Download or read book Biochemical Techniques in the Heart written by John H. McNeill and published by CRC Press. This book was released on 1996-12-12 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Techniques in the Heart fully describes classical biochemical measurements of parameters involved in contraction and relaxation in the heart. This fully detailed guide tells you how to make preparations of sarcoplasmic reticulum, sarcolemma, and cardiomyocytes and how to measure sodium-calcium and sodium-hydrogen exchange. Two chapters explain the measurement of the important enzyme sodium-potassium ATPase. This book examines the most widely used tools in experimental cardiology and provides you with the recipe-setting up the technique, procurement of equipment, sample data and calculations, problems and trouble shooting, adapting to other species, modifications, and applicability. Undoubtedly, this text will be a great asset to cardiovascular physiologists, pharmacologists, experimental cardiologists, and students of physiology and pharmacology.
Download or read book New Aspects in the Treatment of Failing Heart written by Hisakazu Yasuda and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular biology and biochemical techniques, the avant-garde of medical research, are now also being used to investigate cardiovascular events. The fifty-one selected contributions in this volume based on the 14th International Society of Heart Research (ISHR) Meeting in 1992 document the discoveries being made at the frontiers of research with cardiac molecular and genetic biology and technology. The contents may be divided into five categories: 1) the process of ischemic myocardial damage in heart failure, 2) biochemical abnormalities in cardiomyopathy, 3) signal transduction in diseased myocardial cells, 4) electrophysiological abnormalities of the failing heart, and 5) recent concepts in drug therapy. The book builds a bridge for the flow of up-to-date information from active veteran researchers to young talented investigators who offer great promise for the future.
Download or read book Biochemical Mechanisms in Heart Function written by Ernst-Georg Krause and published by Springer. This book was released on 1996-10-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue of Molecular and Cellular Biochemistry good source of information in this regard. contains original research papers as well as invited reviews We wish to thank all of the contributors for their help and dedicated, on the occasion of the 40th anniversary of the in cooperation. We also wish to thank Mrs. Verona Kuhle for auguration of the Heart Research Group in Beriin-Buch that her secretarial help. We are grateful to Dr. Naranjan S. Dhalla, today forms a part there ofthe Max Delbriick Center for Mo Editor-in-Chief of Molecular and Cellular Biochemistry for his lecular Medicine, to Professor Albert Wollenberger, founder interest and encouragement, and for agreeing to publish this of the Heart Research Group and for 21 years its head. issue in honor of Albert Wollenberger. The papers in this issue are written by researchers work ing in the field of cardiovascular research who together with ERNST-GEORG KRAUSE and ROLAND VETTER Albert Wollenberger share the belief that an integrative ap Max Delbriick Center for Molecular Medicine plication of advances in molecular and cellular biology will Robert-Rossle-StraBe 10 lead to new concepts for treatment and prevention of cardio 13122 Beriin-Buch vascular diseases. We hope that this special will serve as a Gennany ALBERT WOLLENBERGER, Professor, Ph. D. (Harvard), Dr. Sc. Med. (Berlin) The dedication is accorded to Prof.
Download or read book Biophysics of the Failing Heart written by R. John Solaro and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.
Download or read book Cell Culture Techniques in Heart and Vessel Research written by H.M. Piper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the cardiovascular sciences, an increasing demand for the use of modern methods of cell biology has developed. The use of specific cell culture models of the various tissues involved is essential for most of these novel approaches. This book meets the demand for acomprehensive and easy accessible source for cell cul- ture methods in cardiovascular research as it was not previously available. The basic methods for cultures of cardiomyocytes (embryonic and adult), endothelial cells (micro- and macrovascular), smooth muscle cells and pericytes are described in detail by an international selection of experts. Special chapters discuss the use of growth factors and attachment substrates, techniques for co-cultures, cultures on permeable filter membranes and microcarrier cultures. The methodological descriptions are sufficiently detailed for an immediate application in the laboratory. All chapters also contain a critical evaluation of alternative approaches.
Download or read book The Developing Heart written by Marianne J. Legato and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart disease, despite recent improvements, continues to be the single most im portant cause of death and disability in the United States. It is estimated that the direct cost of medical care for cardiovascular disease is $6 billion dollars per year. Data compiled by the National Center for Health Statistics reveal a dramatic de cline in deaths from cardiovascular disease in the United States (greater than 20% since 1968). This phenomenon has been the subject of in-depth study. It is clear that the decline is real and not a statistical artifact. The decrease in mortality has been noted in all sections of the country, though the onset and rate of decline varies in different regions of the country. Both primary prevention, through changes in risk factors, and basic and applied research leading to earlier recognition and im proved treatment have contributed to the decline. They do not fully explain the decline. Further research is needed to clarify this issue. Clinical cardiologists have been exposed to a veritable explosion of new knowl edge of mechanisms of cardiovascular disease, development of new improved non-invasive diagnostic techniques, and the pharmacodynamics of agents affect ing the cardiovascular system. This new knowledge results from contributions made by individuals from diverse disciplines including cellular and molecular bi ologists, geneticists, hematologists, cardiologists, and cardiovascular surgeons.
Download or read book Heart Proteomics written by Fernando Vivanco and published by . This book was released on 2013 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of proteomics to study complex diseases such as cardiovascular disease, the leading cause of death in developed countries, has grown exponentially in recent years. Proteomics is a rapidly expanding investigation platform in cardiovascular medicine and is becoming integrated and incorporated into cardiovascular research. The proteomics field continues to develop with major improvements in mass spectrometry instrumentation, methodology and data analysis. Heart Proteomics: Methods and Protocols complies a selection of techniques and methods that target the numerous processes implicated in the pathophysiology of heart. Chapters cover protocols and updated methods in the heart proteomic area with a particular focus on MS-based methods of protein and peptide quantification and the analysis of posttranslational modifications as well as descriptions of system biology approaches, which provide a better understanding of normal and pathological processes. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Heart Proteomics: Methods and Protocols is a representative selection of methods that will prove to be a useful resource for experienced proteomics practitioners and newcomers alike.
Download or read book Novel Methods in Molecular and Cellular Biochemistry of Muscle written by Grant N. Pierce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental techniques are the life blood of science. The better the methodology is, the more reliable and accurate the results will be. Ultimately, this will lead to a clearer interpretation of those results and firmer conclusions from any set of experiments. Experimental methodology in the area of cardiovascular biochemistry and molecular biology has advanced considerably in the last decade. Because of these factors, it was thought that a focused issue of Molecular and Cellular Biochemistry dedicated to the novel, latest technological advances in the field was warranted. We must thank Dr Naranjan S. Dhalla, Editor-in-Chief of Molecular and Cellular Biochemistry, for his willingness to publish an issue with such a focus. We have attracted some of the leaders in the field of cardiovascular biology to submit articles describing some of the most novel, significant techniques currently in use in their laboratories. The purpose of the manuscripts was not to describe the recent experimental findings from each laboratory as is done in most conventional manuscripts. Instead, the purpose of the articles found within this focused volume of Molecular and Cellular Biochemistry was to describe how the technique is performed on the laboratory bench so that others less familiar with the technique may be able to use it in their own labs. The subjects described in this volume can be generally subdivided into three categories: molecular biology, cell biology and basic biochemistry. The methods cover wide areas including various DNA and RNA expression technologies, transfection techniques, quantification of ion flux movement, measurements of lipid metabolism, advances in the culture of specific cardiovascular cell populations, and the use of confocal microscopy to examine cell structure and function. We thank all of the authors who have contributed so much of their time and efforts and, most importantly, shared the `secrets' of these valuable techniques with the rest of the cardiovascular research community.
Download or read book The Developing Heart written by Marianne J Legato and published by . This book was released on 1984-11-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Markers written by Alan H. B. Wu and published by Springer Science & Business Media. This book was released on 2003-06-12 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard.
Download or read book ATP and the Heart written by Joanne S. Ingwall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.
Download or read book Cardiovascular Proteomics written by Fernando Vivanco and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book presents protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels.
Download or read book Dissecting Traditional Medicine via Chemical and Biochemical Techniques Advanced Analytics and Novel Paradigms written by Yi Wang and published by Frontiers Media SA. This book was released on 2022-11-29 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Biology of the Heart written by Alexander V. Panfilov and published by Wiley-Blackwell. This book was released on 1997-03-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling the genesis and propagation of electrical activity in the heart in quantitative terms is one of the most important recent applications of mathematical modelling in biology. The main research direction, and the most important for biological and medical applications, is the development of realistic models of electrical activity in cardiac tissue and the whole mammalian heart. Recent progress in nonlinear dynamics, advances in computer technology and experiments on cardiac tissue have made feasible the construction of such models. Computational Biology of the Heart is the first book to provide a comprehensive survey of recent research together with a systematic overview of the subject. The contributions, all written by experts in the different areas of the subject, cover all main aspects of whole heart modelling: from excitation in single cells, to two and three dimensional models of cardiac tissue and the whole heart. Various computational models and techniques are described and then applied to reconstruct and visualise modelled activity in both normal and pathological heart tissues. The models are nonlinear and use techniques of ordinary differential equations, partial differential equations and eikonal equations. The book also provides a review of modelling cardiac contraction, mapping electrical activity from electrocardiograms, and recent experimental observations of wave propagation in the whole heart. Graduate students and researchers in such areas as applied mathematical biology, clinical physiology and cardiology will find this book to be an invaluable resource for their work.
Download or read book Biological and Psychological Factors in Cardiovascular Disease written by Thomas H. Schmidt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: An opening address should ask the right questions, which we expect to answer during the coming years. A good opening address should formu late hypotheses for falsification during the conference or in the near fu ture. Mter Dr. Groen's excellent lecture yesterday, I feel better about my task, because I feel I am not alone in asking the ten questions in my ab stract. It is an honor for me to give this short paper largely based on my expe riences during 15 years as medical director of a rehabilitation center in Ba varia, as a teacher at two medical schools in Munich and Innsbruck, and as an old-fashioned holistic cardiologist. However, it also is a difficult task for me because the subject of this conference concerning biobehavioral factors in coronary heart disease is controversial, not only in the medical society, but in my own mind as well. When I organized one of the first conferences on stress and coronary heart disease in West Germany in 1976, followed by conferences in 1979 and 1980, the semantic problems between physicians and psychologists were very significant. However, communication has improved in this area during the last decade. The most encouraging event in this field was a sym posium in May 1984 in Rotenburg/Fulda on the topic "Return to Work af ter Bypass Surgery", organized by a cardiac surgeon, Dr. Walter.
Download or read book Nanoscale Technology in Biological Systems written by Ralph S. Greco and published by CRC Press. This book was released on 2004-12-20 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscale Technology in Biological Systems reviews recent accomplishments in the field of nanobiology and introduces the application of nanoscale matrices to human biology. It focuses on the applications of nanotechnology fabrication to biomedical devices and discusses new physical methods for cell isolation and manipulation and intracellular commu
Download or read book Natural and Artificial Models in Computation and Biology written by Jose Manuel Ferrandez Vicente and published by Springer. This book was released on 2013-06-03 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two volume-set, LNCS 7930 and LNCS 7931, constitutes the refereed proceedings of the 5th International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2013, held in Mallorca, Spain, in June 2013. The 92 revised full papers presented in LNCS 7930 and LNCS 7931 were carefully reviewed and selected from numerous submissions. The first part, LNCS 7930, entitled "Natural and Artificial Models in Computation and Biology”, includes all the contributions mainly related to the methodological, conceptual, formal, and experimental developments in the fields of neurophysiology and cognitive science. The second part, LNCS 7931, entitled “Natural and Artificial Computation in Engineering and Medical Applications”, contains the papers related to bioinspired programming strategies and all the contributions related to the computational solutions to engineering problems in different application domains, specially Health applications, including the CYTED “Artificial and Natural Computation for Health” (CANS) research network papers. In addition, this two volume-set reflects six interesting areas: cognitive robotics; natural computing; wetware computation; quality of life technologies; biomedical and industrial perception applications; and Web intelligence and neuroscience.
