Download or read book Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Microbial Growth in Drinking Water Supplies written by Dick van der Kooij and published by IWA Publishing. This book was released on 2013-09-14 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining the microbial quality in distribution systems and connected installations remains a challenge for the water supply companies all over the world, despite many years of research. This book identifies the main concerns and knowledge gaps related to regrowth and stimulates cooperation in future research. Microbial Growth in Drinking Water Supplies provides an overview of the regrowth issue in different countries and the water quality problems related to regrowth. The book assesses the causes of regrowth in drinking water and the prevention of regrowth by water treatment and distribution. Editors: Dirk van der Kooij and Paul W.J.J. van der Wielen, KWR Watercycle Research Institute, The Netherlands
Download or read book New Testament Conjectural Emendation in the Nineteenth Century Jan Hendrik Holwerda as a Pioneer of Method written by Bart L.F. Kamphuis and published by BRILL. This book was released on 2018-05-07 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In New Testament Conjectural Emendation in the Nineteenth Century Bart L.F. Kamphuis analyses life and work of Jan Hendrik Holwerda (1805-1886), who should be seen as the father of the Dutch Movement of Conjectural Criticism.
Download or read book Bacterial Exotoxins How Bacteria Fight the Immune System written by Inka Sastalla and published by Frontiers Media SA. This book was released on 2016-10-07 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Download or read book Cytokine Ion Channel Interactions in Pulmonary Inflammation written by István Vadász and published by Frontiers Media SA. This book was released on 2019-01-24 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic assembles original contributions and reviews from an international consortium of PIs related to interactions between pro-inflammatory cytokines and ion channels during acute lung injury and chronic heart failure.
Download or read book Critical CALL Proceedings of the 2015 EUROCALL Conference Padova Italy written by Francesca Helm and published by Research-publishing.net. This book was released on 2015-12-02 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: The theme of the conference this year was Critical CALL, drawing inspiration from the work carried out in the broader field of Critical Applied Linguistics. The term ‘critical’ has many possible interpretations, and as Pennycook (2001) outlines, has many concerns. It was from these that we decided on the conference theme, in particular the notion that we should question the assumptions that lie at the basis of our praxis, ideas that have become ‘naturalized’ and are not called into question. Over 200 presentations were delivered in 68 different sessions, both in English and Italian, on topics related specifically to the theme and also more general CALL topics. 94 of these were submitted as extended papers and appear in this volume of proceedings.
Download or read book Learning Science in Informal Environments written by National Research Council and published by National Academies Press. This book was released on 2009-05-27 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Informal science is a burgeoning field that operates across a broad range of venues and envisages learning outcomes for individuals, schools, families, and society. The evidence base that describes informal science, its promise, and effects is informed by a range of disciplines and perspectives, including field-based research, visitor studies, and psychological and anthropological studies of learning. Learning Science in Informal Environments draws together disparate literatures, synthesizes the state of knowledge, and articulates a common framework for the next generation of research on learning science in informal environments across a life span. Contributors include recognized experts in a range of disciplines-research and evaluation, exhibit designers, program developers, and educators. They also have experience in a range of settings-museums, after-school programs, science and technology centers, media enterprises, aquariums, zoos, state parks, and botanical gardens. Learning Science in Informal Environments is an invaluable guide for program and exhibit designers, evaluators, staff of science-rich informal learning institutions and community-based organizations, scientists interested in educational outreach, federal science agency education staff, and K-12 science educators.
Download or read book Guide to Microforms in Print written by and published by . This book was released on 1997 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clothing Sacred Scriptures written by David Ganz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-03 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to a longstanding interpretation, book religions are agents of textuality and logocentrism. This volume inverts the traditional perspective: its focus is on the strong dependency between scripture and aesthetics, holy books and material artworks, sacred texts and ritual performances. The contributions, written by a group of international specialists in Western, Byzantine, Islamic and Jewish Art, are committed to a comparative and transcultural approach. The authors reflect upon the different strategies of »clothing« sacred texts with precious materials and elaborate forms. They show how the pretypographic cultures of the Middle Ages used book ornaments as media for building a close relation between the divine words and their human audience. By exploring how art shapes the religious practice of books, and how the religious use of books shapes the evolution of artistic practices this book contributes to a new understanding of the deep nexus between sacred scripture and art.
Download or read book The Reception of the Virgin in Byzantium written by Thomas Arentzen and published by Cambridge University Press. This book was released on 2019-08-15 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Images and texts tell various stories about the Virgin Mary in Byzantium, reflecting an important cult with strong doctrinal foundations.
Download or read book Christian Muslim Relations A Bibliographical History Volume 9 Western and Southern Europe 1600 1700 written by and published by BRILL. This book was released on 2017-12-05 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christian-Muslim Relations, a Bibliographical History 9 (CMR 9) covering Western and Southern Europe in the period 1600-1700 is a further volume in a general history of relations between the two faiths from the seventh century to the early 20th century. It comprises a series of introductory essays and also the main body of detailed entries which treat all the works, surviving or lost, that have been recorded. These entries provide biographical details of the authors, descriptions and assessments of the works themselves, and complete accounts of manuscripts, editions, translations and studies. The result of collaboration between numerous leading scholars, CMR 9, along with the other volumes in this series is intended as a basic tool for research in Christian-Muslim relations. Section Editors: Clinton Bennett, Luis F. Bernabé Pons, Jaco Beyers, Karoline Cook, Lejla Demiri, Martha Frederiks, David D. Grafton, Stanisław Grodź, Alan Guenther, Emma Loghin, Gordon Nickel, Claire Norton, Reza Pourjavady, Douglas Pratt, Radu Păun, Peter Riddell, Umar Ryad, Mehdi Sajid, Cornelia Soldat, Karel Steenbrink, Davide Tacchini, Ann Thomson, Carsten Walbiner.
Download or read book Handbook of Stemmatology written by Philipp Roelli and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-09-07 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stemmatology studies aspects of textual criticism that use genealogical methods to analyse a set of copies of a text whose autograph has been lost. This handbook is the first to cover the entire field, encompassing both theoretical and practical aspects of traditional as well as modern digital methods and their history. As an art (ars), stemmatology’s main goal is editing and thus presenting to the reader a historical text in the most satisfactory way. As a more abstract discipline (scientia), it is interested in the general principles of how texts change in the process of being copied. Thirty eight experts from all of the fields involved have joined forces to write this handbook, whose eight chapters cover material aspects of text traditions, the genesis and methods of traditional "Lachmannian" textual criticism and the objections raised against it, as well as modern digital methods used in the field. The two concluding chapters take a closer look at how this approach towards texts and textual criticism has developed in some disciplines of textual scholarship and compare methods used in other fields that deal with "descent with modification". The handbook thus serves as an introduction to this interdisciplinary field.
Download or read book Wine Chemistry and Biochemistry written by M. Victoria Moreno-Arribas and published by Springer Science & Business Media. This book was released on 2008-11-06 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to describe chemical and biochemical aspects of winemaking that are currently being researched. The authors have selected the very best experts for each of the areas. The first part of the book summarizes the most important aspects of winemaking technology and microbiology. The second most extensive part deals with the different groups of compounds, how these are modified during the various steps of the production process, and how they affect the wine quality, sensorial aspects, and physiological activity, etc. The third section describes undesirable alterations of wines, including those affecting quality and food safety. Finally, the treatment of data will be considered, an aspect which has not yet been tackled in any other book on enology. In this chapter, the authors not only explain the tools available for analytical data processing, but also indicate the most appropriate treatment to apply, depending on the information required, illustrating with examples throughout the chapter from enological literature.
Download or read book Dynamics of Cancer written by Steven A. Frank and published by Princeton University Press. This book was released on 2018-06-05 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer. This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design.
Download or read book Guide to Microforms in Print 1997 written by and published by K. G. Saur. This book was released on 1997 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Targeted Therapies in Cancer written by Francesco Colotta and published by Springer Science & Business Media. This book was released on 2007-12-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Billions of dollars are spent every year on research into targeted therapies for cancer. That’s why it’s more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a forum for scientists and clinicians working in cancer drug discovery and therapy to share their opinions and experiences. The text here offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.
Download or read book Western Plainchant written by David Hiley and published by Oxford University Press. This book was released on 1995 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plainchant is the oldest substantial body of music that has been preserved in any shape or form. It was first written down in Western Europe in the eighth to ninth centuries. Many thousands of chants have been sung at different times or places in a multitude of forms and styles, responding to the differing needs of the church through the ages. This book provides a clear and concise introduction, designed both for those to whom the subject is new and those who require a reference work for advanced study. It begins with an explanation of the liturgies that plainchant was designed to serve. It describes all the chief genres of chant, different types of liturgical book, and plainchant notations. After an exposition of early medieval theoretical writing on plainchant, Hiley provides a historical survey that traces the constantly changing nature of the repertory. He also discusses important musicians and centers of composition. Copiously illustrated with over 200 musical examples, this book highlights the diversity of practice and richness of the chant repertory in the Middle Ages. It will be an indispensable introduction and reference source on this important music for many years to come.
