Download or read book Art in Organic Synthesis written by Nitya Anand and published by Wiley-Interscience. This book was released on 1988-02-18 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than any other branch of organic chemistry, synthesis has improved our understanding of the structure, dynamics, and transition of molecules. The availability of sophisticated tools and new techniques has made organic synthesis more challenging than ever for those in the field. This updated edition of the 1970 work highlights significant and intriguing synthetic achievements: their ingenuity in design, extent of stereochemical control, new reactions, and new reagents. Approximately 100 examples illustrate various aspects of organic synthesis, with particular emphasis on bond-making and bond-breaking, dissymetry, conformation, and stereoelectric considerations. Each describes the synthesis of a natural product or of an unusual or strained molecule. Numerous flow sheets and perspective structural formulas illustrate the force of arguments predicting the stereochemical outcome of important steps. Also included is a type-transformation index which highlights some less common reactions.
Download or read book Art in Biosynthesis written by Darshan Ranganathan and published by Elsevier. This book was released on 2013-10-22 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Art in Biosynthesis: The Synthetic Chemists Challenge, Volume 1 presents representative examples whose biosynthetic pathways are known on the basis of experimentation. This book is divided into 44 chapters that demonstrate the creativity associated with the construction of molecular frameworks. It is a work of appreciation and criticism of the complexity of biosynthetic processes and of the interaction between man, the organic chemist, and Nature. This text describes an established biosynthetic sequence which is a challenge to the synthetic organic chemist to imitate and to equal Nature. The aim of each chapter is to enable a quick comparison of the specific synthetic strategies. This work covers the biosynthesis of natural antibiotics, amino acids, enzymes, fatty acids, and vitamins. This book will prove useful to organic chemists and researchers.
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2017-02-17 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Download or read book The Citrus Genome written by Alessandra Gentile and published by Springer Nature. This book was released on 2020-03-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews how the release of the citrus genome facilitates the investigation of ancestral species, the study of their complex biological features, and the genetic basis of agronomic traits of paramount importance for their sustainable cultivation. The first chapters discuss citrus origin and distribution, and the economic importance and varietal composition of the cultivated species, providing an overview of citrus and related genera genetic resources. The book then describes the role of traditional breeding techniques (for scion and rootstocks) as well as the potential of genomic breeding and innovative protocols for biotechnological approaches. The second part provides essential information on the genus Citrus, the attributes of pure citrus species, genetic admixtures, hybrids and citrus relatives, and on the horticultural classification of cultivated species, varieties and rootstocks. The third part then focuses on the different molecular mechanisms, covering various aspects of citrus biology, including the role of beneficial compounds of citrus fruits. In addition, it examines the molecular responses of citrus to abiotic stresses and to field and post-harvest diseases. Providing insights gained in recent years, it is a valuable guide for those who are interested in gene discovery, comparative genomics, molecular breeding and new breeding techniques. It is particularly useful for scientists, breeders and students at universities and public sector institutes involved in research for the citrus industry.
Download or read book Artemisinin and Nitric Oxide written by Qing-Ping Zeng and published by Springer. This book was released on 2015-06-23 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses both the beneficial and harmful aspects of NO in biology and medicine, and also introduces the emerging discovery of artemisinin in antitumor, antibacterial infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) was voted “Molecule of the Year” by Science magazine, and the discovery of its physiological roles has led to Nobel Prize-winning work in neuroscience, physiology and immunology. The book explains why we should maintain a steady-state NO level that is derived from neuronal or epithelial NO synthase, and avoid the extremely high NO level resulting from inducible NO synthase. The book offers a valuable resource for medical chemists, clinicians, biologists and all those interested in health and disease.
Download or read book Artemisinin From Traditional Chinese Medicine to Artemisinin Combination Therapies Four Decades of Research on the Biochemistry Physiology and Breeding of Artemisia annua written by Tomasz Czechowski and published by Frontiers Media SA. This book was released on 2020-12-04 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Current Developments in Biotechnology and Bioengineering written by P Gunasekaran and published by Elsevier. This book was released on 2016-09-19 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Developments in Biotechnology and Bioengineering: Functional Genomics and Metabolic Engineering provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends in the field, compiling the latest ideas from across the entire arena of biotechnology and bioengineering. This volume provides data-based scientific knowledge and state-of-art information on functional genomics and metabolic engineering. It covers the core subjects of functional genomics, such as epigenomics, metagenomics, genomics of extremophiles, genomics studies in nutrient transport, genomics of miRNA, and genomics of pathogenesis. An overview of metabolic engineering theories and approaches is supported with specific important examples of secondary metabolites, including Streptomyces, pentose utilization in E. coli, bacterial ethanol fermentation, yeast mediated benzaldehyde biotransformation, carotenoid production, acetic acid production by E. coli, and NADH regeneration. Provides state-of-the-art information and applications of functional genomics and metabolic engineering as applied to biotechnology Supports the education and understanding of biotechnology education and R&D Demonstrates new means of enabling cells to produce valuable proteins, polypeptides, and primary and secondary metabolites
Download or read book Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids written by Majid M. Heravi and published by Elsevier. This book was released on 2021-06-12 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions. In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists. - Includes an introduction of alkaloids, their origins and biological properties - Features the applications of special name reactions as the key step in the total synthesis of featured alkaloids - Covers the pathway for the synthesis of alkaloids from commercially available or easily accessible starting materials by using at least one name reaction to achieve the desired target products
Download or read book New Light on Alkaloid Biosynthesis and Future Prospects written by and published by Academic Press. This book was released on 2013-07-27 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 68th volume, the series features varied reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on a new light on alkaloid biosynthesis and future prospects. - In-depth and up-to-date reviews on a wide range of topics in plant sciences - Features varied reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology - Features reviews on biosynthesis of alkaloids in plants
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-03-17 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Download or read book Combinatorial Synthesis of Natural Product Based Libraries written by Armen M. Boldi and published by CRC Press. This book was released on 2006-05-16 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato
Download or read book The Way of Synthesis written by Tomas Hudlicky and published by Wiley-VCH. This book was released on 2007-09-04 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)
Download or read book Strategies and Tactics in Organic Synthesis written by Michael Harmata and published by Academic Press. This book was released on 2004-11-03 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. There are stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.
Download or read book Engineering of Microbial Biosynthetic Pathways written by Vijai Singh and published by Springer Nature. This book was released on 2020-07-16 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.
Download or read book Sesquiterpenes Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sesquiterpenes: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Sesquiterpenes in a concise format. The editors have built Sesquiterpenes: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Sesquiterpenes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sesquiterpenes: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
