Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

Download or read book Pathways and Patterns in History written by Peter J. Morden and published by Wipf and Stock Publishers. This book was released on 2020-10-06 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professor David Bebbington is a highly regarded historian. He holds a chair at the University of Stirling, has been President of the Ecclesiastical History Society, and has delivered numerous endowed lecture series, as well as being deeply involved in the Dr Williams’s Dissenting Academies Project. He is both a popular and influential academic historian, whose writings have significantly shaped our thinking about the history of evangelicalism, Baptist life, and political developments. In Pathways and Patterns, colleagues, former research students and friends who are indebted to Professor Bebbington and value his contribution to scholarship join together to pay tribute to his outstanding work. Not only has he stimulated academic endeavour, he has also given much personal support, not least to those in the Baptist Historical Society and in Colleges, among them Spurgeon’s College and Baylor University (USA) where he is a Distinguished Visiting Professor. This volume reflects his wide involvements and the grateful esteem in which he is held. Among Professor Bebbington’s achievements has been both instituting and masterminding the very important International Conference on Baptist Studies (ICOBS), held every three years in different parts of the world. It is appropriate, then, that this volume was presented to him at the Seventh ICOBS Conference held in Manchester, July 2015.

Download or read book History of Nottinghamshire written by Robert Thoroton and published by . This book was released on 1797 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book History and GIS written by Alexander Lünen and published by Springer Science & Business Media. This book was released on 2012-12-05 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geographical Information Systems (GIS) – either as “standard” GIS or custom made Historical GIS (HGIS) – have become quite popular in some historical sub-disciplines, such as Economic and Social History or Historical Geography. “Mainstream” history, however, seems to be rather unaffected by this trend. More generally speaking: Why is it that computer applications in general have failed to make much headway in history departments, despite the first steps being undertaken a good forty years ago? With the “spatial turn” in full swing in the humanities, and many historians dealing with spatial and geographical questions, one would think GIS would be welcomed with open arms. Yet there seems to be no general anticipation by historians of employing GIS as a research tool. As mentioned, HGIS are popular chiefly among Historical Geographers and Social and Economic Historians. The latter disciplines seem to be predestined to use such software through the widespread quantitative methodology these disciplines have employed traditionally. Other historical sub-disciplines, such as Ancient History, are also very open to this emerging technology since the scarcity of written sources in this field can be mitigated by inferences made from an HGIS that has archaeological data stored in it, for example. In most of Modern History, however, the use of GIS is rarely seen. The intellectual benefit that a GIS may bring about seems not be apparent to scholars from this sub-discipline (and others). This book wants to investigate and discuss this controversy. Why does the wider historian community not embrace GIS more readily? While one cannot deny that the methodologies linked with a GIS follow geographical paradigms rather than historical ones, the potential of GIS as a 'killer application' for digital historical scholarship should be obvious. This book brings together authors from Geography and History to discuss the value of GIS for historical research. The focus, however, will not be on the "how", but on the "why" of GIS in history.

Download or read book Thoroton s History of Nottinghamshire written by Robert Thoroton and published by . This book was released on 1797 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Appliable Approaches to Analyzing Texts in Academic Discourse written by Alireza Jalilifar and published by Cambridge Scholars Publishing. This book was released on 2024-01-03 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of approaches to problems of language learning, aimed at graduate students and researchers interested in English for academic purposes. Its primary focus is the complexity and nuances of academic writing such as phraseology, nominalization, thematicity, and phrasal complexity features. The book will clarify the issue of how language is used to communicate discipline-related content, viewed through the lens of linguistics as one of the human sciences. Each chapter concludes with several tasks that enable users to substantiate what has been presented in that chapter. The book primarily addresses non-native speakers of English who are studying for master’s and PhD qualifications through the medium of English; however, non-native researchers may also find some chapters of the book useful for their underlying focus on academic writing and publishing.

Download or read book Modern Methods for Analysing Archaeological and Historical Glass written by Koen H. A. Janssens and published by John Wiley & Sons. This book was released on 2013-01-29 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first scientific volume to compile the modern analytical techniques for glass analysis, Modern Methods for Analysing Archaeological and Historical Glass presents an up-to-date description of the physico-chemical methods suitable for determining the composition of glass and for speciation of specific components. This unique resource presents members of Association Internationale pour l'Histoire du Verre, as well as university scholars, with a number of case studies where the effective use of one or more of these methods for elucidating a particular culturo-historical or historo-technical aspect of glass manufacturing technology is documented.

Download or read book Approaches to Nottingham s History written by Alan Rogers and published by . This book was released on 1980* with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Biblical Approach to Mission in Context written by Michael Ufok Udoekpo and published by Wipf and Stock Publishers. This book was released on 2022-12-19 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Biblical Approach to Mission in Context is an erudite collection of twenty essays with forewords and epilogue produced to honor Professor Teresa Okure’s contribution to the study of biblical theology in context. It also stands in its own right as a vade mecum of current trends in biblical scholarship, gender, and contextual hermeneutics. Written by an international array of respected scholars—Okure’s colleagues, former students, siblings, and fellow commentators—this volume includes detailed exegetical studies, discussion on theological methods and contextual approaches from a variety of standpoints, and an effort to relate biblical exegesis, theology, and inculturation—faith—hermeneutics to the current interest in social-contextual interpretation that reflects values beyond the African context. In sum, the breadth of interests and enthusiasm found in this volume is a testimony to the intellectual and pastoral vitalities and passion that Teresa Okure herself brought to the discipline of biblical studies. The brief narrative of personal encounter written by Bernadette Okure, SHCJ, forewords by John Cardinal Onaiyekan and Bishop Camillus Raymond Umoh, as well as an insightful epilogue by Fr. Aniedi Okure, OP, provide additional insight into the historical and socio-cultural contexts within which Okure’s formation and contributions unfolded.

Download or read book The Civil Wars Experienced written by Martyn Bennett and published by Routledge. This book was released on 2005-08-18 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Civil Wars Experienced is an exciting new history of the civil wars, which recounts their effects on the 'common people'. This engaging survey throws new light onto a century of violence and political and social upheaval By looking at personal sources such as diaries, petitions, letters and social sources including the press, The Civil War Experienced clearly sets out the true social and cultural effects of the wars on the peoples of England, Scotland, Wales and Ireland and how common experiences transcended national and regional boundaries. It ranges widely from the Orkneys to Galway and from Radnorshire to Norfolk. The Civil Wars Experienced explores exactly how far-reaching the changes caused by civil wars actually were for both women and men and carefully assesses individual reactions towards them. For most people fear, familial concerns and material priorities dictated their lives, but for others the civil revolutions provided a positive force for their own spiritual and religious development. By placing the military and political developments of the civil wars in a social context, this book portrays a very different interpretation of a century of regicide and republic.

Download or read book An Analysis of Griselda Pollock s Vision and Difference written by Karina Jakubowicz and published by CRC Press. This book was released on 2018-02-21 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vision and Difference, published in 1988, is one of the most significant works in feminist visual culture arguing that feminist art history of is a political as well as academic endeavour. Pollock expresses how images are key to the construction of sexual difference, both in visual culture and in broader societal experiences. Her argument places feminist theory at the centre of art history, proffering the idea that a feminist understanding of art history is an analysis of art history itself. This text remains key not only to understand feminine art historically but to grasp strategies for representation in the future and adding to its contemporary value.

Download or read book Early Medieval Text and Image Volume 2 written by Jennifer O'Reilly and published by Routledge. This book was released on 2019-06-19 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: When she died in 2016, Dr Jennifer O’Reilly left behind a body of published and unpublished work in three areas of medieval studies: the iconography of the Gospel Books produced in early medieval Ireland and Anglo-Saxon England; the writings of Bede and his older Irish contemporary, Adomnán of Iona; and the early lives of Thomas Becket. In these three areas she explored the connections between historical texts, artistic images and biblical exegesis. This volume brings together seventeen essays, published between 1984 and 2013, on the interplay of texts and images in medieval art. Most focus on the manuscript art of early medieval Ireland and England. The first section includes four studies of the Codex Amiatinus, produced in Northumbria in the monastic community of Bede. The second section contains seven essays on the iconography and text of the Book of Kells. In the third section there are five studies of Anglo-Saxon Art, examined in the context of the Benedictine Reform. A concluding essay, on the medieval iconography of the two trees in Eden, traces the development of a motif from Late Antiquity to the end of the Middle Ages.(CS1080)

Download or read book Contemporary Theory and Pragmatic Approaches in Fuzzy Computing Utilization written by Chen, Toly and published by IGI Global. This book was released on 2012-07-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book presents the most innovative systematic and practical facets of fuzzy computing technologies to students, scholars, and academicians, as well as practitioners, engineers, and professionals"--

Download or read book Europe s Changing Woods and Forests written by Keith Kirby and published by CABI. This book was released on 2015-06-30 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the ecological history of European forests has been transformed in the last twenty years. Bringing together key findings from across the continent, this book provides a comprehensive account of the relevance of historical studies to current conservation and management of forests. It combines theory with a series of regional case studies to show how different aspects of forestry play out according to the landscape and historical context of the local area.

Download or read book The Spectre of Promiscuity written by Christian Klesse and published by Routledge. This book was released on 2016-03-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wide-ranging research suggests that partners in gay male and bisexual relationships do not necessarily expect monogamy, or see it as an important issue. Although the frequency of gay male and bisexual non-monogamous partnerships tends to be widely acknowledged in social science literature, these relationships have rarely been explored in more detail. By providing rich empirical data, thoughtful analysis and theoretical debate, this book makes a significant contribution to the sociological literature on sexual and intimate relationships. More specifically it explores the diversity of gay male and bisexual relationship practices in the context of heteronormative citizenship and intra-social movement conflict, and highlights the complexity of power relations that circumscribe queer people's relationships and sexual lives. Written in an accessible and engaging manner, The Spectre of Promiscuity provides important insights for further studies on sexual culture, discourse, citizenship, politics and ethics.

Download or read book Forest History written by Mauro Agnoletti and published by CABI. This book was released on 2000-06-09 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents edited and revised versions of more than 30 papers selected from those presented at a major conference on History and Forest Resources, held in Florence in 1998. The conference was organised by the Italian Academy of Forestry Science and working group on Forest History of the International Union of Forestry Research Organisations (IUFRO). As a whole the papers present detailed analyses of the interrelationships between forest ecosystems and socioeconomic development from thirteen different countries of the world. Main economic and social factors, techniques and local practices, as well as legal and political aspects related to forest changes are discussed, according to the latest achievements in forest history research. The book is a companion volume to Methods and Approaches in Forest History.

Download or read book Changes in Attitudes to Immigrants in Britain 1841 1921 written by Ben Braber and published by Anthem Press. This book was released on 2020-11-25 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews changes in attitudes to immigrants in Britain and the language that was used to put these feelings into words between 1841 and 1921. Using a historical and linguistic method for an analysis of so far for this purpose relatively unused primary sources, it offers novel findings. It has found that changes in the meaning and use of the word alien in Britain coincided during the period between 1841 and 1921 with the expression of changing attitudes to immigrants in this country and the modification of the British variant of the English language. When people in Britain in these years used the term ‘an alien’, they meant most likely a foreigner, stranger, refugee or immigrant. In 1841 an alien denoted a foreigner or a stranger, notably a person residing or working in a country who did not have the nationality or citizenship of that country. However, by 1921 an alien mainly signified an immigrant in Britain – a term which, as this book shows, had in the course of the years since 1841 acquired very negative connotations.