Download or read book Biochemistry of Halogenated Organic Compounds written by Kenneth L. Kirk and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Halogenated Organic Compounds has been written as a general reference source for researchers in several related areas, including organic chemists, medicinal chemists, pharmacologists, toxicologists, and medical researchers. The development of halogenated compounds as medicinal agents and pharmacological tools and the fascinating biochemi cal processes that have been discovered and studied using these analogues have generated extremely active areas of research and an enormous volume of literature. Thus, halogenated organic compounds pervade every aspect of biochemistry, a fact made apparent by the numerous reviews and monographs available on individual topics-halogenated nucleosides, halogenated carbohydrates, and so forth. Given the quantity of material already written on these topics, some of which material is quite current, it might be asked whether a one-volume review of these subjects is useful, or possible. Having now completed this work, I feel the answer to both questions is an emphatic yes. There are fascinating stories to be related in each area, and, where appropriate, I have attempted to develop these topics . from a historical perspective. For example, the discovery of the anticancer activity of fluorouracil, the unraveling of the several mechanisms of its action, and the development of a host of later generations of anticancer and antiviral agents based on the parent fluoro-, iodo-, bromo-, and trifluoromethylpyrimidines were, and are, contributions of major magnitude to medical science.
Download or read book Metabolism Summaries of Selected Halogenated Organic Compounds in Human and Environmental Media written by and published by . This book was released on 1979 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemistry of the Elemental Halogens and Inorganic Halides written by Kenneth L. Kirk and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elements in group 17 (VIlA) of the periodic table of elements-fluorine (F), chlorine (CI), bromine (Br), and iodine (I)-were designated by Berzelius as "halogens" (Greek hals, sea salt; gennao, I beget) because of their propensity to form salts. In this first of the two volumes of Bio chemistry of the Halogens, the biochemistry of the elemental halogens and inorganic halides is reviewed. Discovery, properties, and biochemistry of the elemental halogens are reviewed first (Chapter 1). This is followed by a review of the developments in the various areas of inorganic halide biochemistry (Chapters 2 through 5). The biochemistry of thyroid hor mones is considered in Chapter 6, while biohalogenation, an important link between inorganic and organic halogen biochemistry, is reviewed in Chapter 7. Chapter 8 covers the biochemistry of products produced by human-inspired halogenation, in particular, poly halogenated compounds that present environmental problems. In Chapter 9, the process is reversed and biodehalogenation is reviewed. In each subject, the attempt has been made to find an appropriate balance between depth and breadth of treatment, since a thorough, in depth review of this field would not be possible in a single volume. To provide readers not familiar with subjects with the necessary background to place subsequent discussions in perspective, brief historical develop ments of many of the topics are given.
Download or read book Dehalogenation written by Max M. Häggblom and published by Springer. This book was released on 2013-06-05 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Halogenated organic compounds constitute one of the largest groups of environmental chemicals. The industrial production of new halogenated organic compounds has increased throughout the last century peaking in the 1960s, and continuing in widespread use today. Organohalides are integral to a variety of industrial applications, including use as solvents, degreasing agents, biocides, pharmaceuticals, plasticizers, hydraulic and heat transfer fluids, and intermediates for chemical synthesis, to name a few. It is important to recognize the beneficial aspects of halogenated organic compounds, as well as their potentially deleterious impact on the environment and health. Recognition ofthe adverse environmental effects ofmanytypes oforganohalide compounds has led to efforts to reduce or eliminate the most problematic ones. Although organohalide compounds are typically considered to be anthropogenic industrial compounds, they have their counterpart in several thousands of natural biogenic and geogenic organohalides, representing most classes of organic chemicals. Natural sources account for a significant portion of the global organohalogen budget. This volume authored by recognized experts in the field provides a current perspective on how both natural and synthetic organohalides are formed and degraded, and how these processes are incorporated into a global halogen cycle. The focus is on microbial processes, since these play a major role both in the production and degradation, i. e. , cycling of halogenated organic compounds inthe environment. This book is organized into five parts. Part I, Introduction, provides a global perspective on the issues of organohalides and their fate in the environment.
Download or read book Dehalogenation written by Max M. Häggblom and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Halogenated organic compounds constitute one of the largest groups of environmental chemicals. The industrial production of new halogenated organic compounds has increased throughout the last century peaking in the 1960s, and continuing in widespread use today. Organohalides are integral to a variety of industrial applications, including use as solvents, degreasing agents, biocides, pharmaceuticals, plasticizers, hydraulic and heat transfer fluids, and intermediates for chemical synthesis, to name a few. It is important to recognize the beneficial aspects of halogenated organic compounds, as well as their potentially deleterious impact on the environment and health. Recognition ofthe adverse environmental effects ofmanytypes oforganohalide compounds has led to efforts to reduce or eliminate the most problematic ones. Although organohalide compounds are typically considered to be anthropogenic industrial compounds, they have their counterpart in several thousands of natural biogenic and geogenic organohalides, representing most classes of organic chemicals. Natural sources account for a significant portion of the global organohalogen budget. This volume authored by recognized experts in the field provides a current perspective on how both natural and synthetic organohalides are formed and degraded, and how these processes are incorporated into a global halogen cycle. The focus is on microbial processes, since these play a major role both in the production and degradation, i. e. , cycling of halogenated organic compounds inthe environment. This book is organized into five parts. Part I, Introduction, provides a global perspective on the issues of organohalides and their fate in the environment.
Download or read book Rodd s Chemistry of Carbon Compounds written by E. H. Rodd and published by . This book was released on 1983 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanistic Aspects of the Thermal Formation of Halogenated Organic Compounds Including Polychlorinated Dibenzo p dioxins written by Ghulam Ghaus Choudhry and published by CRC Press. This book was released on 1983 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tropospheric Chemistry of Halogenated Organic Compounds written by Caroline M. Greenacre and published by . This book was released on 2004 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New and Future Developments in Catalysis written by Ram Singh and published by Elsevier Inc. Chapters. This book was released on 2013-07-17 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Naturally Produced Organohalogens written by Anders Grimvall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Should the production and use of chlorine and all chlorinated organic compounds be halted, in view of their adverse effects on the environment and human health? Those in favour argue that certain chlorinated compounds (PCBs, DDT, CFCs, etc.) have large negative environmental effects. The use of chlorine in disinfectants leads to the production of chloroform, while bulk products (PVC) contribute to the production of chlorinated dibenzo-p-dioxins and dibenzofurans when they are burned. Those against argue that chlorine and many chlorinated compounds are essential in the control of human health (the prevention of disease transmitted through drinking water that has not been disinfected), and that chlorinated compounds are indispensable intermediates in many production processes, representing a vast economic value. But such discussions often ignore the fact that Nature contributes significantly to the production of chlorinated organic compounds. More than 1000 such compounds are known, and their contribution to the biogeochemical cycling of chlorine is underestimated. Chlorine is organically bound in large quantities to humic materials, and natural production mechanisms are known for low molecular weight compounds (methyl chloride, chloroform, chlorinated dibenzo-p-dioxins and dibenzofurans). The role of these compounds in the environment is largely unknown. Naturally-Produced Organohalogens gives a complete overview of the present state of knowledge on the subject, giving a much needed balance to the argument sketched out above.
Download or read book Halogenated Heterocycles written by Jernej Iskra and published by Springer Science & Business Media. This book was released on 2012-02-09 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores topics in Heterocyclic chemistry, including Perfluoroheteroaromatic Chemistry; Monofluorinated Heterocycles; Synthesis of beta-Halofurans; Halogenated Heterocycles as Pharmaceuticals; Green Methods in Halogenation of Heterocycles and more.
Download or read book Electrophilic Halogenation written by Peter Bernard David De la Mare and published by CUP Archive. This book was released on 1976-08-26 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 1976 book shows how those halogenations involving the whole gamut of unsaturated organic molecules can be linked.
Download or read book Analytical Chemistry of Organic Halogen Compounds written by László Mázor and published by Pergamon. This book was released on 1975 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tropospheric Chemistry of Halogenated Organic Compounds written by David J. A. Kinnison and published by . This book was released on 1994 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurotoxicity of Halogenated Organic Compounds written by and published by Elsevier. This book was released on 2023-10-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotoxicity of Halogenated Organic Compounds, Volume 10 covers three groups of Halogenated Organic Compounds (Chlorinated, Brominated, and Fluorinated Compounds) that are legacy and emerging contaminants, providing background information, characteristics, physicochemical properties, environmental contamination, and human exposure. Specific chapters covered in this release include Perspective on Halogenated Organic Compounds, The Neurotoxicity of Polychlorinated Biphenyls (PCBs), Neuroendocrine Effects of Polychlorinated Biphenyls (PCBs), Mechanisms of PCB Neurotoxicity: AHR and THR Dogma meet RYR reality, Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs), and much more. Other chapters cover Neuroendocrine Effects of Brominated Flame Retardants (BFRs), Focused on Polybrominated Diphenyl Ethers (PBDEs), Neurochemical Effects of Halogenated Organic Compounds: Possible Mode(s) of action and Structure-Activity Relationships, The Neurotoxic Effects of Perfluoroalkyl Substances (PFAS) in Animal Models and Human Cohorts, Neurochemical Mechanisms of Perfluoroalkyl Substances (PFAS) Neurotoxic Action, and Future Directions and Regulatory aspects of Halogenated Organic Compounds. Presents the latest on the Neurotoxicity of Halogenated Organic Compounds: Epidemiological, Behavioral and other effects Covers Neurochemical and Neuroendocrine effects of Halogenated Organic Compounds Provides Regulatory aspects of Halogenated Organic Compounds
Download or read book Metabolism Summaries of Selected Halogenated Organic Compounds in Human and Environmental Media a Literature Survey written by U. S. Environmental Protection Agency and published by BiblioGov. This book was released on 2013-07 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Environmental Protection Agency (EPA) was introduced on December 2, 1970 by President Richard Nixon. The agency is charged with protecting human health and the environment, by writing and enforcing regulations based on laws passed by Congress. The EPA's struggle to protect health and the environment is seen through each of its official publications. These publications outline new policies, detail problems with enforcing laws, document the need for new legislation, and describe new tactics to use to solve these issues. This collection of publications ranges from historic documents to reports released in the new millennium, and features works like: Bicycle for a Better Environment, Health Effects of Increasing Sulfur Oxides Emissions Draft, and Women and Environmental Health.
Download or read book Metabolism Summaries of Selected Halogenated Organic Compounds in Human and Environmental Media written by U. S. Environmental Protection Agency and published by BiblioGov. This book was released on 2013-07 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Environmental Protection Agency (EPA) was introduced on December 2, 1970 by President Richard Nixon. The agency is charged with protecting human health and the environment, by writing and enforcing regulations based on laws passed by Congress. The EPA's struggle to protect health and the environment is seen through each of its official publications. These publications outline new policies, detail problems with enforcing laws, document the need for new legislation, and describe new tactics to use to solve these issues. This collection of publications ranges from historic documents to reports released in the new millennium, and features works like: Bicycle for a Better Environment, Health Effects of Increasing Sulfur Oxides Emissions Draft, and Women and Environmental Health.
