Download or read book Bioreaction Engineering Bioprocess Monitoring written by Karl Schügerl and published by John Wiley & Sons. This book was released on 1997-04-03 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 3 of Bioreaction Engineering covers the general principles and techniques of bioprocess monitoring and their application for various bioprocesses. Methods based on the author's long standing experience working with various bioprocesses are applied within the book. In particular, the cultivation of Baker's yeast; production of fusion protein with recombinant E. Coli, alkaline serine protease production with Bacillus licheniformis; production of penicillin V with Penicillin chrysogenum; Cephalosporin C with Acremonium chrysogenum and tetracycline with Streptomyces aureofaciens are considered. This book deals with the monitoring of batch and perfusion cultivations of animal cells and production of monoclonal antibodies with hybridoma cells, Antithrombin III with BHK and CHO cells and ß -galactosidase with insect cells. The topics covered include: Bioprocess monitoring techniques Cultivation of Saccharomyces cerevisiae Production of Fusion Protein with Recombinanat E. coli Alkaline Protease Production with Bacillus licheniformis Antibiotica Production by Fungi and Streptomycetes Continuous Production of Primary Metabolites with Suspended and Immobilized Microorganisms Cultivation of Animal Cells and Production of Proteins Anaerobic Waste Water Treatment Fast Process Monitoring Techniques Image Analysis of Cells and Cell Aggregates Evaluation of Experimental Data to the Calculation of Metabolite Flux in Microorganisms and Animal Cells Signal Evaluation, Automation and Expert Systems for Process Monitoring Bioprocess Monitoring is invaluable for process engineers, analytical chemists and researchers in biotechnological, pharmaceutical, environmnental and chemical industries.
Download or read book Bioreaction Engineering Fundamentals Thermodynamics Formal Kinetics Idealized Reactor Types and Operation Modes written by Karl Schügerl and published by Wiley. This book was released on 1987-10-27 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreaction Engineering Reactions Involving Microorganisms and Cells Volume 1 Fundamentals, Thermodynamics, Formal kinetics, Idealized reactor types and Operation modes Karl Schügerl, Professor of Technical Chemistry, Institut für Technische Chemie, Universität Hannover, West Germany This book is designed to provide a basic introduction to the principles of bioreactors, their operating parameters, and their dynamic behaviour under different conditions. The following topics are covered: Introduction Principles Modus operandi of bioreactors Idealized types Formal kinetics of cell growth and product formation in idealized reactors Operation modes in stirred reactors The book will be valuable to both process and control engineers in the fermentation industry and to researchers and lecturers in biotechnology departments of universities.
Download or read book Control in Bioprocessing written by Pablo A. López Pérez and published by John Wiley & Sons. This book was released on 2020-03-10 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.
Download or read book Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts written by Claire Komives and published by John Wiley & Sons. This book was released on 2018-12-27 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies
Download or read book Bioreaction Engineering Principles written by Jens Nielsen and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating recent research on the physiology and modelling of bioreactions and bioreactors, the authors present a comprehensive, unified introduction to the principles and practices of the field. The work features nearly 100 detailed design examples and problems, many of which are suitable for hands-on demonstrations on a personal computer or for expanded research. The text will serve as a highly instructive guide for students in bioengineering and biotechnology, as well as biochemical, chemical, and environmental engineering.
Download or read book Bioprocess Engineering written by Shijie Liu and published by Newnes. This book was released on 2012-11-21 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioprocess Engineering involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering- introducing key principles that enable bioprocess engineers to engage in the analysis, optimization, design and consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme of this book, while more advanced techniques and applications are covered with some depth. Many theoretical derivations and simplifications are used to demonstrate how empirical kinetic models are applicable to complicated bioprocess systems. Contains extensive illustrative drawings which make the understanding of the subject easy Contains worked examples of the various process parameters, their significance and their specific practical use Provides the theory of bioprocess kinetics from simple concepts to complex metabolic pathways Incorporates sustainability concepts into the various bioprocesses
Download or read book Measurement Monitoring Modelling and Control of Bioprocesses written by Carl-Fredrik Mandenius and published by Springer. This book was released on 2014-07-08 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, by Bernhard Sonnleitner Automatic Control of Bioprocesses, by Marc Stanke, Bernd Hitzmann An Advanced Monitoring Platform for Rational Design of Recombinant Processes, by G. Striedner, K. Bayer Modelling Approaches for Bio-Manufacturing Operations, by Sunil Chhatre Extreme Scale-Down Approaches for Rapid Chromatography Column Design and Scale-Up During Bioprocess Development, by Sunil Chhatre Applying Mechanistic Models in Bioprocess Development, by Rita Lencastre Fernandes, Vijaya Krishna Bodla, Magnus Carlquist, Anna-Lena Heins, Anna Eliasson Lantz, Gürkan Sin and Krist V. Gernaey Multivariate Data Analysis for Advancing the Interpretation of Bioprocess Measurement and Monitoring Data, by Jarka Glassey Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks, by Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira Knowledge Management and Process Monitoring of Pharmaceutical Processes in the Quality by Design Paradigm, by Anurag S Rathore, Anshuman Bansal, Jaspinder Hans The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses, by Ian Marison, Siobhán Hennessy, Róisín Foley, Moira Schuler, Senthilkumar Sivaprakasam, Brian Freeland
Download or read book Bioprocess Engineering Principles written by Pauline M. Doran and published by Academic Press. This book was released on 2012-04-23 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This welcome new edition discusses bioprocess engineering from the perspective of biology students. It includes a great deal of new material and has been extensively revised and expanded. These updates strengthen the book and maintain its position as the book of choice for senior undergraduates and graduates seeking to move from biochemistry/microbiology/molecular biology to bioprocess engineering. All chapters thoroughly revised for current developments, with over 200 pgs of new material, including significant new content in: Metabolic Engineering, Sustainable Bioprocessing, Membrane Filtration, Turbulence and Impeller Design, Downstream Processing, Oxygen Transfer Systems Over 150 new problems and worked examples More than 100 new illustrations
Download or read book Advances in Bioprocess Engineering and Technology written by Doraiswami Ramkrishna and published by Springer Nature. This book was released on 2020-09-29 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the select peer-reviewed proceedings of the International Conference on Advances in Bioprocess Engineering and Technology (ICABET 2020). The book covers all aspects of bioprocesses, especially related to fermentation technology, food technology, environmental biotechnology, and sustainable energy. Along with this primary theme, the focus is on recent advances in bioprocessing research such as biosensors, micro-reactors, novel separation techniques, bioprocess control, bio-safety, advanced techniques for waste to wealth generation, and nanobiotechnology. This contents are divided according to the major themes of the conference: (i) Fermentation Technology and Bioreactor, (ii) Food Pharmaceuticals and Health care, (iii) Environment and Agriculture, and (iv) Sustainable Energy. This book is intended to help students, researchers, and industry professionals acquire knowledge on innovative technologies and recent advancements in the field of bioprocess engineering and technology.
Download or read book Bioreaction Engineering Principles written by Jens Høiriis Nielsen and published by Taylor & Francis US. This book was released on 2002-12-31 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors (affiliated with BioCentrum-DTU, Denmark and Lund U., Sweden) present the new edition of a textbook that aims to explain the proper analysis of bioreactions in order to change outcomes. They focus on the operation of the cell factory and the interaction of the cell factories with each other and the environment imposed via operation of the bioreactor. Chapters cover the thermodynamics of biochemical reactions, biochemical reaction networks, enzyme kinetics and metabolic control analysis, modeling of growth kinetics, population balance equations, design of fermentation process, mass transfer, and scale-up of bioprocesses. The material should be understandable to most students with a background in chemical engineering. Annotation (c)2003 Book News, Inc., Portland, OR (booknews.com).
Download or read book Bioreactors written by Carl-Fredrik Mandenius and published by John Wiley & Sons. This book was released on 2016-02-16 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
Download or read book Multiphase Bioreactor Design written by Joaquim M.S. Cabral and published by CRC Press. This book was released on 2001-09-20 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreaction engineering is fundamental to the optimization of biotechnological processes and the production of biochemicals by enzymes, microbial, plant and animal cells and higher organisms. A reference text for postgraduate students and researchers in biochemical engineering and bioreactor design, Multiphase Bioreactor Design describes the
Download or read book Bioanalysis and Biosensors for Bioprocess Monitoring written by Bernhard Sonnleitner and published by Springer. This book was released on 2003-06-30 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book Bioreaction Engineering written by K. Schügerl and published by Springer. This book was released on 2011-12-21 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.
Download or read book Bioprocess Engineering written by Michael L. Shuler and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sensors in Bioprocess Control written by John Twork and published by CRC Press. This book was released on 1990-05-25 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the reader with an overview of current chemical sensor technology and outlines a framework relating industrial bioprocess monitoring to modern process control technology. It deals with conventional multivariable control technology, focusing on bioprocess applications.
Download or read book Bioreactors written by Goutam Saha and published by CRC Press. This book was released on 2017-12-01 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.
