Download or read book Biophysics and Nanotechnology of Ion Channels written by Mohammad Ashrafuzzaman and published by CRC Press. This book was released on 2021-09-20 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the biophysics and nanotechnology of ion channels. It details the biological and physiological entities of ion channels in cells and addresses various physical perspectives of ion channel structures and functions. Naturally inbuilt and artificial applicable nanotechnologies of ion channels are modelled and explored. It discusses various methods that can be utilized toward understanding ion channel-based cellular diseases. Physical, biochemical, biomedical, and bioinformatics techniques are taken into consideration to enable the development of strategies to address therapeutic drug discovery and delivery. This book will be of interest to advanced undergraduate and graduate students in biophysics and related biomedical sciences in addition to researchers in the field and industry. Features: Provides a stimulating introduction to the structures and functions of ion channels of biological cell membranes and discusses the biophysics of ion channels in condensed matter state and physiological condition Addresses natural processes and nanotechnology opportunities for their purposeful manipulation Lays the groundwork for vitally important medical advances Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing the principles and techniques of physics. He is an associate professor at King Saud University’s Biochemistry Department of College of Science, Riyadh, Saudi Arabia, the co-founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He also authored Nanoscale Biophysics of the Cell and Membrane Biophysics.
Download or read book Biological Membrane Ion Channels written by Shin-Ho Chung and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Download or read book Voltage Sensitive Ion Channels written by H. Richard Leuchtag and published by Springer Science & Business Media. This book was released on 2008-12-21 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book examines physically oriented approaches not covered in other ion-channel books, and it develops a new physics-based approach to the problem of molecular excitability.
Download or read book Membrane Biophysics written by Mohammad Ashrafuzzaman and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physics, mathematics and chemistry all play a vital role in understanding the true nature and functioning of biological membranes, key elements of living processes. Besides simple spectroscopic observations and electrical measurements of membranes we address in this book the phenomena of coexistence and independent existence of different membrane components using various theoretical approaches. This treatment will be helpful for readers who want to understand biological processes by applying both simple observations and fundamental scientific analysis. It provides a deep understanding of the causes and effects of processes inside membranes, and will thus eventually open new doors for high-level pharmaceutical approaches towards fighting membrane- and cell-related diseases.
Download or read book Biological Membrane Ion Channels written by Shin-Ho Chung and published by Springer. This book was released on 2006-11-17 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Download or read book Sensing with Ion Channels written by Boris Martinac and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells and plants. It summarizes comprehensively the progress that has been made in studies of ion channels and their role in sensory physiology.
Download or read book Ion Channels in Biophysics and Physiology written by Lei Zhou and published by Springer Nature. This book was released on 2022-02-09 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells present in the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse physiological functions, including the secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling, especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, research on ion channels carries significant meaning for the understanding of basic protein biophysics and diverse physiological functions. Such vital information also assists in developing novel and effective treatments for related human diseases. This book provides graduates and scientists in both basic and clinical levels a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.
Download or read book Nanoscale Biophysics of the Cell written by Mohammad Ashrafuzzaman and published by Springer. This book was released on 2018-04-12 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macroscopic cellular structures and functions are generally investigated using biological and biochemical approaches. But these methods are no longer adequate when one needs to penetrate deep into the small-scale structures and understand their functions. The cell is found to hold various physical structures, molecular machines, and processes that require physical and mathematical approaches to understand and indeed manipulate them. Disorders in general cellular compartments, perturbations in single molecular structures, drug distribution therein, and target specific drug-binding, etc. are mostly physical phenomena. This book will show how biophysics has revolutionized our way of addressing the science and technology of nanoscale structures of cells, and also describes the potential for manipulating the events that occur in them.
Download or read book Towards Molecular Biophysics of Ion Channels written by M. Sokabe and published by Elsevier Science & Technology. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the proceedings of the 19th Taniguchi symposium in biophysics held at Nagoya, Japan, organized to help find a path towards the molecular biophysics of the ion channel.
Download or read book Ion Channels written by David J. Aidley and published by Cambridge University Press. This book was released on 1996-08-13 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.
Download or read book Ion Channels written by T. Narahashi and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Further establishes the reputation of the series...an invaluable resource.' -Trends in Pharmacological Sciences, from a review of Volume 3 Volume 4 explores such emergent topics as: three-dimensional conceptions of ion channel proteins based on the available structural and functional data; the structure, pharmacology, and regulation of the GABAA receptors; and the Ca2+-dependent K+ channels in adrenal chromatic cell membranes.
Download or read book Ion Channels in Biophysics and Physiology written by Lei Zhou and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells from the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse function including secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, researches on ion channels carry significant meaning for the understanding of basic protein biophysics and diverse physiological functions and for developing novel and effective treatment for related human diseases. This book could provide graduates and scientists in both basic and clinical levels, a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.
Download or read book Biophysics Of Ion Channels And Diseases written by Hervé Duclohier and published by . This book was released on 2009-01-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foreword:- This book is devoted to Ion Channels, membrane proteins allowing ions to cross biological membranes, whether excitable or not, under the action of various stimuli (mainly voltage changes and ligand binding). The first four chapters deal with some biophysical aspects with the gating of calcium-activated potassium channels and gap junctions (or connexins). IP3 Receptors in skeletal muscle and at the neuromuscular junction (or end-plate) are also dealt with. A chapter describes a new near-field microscopy particularly suited to study membrane topography that can be coupled to patch-clamp. The remaining chapters really constitute the bulk of this book describing various channelopathies (diseases associated with dysfunctions of ion channels through for instance mutations). These abnormalities affect heart (long QT and Brugada syndromes), involving for instance potassium (KCNE1/KCNQ1) and sodium channels (Nav 4 and 5), skeletal muscle with myopathies such as Duchenne dystrophy and Andersen s syndrome (periodic paralysis, cardiac arrhythmia and development abnormalities) linked to the potassium channel inward rectifier Kir2.1. Finally, the last two chapters deal with cancer induced by sodium and gap junctions dysfunction, respectively. No doubt, this field will continue to grow with more basic insights into structural and functional studies of ion channels and receptors with potential fall-outs for the treatment of both rare and numerous diseases associated with channel malfunctions.
Download or read book Introduction to Modern Biophysics written by Mohammad Ashrafuzzaman and published by CRC Press. This book was released on 2023-12-15 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an introduction to the fundamental and applied aspects of biophysics for advanced undergraduate and graduate students of physics, chemistry, and biology. The application of physics principles and techniques in exploring biological systems has long been a tradition in scientific research. Biological systems hold naturally inbuilt physical principles and processes which are popularly explored. Systematic discoveries help us understand the structures and functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and even the physiological systems of animals and plants. Utilizing a physics- based scientific understanding of biological systems to explore disease is at the forefront of applied scientific research. This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizons and directions of research. It contains models based on both classical and quantum mechanical treatments of biological systems. It explores diseases related to physical alterations in biomolecular structures and organizations alongside drug discovery strategies. It also discusses the cutting- edge applications of nanotechnologies in manipulating nanoprocesses in biological systems. Key Features: • Presents an accessible introduction to how physics principles and techniques can be used to understand biological and biochemical systems. • Addresses natural processes, mutations, and their purposeful manipulation. • Lays the groundwork for vitally important natural scientific, technological, and medical advances. Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing physics principles and techniques. He is a professor of biophysics at King Saud University’s Biochemistry Department in the College of Science, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology of Ion Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also published about 50 peer- reviewed articles and several patents, edited two books, and has been serving on the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has held research and academic ranks at Bangladesh University of Engineering & Technology, University of Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College of Cornell University (USA), and University of Alberta (Canada). During 2013– 2018 he also served as a Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology, of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor of Science (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.
Download or read book Ion Channels Channel Biochemistry Reconstitution and Function written by and published by Academic Press. This book was released on 2021-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series
Download or read book Ion Channel Reconstitution written by C. Miller and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now over 30 years since the idea of ion-conducting pores burst on the elec trophysiological scene, 15 years since these were generalIy realized to be mem brane-spanning proteins, and 10 years since the first observations of single ion channels from higher organisms were made. During the past 5 years, several integral membrane channel proteins have been purified in a functionalIy competent state: the nicotinic acetylcholine receptor, the Na + channel, mitochondrial "VDAC," and a variety of porins. The stage is thus set to attack ion channels in the same ways that biochemists have been attacking enzymes for decades: isolation folIowed by functional analysis in as simple a system as possible, with a view towards understanding the molecular mechanisms ofthe protein's behavior and how this is related to the underlying molecular structure. This is always a daunting task, alI the more so with ion channels because of our still primitive and scanty understanding of channel structures and because of the difficulty in iso lating functionally active channel proteins. In this volume, which can be considered a biochemically slanted companion to Sakmann and Neher's Single-Channel Recording, I have tried to present a view of the current landscape of ion-channel reconstitution. These chapters illustrate not only the different approaches and techniques of the major practitioners of ion channel reconstitution but, as importantly, the varied motivations for doing this kind of work.
Download or read book Ion Channels and Disease written by Frances M. Ashcroft and published by Academic Press. This book was released on 1999-10-20 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
