the small saccades. For the large saccades, however, the duration of agonist burst firing significantly affects the control of saccades. The proposed saccadic circuitry establishes a complete model of saccade generation since it not only includes the neural circuits at both the premotor and motor stages of the saccade generator, but it also uses a time-optimal controller to yield the desired saccade magnitude. Table of Contents: Acknowledgments / A New Linear Muscle Fiber Model for Neural Control of Saccades\footnotemark / A Physiological Neural Controller of a Muscle Fiber Oculomotor Plant in Horizontal Monkey Saccades\footnotemark / References / Authors' Biographies

Book Computerized Analysis of Mammographic Images for Detection and Characterization of Breast Cancer

Download or read book Computerized Analysis of Mammographic Images for Detection and Characterization of Breast Cancer written by Arianna Mencattini and published by Springer Nature. This book was released on 2022-05-31 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification and interpretation of the signs of breast cancer in mammographic images from screening programs can be very difficult due to the subtle and diversified appearance of breast disease. This book presents new image processing and pattern recognition techniques for computer-aided detection and diagnosis of breast cancer in its various forms. The main goals are: (1) the identification of bilateral asymmetry as an early sign of breast disease which is not detectable by other existing approaches; and (2) the detection and classification of masses and regions of architectural distortion, as benign lesions or malignant tumors, in a unified framework that does not require accurate extraction of the contours of the lesions. The innovative aspects of the work include the design and validation of landmarking algorithms, automatic Tabár masking procedures, and various feature descriptors for quantification of similarity and for contour independent classification of mammographic lesions. Characterization of breast tissue patterns is achieved by means of multidirectional Gabor filters. For the classification tasks, pattern recognition strategies, including Fisher linear discriminant analysis, Bayesian classifiers, support vector machines, and neural networks are applied using automatic selection of features and cross-validation techniques. Computer-aided detection of bilateral asymmetry resulted in accuracy up to 0.94, with sensitivity and specificity of 1 and 0.88, respectively. Computer-aided diagnosis of automatically detected lesions provided sensitivity of detection of malignant tumors in the range of [0.70, 0.81] at a range of falsely detected tumors of [0.82, 3.47] per image. The techniques presented in this work are effective in detecting and characterizing various mammographic signs of breast disease.