Download or read book Biological Responses to Nanoscale Particles written by Peter Gehr and published by Springer. This book was released on 2019-04-16 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine. Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.
Download or read book Measuring Biological Impacts of Nanomaterials written by Joachim Wegener and published by Springer. This book was released on 2016-02-02 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.
Download or read book Unraveling the Safety Profile of Nanoscale Particles and Materials written by Andreia Ferreira de Castro Gomes and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: As nanomaterials become increasingly present in our daily lives, pertinent questions regarding their safety arise. Nanomaterial risk assessment, as in other areas, directs much of the effort worldwide in defining guidelines that may be translated into national or international directives. Nanomaterials encompass different entities, from nanoparticles to nanostructured materials, with specific effects over cells, tissues, organisms and ecosystems depending on their biophysical characteristics. Such interactions will directly affect the impact of novel nanotechnologies. This book aims to provide the reader with a comprehensive overview of the current state of the art in nanotoxicology, featuring the most important developments and critical issues regarding the use of and exposure to nanoparticles.
Download or read book Protein Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Download or read book Biointeractions of Nanomaterials written by Vijaykumar B. Sutariya and published by CRC Press. This book was released on 2014-07-29 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues. Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials. These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.
Download or read book Soft Nanomaterials written by Zhang Ye and published by World Scientific. This book was released on 2019-09-18 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soft materials with nanometer scale aspects have been heavily used in biomedical science. Instead of providing a broad introduction of soft materials and their biomedical applications, this book focuses on the preparation of molecular assemblies of biotechnologically relevant biomimetic systems with an emphasis on medical applications.
Download or read book Nanodiamonds written by Dean Ho and published by Springer Science & Business Media. This book was released on 2009-11-25 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanodiamonds: Applications in Biology and Nanoscale Medicine highlights the translation of nanodiamonds toward clinical relevance and medical applications. Integrating a spectrum of internationally-recognized experts currently developing these technologies, this book fits as a cornerstone of this exciting field. These include contributions from clinician scientists working at the interface of medicine and nanotechnologies which discuss the critical and requisite properties of nanomaterials, in a concise and cohesive manner. Nanodiamonds: Applications in Biology and Nanoscale Medicine provides a multidisciplinary overview of nanodiamonds and there uses for scientific, engineering and clinical audiences alike.
Download or read book Nanoscale Technology in Biological Systems written by Ralph S. Greco and published by CRC Press. This book was released on 2004-12-20 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscale Technology in Biological Systems reviews recent accomplishments in the field of nanobiology and introduces the application of nanoscale matrices to human biology. It focuses on the applications of nanotechnology fabrication to biomedical devices and discusses new physical methods for cell isolation and manipulation and intracellular commu
Download or read book Molecular Impacts of Nanoparticles on Plants and Algae written by Huseyin Tombuloglu and published by Elsevier. This book was released on 2024-03-26 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Impacts of Nanoparticles on Plants and Algae covers molecular mechanisms of plants/algae related to cellular uptake and translocation of nanoparticles, and genome, transcriptome, proteome, and metabolome responses against it. The book introduces readers to state-of-the-art developments and trends of nanoparticles and plants/algae including interaction of nanoparticles with biological compounds in vitro. Nanoscience and nanotechnology have rapidly been developed in the last few decades, and they have a wide range of applications in industry, medicine, food, and agriculture. In agriculture, nanoparticles (NPs) have successfully been used for growth regulation, crop protection and improvement. They are also employed to cope with plant nutrient deficiencies. A predicted significant increase in the output of NPs will cause the discharge of a remarkable number of NPs to ecosystems, creating a need to understand how to optimize or mitigate their impact depending on their potential impact. These include serious health concerns for living organisms in aquatic, terrestrial, and atmospheric environments as well as human health through their potential existence in plant-based foods. The impact of NPs on living organisms including plants and algae, and uptake, translocation and molecular response mechanisms should be carefully considered before producing and using nanoparticles in large amounts as NPs, when entered to the body, induce changes in gene expressions related to the photosystem, water transport, cell wall formation, and cell division. Further recent studies have showed that NPs are potential agents or stressors to alter proteome, transcriptome, genome and metabolome responses. Impacts of nanoparticles on molecular mechanisms of plants and algae presents the most recent findings on nanoparticle and plant/algae interaction by focusing to molecular response mechanisms at genome, transcriptome, proteome and metabolome levels. In addition, uptake and translocation mechanism of nanoparticles will be assessed both in plant and algae Throughout this book, the latest developments and discoveries will be highlighted as well as open problems and future challenges in molecular mechanisms of plants/algae as a response of nanoparticles. Presents genome, transcriptome, proteome, and metabolome responses in plants/algae, along with cellular uptake and translocation mechanisms Illustrates nano-particle-plant/algae interactions Covers both simple and higher organisms, addressing both algae and plant
Download or read book Nanoparticles in Cancer Theranostics written by Prudhvi Lal Bhukya and published by CRC Press. This book was released on 2024-10-07 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the application of nanoparticles in cancer diagnosis and treatment. The introductory section provides a fundamental understanding of cancer biology, its global incidence and prevalence, and the intricate nano–bio interactions at the cellular level. The subsequent section discusses the pivotal role of nanoparticles in precise cancer detection, enhancing cancer imaging and serving as contrast agents for accurate diagnosis. It also presents cutting-edge nanotechnology-based methods for detecting HTLV-1 retroviruses. The following section covers the utilization of lipid-based nanoparticles, monoclonal antibodies, and advanced nanotherapeutics for targeted cancer treatments. This book is a useful resource for researchers, clinicians, and students in the fields of oncology and nanotechnology.
Download or read book Microstructure and Properties of Micro and Nanoscale Materials Films and Coatings NAP 2019 written by Alexander D. Pogrebnjak and published by Springer Nature. This book was released on 2020-01-28 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the findings of experimental and theoretical (including first-principles molecular dynamics simulation) studies of nanostructured and nanocomposite metal-based materials, and nanoscale multilayer coatings fabricated by physical or chemical vapor deposition, magnetron sputtering, electrospark alloying, ionic layer absorption, contact melting, and high-current electron beam irradiation. It also discusses novel methods of nanocomposite formation, as well as the structure of the deposited films, coatings and other nanoscale materials, their elemental and phase composition, and their physical–mechanical, tribological, magnetic and electrical properties. Lastly, it explores the influence of a various surface modification methods, such as thermal annealing, pulsed laser modification, and thermomechanical and ultrasonic treatment, as well as different properties of nanostructured films.
Download or read book Bio Nanotechnology written by Manashi Bagchi and published by John Wiley & Sons. This book was released on 2012-11-26 with total page 1118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-nanotechnology is the key functional technology of the 21st century. It is a fusion of biology and nanotechnology based on the principles and chemical pathways of living organisms, and refers to the functional applications of biomolecules in nanotechnology. It encompasses the study, creation, and illumination of the connections between structural molecular biology, nutrition and nanotechnology, since the development of techniques of nanotechnology might be guided by studying the structure and function of the natural nano-molecules found in living cells. Biology offers a window into the most sophisticated collection of functional nanostructures that exists. This book is a comprehensive review of the state of the art in bio-nanotechnology with an emphasis on the diverse applications in food and nutrition sciences, biomedicine, agriculture and other fields. It describes in detail the currently available methods and contains numerous references to the primary literature, making this the perfect “field guide” for scientists who want to explore the fascinating world of bio-nanotechnology. Safety issues regarding these new technologies are examined in detail. The book is divided into nine sections – an introductory section, plus: Nanotechnology in nutrition and medicine Nanotechnology, health and food technology applications Nanotechnology and other versatile applications Nanomaterial manufacturing Applications of microscopy and magnetic resonance in nanotechnology Applications in enhancing bioavailability and controlling pathogens Safety, toxicology and regulatory aspects Future directions of bio-nanotechnology The book will be of interest to a diverse range of readers in industry, research and academia, including biologists, biochemists, food scientists, nutritionists and health professionals.
Download or read book Nanotoxicology in Humans and the Environment written by Jamie R. Lead and published by Springer Nature. This book was released on 2021-12-13 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers the area of ‘Nanotoxicology’ but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.Nanotoxicology in Humans and the Environment is written for researchers in nanotoxicology in academia, industry, government, and research students. Given the rapid development, the maturing of the discipline and its importance in current regulation and industry development (eg REACH, TSCA), the book is very timely.
Download or read book Nano Comes to Life written by Sonia Contera and published by Princeton University Press. This book was released on 2019-11-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nanotechnology revolution that will transform human health and longevity Nano Comes to Life opens a window onto the nanoscale—the infinitesimal realm of proteins and DNA where physics and cellular and molecular biology meet—and introduces readers to the rapidly evolving nanotechnologies that are allowing us to manipulate the very building blocks of life. Sonia Contera gives an insider's perspective on this new frontier, revealing how nanotechnology enables a new kind of multidisciplinary science that is poised to give us control over our own biology, our health, and our lives. Drawing on her perspective as one of today's leading researchers in the field, Contera describes the exciting ways in which nanotechnology makes it possible to understand, interact with, and manipulate biology—such as by designing and building artificial structures and even machines at the nanoscale using DNA, proteins, and other biological molecules as materials. In turn, nanotechnology is revolutionizing medicine in ways that will have profound effects on our health and longevity, from nanoscale machines that can target individual cancer cells and deliver drugs more effectively, to nanoantibiotics that can fight resistant bacteria, to the engineering of tissues and organs for research, drug discovery, and transplantation. The future will bring about the continued fusion of nanotechnology with biology, physics, medicine, and cutting-edge fields like robotics and artificial intelligence, ushering us into a new "transmaterial era." As we contemplate the power, advantages, and risks of accessing and manipulating our own biology, Contera offers insight and hope that we may all share in the benefits of this revolutionary research.
Download or read book Polymeric nanoparticles for the treatment of solid tumors written by Santwana Padhi and published by Springer Nature. This book was released on 2022-11-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while reducing side effects. Drug carriers must be biocompatible, biodegradable and non-immunogenic. Coupled to a ligand that has affinity for that particular cell, polymeric nanoparticles are used to target specifically malignant cells or tissues and, in turn, improve drug stability. This book presents the latest advances in the application of polymeric particles for cancer treatment, with focus on the tumor microenvironment, synthesis, active and passive targeting, patents, targeting over-expressed receptors, tumor-targeting ligands, theranostics, glioblastoma tumors, lung cancer, breast cancer, prostate cancer and pH-responsive nanoparticles
Download or read book Nanomaterials for Drug Delivery and Neurological Diseases Management written by Santosh Kumar Rath and published by Springer Nature. This book was released on with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Clinical Nanomedicine written by Raj Bawa and published by CRC Press. This book was released on 2016-04-27 with total page 1472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique handbook (60 chapters) examines the entire "product life cycle," from the creation of nanomedical products to their final market introduction. While focusing on critical issues relevant to nanoproduct development and translational activities, it tackles topics such as regulatory science, patent law, FDA law, ethics, personalized medicin
