Download or read book Attributing illness caused by Shiga toxin producing Escherichia coli STEC to specific foods written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2019-09-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shiga toxin-producing Escherichia coli (STEC) infections are a substantial public health issue worldwide, causing more than 1 million illnesses, 128 deaths and nearly 13 000 Disability-Adjusted Life Years (DALYs) annually. To appropriately target interventions to prevent STEC infections transmitted through food, it is important to determine the specific types of foods leading to these illnesses. An analysis of data from STEC foodborne outbreak investigations reported globally, and a systematic review and meta-analysis of case-control studies of sporadic STEC infections published for all dates and locations, were conducted. A total of 957 STEC outbreaks from 27 different countries were included in the analysis. Overall, outbreak data identified that 16% (95% UI, 2-17%) of outbreaks were attributed to beef, 15% (95% UI, 2-15%) to produce and 6% (95% UI, 1-6%) to dairy products. The food sources involved in 57% of all outbreaks could not be identified. The attribution proportions were calculated by WHO region and the attribution of specific food commodities varied between geographic regions. In the European and American sub-regions of the WHO, the primary sources of outbreaks were beef and produce. In contrast, produce and dairy were identified as the primary sources of STEC outbreaks in the WHO Western Pacific sub-region. The systematic search of the literature identified useable data from 21 publications of case-control studies of sporadic STEC infections. The results of the meta-analysis identified, overall, beef and meat-unspecified as significant risk factors for STEC infection. Geographic region and age of the study population contributed to significant sources of

Download or read book Attributing Illness Caused by Shiga Toxin producing Escherichia Coli STEC to Specific Foods written by and published by . This book was released on 2019 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shiga toxin-producing Escherichia coli (STEC) infections are a significant public health issue worldwide. Circa 2010, the Foodborne Disease Burden Epidemiology Reference Group (FERG) of the World Health Organization (WHO) estimated that every year foodborne STEC (i.e. STEC infections transmitted via food, as opposed to water, person-to-person contact, or other routes of transmission) caused more than 1 million illnesses (95% uncertainty interval [UI]: 754 000 to 2.5 million), 128 deaths (95% UI: 55 to 374) and nearly 13 000 Disability Adjusted Life Years (DALYs; 95% UI: 5951 to 33 664; Kirk et al., 2015). To appropriately target interventions to prevent these foodborne infections, it is important to determine the specific food types leading to these illnesses. Source attribution is a methodology for identification of the food types that are important sources of exposure, which allows such estimates to be generated.

Download or read book Shiga toxin producing Escherichia coli STEC and food attribution characterization and monitoring written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2019-02-18 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shiga toxin-producing Escherichia coli (STEC) infections are a substantial health issue worldwide. Circa 2010, foodborne STEC caused > 1 million human illnesses, 128 deaths, and ~ 13,000 Disability Adjusted Life Years (DALYs). Targeting interventions appropriately relies on identifying those strains of greatest risk to human health and determining the types of foods that cause STEC infections. There are hundreds of STEC serotypes; however, based on the evidence gathered during the review, the Expert Group concluded that the serotype of the STEC strain should not be considered a virulence criterion. All STEC strains with the same serotype should not be assumed to carry the same virulence genes and to pose the same risk, as many STEC virulence genes are mobile and can be lost or transferred to other bacteria. this report proposes a set of criteria for categorizing the potential risk of severity of illness associated with a STEC in food is recommended based on evidence of virulence gene profiles and associations with clinical severity. The criteria could be applied by risk managers in a risk-based management approach to control STEC in food. While ruminants and, other land animals are considered the main reservoirs for STEC, various largescale outbreaks have been linked to other foods. Thus, the report also addresses source attribution of foodborne STEC infections globally in order to inform the development of international standards by the Codex Alimentarius on the control of STEC, and in particular identify the foods which should be the focus of those standards. Finally it provides a review of monitoring programmes and methodology for STEC which can serve as a reference for countries planning to develop such programmes.

Download or read book Shiga Toxin producing Escherichia Coli STEC and Food written by World Health Organization and published by World Health Organization. This book was released on 2019-01-22 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strains of pathogenic Escherichia coli that are characterized by their ability to produce Shiga toxins are referred to as Shiga toxin-producing E. coli (STEC). STEC are an important cause of foodborne disease and infections have been associated with a wide range of human clinical illnesses ranging from mild non-bloody diarrhoea to bloody diarrhoea (BD) and haemolytic uraemic syndrome (HUS) which often includes kidney failure. A high proportion of patients are hospitalized, some develop end-stage renal disease (ESRD) and some die. The information requested by CCFH is divided into three main areas: the global burden of disease and source attribution; hazard identification and characterization; and monitoring, including the status of the currently available analytical methods. This report provides an overview of the work undertaken in response to the request from the CCFH and provides the conclusions and advice of the Expert Group based on the currently available information.

Download or read book Shiga Toxin Producing Escherichia Coli STEC and Food written by World Health Organization and published by . This book was released on 2019 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Control measures for Shiga toxin producing Escherichia coli STEC associated with meat and dairy products written by World Health Organization and published by World Health Organization. This book was released on 2022-12-13 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Shiga toxins written by Christopher J. Silva and published by Springer. This book was released on 2017-02-27 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of Shiga toxin-producing E. coli (STEC), with in-depth coverage of key areas such as recent Shiga toxin-related poisonings in Europe and the US, the structure, production, and mechanism of action of Shiga toxin, and current methods of detection. The globalization of food production has introduced new risk factors and intensified existing hazards, complicating the assurance of food safety. Foodborne illness outbreaks, such as those related to STEC, are becoming more common and more dangerous. The threat that these bacterial toxins pose to the food supply is magnified by the frequent occurrence and severity of Shiga toxin-caused disease. As a result, STEC and their toxins remain a primary concern in food safety. This review serves as a key resource for scientists in the field and public health and regulatory officials charged with maintaining food safety. This book also looks to the future of treatment of Shiga toxin-associated disease, specifically the translation of lab bench science into clinical therapeutic strategies.

Download or read book Control measures for Shiga toxin producing Escherichia coli STEC associated with meat and dairy products written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2022-10-12 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although Shiga toxin-producing Escherichia coli (STEC) have been isolated from a variety of food production animals, they are most commonly associated with ruminants from which we derive meat and milk. Because of the widespread and diverse nature of ruminant-derived food production, coupled with the near ubiquity of STEC worldwide, there is no single definitive solution for controlling STEC that will work alone or in all situations. Instead, the introduction of multiple interventions applied in sequence, as a “multiple-hurdle scheme” at several points throughout the food chain (including processing, transport and handling) will be most effective. This report summarises the review and evaluation of interventions applied for the control of STEC in cattle, raw beef and raw milk and raw milk cheese manufactured from cows’ milk, and also evaluated available evidence for other small ruminants, swine and other animals. The information is presented from primary production, to the end of processing, providing the reader with information on the currently available interventions based on the latest scientific evidence. This work was undertaken to support the development of guidelines for the control of STEC in beef, raw milk and cheese produced from raw milk by the Codex Committee on Food Hygiene (CCFH).

Download or read book Food Source Prediction of Shiga Toxin producing Escherichia Coli STEC Outbreaks Using Demographic and Outbreak Characteristics United States 1998 2013 written by Alice Eva White and published by . This book was released on 2015 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foodborne illness is a major cause of disease in the United States. Although outbreak-associated foodborne illness represents a small proportion of the overall burden, outbreaks provide critical information on food-pathogen pairs causing illnesses and factors contributing to food contamination. Epidemiologic tools can improve hypothesis-generation during an investigation; thus, increasing the likelihood of identifying the causative agent and implicated food item. The aims of this study were to systematically identify demographic and outbreak characteristics predictive of food sources and develop a predictive model for public health professionals during a foodborne outbreak investigation. Case demographic and outbreak characteristics were compared by food source in Shiga toxin-producing Escherichia coli (STEC) simple food outbreaks reported to the Centers for Disease Control and Prevention (CDC) from 1998-2013. Factors were compared univariately using parametric and non-parametric tests, as appropriate. Candidate predictors included gender, age, number of ill cases, percent hospitalized, multistate exposure, exposure setting, season, and outbreak duration. Multinomial logistic regression was used to build a prediction model. The model was validated using 2013 outbreak data and complex food outbreaks from 1998-2013 where the complex food could be classify into a “likely” food source category. There were 179 STEC outbreak reported to CDC from 1998-2012 where the implicated food was beef (66%), dairy (14%) or leafy vegetable (20%). The final prediction model included gender, age, ill cases, multistate exposure, exposure setting, and season. The model correctly classified 79% of outbreaks in the derivation set (88% beef; 48% dairy; 97% leafy greens). Of 14 outbreaks in 2013 and 33 complex food outbreaks, 56% and 55% were classified correctly, respectively. All (100%) 2013 outbreaks and 90% of complex food outbreaks were correctly classified by the model’s second choice. In conclusion, case demographic and outbreak characteristics differ by food source. Public health professionals can use the descriptive profiles, univariate comparisons, and prediction rule developed here during hypothesis-generation in a foodborne outbreak investigation to improve efficiency and complement existing methods. Using STEC outbreaks as an example, this study demonstrates the feasibility of using prior outbreak data to develop a food source prediction rule to exclude food sources.

Download or read book Improving Food Safety Through a One Health Approach written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-10 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.

Download or read book Listeria monocytogenes in ready to eat RTE foods attribution characterization and monitoring written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2022-10-14 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the 2004 risk assessment, outbreaks of illness and resultant deaths due to L. monocytogenes continue to occur across the globe. Continued effort is needed to summarize and critically evaluate the most recent information on L. monocytogenes in RTE foods. New data to improve and further inform the 2004 Risk Assessment is available for nearly every factor considered previously, including new quantitative data on L. monocytogenes contamination of foods. To facilitate this work, an FAO/WHO expert meeting was held by virtual means from 20 October to 6 November 2020 to review and discuss the available data and background documents, and to assess the need to modify and update risk assessment models/tools. This report focuses on the deliberations and conclusions of the expert meeting.

Download or read book Escherichia coli written by Marjanca Starčič Erjavec and published by BoD – Books on Demand. This book was released on 2023-03-01 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illuminates the various aspects of Escherichia coli, including its pathotypes, virulence factors, and antimicrobial resistance. It also presents new insights into the scientometric analysis of the E. coli knowledge landscape, novel molecular diagnostic platforms, novel antimicrobial agents, and E. coli-based DNA amplification-expression technology for the automatic assembly of concatemeric open reading frames and proteins.

Download or read book Ranking of low moisture foods in support of microbiological risk management written by World Health Organization and published by World Health Organization. This book was released on 2021-02-28 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Ranking of low moisture foods in support of microbiological risk management Meeting report and systematic review written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2022-07-22 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Low-moisture foods (LMF) are foods that are naturally low in moisture or are produced from higher moisture foods through drying or dehydration processes. These foods typically have a long shelf life and have been perceived for many years to not represent microbiological food safety risk hazards. However, in recent years, a number of outbreaks of foodborne illnesses linked to LMF has illustrated that despite the fact that microorganisms cannot grow in these products, bacteria do have the possibility to persist for long periods of time in these matrices. Responding to a request from the Codex Committee on Food Hygiene (CCFH), the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) implemented a series of activities aimed at collating and analysing the available information on microbiological hazards related to LMF and ranking the foods of greatest concern from a microbiological food safety perspective. Seven categories of LMF which were ultimately included in the ranking process, and the output of the risk ranking, in descending order was as follows: cereals and grains; dried protein products; spices and dried herbs; nuts and nut products; confections and snacks; dried fruits and vegetables; and seeds for consumption.

Download or read book Prevention and control of microbiological hazards in fresh fruits and vegetables Part 4 Specific commodities written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2023-09-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2019, following a request from the Codex Committee on Food Hygiene (CCFH), the Codex Alimentarius Committee (CAC) approved new work at its 42nd Session on the development of guidelines for the control of Shiga toxin-producing Escherichia coli (STEC) in leafy vegetables and in sprouts. The objective of the report was to evaluate commodity-specific interventions used at all stages of fresh fruit and vegetable production from primary production to post-harvest activities, transportation, point of sale and consumer use. Emphasis was placed on the identification and evaluation of interventions used throughout the world to reduce microbiological hazards of fresh fruits and vegetables that contribute to the risk of foodborne illnesses, taking into consideration their effectiveness, practicality and suitability. The expert committee addressed four subdivided commodity groups: 1) leafy vegetables and herbs, 2) berries and tropical fruits, 3) melons and tree fruits, and 4) seeded and root vegetables.

Download or read book Microbial safety of lipid based ready to use foods for management of moderate acute malnutrition and severe acute malnutrition Second report written by World Health Organization and published by Food & Agriculture Org.. This book was released on 2021-02-15 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid-based ready-to-use foods (RUFs) for the nutritional management of moderate acute malnutrition (MAM) and severe acute malnutrition (SAM) are provided to children from 6 months to 59 months of age within the context of emergency feeding programmes supervised by governments. Based on the review, the expert committee considered that children with SAM have an increase in susceptibility to bacteraemia and sepsis that is probably between twofold and fivefold compared with children who are not malnourished and are of the same age and live in the same communities. On the basis of its common occurrence as a cause of infections and serious illnesses in children with SAM, and its documented ability to contaminate, survive in, and cause outbreaks of illness associated with low-moisture foods similar to RUFs, the expert committee concluded that Salmonella is the pathogen of most concern in lipid-based RUFs.Many outbreaks of foodborne salmonellosis have been determined to be associated with low-moisture foods that were contaminated at low levels. Therefore, the expert committee carefully considered the qualitative microbiological analyses of RUFs and the contamination levels that could be inferred, and entered into an extended deliberation of dose-response modelling to find a path toward a reasonable approximation of the likely morbidity and mortality in SAM children that could be anticipated from consumption of RUFs contaminated at the estimated levels and observed frequency.The expert committee described three approaches that purchasers of RUFs might use to establish microbiological criteria to assure the safety of RUFs and to communicate to manufacturers their safety expectations. These approaches are: (i) reference to existing standards established for similar low-moisture foods; (ii) determining an acceptable increase in risk over the pre-existing baseline of illness from other sources of exposure; and (iii) process verification sampling using the moving window technique. The microbiological criteria derived by each of these approaches accomplish different purposes, and which is most appropriate is determined by the conditions of manufacture and use.

Download or read book Safety and quality of water used in the production and processing of fish and fishery products written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2023-03-09 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2020, the 43rd Session of the Codex Alimentarius Commission approved the “Development of Guidelines for the Safe Use and Reuse of Water in Food Production” proposed at the 51st Session of the Codex Committee on Food Hygiene. To support this work, JEMRA was asked to provide scientific advice on sector-specific applications and case studies for determining appropriate and fit-for-purpose microbiological criteria for water sourcing, use and reuse in fish and fishery products from primary production to retail. This report presented the outcome from the JEMRA meeting, which includes the: situation analysis concerning water use and reuse in the production and processing of fish and fishery products, analysis of case studies for different risk-based water use and reuse processing scenarios and species, water quality monitoring and the use of non-culture based microbiological methods, recommendations concerning the safety and quality of water used in fish production and processing, and critical research gaps and policy developments.