Download or read book Biomarkers in Allergy and Asthma An Issue of Immunology and Allergy Clinics of North America E Book written by Flavia Hoyte and published by Elsevier Health Sciences. This book was released on 2018-10-23 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Immunology and Allergy Clinics, guest edited by Drs. Flavia Hoyte and Rohit Katial, is devoted to Biomarkers in Allergy and Asthma. Articles in this issue include: Exhaled Nitric Oxide; Biomarkers in Exhaled Breath Condensate (EBC); Role of Eosinophils in Asthma; Bronchoprovocation Testing in Asthma; Periostin and DPP4; Role of Neutrophils in Asthma; Urinary LTE4; Biomarkers in Nasal Polyps; IgE as a Biomarker in Asthma; Genetics of Asthma; and Biomarker-directed Therapies for Asthma.
Download or read book Update on Biomarkers in Allergy and Asthma An Issue of Immunology and Allergy Clinics written by Rohit K. Katial and published by Elsevier Health Sciences. This book was released on 2012-10-31 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.
Download or read book Update on Biomarkers in Allergy and Asthma written by and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomarkers in Allergy and Asthma written by Rohit Katial and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Update on Biomarkers in Allergy and Asthma an Issue of Immunology and Allergy Clinics written by Rohit K. Katial and published by Saunders. This book was released on 2012-08-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.
Download or read book Biomarkers in Allergy and Asthma written by Rohit Katial and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Exhaled Biomarkers written by I. Horvath and published by European Respiratory Society. This book was released on 2010-09-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.
Download or read book Severe Asthma An Issue of Immunology and Allergy Clinics of North America E Book written by Rohit K. Katial and published by Elsevier Health Sciences. This book was released on 2016-07-20 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Immunology and Allergy Clinics of North America, guest edited by Dr. Rohit Katial, is devoted to Severe Asthma. Articles in this issue include: Epidemiology and Pulmonary Physiology of Severe Asthma; Linkage and Genetic Associations in Severe Asthma; Asthma COPD Overlap Syndrome (ACOS); Biomarkers in Severe Asthma; Imaging in Severe Asthma; Eosinophilic Phenotype; Neutrophilic and Pauci-immune Phenotypes; Role of Sleep Apnea and Gastroesophageal Reflux Disease in Severe Asthma; Role of Small Airways in Severe Asthma; Chronic Infection and Severe Asthma; Chronic Rhinosinusitis and Aspirin Associated Respiratory Disease; Psychosocial Factors in Severe Asthma; Traditional Therapies for Severe Asthma; and Emerging Biologics for Severe Asthma.
Download or read book Biomarkers in Drug Hypersensitivity written by José A. G. Agúndez and published by Frontiers Media SA. This book was released on 2017-07-25 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions. Drug-induced hypersensitivity reactions involve complex mechanisms that include, among others, the metabolic activation and haptenization of drug metabolites. Hence, factors that influence the pharmacokinetics of drug and metabolites may contribute to the development of some drug-induced hypersensitivity reactions. This implies that processes such as ADME (absorption, distribution, metabolism and excretion) that are typically involved in type A adverse drug reactions, may have a role in hypersensitivity reactions too. In addition to metabolic activation, several signal transduction pathways participate and modulate the development and the clinical presentation of drug hypersensitivity. The diverse mechanisms underlying such drug-hypersensitivity reactions lead to four major groups of reactions according to the Gell and Coombs classification: immediate, cytotoxic, immune complex and delayed. The enormous complexity of drug-hypersensitivity reactions is a consequence of the variety of mechanisms involved, which may be related, among others, to drug metabolism, generation of antigenic signals, stimulation and maturation of dendritic cells, presentation of haptens and mechanisms of cytotoxicity. In addition, a plethora of possible clinical presentations exists, including urticaria, angioedema, anaphylaxis, cytopenias, nephritis, serum sickness, vasculitis, contact dermatitis, drug rash, eosinophilia and systemic symptoms, Stevens–Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis. The rapid progress in the field in recent years indicates that the combination of several disciplines is essential to understand the mechanisms involved in this particular, and not completely understood, type of adverse drug reactions. The objective of this Research Topic is to present insights obtained from both basic and clinical scientists, which may include studies related to the identification, validation, refinement and clinical implementation of biomarkers for drug-induced hypersensitivity. The Topic aims to include recent findings related, but not limited to, potential phenomic, genomic, proteomic, metabolomic and signal transduction biomarkers. These biomarkers could eventually be used in clinical practice and/or these might contribute, as a proof of concept, to our understanding of the complex events leading to drug hypersensitivity reactions. In addition the Topic will cover recent developments and methodological advances in the diagnosis, prevention and therapeutic management of drug-induced hypersensitivity.
Download or read book Implementing Precision Medicine in Best Practices of Chronic Airway Diseases written by Ioana Agache and published by Academic Press. This book was released on 2018-09-19 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice. Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease
Download or read book Immunological Biomarkers of Allergic Bronchopulmonary Aspergillosis in Patients with Asthma written by Yana Kozlova and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological biomarkers of allergic bronchopulmonary aspergillosis in patients with asthma1 Kozlova Y (Assistant - professor), 2Frolova E (head of the laboratory), 2 Uchevatkina A (senior scientific researcher), 2 Filippova L (senior scientific researcher), 1 Sobolev A (professor of the department), 1 1Nikitin O., Klimko N (head of the department)1 Department of Clinical Mycology, Allergy and Immunology of North Western State Medical University named after I.I.Mechnikov; 2 Kashkin Research Institute of Medical Mycology of North Western State Medical University St. Petersburg, RussiaObjective. To study the immunological biomarkers of allergic bronchopulmonary aspergillosis (ABPA) in patients with bronchial asthma.Methods. In prospective study were included 44 adult patients (Me - 43 years) with severe asthma. The control group consisted of 12 healthy people, matched by age and sex, without a history of allergic diseases (Me - 33 years). The severity of asthma and level of symptoms control were determined with GINA, 2016 criteria. The pulmonary function was assessed with FEV1 and FVC. An Asthma Control Test (AST) questionnaire was used. Allergy examination included skin testing with A. fumigatus allergen (u00abAllergopharmau00bb, Germany), determination of the serum total IgE level (u00abPolygnostu00bb, Russia) and specific IgE (sIgE) for fungal allergens (u00abAlkorBiou00bb, Russia). Determination of the serum concentration of TARC (u00abR&D Systemsu00bb, USA), TSLP (u00abR&D Systemsu00bb, USA), IL-8 (u00abVector-Bestu00bb, Russia) was performed by ELISA. The obtained data were processed using the software system STATISTICA 10 and presented as the median (Me) and upper and lower quartiles (Lq-Hq). Severe asthma with fungal sensitization (SAFS) and ABPA were diagnosed with R. Agarwal et al. 2013 criteria.Results. SAFS (positive skin test results and fungal allergens sIgE levels (.35 IU/ml) was diagnosed in 14 (32%) patients, ABPA u2013 13 (30%). In ABPA patients were identified significantly lower AST score and FVC, FEV1. The TSLP serum levels did not differ between ABPA patients u2013 12.0 (8.8u00f724.7), SAFS u2013 16.8 (9.7u00f727.7), asthma u2013 22.8 (14.6u00f731.8), and the control group u2013 13,2 (9,1u00f722,1) pg/ml. The serum TARC concentration was significantly higher in ABPA patients u2212 733.5 (540.0u00f7812.0) compared with the asthma group u2013 429.1 (218.0 u00f7 571.3, p=0.001) and control group 202.5 (195.9u00f7256.0, p=0.001) pg/mg. A negative correlation between TARC levels and FVC (r = - 0.47, p
Download or read book Allergy and Asthma written by and published by Springer. This book was released on 2019-06-25 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergy and Asthma: The Basics to Best Practices is intended to serve as a single comprehensive reference covering all needed knowledge of allergic diseases. Allergy is a unique and distinctive area of medicine wherein learning the fundamentals requires gathering information from various different disciplines. Allergic diseases affect various organ systems and the practice of a wide range of physicians from otolaryngologists, and pulmonologists, to gastroenterologists, dermatologists, and ophthalmologists. Clinicians and trainees alike will benefit from a resource that introduces the basic concepts, as well as providing comprehensive, consistently up-to-date instruction on intermediate and advanced conditions, research, and treatment strategies. The book is divided into nine sections and is written by some of the foremost experts in the field. Allergy and Asthma opens with an introduction which covers the epidemiology of allergic diseases, fundamentals of allergy and immunology, and a thorough grounding of different types of allergens. Early sections address allergic upper airway diseases, allergic skin diseases, and asthma in detail, using a structured, consistent format from chapter to chapter to provide continuity and ease of reference. Later sections thoroughly cover various food allergies, insect allergies, drug allergy, anaphylaxis, and utilize ample tables and illustrations to provide additional learning tools for the reader. This major reference not only provides basic knowledge on diagnosing and treating allergies, but moves beyond these basics to emphasize using a systematic approach to working up and treating a patient. A variety of techniques used in diagnosing asthma and allergy will be examined, of which include prick skin tests, in-vitro testing, patch testing and non-conventional allergy tests. Concluding this book are sections dedicated to management, therapeutic strategies of allergy and asthma, with a look to future research directions for this unique field. Physicians and residents in allergy and immunology, pulmonology, otolaryngology, gastroenterology, dermatology, ophthalmology and other specialties will find the work of value in enhancing their practice and studies. Researchers in a range of areas especially immunology and food science will also find this text to be a compelling and reliable resource.
Download or read book Severe Asthma written by Yong Chul Lee and published by Springer. This book was released on 2017-10-30 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients’ symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff.
Download or read book Asthma written by Celso Pereira and published by BoD – Books on Demand. This book was released on 2016-07-06 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical specificities developed in this book, particularly from those reported in the pediatric population to those reported in complex shapes at ACOS patients, emphasize the importance of identifying not only biomarkers but also critical aspects regarding the variability in pharmacogenomics responsible for the individual response to the different drugs on the therapeutic plan. The contribution of several well-known specialists with their profound knowledge inherent to this issue into different age groups and socio geographical contexts has resulted in this interesting book with relevant key contents in asthma.
Download or read book Non invasive Sampling Methods of Inflammatory Biomarkers in Asthma and Allergic Rhinitis written by Johan Diderik Boot and published by . This book was released on 2009 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genomic Biomarkers for Pharmaceutical Development written by Joseph R. Arron and published by Elsevier Inc. Chapters. This book was released on 2013-07-16 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma is a heterogeneous disorder on molecular, cellular, physiological, and clinical levels, but there is a lack of consensus on how discrete subtypes of asthma should be defined. Gene expression profiling of bronchial samples from asthma patients and healthy controls has enabled the definition of molecular subtypes of asthma which correspond to distinct pathophysiological features. Genomic data from bronchial samples has been used to identify non-invasive biomarkers such as serum periostin, fractional exhaled nitric oxide (FeNO), and blood eosinophil counts which correspond to these molecular subtypes. These biomarkers have been used in recent proof-of-concept clinical trials of investigational biologic therapies directed at the type 2 cytokines interleukin (IL) 5 and 13 to stratify patients according to the activity of the targeted pathways, enabling the enrichment of subsets of patients most likely to show clinical benefit from those interventions. However, translating these biomarkers into companion diagnostic tests subject to regulatory approval will be a complex process, and intriguing initial findings must be verified prospectively in pivotal clinical trials.
Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
