Download or read book Attachment of Polyelectrolyte Multilayers to Cells and the Implications on Cell Behavior written by Rosanna Marie Lim and published by . This book was released on 2016 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of targeted drug delivery systems is of fundamental importance for the transport of highly toxic drugs to diseased cells. One way of achieving this is using biohybrid materials, which integrates synthetic components with cells in order to confer unique properties to existing biological systems. An example of this is the cell backpack, which consists of a circular, polymeric patch, microns in diameter and hundreds of nanometers thick, attached to the surface of a cell. Unlike passive delivery systems, cells have the ability to use signaling and trafficking to actively target a disease site. Cells carrying drug-loaded backpacks would thus be able to efficiently carry drugs to unhealthy cells. The cell backpack material itself is a polymeric patch consisting of stratified layers forming nanostructured compartments. In this thesis, the cell backpack is further developed to improve versatility and drug loading. First, a new, sacrificial thin film is developed to detach the cell backpacks from the substrates that they are fabricated on. This sacrificial multilayer, composed of bovine submaxillary mucin and jacalin lectin, is stable in a wide pH and ionic strength range and dissolves using a chemical stimulus. This mucin/lectin releasable region increases versatility by allowing more materials to be incorporated into the cell backpack, such as drug-containing liposomes. Echogenic liposomes containing doxorubicin were embedded into cell backpacks, and the ability of using these cell backpacks as a targeted, anti-cancer therapy was evaluated by studying the effects on mouse monocytes. Finally, thin films containing maleimide groups were developed for the cell backpacks to covalently attach these polymeric patches to cell surfaces. Former cell surface attachment techniques relied on cell-specific receptors, so covalent attachment would allow backpacks to attach to a greater variety of cells. The advancements investigated in this thesis work help to bring cell backpack technology one step closer to becoming a viable, therapeutic product.
Download or read book Application of Polyelectrolyte Multilayers for Photolithographic Patterning of Diverse Mammalian Cell Types in Serum Free Medium written by Vipra Dhir and published by . This book was released on 2008 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integration of living cells with novel microdevices requires the development of innovative technologies for manipulating cells. Chemical surface patterning has been proven as an effective method to control the attachment and growth of diverse cell populations. Patterning polyelectrolyte multilayers through the combination of layer-by-layer self-assembly technique and photolithography offers a simple, versatile and silicon compatible approach that overcomes chemical surface patterning limitations, such as short-term stability and low protein adsorption resistance. In this study, direct photolithographic patterning of poly(acrlic acid)(PAA)/poly(acryl amide (PAAm) and PAA/poly(ally amine hydrochloride) (PAH) polyelectrolyte multilayers was developed to pattern mammalian neuronal, skeletal and cardiac muscle cells. For all studied cell types, PAA/PAAm multilayers behaved as a negative surface, completely preventing cell attachment. In contrast, PAA/PAH multilayers have shown a cell-selective behavior, promoting the attachment and growth of neuronal cells (embryonic rat hippocampal and NG108-15 cells) to a greater extent, while providing a little attachment for neonatal rat cardiac and skeletal muscle cells (C2C12 cell line). PAA/PAAm multilayer cellular patterns have also shown a remarkable protein adsorption resistance. Protein adsorption protocols commonly used for surface treatment in cell culture did not compromise the cell attachment inhibiting feature of the PAA/PAAm multilayer patterns. The combination of polyelectrolyte multilayer patterns with different adsorbed proteins could expand the applicability of this technology to cell types that require specific proteins either on the surface or in the medium for attachment or differentiation, and could not be patterned using the traditional methods.
Download or read book Engineering Invitro Cellular Microenvironment Using Polyelectrolyte Multilayer Films to Control Cell Adhesion and for Drug Delivery Applications written by Srivatsan Kidambi and published by . This book was released on 2007 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Layer by Layer Films for Biomedical Applications written by Catherine Picart and published by John Wiley & Sons. This book was released on 2015-02-09 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: The layer-by-layer (LbL) deposition technique is a versatile approach for preparing nanoscale multimaterial films: the fabrication of multicomposite films by the LbL procedure allows the combination of literally hundreds of different materials with nanometer thickness in a single device to obtain novel or superior performance. In the last 15 years the LbL technique has seen considerable developments and has now reached a point where it is beginning to find applications in bioengineering and biomedical engineering. The book gives a thorough overview of applications of the LbL technique in the context of bioengineering and biomedical engineering where the last years have witnessed tremendous progress. The first part familiarizes the reader with the specifics of cell-film interactions that need to be taken into account for successful application of the LbL method in biological environments. The second part focuses on LbL-derived small drug delivery systems and antibacterial agents, and the third part covers nano- and microcapsules as drug carriers and biosensors. The fourth and last part focuses on larger-scale biomedical applications of the LbL method such as engineered tissues and implant coatings.
Download or read book Biological and Biomedical Coatings Handbook written by Sam Zhang and published by CRC Press. This book was released on 2011-05-24 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in a versatile, contemporary style that will benefit both novice and expert alike, Biological and Biomedical Coatings Handbook, Two-Volume Set covers the state of the art in the development and implementation of advanced thin films and coatings in the biological field. Consisting of two volumes-Processing and Characterization and Applicatio
Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2018-08-09 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. - Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery - Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs - Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine
Download or read book Bioactive Surfaces written by Hans G. Börner and published by Springer Science & Business Media. This book was released on 2011-06-01 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erik Wischerhoff, Nezha Badi, André Laschewsky and Jean-François Lutz Smart Polymer Surfaces: Concepts and Applications in Biosciences; S. Petersen, M. Gattermayer and M. Biesalski Hold on at the Right Spot: Bioactive Surfaces for the Design of Live-Cell Micropatterns; Julien Polleux Interfacing Cell Surface Receptors to Hybrid Nanopatterned Surfaces: A Molecular Approach for Dissecting the Adhesion Machinery; Abigail Pulsipher and Muhammad N. Yousaf Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology; D. Volodkin, A. Skirtach and H. Möhwald LbL Films as Reservoirs for Bioactive Molecules; R. Gentsch and H. G. Börner Designing Three-Dimensional Materials at the Interface to Biology; Joerg C. Tiller Antimicrobial Surfaces;
Download or read book Biomaterials Science written by Buddy D. Ratner and published by Academic Press. This book was released on 2012-12-31 with total page 1610 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. - Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today - Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials - Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank
Download or read book Polymeric Biomaterials written by Severian Dumitriu and published by CRC Press. This book was released on 2020-03-05 with total page 1764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctiona
Download or read book Tissue Engineering written by Daniel Eberli and published by BoD – Books on Demand. This book was released on 2010-03-01 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues that closely match the patient’s needs can be reconstructed from readily available biopsies and subsequently be implanted with minimal or no immunogenicity. This eventually conquers several limitations encountered in tissue transplantation approaches. This book serves as a good starting point for anyone interested in the application of Tissue Engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications.
Download or read book Nanomembranes written by Yongfeng Mei and published by John Wiley & Sons. This book was released on 2022-06-15 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomembranes Provides a thorough overview of the field of nanomembranes, covering materials science, fabrication processes, properties, and applications In recent years, the unique nature of the nanomembrane has led to new technology and applications in areas including flexible electronics, photonics, robotics, biology, microelectromechanical systems, and lab-on-a-chip (LOC) devices. Highly suitable for assembling three-dimensional structures, the nanomembrane can be integrated into devices and systems using conventional thin film technology. Nanomembranes: Materials, Properties, and Applications is an up-to-date review of recent advances in the rapidly expanding area within nanoscience and technology. Edited by leading researchers, the book covers the fabrications, properties, applications, design concepts, and challenges of nanomembranes and other nano-scale assembled structures. In-depth chapters address topics including three- and four-dimensional origami, nanomembrane-based transient electronics, development of inorganic flexible electronics, magnetic nanomembranes, bio-applications of three-dimensional scaffolds, nanomembrane-based micro and nanorobots, passive electronic components based on self-rolled-up nanomembranes, and more. Covers nanomembranes as well as nanostructures made from semiconductor, metal, insulator, polymer, and composite materials Provides broad overview of two-dimensional materials and assembled structures including origami and kirigami structures Explores applications of nanomembrane such as batteries, supercapacitors, robotics, electronics, and cell scaffolding Discusses nanomembranes made from polymeric materials, mechanical forces during deformation, and assembly of nanomembranes, Addresses monolayer two-dimensional materials such as graphene and transition metal dichalcogenides Nanomembranes: Materials, Properties, and Applications is an invaluable resource for material scientists, engineers, physicists, and chemists in academia and industry, and an excellent text for graduate students and researchers across disciplines with interest in the rapidly growing field.
Download or read book Biomimetic Lipid Membranes Fundamentals Applications and Commercialization written by Fatma N. Kök and published by Springer. This book was released on 2019-04-16 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes; Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques; Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques; Describes the integration of biomimetic membranes with current top-notch tools and platforms; Examines applications in medicine, pharmaceutical industry, and environmental monitoring.
Download or read book Polymeric Biomaterials for Tissue Regeneration written by Changyou Gao and published by Springer Nature. This book was released on 2024-02-01 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.
Download or read book Multilayer Thin Films written by Gero Decher and published by John Wiley & Sons. This book was released on 2012-05-07 with total page 1157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second, comprehensive edition of the pioneering book in this fi eld has been completely revised and extended, now stretching to two volumes. The result is a comprehensive summary of layer-by-layer assembled, truly hybrid nanomaterials and thin fi lms, covering organic, inorganic, colloidal, macromolecular, and biological components, as well as the assembly of nanoscale fi lms derived from them on surfaces. These two volumes are essential for anyone working in the field, as well as scientists and researchers active in materials development, who needs the key knowledge provided herein for linking the field of molecular self-assembly with the bio- and materials sciences.
Download or read book Chitin in Nature and Technology written by G.W. Gooday and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exegi monumentum ael'e perennius. The monument I have built will last longer than bronze. Horace My previous book, "Chitin", (1977) was listed by the publisher, as a "key research book", among the most requested books by libraries. It received favorable comments from. each of the journals which reviewed it, Science, 198, 28 Oct. 1977, Physiological Entomology, 2(4), Dec. 1977, The Canadian Institute of Food Science and Technology Journal, April 1978, The Quarterly Review of Biology, 53:361, 1978, Oceanographic Abstracts, 15:182, 1979, Annales de Zoologie-Ecologie Animale, 11:127, 1979, and Enzyme & Microbial Technology, 2, 1980. The variety of these journals testifies to the interdisci plinary character of chitin studies. "Chitin" has really been a landmark, to use the definition given by Science, because it stimulated interest in the less known polysaccharides and in modified chitins, besides chitin itself, to the point that three International Conferences on Chitin / Chitosan were convened (Boston, U. S. A. 1977, Sapporo, Japan 1982 and Senigallia, Italy 1985). In convening the 3rd International Conference on Chitin / Chitosan (1-4 April 1985), one of the main objectives was the preparation of the present book. While the proceedings of the previous two Conferences were very valuable, they did not appear in any book catalogs and this severely Ii mi ted their distribution.
Download or read book Multilayer Thin Films written by Gero Decher and published by John Wiley & Sons. This book was released on 2012-06-11 with total page 1157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second, comprehensive edition of the pioneering book in this fi eld has been completely revised and extended, now stretching to two volumes. The result is a comprehensive summary of layer-by-layer assembled, truly hybrid nanomaterials and thin fi lms, covering organic, inorganic, colloidal, macromolecular, and biological components, as well as the assembly of nanoscale fi lms derived from them on surfaces. These two volumes are essential for anyone working in the field, as well as scientists and researchers active in materials development, who needs the key knowledge provided herein for linking the field of molecular self-assembly with the bio- and materials sciences.
