Download or read book Automation Technologies for Genome Characterization written by Tony J. Beugelsdijk and published by Wiley-Interscience. This book was released on 1997-09-30 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible overview of the latest advancements in automation technologies for genetic mapping—a blueprint for the laboratory of the future Although much has been written about the genetic science at work in the Human Genome Project, to date there has been a serious gap in the literature about the technology that propels the project. Bringing together a group of leading researchers, this work presents a unified vision of the vital role played by technological innovation in tackling the tremendous challenges of genome characterization. Areas covered include informatics, robotics, optical and microfabrication techniques, and information management systems. Accessible to geneticists and nongeneticists alike, this clearly written resource provides: Illuminating, firsthand case studies of laboratory automation and control systems at highly successful facilities, including workable models for standardized hardware and software interfaces Examinations of promising emergent technologies in such areas as capillary gel electrophoresis, miniaturization, and mass spectrometry Practical discussions of computer simulation and information management for use in the creation of efficient genome factories Tutorials throughout to clarify biological issues underlying each technology As one of the first books to address the spectrum of technologies that will carry genetic research into the next millennium, Automation Technologies for Genome Characterization is an indispensable reference for genome researchers as well as biologists, engineers, and computer scientists working in this exciting field. Wiley-Interscience Series on Laboratory Automation
Download or read book Automated Technologies for Genome Characterization written by Beugelsdijk and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Automation in Proteomics and Genomics written by Gil Alterovitz and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.
Download or read book Automation Genomic and Functional Analyses written by Alister G. Craig and published by Elsevier. This book was released on 1999-02 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening. Key Features * Describes automated procedures used in microbiology and molecular biology * Includes developments in robotics and vision systems * Features automation in library picking, presentation and analysis * Discusses paralogous duplications in microbial genomes * Covers deciphering genomes through automated large-scale sequencing * Describes and stresses the need for functional analyses * Internationally acclaimed contributors, including Professor Leroy Hood.
Download or read book Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2007-12-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Genome Annotation written by Jung Soh and published by CRC Press. This book was released on 2016-04-19 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including sequencing strategies, statistical models, and early annotation systems. The authors then present visualization techniques for displaying integrated results as well as state-of-the-art annotation tools, including MAGPIE, Ensembl, Bluejay, and Galaxy. They also discuss the pipelines for the analysis and annotation of complex, next-generation DNA sequencing data. Each chapter includes references and pointers to relevant tools. As very few existing genome annotation pipelines are capable of dealing with the staggering amount of DNA sequence information, new strategies must be developed to accommodate the needs of today’s genome researchers. Covering this topic in detail, Genome Annotation provides you with the foundation and tools to tackle this challenging and evolving area. Suitable for both students new to the field and professionals who deal with genomic information in their work, the book offers two genome annotation systems on an accompanying CD-ROM.
Download or read book Automated DNA Sequencing and Analysis written by Mark D. Adams and published by Academic Press. This book was released on 1994-06-29 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely book for DNA researchers, Automated DNA Sequencing and Analysis reviews and assesses the state of the art of automated DNA sequence analysis-from the construction of clone libraries to the developmentof laboratory and community databases. It presents the methodologies and strategies of automated DNA sequence analysis in a way that allows them to be compared and contrasted. By taking a broad view of the process of automated sequence analysis, the present volume bridges the gap between the protocols supplied with instrument and reaction kits and the finalized data presented in the research literature. It will be an invaluable aid to both small laboratories that are interested in taking maximum advantageof automated sequence resources and to groups pursuing large-scale cDNA and genomic sequencing projects. The field of automation in DAN sequencing and analysis is rapidly moving, this book fulfils those needs, reviews the history of the art and provides pointers to future development.
Download or read book Integrated Microfabricated Biodevices written by Michael J. Heller and published by CRC Press. This book was released on 2002-01-03 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the new generation of integrated microfabricated devices, including DNA chips, Lab-on-a-Chip, microcapillary electrophoresis systems, biosensors, and microanalytical systems. It traces their development with the established and evolving technologies such as microlithography, micromachining, microelectromechanical systems, microfluids, and nanotechnology.
Download or read book New Methodologies for Genome Analysis written by Jason C. Reed and published by . This book was released on 1998 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Applied Molecular Genetics written by Roger L. Miesfeld and published by John Wiley & Sons. This book was released on 1999-04-13 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text explains the key biochemical and cell biological principles behind some of today's most commonly used applications of molecular genetics, using clear terms and well-illustrated flow schemes. The book is divided into several sections and moves from basic to advanced topics while providing a concise overview of fundamental concepts in modern biotechnology. Each chapter concludes with a Laboratory Practicum describing a hypothetical research objective and the sequence of steps that are most often used to investigate biological questions using molecular genetic methods. In addition, the book provides informative summaries of the latest advances in molecular genetics, using attractive illustrations and a comprehensive reference list. This text also introduces the use of Internet resources through the World Wide Web as a powerful new tool in molecular genetic research. Seven appendices are included in the book, providing a convenient information resource for properties of nucleic acids, protein and restriction enzymes, a description of common E. coli genetic markers and gel electrophoresis parameters, as well as a list of useful Internet address sites.
Download or read book Genetics Manual written by G. P. Rdei and published by World Scientific. This book was released on 1998 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Redei has created an outstanding compendium of genetics. Arranged as a dictionary, the book is almost an encyclopedic collection of terms & concepts ... The author has managed to define terms with appropriate mixtures of depth & detail for the researcher, along with clarity useful for the nonexpert." Choice, 1998
Download or read book Firepower in the Lab written by N. Patel and published by Joseph Henry Press. This book was released on 2001-05-31 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's world poses a triple threat to the American population: infectious diseases, contamination of food and water, and bioattacks (biowarfare or bioterrorism). At least 17 countries are producing weapons of mass destruction using viruses, bacteria, or their toxins. AIDS, E. coli contamination, drug-resistant tuberculosis, and virulent flu strains are perhaps the best known of a host of disease threats. What these dangers have in common is the amount of data required to achieve solutions; in some cases, as much as a petabit (1 followed by 15 zeros) of data is required to study large numbers of samples from widespread locations. Firepower in the Lab examines how the nation can combat this triple threat by improving our ability to detect, measure, and monitor harmful biological agents. It explores the potential of today's exciting new laboratory automation and computer technologies as well as the emerging tools of molecular biology-how we can generate and analyze more data quickly and reduce human hands-on involvement, which inevitably introduces errors. The book discusses how to improve and apply technologies such as robotics, laboratory automation, "lab-on-a-chip," bioinformatics, and Internet control innovations. It reviews lessons learned from our experience with pandemic flu viruses. It also presents strategies for developing new high-throughput technologies, including how to address the lack of public funding for critical research undertakings.
Download or read book Automation and Emerging Technology in Clinical Microbiology An Issue of Clinics in Laboratory Medicine written by Carey-Ann D. Burnham and published by Elsevier Health Sciences. This book was released on 2013-09-28 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of Clinical Microbiology is evolving at a rapid pace, perhaps more so than any other arm of laboratory medicine. This can be attributed to new technology, including high throughput gene sequencing, multiplex molecular assays, rapid evolution of antimicrobial resistance, and discovery of new pathogens. In addition, modern medical procedures, such as solid organ and stem cell transplantation, have resulted in an explosion of infections with agents that historically have been considered to be of low virulence. This issue of Clinics in Laboratory Medicine will highlight some of the advances in diagnostic microbiology, including MALDI-TOF MS, pathogen discovery, and personalized antimicrobial chemotherapy. In addition, one of the papers will focus on implementation of new technologies and how to maximize patient impact of these new methods.
Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1987 with total page 1398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mass Spectrometry and Genomic Analysis written by J.N. Housby and published by Springer Science & Business Media. This book was released on 2001-10-31 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genome project is set to revolutionise health care and medicine in the near future. The genetic make up of each individual gives clues as to the genetic factors that predispose one to a particular genetic disease. Single Nucleotide Polymorphisms (SNPs), single base changes in the nucleotide DNA sequence of individuals, are thought to be the main cause of genetic variation. By comparing patterns of SNP allele frequencies between disease affected and control populations, disease associated SNPs can be identified and potential disease gene(s) located. These types of study necessitate genotyping of thousands of SNPs which requires the use of powerful, high throughput, systems of analysis. Mass spectrometry is fast becoming the preferred technology for this type of high throughput analysis. This book contains a collection of descriptions of some of the most outstanding advances in the field of mass spectrometry from which, I hope, the reader will be able to learn both the principles and the most up to date methods for its use in genomic analysis. It covers the general principles of the technologies and more in depth detailed descriptions for more academic reading and information. Audience: Whether you are a student, a post-doctoral researcher or experienced MS user, this book will be a stimulating addition to the analytical arena of mass spectrometry and genomic analysis.
Download or read book Plant Genome Analysis written by Peter M. Gresshoff and published by CRC Press. This book was released on 2020-09-10 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Genome Analysis presents outstanding analyses of technologies, as well as explanations of molecular technology as it pertains to agriculture. Advances in genome analysis, including DNA amplification (DAF and RAPD) markers, RFLPs, and microsatellites are reviewed by accomplished scientists, many of whom are the developers of the technique. Articles by patent lawyers experienced in plant biotechnology present the legal viewpoint. Chapters focus on special elements of genome analysis, such as the: use of antisense technology investigation of telomeres production of plant YACs importance of cell cycle genes in plants. Other chapters focus on specialized topics of genome analysis. These include a description of antisense technology in the study of photosynthesis and a comprehensive review of the characterization and isolation of plant telomere, including their use in varietal discrimination. A detailed anaysis of cytoplasmic male sterility in the french bean that focuses on the mitochondrial genome is described. The book provides a chapter on the production of yeast artificial chromosomes (YACs) carrying soybean DNA. Genes of the cell cycle in plants and their importance in developmental processes are presented, as well as detailed chapters on the molecular mapping of trees (apples and pines), and nodulation-related genes in legumes. A comprehensive index and a complete glossary are included.
