Download or read book Cancer Associated Thrombosis written by Alok A. Khorana and published by CRC Press. This book was released on 2007-09-26 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides

Download or read book Cancer Associated Thrombosis CAT written by Nikolaos Tsoukalas and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer-Associated Thrombosis (CAT): management of thromboprophylaxis in cancer patients in GreeceN. Tsoukalas, A. Bokas, A. Christopoulou, A. Ardavanis, G. Koumakis, Ch. Papandreou, G. Papatsimpas, P. Papakostas, Ch. Andreadis, G. Aravantinos, N. Ziras, Ch. Kalofonos, E. Samantas, M. Souggleri, P. Makrantonakis, G. Pentheroudakis, A. Athanasiadis, I. Varthalitis, P. Papakotoulas, I. BoukovinasHellenic Society of Medical Oncology (HeSMO, http://www.hesmo.gr/en), Athens, GRBackgroundVenous thromboembolism (VTE) is a common cause of adverse outcomes in oncology. The risk of VTE varies with cancer type, stage, grade, therapy and other patientsu2019 characteristics.VTE prophylaxis should be provided to hospitalized cancer patients and highu2010risk outpatients according to Khorana score. Lowu2010molecularu2010weight heparin (LMWH) remains the standard therapy for VTE in cancer patients.MethodsThis is an observational study conducted by the Hellenic Society of Medical Oncology (HeSMO) that aims to record and highlight the current clinical practice and management of VTE in Greek cancer patients.ResultsThe 18 centers reported approximately 4300 cancer patients managed on monthly basis, where the vast majority (80%) in outpatient setting. 340 patients with active cancer enrolled in this study: 53,2% males, mean age 64,3 years, PS 0u20101:62,1%, tumor types lung:22,3%, pancreas:16,3%, colon:13,6%, breast:11%, stomach:8,3%, ovarian:6,5% and other:21,7%. Moreover, 95,3% received treatment while 21,3% were inpatients and 78,6% outpatients. Among 340 patients, 254 had no VTE and 56,8% had PS 0-1. In the cohort of 254 patients, 72,8% were outpatients, 77,5% had metastatic disease and 95,7% were on treatment. Regarding cancer types 66,5% had high thrombotic risk cancers (23,2% lung, 18% pancreatic, 10,4% colon and 8% stomach). Interestingly, the Khorana mean risk in this population was 2 and all patients received prophylactic antithrombotic treatment with LMWH.ConclusionsGreek Oncologists are aware of cancer-associated thrombosis (CAT), especially in high thrombotic risk cancer types and advanced disease stages. Of interest, the majority of patients who received thomboprophylaxis had good PS and the Khorana mean risk score was 2.Key words: Venous ThromboEmbolism (VTE), Cancer-Associated Thrombosis (CAT), Khorana score, Thromboprophylaxis, Lowu2010molecularu2010weight heparin (LMWH).

Download or read book Precision Anticoagulation Medicine written by Hadi Goubran and published by Springer Nature. This book was released on 2019-12-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical guide to the use of novel and conventional anticoagulants for a variety of medical conditions and patients profiled. It reviews data for selecting the most appropriate medication for a given presentation based on a patient’s background while highlighting current best practices. Chapters discuss the choice of agents and optimum duration of therapy while including the relevant literature review and evidence. Specific sections focus on the use of anticoagulants in patients with cardiovascular disease, autoimmune and rheumatologic disorders, antiphospholipid syndrome, cancer, and in the surgical contexts. The book also examines anticoagulation in pregnant and lactating women, pediatric and elderly populations, and patients with extreme weights. Intended for use in daily practice, Precision Anticoagulation Medicine - A Practical Guide is an essential resource for physicians and related professionals, residents, fellows, and graduate students in hematology, cardiology, rheumatology, oncology, surgery, anesthesiology, and intensive care.

Download or read book REAL WORLD DATA REGARDING MANAGEMENT OF CANCER ASSOCIATED THROMBOSIS CAT written by Nikolaos Tsoukalas and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Real world data regarding management of Cancer Associated Thrombosis (CAT) N. Tsoukalas, P. Papakotoulas, A. Christopoulou, A. Ardavanis, G. Koumakis, Ch. Papandreou, G. Papatsimpas, P. Papakostas, Ch. Andreadis, G. Aravantinos, N. Ziras, Ch. Kalofonos, E. Samantas, M. Sougleri, P. Makrantonakis, G. Pentheroudakis, A. Athanasiadis, E. Bournakis, I. Varthalitis, I. Boukovinas [email protected] behalf of the Hellenic Society of Medical Oncology (HeSMO, http://www.hesmo.gr/en), Athens, GreeceBackground: Thrombosis is the 2nd cause of death in cancer patients. CAT is common, could delay anti-cancer therapy and increase costs. Oncologists should be aware of CAT and its clinical significance.Methods: Prospective observational study conducted by HeSMO to record CAT clinical management. Patients with active cancer received antithrombotic agents for treatment or thromboprophylaxis were enrolled.Results: 546 patients enrolled. Primary cancers were: lung 24%, pancreas 13.4%, breast 8.8%, colorectal 8.1%, stomach 8.1%, ovarian 6.6% and other 39.1%. 120 received Low Molecular Weight Heparin (LMWH) for Venus ThomboEmbolism (VTE) treatment (Group A), 426 for thromboprophylaxis (Group B).Group A: 35% of 120 VTEs were diagnosed incidentally and treated as symptomatic [mean duration 5.51 months (SD+/-3.42)]. Recurrences occurred in 3 (2.5%) patients. Four (3%) grade 1 bleedings.Group B: 213 (50%) received LMWH at prophylactic doses while the rest received therapeutic doses [mean duration 4.42 months (SD +/- 2.68)]. 126 (30%) patients had Khorana score u22653. Even though, 300 (70%) patients had Khorana score u22642, 68% were metastatic and 58% were receiving high thrombotic chemotherapy agents. 16 (3.8%) patients experienced VTE while 9 (56%) of them were incidental. Notably, lower VTE risk [OR: 0.32 (95% CI 0.10, 1.0) p=0.04] was observed in patients on therapeutic doses LMWH while higher VTE risk [OR: 3,14 (1.01, 9.9)] was observed in patients on prophylactic doses LMWH. Six (1.4%) grade 1 bleedings.Conclusions: Oncologists use LMWH for the CAT management. Incidental VTE is a common and insidious clinical entity. Therapeutic doses of LMWH for thromboprophylaxis are effective and safe. Key words: Venous ThromboEmbolism (VTE), Cancer-Associated Thrombosis (CAT), Khorana score, Thromboprophylaxis, Lowu2010molecularu2010weight heparin (LMWH), prognosis.

Download or read book Development Of International Guidelines And Education Resources For Cancer Associated Thrombosis CAT written by Taylor Butler and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: IntroductionThrombosis risk is estimated to be as high as 18% in cancer patients and a source of morbidity and mortality. The hemostasis study group organized members to develop clinical practice guidelines for cancer-associated thrombosis (CAT). The 2017 MASCC/ISOO workshop hosted by the hemostasis/education study group revealed that further education materials might be indicated to improve patient understanding.ObjectivesTo review the recent literature to determine recommendations on CAT with an initial focus on inpatient practice primary prevention. Of note, information will also be collected to develop patient friendly educational tools. MethodsThe co-chairs met with MASCC members periodically through teleconference to discuss project development. We adapted literature search methods similar to previous clinical practice guidelines published by MASCC/ISOO. The co-chairs conducted the initial literature search using MEDLINE and the Cochrane database and eliminated studies if the abstract revealed exclusion criteria. All other studies were pulled and divided to each participant. Grading and recommendations will follow previous guidelines by MASCC/ISOO.Results1589 studies were reviewed during the literature search. 1336 were eliminated based on the abstract. The following 253 studies have been assigned to each member and the full article will be reviewed for inclusion/exclusion criteria and grading, if applicable.ConclusionEach study participant will review at least 21 studies with the goal of developing guidelines and educational tools for inpatient CAT prophylaxis. The target date is to present to the participants of the Hemostasis study group in Vienna and to the executive leaders of MASCC/ISOO in 2019.

Download or read book Handbook of Venous Thromboembolism written by Jecko Thachil and published by John Wiley & Sons. This book was released on 2017-11-09 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clinically oriented handbook providing up-to-date recommendations for mastering the practical aspects of patient management for venous thromboembolism Venous thromboembolism (VTE) is associated with high morbidity and mortality both in and out of the hospital setting, and is one of the commonest reasons for hospital attendances and admissions. Designed as a practical resource, the Handbook of Venous Thromboembolism covers the practical aspects of venous thromboembolism management in short and easily followed algorithms and tables. This important text helps physicians keep up-to-date with the latest recommendations for treating venous thromboembolism in clinic-oriented settings. Experts in fields such as the radiological diagnosis of pulmonary embolism and thrombophilia testing, give a succinct summary of the investigation, diagnosis and treatment of venous thromboembolism and include evidence-based guidelines. With contributions from a team on internationally recognized experts, Handbook of Venous Thromboembolism is a source of information that specialists in the field can recommend to non-specialists and which the latter will be able to review to assist in their education and management of this wide-spread condition. This vital resource: Comprises of a clinically focused handbook, useful as a daily resource for the busy physician Offers a handbook written by an international team of specialists offering their experience on the practical aspects of venous thromboembolism management Addresses venous thrombosis prevention, a major focus for healthcare providers Includes coverage on controversies in the management of venous thromboembolism so clinicians can understand how experts are practicing in real scenarios Written for hematology trainees, emergency and acute medicine physicians, junior doctors, and primary care physicians, Handbook of Venous Thromboembolism covers the basics for treating patients with venous thromboembolism and offers guidelines from noted experts in the field.

Download or read book Thrombosis in Cancer A Medical Professional s Guide to Cancer Associated Thrombosis written by Supratik Rayamajhi and published by Bentham Science Publishers. This book was released on 2021-05-24 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever since the association between cancer and thrombosis was reported by Jean-Baptiste Bouillaud in the early 19th century, cancer-associated thrombosis has remained a challenging domain of cancer management. Thrombosis can at times be a lead to cancer diagnosis, while it often complicates medical situations as a coexisting disorder. In this handbook, the contributors have compiled comprehensive information on the subject to provide the reader a comprehensive review of current medical literature and guidelines for cancer-associated thrombosis. Key Features -clinically oriented text for application in healthcare settings -current, evidence-based literature reviews and references -includes guidelines on VTE prophylaxis, heparin effects and more -includes information about special cases Thrombosis in Cancer: A Medical Professional's Guide to Cancer Associated Thrombosis is an informative handbook for a broad range of readers in medicine, including generalists, residents, and graduate-level trainees.

Download or read book Thrombosis and Cancer written by Gilles Lugassy and published by CRC Press. This book was released on 2004-02-23 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides comprehensive and timely coverage of the current knowledge of cancer-associated thrombosis, its pathogenesis, clinical features, prevention, and therapy. It specifically addresses the relationship between hemostatic systems and cancer, thus providing a unique and much needed focus. All of the contributors are acknowledged specialists in their fields and have experience conducting large clinical trials in oncology and thrombosis. Their discussions cover all aspects of the topic, from long-term complications to cancer surgery. It will be of interest to general practitioners, internists, oncologists, hematologists, and all physicians involved in the management of cancer patients.

Download or read book A Killer Harvest written by Paul Cleave and published by Simon and Schuster. This book was released on 2017-08 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A blind teenager ... receives a corneal donation and begins to see and feel memories from their previous owner--a homicide detective who was also his father"--Amazon.com.

Download or read book Etiology of Cancer Associated Thromboembolism CAT and Diet Lifestyle and Medicine to Reduce Cancer and Venous Thromboembolism written by Kenji Yokoyama and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is one of the leading causes of death in developed countries, and cancer patients often develop venous thromboembolism (VTE). VTE is the second leading cause of death in cancer patients receiving chemotherapy. The incidence of VTE varies among cancers, and it is highest in pancreatic cancer patients. Increased white blood cells and thrombocytosis are risk factors for developing cancer-associated VTE. Some other proteins (tissue factor, podoplanin, P-selectin, and plasminogen activator inhibitor-1) may also play roles in thrombus formation in cancer patients. Certain diets and nutrition (e.g., enough fish, vegetables, and fruits) may reduce the risk of VTE. Certain diets and nutrition also may reduce the risk of cancer, and alcohol drinking and cigarette smoking definitely increase risk of cancer. Some studies suggest that aspirin, a widely used antiplatelet drug, may reduce cancer incidence and mortality, but other studies fail to show the beneficial effects of aspirin.

Download or read book Cancer Associated Thrombosis written by Bastien Petit and published by . This book was released on 2022 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the results of randomized clinical trials (RCT) assessing direct oral anticoagulants (DOACs) for the treatment of patients with cancer-associated thrombosis (CAT), DOACs have been proposed as alternative to low molecular weight heparin (LMWH) by several international guidelines. However, the proportion of CAT patients who would have not been eligible for such trials is currently unknown. Aim. The primary aim of our study was to assess the proportion of patients seen in clinical practice for acute CAT and who would not have been eligible for a RCT. Secondary aims were to describe patients outcomes according to this eligibility. Methods. In a multicenter, observational study, all patients consecutively admitted from January 2017 to December 2019 for an acute CAT event were retrospectively analysed. Patients were classified according to the presence or absence of non-inclusion criteria from the CARAVAGGIO study. Death, venous thromboembolism (VTE) recurrence and major bleeding during a 6-month follow-up were analysed as secondary endpoints. Results. Three hundred and two patients with CAT were included (women: 53%, mean age: 67.9 ± 13.2). Among them, 161 (53%) met one or more criteria for non-inclusion (IC95% [47.68, 58.93]). Main exclusion criteria were unusual deep vein thrombosis (DVT) sites (n=56, 18.5%), bleeding risk (n=43, 14.2%), brain tumour (n=33, 10.9%), ECOG PS >2 (n=28, 9.3%), renal failure (n=16, 5.3%). At 6 months, the event-free survival rate was not statistically different between the two groups (55% for the non- eligible group versus 60% for the eligible group, P= 0.24). Conclusion. Among patients with CAT, a significant proportion would have not been able to participate in a trial as CARAVAGGIO. Evaluation of DOACs safety and efficacy in some of these specific setting needs further research.

Download or read book Handbook of Advanced Cancer Care written by European Society for Medical Oncology and published by CRC Press. This book was released on 2006 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in association with ESMO, this timely handbook is a concise and practical reference for all oncologists who are responsible for the care of patients with advanced cancer.

Download or read book Haematology in Critical Care written by Jecko Thachil and published by John Wiley & Sons. This book was released on 2014-06-03 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues of thrombosis, bleeding, and transfusion are extremely common, and often complex, in critically ill patients. Haematology in Critical Care: A Practical Handbookprovidesa dependable source of expert guidance on how to handle common haematological problems seen in the critical care setting, as well as the acute care of patients with a primary haematological disorder. Full-time clinical haematologists, regularly attending on intensive care, the Editors begin with an approach to abnormal laboratory tests, following with a disease-orientated approach to topics such as coagulation and haematological malignancy. Other key topics include paediatric and neonatal care, transfusion, point of care testing and the emergency presentation of haematological disease. This title brings together two of the most highly scientific specialties in clinical practice, delivering a practical approach to these problems, and guiding the clinician through the diagnosis and management of common scenarios encountered in the ICU.

Download or read book Thrombosis and Hemostasis in Cancer written by Gerald Soff and published by Springer. This book was released on 2020-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.

Download or read book Cancer Biology and Therapeutics written by Joseph G. Cory and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: In anticipation of the opening of the H. Lee Moffitt Cancer Center and Research lnstitut~ on the campus of the University of South Florida, an international symposium, "The First Annual H. Lee Moffitt Symposium on Cancer Biology and Therapeutics" was held in Tampa, Florida on January 20-22, 1986. In this first symposium we decided to present a broad-based series of topics dealing with the major issues in the field of cancer. These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment. The speakers chosen represented individuals of international acclaim who are very active in the area of cancer research and treatment. The symposium brought together scien tists/physicians from six nations including Austria, Canada, France, Hungary, West Germany, and of course, the United States. The congeniality of the participants promoted the friendly exchange of knowledge which, it is hoped, will greatly hasten the time when successful management of human cancer will become routine. Future symposia in this series will be highly focused and will deal with a single facet of this vast field of cancer research and treatment. Joseph G. Cory, Editor Andor Szentivanyi, Editor University of South Florida, 1986 V ACKNOWLEDGMENTS This volume presents the Proceedings of the H. Lee Moffitt International Syn~osium on Cancer Biology and Therapeutics which was held in Tampa, Florida on January 20, 21, and 22, 1986.

Download or read book Management of Acute Pulmonary Embolism written by Stavros V. Konstantinides and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.

Download or read book Trauma Induced Coagulopathy written by Hunter B. Moore and published by Springer Nature. This book was released on 2020-10-12 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.