Download or read book Bone Regeneration by Tuning the Drug Release from the Calcium Phosphate Scaffolds written by Kanupriya Khurana and published by . This book was released on 2018 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone is among the most transplanted tissues for regeneration of bone defects, caused by trauma, age-related bone loss or bone infections. Due to their similar characteristics to the mineral phase of bone, calcium phosphates (CaPs) have raised a lot of interest. Some properties of CaPs, like biodegradability, biocompatibility, bioactivity and osteoconduction represent a great potential for this application. Among them, calcium phosphate cements (CPCs) have additional advantages like injectability and in situ hardening ability. Moreover, the possibility to tune the porosity of CaPs in general and of CPCs in particular, makes them suitable vehicles for local delivery of drugs. Loading CaPs with drugs allows conferring additional functionalities to the synthetic bone grafts, which is of great interest. The main aim of this thesis is to explore CaP bioceramics as vehicles for local delivery of drugs, covering both low temperature biomimetic ceramics, like calcium deficient hydroxyapatite (CDHA), and high temperature sintered ceramics, like beta tricalcium phosphate (ß-TCP), in the form of microporous and macroporous substrates. The physic-chemical nature of these bioceramics, their porosity and textural properties plays an essential role in their drug delivery properties. In order to be able to tailor the drug release kinetics of the bioceramics beyond their intrinsic properties, plasma polymerization has been investigated. Plasma is a particular state of a gas, electrically neutral, which can be employed in different applications. Although plasma polymerization has been widely studied for biomedical applications, its combination with bioceramics is rather unexplored. To select a suitable drug for bone regeneration, an extensive literature review was done on statins, and more particularly on simvastatin as a potential osteogenic and angiogenic promoter. This drug was evaluated within macroporous scaffolds of either CDHA or ß-TCP as drug delivery vehicles. The drug-loaded materials were plasma-coated with polycaprolactone: poly ethylene glycol (PCL:PEG) co-polymers. The coating covered the micro and nanopores of the CaPs surface and produced complex geometries presenting a nano and micro rough morphology which led to low wettability despite the hydrophilicity of the copolymer. Plasma coating with PCL-co-PEG on scaffolds loaded with simvastatin acid allowed delaying and modulating the drug release from the bone scaffolds depending on the thickness of the layer deposited, which, in turn depended on the initial specific surface area of the CaP. To further investigate the fundamentals of plasma polymerization on bioceramics, PEG-like polymer coatings of different thickness were deposited on microporous ß-TCP loaded with antibiotics. The rough ß-TCP surface was associated to strong hydrophobic surface properties, which nevertheless retained their suitable biological behavior with regard to human osteoblast cells. The microbiological activity of the antibiotics was preserved, and the coatings reduced the total amount of drug released as a function of the increasing plasma treatment time. In another approach, a statin that had never before been employed in combination with CaPs, Pitavastatin (PITA), was investigated as potentially osteogenic and angiogenic promoter through in vitro studies which revealed dose-dependent enhancement of mineralization and vascularization. The incorporation of PITA to the liquid phase of an injectable CDHA foam allowed obtaining injectable local drug delivery scaffolds, without altering their macroporosity or textural properties. The drug release kinetics was affected by the evolving microstructure of the setting of the macroporous cement. Overall the results obtained proved that PITA seems to be a suitable novel candidate to enhance the osteogenic potential of synthetic bone grafts and identified the required doses to obtain the desired biological effects.
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Bone graft substitutes written by Cato T. Laurencin and published by ASTM International. This book was released on 2003 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Calcium Phosphate Biomaterials written by Besim Ben-Nissan and published by Springer Science & Business. This book was released on 2014-04-17 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Download or read book Smart Biomaterials written by Mitsuhiro Ebara and published by Springer. This book was released on 2014-05-28 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
Download or read book Conversion of Coral Sand to Calcium Phosphate as a Drug Delivery System for Bone Regeneration written by Joshua Chou and published by . This book was released on 2011 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advanced Techniques in Bone Regeneration written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2016-08-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.
Download or read book Biomedical Therapeutic and Clinical Applications of Bioactive Glasses written by Gurbinder Kaur and published by Woodhead Publishing. This book was released on 2018-09-22 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses is an essential guide to bioactive glasses, offering an overview of all aspects of the development and utilization of this cutting-edge material. The book covers vital issues, including mesoporosity, encapsulation technologies, scaffold formation and coatings for a number of applications, including drug delivery, encapsulation, scaffolds and coatings. Readers will gain a strong understanding and practical knowledge of the therapeutic aspects of bioceramics, with a focus on glasses from a clinical point-of- view. Researchers, students and scientists involved in bioceramics, bone tissue engineering, regeneration and biomedical engineering will find this to be a comprehensive resource. Presents detailed coverage of bioactive glasses, including technologies and applications Includes all the major development areas related to bioactive glasses, enabling readers to understand the latest research Considers the potential future developments of bioactive glasses as a drug carrier
Download or read book Cutting Edge Enabling Technologies for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.
Download or read book Smart Stimuli responsive Biomaterials for Programmed Drug Delivery written by Seyed Morteza Naghib and published by Frontiers Media SA. This book was released on 2023-06-08 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advanced Synthesis and Medical Applications of Calcium Phosphates written by S.S. Nanda and published by CRC Press. This book was released on 2024-05-15 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium phosphate materials are used in many medical and dental applications. Advanced Synthesis and Medical Applications of Calcium Phosphates covers the structure, chemistry, synthesis, and properties of both natural and synthetic calcium-based biomaterials and details a variety of medical applications. Depicts the latest advances in using calcium phosphates in bone regeneration and tissue engineering Includes the latest generation of regenerative biomaterials with an integrated perspective combining both research and clinical issues Provides an understanding of the clinical targets and requirements for regenerative medicine Detailing fundamentals through applications, this book helps biomaterials researchers to better understand the clinical targets and requirements for use of these materials for optimal synthesis and development.
Download or read book Developments and Applications of Calcium Phosphate Bone Cements written by Changsheng Liu and published by Springer. This book was released on 2017-10-20 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Download or read book Smart Stimuli responsive Biomaterials for Programmed Drug Delivery 2nd edition written by Seyed Morteza Naghib and published by Frontiers Media SA. This book was released on 2024-08-29 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most drugs are toxic to cells that often kill healthy cells and establish several side effects. Conventional chemotherapy cargoes are not tumor-specific and commonly their nature leads to significant toxic effects on healthy tissues. Therefore, several drug delivery systems (DDSs) were developed to amend the therapeutic properties of drugs and made them safer and more effective. Local drug delivery which decreases systemic drug exposure, is an important approach for maximal efficacy, high levels of patient compliance, and fewer side effects. Smart drug delivery systems (SDDSs) have gained much attention and paved the way for more effective treatment of patients. SDDSs with stimuli-responsive characteristics are determined as the process that the payloads are not released before reaching the target site. This triggered release occurs due to the variations in the nano/microcarrier chemistry and structure, in response to endogenous and/or exogenous stimulus, establishing the release of the cargoes to the exact place. Responsive and smart materials/biomaterials are responsive/sensitive to signals originating from physiological systems, or to abnormalities originating from pathological defects, that can interact with or be triggered by the biological environments, and are interesting in drug delivery platforms/devices for developing next-generation accurate medicines. In exogenous-triggered delivery, drug/gene release is controlled by external stimulus, which can be controlled exactly. Different exogenous triggers have been reported, such as light, magnetic field, temperature, electrical field, and ultrasound. The endogenous triggers such as pH, redox, enzyme concentration, and bio-molecules are related to the disease's pathological characteristics. Disease pathological characteristics are key parameters as physiological triggers for designing programmed delivery devices that may be used for the non-invasive and effective treatment of a wide range of pathological conditions such as cancer, infections, diabetes, cardiovascular diseases, autoimmune disorders, stroke, and chronic wounds, and degenerative diseases. Endogenously triggered drug release is the same as exogenously triggered drug release, which can lead to enhanced release of therapeutic molecules at the target place in its therapeutic concentration, reducing local toxicity and side effects, reducing the need for repeat administrations, and increasing patient compliance. Here, we focused on smart endogenous and exogenous stimuli-responsive biomaterials for programmed drug delivery. The conventional drug delivery systems are not without any limitations and challenges. One of the most important challenges is related to their degradability or insufficient biocompatibility of most materials which are used in smart delivery system. Another challenge is related to the using of 2D in vitro models or in vivo animal studies to evaluate the performance of these systems, and there is a poor relation between such results and human clinical trials. Thus, these incompatibilities can lead to the failing of the numerous smart systems in clinical studies. In this special issue, we focus on smart multi-responsive drug delivery systems that can address some challenges and drawbacks. Research paper, commutation (letter), mini-review and review are acceptable for publications in this special issue. Main topics: 1- Smart exogenous-triggered delivery systems 2- Smart endogenous-triggered delivery systems 3- Multi-responsive targeted vehicles 4- Stimuli-responsive niosomes and liposomes 5- Multifunctional biomaterials for cancer treatment 6- Smart 3D and 4D scaffolds for localized delivery systems
Download or read book Tissue Engineering and Regeneration in Dentistry written by Rachel J. Waddington and published by John Wiley & Sons. This book was released on 2016-11-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Engineering and Regeneration in Dentistry: Current Strategies presents a thorough update on the current advances, methods and understanding in tissue engineering in dentistry. It offers invaluable tools, case studies, and methodologies for undertaking research, including important biological and practical considerations to facilitate successful migration of research from the bench to the clinic. Offers detailed coverage of the basic underlying principles and scientific evidence, and includes protocols to highlight practical applications Written by an internationally renowned team of expert contributors A must-have read for researchers and specialist clinicians in tissue engineering, oral biology, dental materials science, periodontology and oral surgery
Download or read book Injectable Biomaterials written by Brent Vernon and published by Elsevier. This book was released on 2011-01-24 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems
Download or read book Mimicking the Extracellular Matrix written by Gregory H. Hudalla and published by Royal Society of Chemistry. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
Download or read book Regenerative Pharmacology written by George J. Christ and published by Cambridge University Press. This book was released on 2013-04-15 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.
