Download or read book Biotechnological Applications of Quorum Sensing Inhibitors written by Vipin Chandra Kalia and published by Springer. This book was released on 2018-05-30 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the practical applications of quorum sensing inhibitors for both human and plant health. Quorum sensing inhibitors that disrupt microbial biofilms can be employed to treat bacterial infections. The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors. Quorum sensing is the mechanism through which bacteria develop antibiotic resistance. Intended to provide a clearer understanding of the practical applications of quorum sensing inhibitors, the book details how the problem of antibiotic resistance can be countered through the intelligent application of quorum sensing inhibitors.
Download or read book Quorum Sensing and its Biotechnological Applications written by Vipin Chandra Kalia and published by Springer. This book was released on 2018-08-11 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delves into the biotechnological applications of Quorum sensing (QS)- a peculiar gene-regulatory process of some microorganisms. Quorum Sensing allows a large bacterial population to work together in a coordinated manner to carry out metabolic activities, which individual bacterium cannot. The different chapters describe how, associating bioremediation process with energy generation is an economical proposal, for reducing pollution and managing biowastes. The book discusses how QS can be exploited for biotechnological applications in generating bioproducts, bioenergy, bioremediation, biosensors, health and agricultural activities. It further highlights how QS is becoming an integral part of synthetic biology for genetic circuits for producing: (i) novel products, (ii) biosensors, (iii) bioactive molecules, etc. The book is divided into different sections for a clear understanding of the applicability of QS in, the Environment, Energy, Agriculture and Health sectors.
Download or read book Quorum Sensing written by Giuseppina Tommonaro and published by Academic Press. This book was released on 2019-04-08 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals. Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists. Describes Quorum Sensing (QS) mechanisms from their molecular basis, to their clinical applications Spans several fields in relation to QS, including microbiology, chemistry, biochemistry and ecology Considers QS as an approach to the discovery of new antibiotics Looks at QS as a means to understand the microbial world and towards use of bacteria and their products in biotechnological applications Summarizes key results on QS mechanisms’ molecular basis and fields of application
Download or read book Quorum Sensing vs Quorum Quenching A Battle with No End in Sight written by Vipin Chandra Kalia and published by Springer. This book was released on 2014-09-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?
Download or read book Natural Products written by Moupriya Nag and published by CRC Press. This book was released on 2023-12-01 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial biofilm plays an important role in the life cycle of microorganisms surviving in diverse and harsh environments such as extremes of temperatures, pH, salinity, nutrient scarcity etc. Biofilm formation is a survival strategy adopted by microorganisms allowing colonization in new niches by dispersal of microbes from the microbial clusters embedded within an outer polymer layer produced by the microorganism itself. This layer comprises of extracellular polymeric substances (EPS) that helps the indwelling microbes to grow and divide in a protected environment against invaders like antimicrobial agents, surfactant, biocides and phagocytic cells of host organisms. Thus, EPS matrix prevents the penetration of antimicrobials thereby allowing the indwelling microbes to survive and give rise to antimicrobial resistance posing threat to human health. The present book highlights a detailed analysis of the mechanism of biofilm formation in both Gram positive and Gram-negative bacteria and the role of quorum sensing signaling mechanism in the genetic regulation pathway. The book titled "Natural Products: Alternative therapeutics as Quorum Sensing (QS) inhibitors" provides a detailed and systematic review of mechanism of quorum sensing in both Gram positive and Gram-negative bacteria and alternative pharmacological developments as a potent solution to the rise of antimicrobial resistance during biofilm formation. Features: A systematic overview of the mechanism of quorum sensing in the development of microbial biofilms Biofilm formation and its role in the emergence of antimicrobial resistance. Recent pharmacological development of antibiofilm remedies involving biogenic compounds. This book serves as a reference book for researchers investigating the progression of events during microbial biofilm formation starting from the genetic cascade regulating quorum sensing to secretion of autoinducers and design of safer methodologies for the successful eradication of microbial biofilm. It may also be used as a textbook for a undergraduate level course in microbiology or microbial biotechnology.
Download or read book Trends in Quorum Sensing and Quorum Quenching written by Jamuna A. Bai and published by CRC Press. This book was released on 2020-05-25 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies for quorum sensing inhibition. The topics covered are multidisciplinary and wide ranging from quorum sensing phenomenon in pathogenic bacteria, food spoilers and agriculturally relevant bacteria. The potential application of quorum sensing inhibitors including small molecules, bioactives, natural compounds and quorum quenching enzymes in controlling bacterial infections, in aquaculture and biofouling are also discussed. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests, various tropical soils and oceans. Key features: Covers the fundamental aspects and the progresses and the challenges in the field and the future trend Reviews quorum sensing in gram positive and gram negative bacteria of clinical, agricultural and industrial relevance Discusses the application of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on bacterial signaling mechanism V. Ravishankar Rai earned his MSc and PhD from the University of Mysore, India. Currently, Dr. Rai is working in the Department of Studies in Microbiology, University of Mysore, India. He has been awarded fellowship of UNECSO Biotechnology Action Council, Paris (1996) to visit Murdoch University, Perth, Indo-Israel Cultural Exchange Fellowship (1998), Biotechnology Overseas fellowship, Government of India (2008), Indo-Hungarian Exchange fellowship to visit Budapest (2011) and Bilateral Exchange Fellowship by Indian National Academy of Sciences to visit Turkey (2016). He was invited by Academia Sinica, Taiwan as Visiting Fellow (2010). He received Incoming fellowship from Cardiff University, United Kingdom (2017). Recently, he was invited by Centre of Excellence for Biomedical and Biomaterials Research, Mauritius (2018). He has been awarded Bilateral Exchange Fellowship by Indian National Academy of Sciences to visit Germany (2019), Eric Ojala fund International Travel Fellowship to visit Massey University (2019) and Cambridge-Hamied Visiting Lecture Scheme (2020). Jamuna A Bai has completed her MSc and PhD in Microbiology from University of Mysore, India. She is currently working as an Assistant Professor in JSS Academy of Higher Education Research, India. She has previously worked as Research Associate in UGC sponsored University with Potential Excellence Project and ICMR Senior Research Fellow in University of Mysore, India. Her research interest includes food safety, role of quorum sensing and biofilms in food-related bacteria and developing quorum-sensing inhibitors. She is presently working on antimicrobial application of functionalized nanomaterials against pathogens.
Download or read book Trends in Quorum Sensing and Quorum Quenching written by V. Ravishankar Rai and published by CRC Press. This book was released on 2020-05-04 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. The applications of quorum sensing inhibitors such as small molecules, bioactives, natural compounds, and quorum quenching enzymes in controlling bacterial infections in clinical settings, agriculture and aquaculture are discussed. The potential use of quorum quenching enzymes for mitigating biofouling is also covered. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests and marine environments. Key features: Covers the fundamental aspects, the progress and challenges in the field of quorum sensing and quorum quenching Reviews quorum sensing in Gram-positive and Gram-negative bacteria of clinical, agricultural, and industrial relevance Discusses the application and future trends of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on molecular mechanisms in bacterial signaling
Download or read book Fundamentals of and Applications Based on Quorum Sensing and Quorum Sensing Interference written by Cristina García-Aljaro and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Bacteria use quorum sensing (QS) circuits to coordinate various activities (among which biofilm formation and the expression of virulence factors) based on the presence of signaling molecules. Different families of signal molecules have been identified in Gram positive and Gram negative bacteria (e.g. autoinducer peptides and acyl homoserine lactones). Similarly, different quorum sensing antagonists interfering with these system have been found in nature, promoting a new and promising field of research, quorum sensing interference. One of the most intensively studied applications of quorum sensing interference is its use as an alternative or synergycally with antibiotics to fight (antibiotic-resistant) bacterial pathogens. Many studies have been published claiming quorum sensing inhibitory activity of natural and synthetic compounds. However, after decades of research, several questions regarding the suitability of this approach to fight bacterial pathogens remain unanswered, including the risk that pathogens will develop resistance against quorum quenching. Meanwhile, the interest in quorum sensing has increased considerably, and this has broadened the fields where it can find biotechnological, environmental and industrial applications, such as anti biofouling, steering fermentations, bioremediation and wastewater treatment. Goal and scope The goal of this Research Topic is to broaden the knowledge of the phenotypes regulated by quorum sensing and the advances in quorum sensing interference. Deciphering microorganism language and the different phenotypes regulated by microbial signalling systems is a frontier for the development of new tools for the management of microorganisms to fulfil human needs with a broad application in different areas such as medicine, environmental sciences and industry.
Download or read book Bacterial Signaling written by Reinhard Krämer and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.
Download or read book Quorum Sensing written by Saurabh Sudha Dhiman and published by . This book was released on 2021 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: New developments in researching quorum sensing Microbial growth affects industries as diverse as agriculture, engineering, and medicine, to name a few. As more precise solutions are needed for modern challenges, researchers must understand the mechanisms of microbial growth. Quorum sensing (QS) is an essential part of microbial growth, and this work contains key areas such as signal molecules; mechanisms of signal transfer, role, and type of signal receptors; quorum quenching; characterization of microbial plasmids in quorum sensing; and novel and underexplored molecules involved in QS, along with therapeutic roles of quorum sensing inhibitors. This volume is perfect for researchers working on microbiology or biotechnology.
Download or read book Bacterial Biofilms written by Tony Romeo and published by Springer Science & Business Media. This book was released on 2008-02-26 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.
Download or read book Natural Products written by Moupriya Nag and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Microbial biofilm plays an important role in the life cycle of microorganisms surviving in diverse and harsh environments such as extremes of temperatures, pH, salinity, nutrient scarcity etc. Biofilm formation is a survival strategy adopted by microorganisms allowing colonization in new niches by dispersal of microbes from the microbial clusters embedded within an outer polymer layer produced by the microorganism itself. This layer comprises of extracellular polymeric substances (EPS) that helps the indwelling microbes to grow and divide in a protected environment against invaders like antimicrobial agents, surfactant, biocides and phagocytic cells of host organisms. Thus, EPS matrix prevents the penetration of antimicrobials thereby allowing the indwelling microbes to survive and give rise to antimicrobial resistance posing threat to human health. The present book highlights a detailed analysis of the mechanism of biofilm formation in both Gram positive and Gram-negative bacteria and the role of quorum sensing signaling mechanism in the genetic regulation pathway. The book titled "Natural Products: Alternative therapeutics as Quorum Sensing (QS) inhibitors" provides a detailed and systematic review of mechanism of quorum sensing in both Gram positive and Gram-negative bacteria and alternative pharmacological developments as a potent solution to the rise of antimicrobial resistance during biofilm formation. Features: A systematic overview of the mechanism of quorum sensing in the development of microbial biofilms Biofilm formation and its role in the emergence of antimicrobial resistance. Recent pharmacological development of antibiofilm remedies involving biogenic compounds. This book serves as a reference book for researchers investigating the progression of events during microbial biofilm formation starting from the genetic cascade regulating quorum sensing to secretion of autoinducers and design of safer methodologies for the successful eradication of microbial biofilm. It may also be used as a textbook for a undergraduate level course in microbiology or microbial biotechnology"--
Download or read book Implication of Quorum Sensing and Biofilm Formation in Medicine Agriculture and Food Industry written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2019-11-26 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book illustrates the role of quorum sensing in the food industry, agriculture, veterinary sciences, and medicine. It highlights the importance of quorum sensing in regulating diverse cellular functions in microbes, including virulence, pathogenesis, controlled-gene expression systems, and antibiotic resistance. This book also describes the role of quorum sensing in survival behavior and antibiotic resistance in bacteria. Further, it reviews the major role played by quorum sensing in food spoilage, biofilm formation, and food-related pathogenesis. It also explores the methods for the detection and quantification of quorum sensing signals. It also presents antimicrobial and anti-quorum sensing activities of medicinal plants. Finally, the book elucidates a comprehensive yet representative description of basic and applied aspects of quorum sensing inhibitors. This book serves an ideal guide for researchers to understand the implications of quorum sensing in the food industry, medicine, and agriculture.
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Download or read book Methods in Actinobacteriology written by Dhanasekaran Dharumadurai and published by Humana. This book was released on 2021-12-19 with total page 747 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details techniques on the study of Isolation, characterization, and exploration of actinobacteria in industrial, food, agricultural, and environmental microbiology. Chapters cover a wide range of basic and advanced techniques associated with research on isolation, characterization and identification of actinobacteria in soil, sediment, estuarine, water, Saltpan, Mangroves, plants, lichens, sea weeds, sea grass, animals-crab, snail, shrimp. Authoritative and cutting-edge, Methods in Actinobacteriology aims to be a useful practical guide to researches to help further their study in this field.
Download or read book Biofilm Mediated Diseases Causes and Controls written by Rina Rani Ray and published by Springer Nature. This book was released on 2021-05-05 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms. This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners.
Download or read book Bacterial Biofilms written by Sadik Dincer and published by BoD – Books on Demand. This book was released on 2020-10-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.
