Download or read book Bioassay Techniques and Environmental Chemistry written by Gary E. Glass and published by Butterworth-Heinemann. This book was released on 1973 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures IV written by Michael Waters and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures.
Download or read book BIOASSAY TECHNIQUES AND ENVIRONMENTAL CHEMISTRY written by GE GLASS (Ed) and published by . This book was released on 1973 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioassay Techniques and Environmental Chemistry Papers Given at a Symposium Held at the National American Chemical Society Meeting Washington 1971 written by G. E. Glass and published by . This book was released on 1973 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Symposium on Bioassay Techniques and Environmental Chemistry at the 162nd National Meeting of the American Chemical Society written by Division of Water, Air and Waste Chemistry, American Chemical Society and published by . This book was released on 1971 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures II written by Michael Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing.
Download or read book Methods in Chemical Ecology Volume 2 written by Kenneth F. Haynes and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification of chemicals that affect the naturally occurring interactions be tween organisms requires sophisticated chemical techniques, such as those docu mented in volume 1, in combination with effective bioassays. Without an effective bioassay, the identification becomes akin to looking for a needle in a haystack, but without any idea of what a needle looks like. To a large extent serniochemical identifications must be driven by bioassays. The design of bioassays for use in chemical ecology is governed by the sometimes conflicting objectives of ecological relevance and the need for simplic ity. Bioassay design should be based on observations of the interactions between organisms in their natural context, a theme that appears throughout this volume. As a result, this volume is as much about ecology and behavior as it is about specific methods. It is impossible to design a relevant bioassay, whether it is simple or complex, without understanding at least the fundamentals of how chemical cues or signals mediate the interaction in nature. Thus, the development of bioassay methods must be driven by an understanding of ecology and a knowledge of the natural history of the organisms under study. Given such an understanding, it is often possible to design assays that are both ecologically relevant and easy to perform.
Download or read book Environmental Bioassay Techniques and their Application written by M. Munawar and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the First International Conference held in Lancaster, England, July 11-14, 1988
Download or read book Bioassay Methods in Natural Product Research and Drug Development written by Lars Bohlin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.
Download or read book Environmental Bioassay Techniques and Their Application written by and published by . This book was released on 1989 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Application of Short Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures written by Michael D. Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: vi Williamsburg, Virginia, February 21-23, 1978. This symposium was sponsored by the U. S. Environmental Protection Agency, Office of Energy Minerals and Industry, Washington, DC, and Office of Health and Ecological Effects, Health Effects Re search Laboratory, Biochemistry Branch, Research Triangle Park, NC. The symposium consisted of 24 formal presentations that amplify the three major topics discussed during the symposium: an overview of short-term bioassay systems; current methodology involving the collection and chemical analysis of environmental samples; and current research in volving the use of short-term bioassays in the fractionation and analysis of complex environmental mixtures. The purpose of this symposium was to present the state-of-the-art tech niques in bioassay and chemical analysis as applied to com plex mixtures and to foster continued advancement of this important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, syn thetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a refer ence to catalyze and encourage further research in this field. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment We would like to thank Gerald Rausa, Office of Energy Minerals and Industry, for his advice, encouragement, and support of this program. We would also like to express our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa Systems, Inc.
Download or read book Biosensors for the Environmental Monitoring of Aquatic Systems written by Damià Barceló and published by Springer. This book was released on 2009-05-27 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: sector. This ensured eventual transfer of the technology demonstrated at the wo- shops and Technical Meetings to marketable devices. BIOSET provided assistance for researchers from European laboratories to meet to exchange ideas, use equ- ment, and establish a basis for new joint projects. The secretariat of the Concerted Action BIOSET supported the Technical Meetings. There were three Technical Meetings held, two in Berlin in 1997 and 1998, and the third in Barcelona, in April 2000. The goal of these technical meetings was to join different research and industrial teams to evaluate the performance of their biosensor technology in field conditions with common and standardized surface and waste waters. As a result of these field experiments, the additional information that biosensors can offer to environmental monitoring was also evaluated. Thus, these three Technical Meetings were useful accompanying measures and practical additions to the currently organized yearly workshops. The concerted action BIOSET was f- lowed by the SENSPOL network. The 1st SENSPOL Workshop was held on the 9–11 May 2001 on Sensing Technologies for Contaminated Sites and Groundwater at the University of Alcala. There was one special Workshop on “Genotoxicity Biosensing (TECHNOTOX)” supported by the European Commission DG XII D-1 and BIOSET in the year 2000. The TECHNOTOX meeting at the Flemish Institute for Technological Research (VITO) in Mol was organized by Phillippe Corbisier (VITO), Peter-D. Hansen (TU Berlin) and Damia Barcelo (CSIC Barcelona).
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures III written by Michael D. Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.
Download or read book Pharmaceutical Bioassays written by Shiqi Peng and published by John Wiley & Sons. This book was released on 2009-11-09 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer’s, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications
Download or read book Short Term Bioassays in the Analysis of Complex Environmental Mixtures V written by Shahbeg S. Sandhu and published by Springer. This book was released on 1987 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experiments in Environmental Chemistry written by P D Vowles and published by Elsevier. This book was released on 2013-10-02 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experiments in Environmental Chemistry presents experimental activities that provide practical, first hand experience in the observation of chemical processes occurring in the environment. A variety of techniques with applications in governmental laboratories, industry, and research are described. The experiments are divided into five parts: biochemical processes in aquatic systems; toxic substances in the environment; food additives and contaminants; chemical ecology; and field surveys. This book is divided into five sections and begins with a discussion on the transformations of carbon, nitrogen, phosphorus, and energy in aquatic systems. Various aspects of environmental chemistry including photosynthesis, respiration, biogeochemical cycling, primary production, plant nutrients, water quality, eutrophication, and wastewater treatment are considered. The next section focuses on a wide assortment of environmental contaminants in terms of their behavior and occurrence in various sectors of the environment. In this section, the reader is introduced to gas chromatography, atomic absorption spectroscopy, thin layer chromotography, column chromatography, and techniques for the measurement of atmospheric contaminants. Food and the occurrence of foreign substances that result from deliberate additions or other processes are also analyzed, along with chemical compounds such as allelochemicals, pheromones, and chemical defense substances. This monograph will be a valuable resource for environmental chemists.
Download or read book Bioassay Analytical and Environmental Chemistry written by and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
