Download or read book Binding Time written by Mark Halpern and published by Intellect Books. This book was released on 1990 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of related but independent and critical essays addressing the relationship within the computing world between intellectual constructs, thought experiments, theories, theorems, proofs, and observable facts.
Download or read book Time binding written by Alfred Korzybski and published by . This book was released on 1924 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Time Bind written by Arlie Russell Hochschild and published by Macmillan. This book was released on 1997-05-15 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hochschild's groundbreaking study exposes our crunch-time world and reveals how, after the first shift at work and the second at home, comes the third, and hardest, shift of repairing the damage created by the first two.
Download or read book Reversible Ligand Binding written by Andrea Bellelli and published by John Wiley & Sons. This book was released on 2018-01-09 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. Bridges theory of ligand binding and allostery with experiments Applies historical and physical insight to provide a clear understanding of ligand binding Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery Based on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.
Download or read book Receptors Models for Binding Trafficking and Signaling written by Douglas A. Lauffenburger and published by Oxford University Press, USA. This book was released on 1996-05-02 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a bridge at the interface between engineering and cell biology, demonstrating how a mathematical modelling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor ligand interactions. Model frameworks are described over the entire spectrum of receptor processes, from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioural functions they govern, including proliferation, adhesion, and migration.
Download or read book Thermodynamics and Kinetics of Drug Binding written by György Keserü and published by John Wiley & Sons. This book was released on 2015-08-17 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
Download or read book Receptor Binding Techniques written by Mary Keen and published by Springer Science & Business Media. This book was released on 1999 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge collection of step-by-step experimental protocols demonstrates
Download or read book The Binding written by Bridget Collins and published by HarperCollins. This book was released on 2019-04-09 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER A NEW YORK TIMES BOOK REVIEW EDITORS' CHOICE Proclaimed as “truly spellbinding,” a “great fable” that “functions as transporting romance” by the Guardian, the runaway #1 international bestseller "A rich, gothic entertainment that explores what books have trapped inside them and reminds us of the power of storytelling. Spellbinding.” — TRACY CHEVALIER Imagine you could erase grief. Imagine you could remove pain. Imagine you could hide the darkest, most horrifying secret. Forever. Young Emmett Farmer is working in the fields when a strange letter arrives summoning him away from his family. He is to begin an apprenticeship as a Bookbinder—a vocation that arouses fear, superstition, and prejudice amongst their small community, but one neither he nor his parents can afford to refuse. For as long as he can recall, Emmett has been drawn to books, even though they are strictly forbidden. Bookbinding is a sacred calling, Seredith informs her new apprentice, and he is a binder born. Under the old woman’s watchful eye, Emmett learns to hand-craft the elegant leather-bound volumes. Within each one they will capture something unique and extraordinary: a memory. If there’s something you want to forget, a binder can help. If there’s something you need to erase, they can assist. Within the pages of the books they create, secrets are concealed and the past is locked away. In a vault under his mentor’s workshop rows upon rows of books are meticulously stored. But while Seredith is an artisan, there are others of their kind, avaricious and amoral tradesman who use their talents for dark ends—and just as Emmett begins to settle into his new circumstances, he makes an astonishing discovery: one of the books has his name on it. Soon, everything he thought he understood about his life will be dramatically rewritten. An unforgettable novel of enchantment, mystery, memory, and forbidden love, The Binding is a beautiful homage to the allure and life-changing power of books—and a reminder to us all that knowledge can be its own kind of magic.
Download or read book Biosensors Kinetics of Binding and Dissociation Using Fractals written by Ajit Sadana and published by Elsevier. This book was released on 2003-12-17 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces. The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase due to the advances in miniaturization, (wireless) communications, and the development of new materials (especially biological and chemical). Other applications of biosensors on the increase can be found in: the protection of civilian structures and infrastructures; protection from possible biological and chemical threats; health care; energy; food safety; and the environment to name a few. Covers all areas of applications of biosensors No other book on biosensors describes the kinetics of binding Provides numerous examples of where biosensors may be used
Download or read book Dynamics and Mechanism of DNA Bending Proteins in Binding Site Recognition written by Yogambigai Velmurugu and published by Springer. This book was released on 2016-11-29 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.
Download or read book Receptor Binding in Drug Research written by Robert A. O'Brien and published by CRC Press. This book was released on 2020-08-27 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the applications of receptor techniques in many different areas in addition to conventional drug and neurotransmitter binding sites. It reviews humoral modulators such as a leukotrienes, interferon, platelet-derived growth factor, and novel endogenous ligands.
Download or read book Binding Vows written by Catherine Bybee and published by . This book was released on 2013-01-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Duncan MacCoinnich’s task… Travel to the twenty-first century Renaissance Faire, deflower the Druid virgins, and go home. Only his job is not so easily accomplished with the virgin in question, Tara McAllister. Time is running out. The evil is closing in on them both. Tara finds Duncan irresistible after what was supposed to be a mock Hand-fasting binds them. When Duncan whisks her to his home in Scotland she could accept that. But, can she forgive him for taking away her modern life when she finds herself in the sixteenth century? And is it love they feel? Or something else?
Download or read book Women in the Bookbinding Trade written by Mary Van Kleeck and published by . This book was released on 1913 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mathematical Philosophy written by Cassius Jackson Keyser and published by . This book was released on 1922 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Software Product Lines written by Patrick Donohoe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Software product lines are emerging as a critical new paradigm for software development. Product lines are enabling organizations to achieve impressive time-to-market gains and cost reductions. With the increasing number of product lines and product-line researchers and practitioners, the time is right for a comprehensive examination of the issues surrounding the software product line approach. The Software Engineering Institute at Carnegie Mellon University is proud to sponsor the first conference on this important subject. This book comprises the proceedings of the First Software Product Line Conference (SPLC1), held August 28-31, 2000, in Denver, Colorado, USA. The twenty-seven papers of the conference technical program present research results and experience reports that cover all aspects of software product lines. Topics include business issues, enabling technologies, organizational issues, and life-cycle issues. Emphasis is placed on experiences in the development and fielding of product lines of complex systems, especially those that expose problems in the design, development, or evolution of software product lines. The book will be essential reading for researchers and practitioners alike.
Download or read book Biophysical Approaches Determining Ligand Binding to Biomolecular Targets written by Alberto Podjarny and published by Royal Society of Chemistry. This book was released on 2011-04-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational approaches to drug discovery and design. This book reviews the latest advances in the application of biophysics to the study of ligand binding. It provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand their binding mechanisms. Particular emphasis is given to the combined use of different techniques and their relative strengths and weaknesses. Consistency in the way each technique is described makes it easy for readers to select the most suitable protocol for their research. The introduction explains why some techniques are more suitable than others and emphasizes the possible synergies between them. The following chapters, all written by a specialist in the particular technique, focus on each method individually. The book finishes by describing how several complimentary techniques can be used together for maximum effectiveness. This book is suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available.
Download or read book The Elephants in My Backyard written by Rajiv Surendra and published by Simon and Schuster. This book was released on 2016-11-08 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rajiv Surendra was filming Mean Girls, playing the beloved rapping mathlete Kevin Gnapoor, when a cameraman insisted he read Yann Martel's Life of Pi. So begins his "lovely and human" (Jenny Lawson, author of Furiously Happy) tale of obsessively pursuing a dream, overcoming failure, and finding meaning in life. “This was a once-in-a-lifetime chance. I found myself standing dangerously close to the edge of a cliff. Far below me was an incredible abyss with no end in sight. I could turn back and safely return to where I had come from, or I could throw caution to the wind, lift my arms up into the air . . . and jump.” —From The Elephants in My Backyard What happens when you spend ten years obsessively pursuing a dream, and then, in the blink of an eye, you learn that you have failed, that the dream will not come true? In 2003, Rajiv Surendra was filming Mean Girls, playing the beloved rapping mathlete Kevin Gnapoor, when a cameraman insisted he read Yann Martel’s Life of Pi. Mesmerized by all the similarities between Pi and himself—both are five-foot-five with coffee-colored complexions, both share a South Indian culture, both lived by a zoo—when Rajiv learns that Life of Pi will be made into a major motion picture he is convinced that playing the title role is his destiny. In a great leap of faith Rajiv embarks on a quest to embody the sixteen-year-old Tamil schoolboy. He quits university and buys a one-way ticket from Toronto to South India. He visits the sacred stone temples of Pondicherry, he travels to the frigid waters off the coast of rural Maine, and explores the cobbled streets of Munich. He befriends Yann Martel, a priest, a castaway, an eccentric old woman, and a pack of Tamil schoolboys. He learns how to swim, to spin wool, to keep bees, and to look a tiger in the eye. All the while he is really learning how to dream big, to fail, to survive, to love, and to become who he truly is. Rajiv Surendra captures the uncertainty, heartache, and joy of finding ones place in the world with sly humor and refreshing honesty. The Elephants in My Backyard is not a journey of goals and victories, but a story of process and determination. It is a spellbinding and profound book for anyone who has ever failed at something and had to find a new path through life.
