Download or read book Automation Genomic and Functional Analyses written by Alister G. Craig and published by Elsevier. This book was released on 1999-02 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening. Key Features * Describes automated procedures used in microbiology and molecular biology * Includes developments in robotics and vision systems * Features automation in library picking, presentation and analysis * Discusses paralogous duplications in microbial genomes * Covers deciphering genomes through automated large-scale sequencing * Describes and stresses the need for functional analyses * Internationally acclaimed contributors, including Professor Leroy Hood.
Download or read book Primer to Analysis of Genomic Data Using R written by Cedric Gondro and published by Springer. This book was released on 2015-05-18 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through this book, researchers and students will learn to use R for analysis of large-scale genomic data and how to create routines to automate analytical steps. The philosophy behind the book is to start with real world raw datasets and perform all the analytical steps needed to reach final results. Though theory plays an important role, this is a practical book for graduate and undergraduate courses in bioinformatics and genomic analysis or for use in lab sessions. How to handle and manage high-throughput genomic data, create automated workflows and speed up analyses in R is also taught. A wide range of R packages useful for working with genomic data are illustrated with practical examples. The key topics covered are association studies, genomic prediction, estimation of population genetic parameters and diversity, gene expression analysis, functional annotation of results using publically available databases and how to work efficiently in R with large genomic datasets. Important principles are demonstrated and illustrated through engaging examples which invite the reader to work with the provided datasets. Some methods that are discussed in this volume include: signatures of selection, population parameters (LD, FST, FIS, etc); use of a genomic relationship matrix for population diversity studies; use of SNP data for parentage testing; snpBLUP and gBLUP for genomic prediction. Step-by-step, all the R code required for a genome-wide association study is shown: starting from raw SNP data, how to build databases to handle and manage the data, quality control and filtering measures, association testing and evaluation of results, through to identification and functional annotation of candidate genes. Similarly, gene expression analyses are shown using microarray and RNAseq data. At a time when genomic data is decidedly big, the skills from this book are critical. In recent years R has become the de facto tool for analysis of gene expression data, in addition to its prominent role in analysis of genomic data. Benefits to using R include the integrated development environment for analysis, flexibility and control of the analytic workflow. Included topics are core components of advanced undergraduate and graduate classes in bioinformatics, genomics and statistical genetics. This book is also designed to be used by students in computer science and statistics who want to learn the practical aspects of genomic analysis without delving into algorithmic details. The datasets used throughout the book may be downloaded from the publisher’s website.
Download or read book Yeast Gene Analysis written by and published by Elsevier. This book was released on 2011-09-21 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on Saccharomyces cerevisiae, the second edition of Yeast Gene Analysis represents a major reworking of the original edition, with many completely new chapters and major revisions to all previous chapters. Originally published shortly after completion of the yeast genome sequence, the new edition covers many of the major genome-wide strategies that have been developed since then such as microarray analysis of transcription, synthetic gene array studies, protein microarrays and chemical genetic approaches. It represents a valuable resource for any research laboratory using budding yeast as their experimental system in which to identify new yeast gene functions. The chapters are written in a readable style with useful background information, technical tips and specific experimental protocols included as appropriate, enabling both the novice and the experienced yeast researcher to adopt new procedures with confidence. New chapters on: Strain construction; genome-wide two-hybrid approaches; use of microarrays for transcript analysis; real-time analysis of chromosome behaviour and FRET; synthetic gene array technology and protein arrays; chemical genomics and yeast prions; RNA gene analysis and mitochondrial gene function analysis; phylogenetic footprinting; discovering human gene function and predicting yeast gene function
Download or read book Automated DNA Sequencing and Analysis written by Mark D. Adams and published by Elsevier. This book was released on 1994-06-29 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely book for DNA researchers, Automated DNA Sequencing and Analysis reviews and assesses the state of the art of automated DNA sequence analysis-from the construction of clone libraries to the developmentof laboratory and community databases. It presents the methodologies and strategies of automated DNA sequence analysis in a way that allows them to be compared and contrasted. By taking a broad view of the process of automated sequence analysis, the present volume bridges the gap between the protocols supplied with instrument and reaction kits and the finalized data presented in the research literature. It will be an invaluable aid to both small laboratories that are interested in taking maximum advantageof automated sequence resources and to groups pursuing large-scale cDNA and genomic sequencing projects. The field of automation in DAN sequencing and analysis is rapidly moving, this book fulfils those needs, reviews the history of the art and provides pointers to future development.
Download or read book Functional Analysis of the Human Genome written by F. Farzaneh and published by Garland Science. This book was released on 2020-09-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.
Download or read book Automation in Proteomics and Genomics written by Gil Alterovitz and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.
Download or read book Measuring Biological Responses with Automated Microscopy written by and published by Elsevier. This book was released on 2006-11-02 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.
Download or read book Forensic DNA Typing written by John M. Butler and published by Elsevier. This book was released on 2005-02-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic DNA Typing, Second Edition, is the only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome. It examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. The book covers topics from introductory level right up to cutting edge research. High-profile cases are addressed throughout the text, near the sections dealing with the science or issues behind these cases. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century. These additional chapters cover statistical genetic analysis of DNA data, an emerging field of interest to DNA research. Several chapters on statistical analysis of short tandem repeat (STR) typing data have been contributed by Dr. George Carmody, a well-respected professor in forensic genetics. Specific examples make the concepts of population genetics more understandable. This book will be of interest to researchers and practitioners in forensic DNA analysis, forensic scientists, population geneticists, military and private and public forensic laboratories (for identifying individuals through remains), and students of forensic science. *The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome *Chapters cover the topic from introductory level right up to "cutting edge" research *High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases *NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions
Download or read book Encyclopedia of Genetics Genomics Proteomics and Informatics written by George P. Rédei and published by Springer Science & Business Media. This book was released on 2008-04-25 with total page 2139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.
Download or read book Comparative Genomics and Functional Genomics Analyses in Plants written by Xiaoming Song and published by Frontiers Media SA. This book was released on 2021-07-05 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Focus on Genome Research written by Clyde R. Williams and published by Nova Publishers. This book was released on 2004 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genomic approach of technology development and large-scale generation of community resource data sets has introduced an important new dimension in biological and biomedical research. Interwoven advances in genetics, comparative genomics, high throughput biochemistry and bioinformatics are combining to attack basic understanding of human life and disease and to develop strategies to combat disease. Genomic Research began with The Human Genome Project (HGP), the international research effort that determined the DNA sequence of the entire human genome, completed in April 2003. The HGP also included efforts to characterize and sequence the entire genomes of several other organisms, many of which are used extensively in biological research. Identification of the sequence or function of genes in a model organism is an important approach to finding and elucidating the function of human genes. Integral to the HGP are similar efforts to understand the genomes of various organisms commonly used in biomedical research, such as mice, fruit flies and roundworms. Such organisms are called "model organisms," because they can often serve as research models for how the human organism behaves. This new book brings together leading research from throughout the world in this cutting-edge field.
Download or read book Advances in Bioinformatics written by Vijai Singh and published by Springer Nature. This book was released on with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional analysis of species specific noncoding RNAs in plants written by Yuepeng Song and published by Frontiers Media SA. This book was released on 2023-02-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glossary of Biotechnology Terms Fourth Edition written by Kimball Nill and published by CRC Press. This book was released on 2005-11-16 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if you studied biotechnology in school, if you haven't stayed current, it's not likely you'll be able to speak the same language as today's biotech scientists. The same is even truer for nanotechnology where everything gets smaller and smaller, except the terminology required to navigate it. In the Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition, Kimball Nill continues to improve upon the reference that for over a decade has helped thousands of professionals, including scientists, attorneys, government workers, lobbyists, venture capitalists, and university tech transfer staff, to communicate successfully with those working on the cutting edge of modern science. Now in its fourth edition, Nill has taken the much appreciated step of adding nanotechnology to his glossary. Just by casually perusing the Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition you will learn a number of enlightening facts. Even those in related sciences will be surprised to discover what the language unveils. The Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition is a handy reference designed for people with little or no training in the biological and chemical sciences, as well as scientists communicating from other disciplines. Unlike other glossaries, this one is both informative and completely accessible. Instead of looking up one term to end up mired in equally difficult terminology, this intelligently designed volume follows what the author refers to as a Reference Chain that steadily leads you to simpler more common terminology, down to a level that anyone with a high school education will be able to understand. The definitions are written utilizing words that enable you to conceptualize the idea embodied in the term, with explanations based on analogy whenever possible. Consider this example: Suppose you just received a funding request, a faculty memo, or patent concern that refers to A-DNA, which happens to be the first definition in the Glossary. A-DNA A particular right-handed helical form of DNA (possessing 11 base pairs per turn), which is the form that DNA molecules exist in when they are partially dehydrated. A-form DNA is found in fibers at 75% relative humidity and requires the presence of sodium, potassium, or cesium as the counterion. Instead of lying flat, the bases are tilted with respect to the helical axis, and there are more base pairs per turn. The A-form is biologically interesting because it is probably very close to the conformation adopted by DNA-RNA hybrids or by RNA-RNA double-stranded regions. The reason is that the presence of the 2'2 hydroxyl group prevents RNA from lying in the B-form. See also B-DNA, DNA-RNA HYBRID, DEOXYRIBONUCLEIC ACID (DNA), BASE PAIR (bp) But then after looking at the above definition, you wonder what exactly is a DNA-RNA Hybrid? DNA-RNA Hybrid A double helix that consists of one chain of DNA hydrogen-bonded to a chain of RNA by means of complementary base pairs. See also HYBRIDIZATION (MOLECULAR GENETICS), HYBRIDIZATION (PLANT GENETICS), DOUBLE HELIX ...however while you've often heard mention of a double helix, you were never quite sure what that meant.... Double Helix The natural coiled conformation of two complementary, antiparallel DNA chains. This structure was first put forward by Watson and Crick in 1953. See also DEOXYRIBONUCLEIC ACID (DNA) And that might brings you to ask, Do you really actually know what DNA is? Deoxyribonucleic Acid (DNA) Discovered by Frederick Miescher in 1869, it is the chemical basis for genes. The chemical building blocks (molecules) of which genes (i.e., paired nucleotide units that code for a protein to be produced by a cell's machinery, such as its ribosomes) are constructed. Every inherited characteristic has its origin somewhere in the code of the organism's complement of DNA. The code is made up of subunits called nucleic acids. The sequence of the four nucleic acids is interpreted by certain molecular systems in order to produce the proteins required by an organism. The structure of the DNA molecule was elucidated in 1953.... The Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition is packed with over 400 pages of exceptionally well-organized and cross-referenced terminology, making it an essential reference for anyone working directly or indirectly with those pioneering the frontiers of modern biology.
Download or read book Functional Analysis of the Human Genome written by Farzin Farzaneh and published by Taylor & Francis. This book was released on 1995 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.
Download or read book Structural Genomics written by Andrzej Joachimiak and published by Academic Press. This book was released on 2008 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.
Download or read book Structural Genomics written by and published by Academic Press. This book was released on 2009-11-26 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission
