Download or read book Biofabrication and 3D Tissue Modeling written by Dong-Woo Cho and published by Royal Society of Chemistry. This book was released on 2019-01-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Download or read book Essentials of 3D Biofabrication and Translation written by Anthony Atala and published by Academic Press. This book was released on 2015-07-17 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

Download or read book 3D Bioprinting written by Dong-Woo Cho and published by Springer Nature. This book was released on 2019-12-04 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text advances fundamental knowledge in modeling in vitro tissues/organs as an alternative to 2D cell culture and animal testing. Prior to engineering in vitro tissues/organs,the descriptions of prerequisites (from pre-processing to post-processing) in modeling in vitro tissues/organs are discussed. The most prevalent technologies that have been widely used for establishing the in vitro tissue/organ models are also described, including transwell, cell spheroids/sheets, organoids, and microfluidic-based chips. In particular, the authors focus on 3D bioprinting in vitro tissue/organ models using tissue-specific bioinks. Several representative bioprinting methods and conventional bioinks are introduced. As a bioink source, decellularized extracellular matrix (dECM) are importantly covered, including decellularization methods, evaluation methods for demonstrating successful decellularization, and material safety. Taken together, the authors delineate various application examples of 3D bioprinted in vitro tissue/organ models especially using dECM bioinks.

Download or read book Engineering 3D Tissue Test Systems written by Karen J.L. Burg and published by CRC Press. This book was released on 2017-07-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

Download or read book 3D Printing and Biofabrication written by Aleksandr Ovsianikov and published by Springer. This book was released on 2018-06-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an in-depth introduction to 3D printing and biofabrication and covers the recent advances in additive manufacturing for tissue engineering. The book is divided into two parts, the first part on 3D printing discusses conventional approaches in additive manufacturing aimed at fabrication of structures, which are seeded with cells in a subsequent step. The second part on biofabrication presents processes which integrate living cells into the fabrication process.

Download or read book Biofabrication written by Joydip Kundu and published by Elsevier Inc. Chapters. This book was released on 2013-03-18 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have advanced from merely interacting with the body to controlling biological processes toward the goal of tissue regeneration. In order to reconstitute a new tissue or repair a damaged/diseased tissue, three components are critical for regenerative medicine or tissue engineering: cells, biomaterials as scaffold substrates, and growth factors. Thus, the design and selection of materials and the methods used for scaffold fabrication play a very important role in tissue engineering and regenerative medicine. Recent developments in biofabrication strategies have created enormous possibilities for the construction of biomimetic 3D scaffolds, where well-defined architectures can be generated with suitable surface chemistry using appropriate materials. This chapter summarizes the materials used for the fabrication of scaffolds, the different types of scaffold manufacturing processes, and the basics of the various tissue-specific scaffolds used in regenerative medicine.

Download or read book Biofabrication written by Gabor Forgacs and published by William Andrew. This book was released on 2013-03-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biofabrication is a practical guide to the novel, inherently cross-disciplinary scientific field that focuses on biomanufacturing processes and a related range of emerging technologies. These processes and technologies ultimately further the development of products that may involve living (cells and/or tissues) and nonliving (bio-supportive proteins, scaffolds) components. The book introduces readers to cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips as a coherent micro-/nano-fabrication toolkit. Real-world examples illustrate how to apply biofabrication techniques in areas such as regenerative medicine, pharmaceuticals and tissue engineering. In addition to being a vital reference for scientists, engineers and technicians seeking to apply biofabrication techniques, this book also provides an insight into future developments in the field, and potential new applications. Discover the multi-disciplinary toolkit provided by biofabrication and apply it to develop new products, techniques and therapies Covers a range of important emerging technologies in a coherent manner: cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips... Readers develop the ability to apply biofabrication technologies through practical examples

Download or read book Biofabrication of 3d Liver Tissue Constructs As Drug Metabolism Models written by Robert Chang and published by LAP Lambert Academic Publishing. This book was released on 2010-06 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coincident with the convergence of a unique layered solid freeform fabrication (SFF) technologies along with microfabrication techniques, a three-dimensional bioprinted micro-organ can serve as an in vitro platform for cell culture, drug screening, or to elicit further biological insights, particularly for NASA's interest of a flight-suitable high-fidelity microscale platform to study drug metabolism in space and planetary environments. This book details the principles, methodology, and engineering science basis that undergird the direct cell writing fabrication process development and adaptation of microfluidic devices for the creation of a in vivo simulating drug screening model. This model involves the combinatorial setup of an automated syringe- based, layered direct cell writing bioprinting process with soft lithographic micro-patterning techniques to fabricate a microscale in vitro device housing a chamber of bioprinted three-dimensional microorgan that biomimics the cell's natural microenvironment for enhanced performance and functionality.

Download or read book 3D Bioprinting written by Ibrahim Tarik Ozbolat and published by Academic Press. This book was released on 2016-11-21 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics

Download or read book Kenzan Method for Scaffold Free Biofabrication written by Koichi Nakayama and published by Springer Nature. This book was released on 2021-01-22 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book about the “Kenzan” method for scaffold-free biofabrication, which does not rely on biomaterials as scaffolds to ensure correct multicellular spheroid positioning for building three dimensional construct only made from cells. The book explains the basic principles and concepts of the microneedle-based (“Kenzan”) method of building surgically-implantable tissue constructs using robotic cell spheroid-based three-dimensional bioprinting, a novel technology that opens up unique opportunities for the bioengineering of tissues and organs. First book on the novel Kenzan method of tissue engineering; Explains basic concepts and applications for organ regeneration modeling; Introduces a unique robotic system for scaffold-free cell construction.

Download or read book Tissue Engineering written by Paulo Rui Fernandes and published by Springer Science & Business Media. This book was released on 2013-07-31 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state of the art on computational modeling and fabrication in Tissue Engineering. It is inspired by the ECCOMAS thematic conference, the European Committee on Computational Methods in Applied Sciences, on Tissue Engineering, held in Lisbon, Portugal, June 2-4, 2011. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. Emphasis is put on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.

Download or read book 3D Bioprinting in Medicine written by Murat Guvendiren and published by Springer. This book was released on 2019-08-02 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides current and emerging developments in bioprinting with respect to bioprinting technologies, bioinks, applications, and regulatory pathways. Topics covered include 3D bioprinting technologies, materials such as bioinks and bioink design, applications of bioprinting complex tissues, tissue and disease models, vasculature, and musculoskeletal tissue. The final chapter is devoted to clinical applications of bioprinting, including the safety, ethical, and regulatory aspects. This book serves as a go-to reference on bioprinting and is ideal for students, researchers and professionals, including those in academia, government, the medical industry, and healthcare.

Download or read book Bioprinting written by Michele Conti and published by Academic Press. This book was released on 2022-05-05 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioprinting: From Multidisciplinary Design to Emerging Opportunities describes state-of-the-art techniques and highlights open issues of different aspects that affect the efficiency of bioprinting protocols. Starting from a description of the main bioprinting technologies, the book addresses the most advanced approaches for the design of "on-demand" biomaterials suitable for incorporating biological components, along with the challenges associated with the development of a cellular model, and with the biological read-out. Coverage includes intelligent process design techniques, emerging technologies, and specific applications. Written by a highly interdisciplinary team of authors and presenting a unified approach to bioprinting, this book is ideal for doctoral and postdoctoral researchers in biotechnology, engineering, and physics, as well as industrial researchers interested in the applications of bioprinting. Presents the basic methodological aspects in common between different applications of bioprinting Covers the most advanced approaches, including novel technologies, printable chemical strategies for 3D biomaterials, multi-criteria bioinks evaluation, bioprinting for skeletal tissue regeneration, and disease modeling Provides protocols, global perspectives, and up-to-date techniques by leading experts in the field

Download or read book Biofabrication written by Bertrand Guillotin and published by Elsevier Inc. Chapters. This book was released on 2013-03-18 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laser-assisted bioprinting (LAB) is an emerging technology in the field of tissue engineering. Its physical mechanism makes it possible to print cells and liquid materials with a cell-level resolution. By giving tissue engineers control over cell density and organization of 3D tissue constructs, LAB holds much promise for fabricating living tissues with physiological functionality. After introducing the rationale of applying LAB to tissue engineering, we present exhaustively the physical parameters related to the laser-induced forward transfer technique (LIFT), which is implemented in LAB. These parameters are critical to controlling the cell printing process and must work together to print viable cell patterns with respect to cell-level histological organization and to high-throughput manufacturing. After describing the experimental requirements that should be considered to fabricate 3D tissues by LAB, we present some of the main breakthroughs, including multicomponent printing, 3D printing approaches, and bioprinting in vivo that may serve in tissue engineering and regenerative medicine.

Download or read book Self Organized 3D Tissue Patterns written by Xiaolu Zhu and published by CRC Press. This book was released on 2022-05-26 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapies for regenerating damaged tissue and organs have been attracting much attention. In order to efficiently regenerate the functions of living tissue and organs, diverse attempts have been made to utilize scaffolds to “mold” artificial tissue structures. However, the structural complexity of reconstituted tissue is limited by the mechanical precision of scaffolds, which still cause problems arising from their degradation, immunogenic reactions, and so forth. It is also being realized that ultimately the best approach might be to rely on the innate self-organizing properties of cells and the regenerative capability of the organism itself. This book investigates the 3D-pattern formation and evolution mechanism in multipotent cells embedded in 3D semi-synthetic hydrogels and the control methodology for self-organized patterns. The authors theoretically and experimentally demonstrate several types of topological 3D-pattern formation by cells in a 3D matrix in vitro, which can be modeled and predicted by mathematical models based on the reaction-diffusion dynamics of various chemical, physical, and mechanical cues. The study, focused on the 3D pattern formation of cells, provides (i) a unique perspective for understanding the self-organized 3D tissue structures based on Turing instability, (ii) the scheme for rationally controlling the cellular self-organization via exogenous factors or tailored inner interfaces inside hydrogels, and (iii) the elaborate and sophisticated regulating method for tuning collective cellular behaviors in 3D matrices.

Download or read book 3D Bioprinting written by Jeremy M. Crook and published by Springer Nature. This book was released on 2020-03-23 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest developments and contributions to the field of 3D bioprinting, and discusses its use for quality R&D and translation. The chapters in this book are divided into two parts: Part one covers generic themes in bioprinting to introduce novice readers to the field, while also providing experts with new and helpful information. Part two discusses protocols used to prepare, characterize, and print a variety of biomaterials, cells, and tissues. These chapters also emphasize methods used for printing defined and humanized constructs suitable for human tissue modelling in research and applicable to clinical product development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, 3D Bioprinting: Methods and Protocols is a valuable resource for researchers and bioprinting laboratories/facilities interested in learning more about this rapidly evolving technology.

Download or read book Emerging Technologies In Biophysical Sciences A World Scientific Reference In 3 Volumes written by and published by World Scientific. This book was released on 2022-10-14 with total page 1078 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1:Biofabrication aims to produce artificially manufactured tissues and organs, potentially revolutionizing conventional paradigm of clinical practice in treating diseases and extending the life span and quality of human beings. In this volume, we invite notable experts in the field of biofabrication and biomanufacturing to summarize recent rapid progress in this field from multifaceted aspects covering biofabrication techniques and building materials such as scaffold and living cells. Specifically, a focus is placed on a variety of techniques derived from 3D bioprinting and bioassembly strategies, such as acoustic assembly and electrofabrication. Moreover, principles and strategies for choosing hydrogels and polymers for biofabrication are also heavily discussed. Overall, this book creates a good opportunity for undergraduate and postgraduate students as well as bioengineers and medical researchers who wish to gain a fundamental understanding of current status and future trends in biofabrication and biomanufacturing.Volume 2:Infertility has become a significant psychosocial burden affecting the lives of couples who cannot reproduce naturally. Advanced reproductive technologies (ARTs) are being developed to treat infertility. This handbook explores significant development of ARTs for fertility testing, selection of sperm, oocyte and embryo, reproductive monitors, automation in embryology, and fertility preservation. This volume provides a comprehensive overview of the myriad of emerging technologies and systems that are being utilized or will be utilized in near future in reproductive clinics. Overall this book creates a good opportunity for undergraduate and postgraduate students as well as scientists and medical researchers who wish to gain fundamental understanding of current status and future trends in fertility and reproductive medicine.Volume 3:Healthcare industry has a notable paradigm transition from centralized care to the point-of-care (POC). During this metamorphosis, a number of new technologies and strategies have been adapted to the current practice, addressing the existing challenges in the fields of medicine and biology. All the efforts aim to improve the clinical management and the effectiveness and quality of care. In particular, diagnostics has pivotal roles in guiding clinical management for the most effective treatment to control and cure the disease. In contrast to the existing diagnostic strategies employing bulky-sized tools, expensive infrastructure, laborious protocols, and lengthy processing steps, the contribution of biosensors to current healthcare system, especially to diagnostics, is paramount. The unprecedented and admirable characteristics of biosensing strategies have expanded our knowledge on medicine and biology by harmonizing materials science, chemistry, physics, and engineering. We believe that biosensors applied to disease diagnostics will not only garner more attention in clinical research to decipher disease biology and mechanism, and also, stimulate innovative perspectives in artificial intelligence (AI) and internet of things (IoT) synergistically, thereby their more facile adaptation to daily-use. Overall this book creates a good opportunity for undergraduate and postgraduate students as well as scientists and medical researchers who wish to gain fundamental understanding of current status and future trends in diagnostic technologies.