Download or read book Applied Uses of Ancient DNA written by Nic Rawlence and published by Frontiers Media SA. This book was released on 2021-06-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ancient DNA Typing written by Susanne Hummel and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the definitive source of information on techniques for the identification and sequencing of old DNA (pieces) and their use in biological and medical research and application. Application of aDNA techniques are useful tools for investigations reaching from evolutionary studies to law enforcement approaches. What brings them together is the interest in specific methods of handling aDNA, i.e. elaborated PCR and sequencing techniques and the interpretation of the results. This books serves as an ideal guideline for it demonstrates how problem-solving strategies can be applied in various areas.
Download or read book Ancient DNA written by Bernd Herrmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ancient DNA refers to DNA which can be recovered and analyzed from clinical, museum, archaeological and paleontological specimens. Ancient DNA ranges in age from less than 100 years to tens of millions of years. The study of ancient DNA is a young field, but it has been revolutionized by the application of polymerase chain reaction technology, and interest is growing very rapidly. Fields as diverse as evolution, anthropology, medicine, agriculture, and even law enforcement have quickly found applications in the recovery of ancient DNA. This book contains contributions from many of the "first generation" researchers who pioneered the development and application of ancient DNA methods. Their chapters present the protocols and precautions which have resulted in the remarkable results obtained in recent years. The range of subjects reflects the wide diversity of applications that are emerging in research on ancient DNA, including the study of DNA to analyze kinship, recovery of DNA from organisms trapped in amber, ancient DNA from human remains preserved in a variety of locations and conditions, DNA recovered from herbarium and museum specimens, and DNA isolated from ancient plant seeds or compression fossils. Ancient DNA will serve as a valuable source of information, ideas, and protocols for anyone interested in this extraordinary field.
Download or read book Ancient DNA written by Erika Hagelberg and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ancient DNA written by Beth Shapiro and published by Humana Press. This book was released on 2012-01-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into ancient DNA began more than 25 years ago with the publication of short mitochondrial DNA sequence fragments from the quagga, an extinct relative of the zebra. Ancient DNA research really gained momentum following the invention of PCR, which allowed millions of copies to be made of the few remaining DNA molecules preserved in fossils and museum specimens. In Ancient DNA: Methods and Protocols expert researchers in the field describe many of the protocols that are now commonly used to study ancient DNA. These include instructions for setting up an ancient DNA laboratory, extraction protocols for a wide range of different substrates, details of laboratory techniques including PCR and NGS library preparation, and suggestions for appropriate analytical approaches to make sense of the sequences obtained. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ancient DNA: Methods and Protocols seeks to aid scientists in the further study of ancient DNA and the methodological approaches in ancient research.
Download or read book Applications of DNA Capture in Ancient DNA Research written by Alexander Immel and published by . This book was released on 2020* with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ancient DNA has become an indispensable resource of fundamental research. Especially the combination of DNA capture methods and Next Generation Sequencing (NGS) has allowed to exploit the full potential of ancient DNA. In this dissertation I present three studies which involve capture of ancient DNA to answer different scientific questions. In my first study I bioinformatically reconstruct the mitochondrial genome of the extinct giant deer Megaloceros giganteus after applying mitochondrial DNA capture and sequencing. Using the giant deer's reconstructed mitochondrial genome I then apply phylogenetic analyses that allow to resolve the giant deer's placement within the cervid family tree and reaffirm the fallow deer being its closest extant relative. Mitochondrial DNA capture also provides the basis for the next study, in which I investigate the effects of X-rays on ancient DNA. Different radiation settings are explored including those commonly used in computed tomography (CT) of anthropological and palaeontological specimens. The results allow to define 200 Gray (Gy) as the maximum absorbed X-ray dose which can still be regarded harmless to ancient DNA molecules. No X-radiation induced effects can be observed below this threshold. In my third study I develop and apply capture of 488 human immunity genes in order to compare the immunogenetic makeup of Late Medieval plague (Yersinia pestis) victims and their modern day successors from Ellwangen, Southern Germany. Applying bioinformatic tools allows me to investigate kinship within both populations, determine genetic continuity between past and present, and reconstruct the Human Leukocyte Antigen (HLA) allelic profiles of both populations. While the majority of HLA alleles do not differ in their frequencies, HLA-B51:01 and HLA-DRB113 show significant frequency differences between both populations, potentially indicative of selective pressure through Yersinia pestis.
Download or read book Who We Are and How We Got Here written by David Reich and published by Oxford University Press. This book was released on 2018-03-29 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed a revolution in our ability to obtain DNA from ancient humans. This important new data has added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations living today are mixes of ancient ones, and often carry a genetic component from archaic humans. David Reich, whose team has been at the forefront of these discoveries, explains what genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial âpurity.' Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?
Download or read book The Use of Ancient DNA to Directly Monitor Genetic Changes in Vertebrate Populations Over Millennium Time Scales written by Jennifer Ann Leonard and published by . This book was released on 2002 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ancient DNA written by Elizabeth D. Jones and published by Yale University Press. This book was released on 2022-03-29 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The story of the search for DNA and protein molecules from fossils, along with the controversy and celebrity that have followed it, helping to define the formation of a new scientific field now widely known as "ancient DNA research.""--
Download or read book DNA for Archaeologists written by Elizabeth Matisoo-Smith and published by Routledge. This book was released on 2016-09-16 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to use DNA evidence is revolutionizing our understanding of the past. This book introduces archaeologists to the basics of DNA research so they can understand the powers and pitfalls of using DNA data in archaeological analysis and interpretation. By concentrating on the principles and applications of DNA specific to archaeology, the authors allow archaeologists to collect DNA samples properly and interpret the laboratory results with greater confidence. Written by archaeologists who conduct fieldwork as well as laboratory analysis, the volume is replete with case examples of DNA work in a variety of archaeological contexts and is an ideal teaching tool for archaeologists and their students.
Download or read book Paleogenomics written by Charlotte Lindqvist and published by Springer. This book was released on 2019-01-07 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genome-scale DNA sequencing technologies have revolutionized genetic research on ancient organisms, extinct species, and past environments. When it is recoverable after hundreds or thousands of years of unintended preservation, “ancient DNA” (or aDNA) is often highly degraded, necessitating specialized handling and analytical approaches. Paleogenomics defines the field of reconstructing and analyzing the genomes of historic or long-dead organisms, most often through comparison with modern representatives of the same or similar species. The opportunity to isolate and study paleogenomes has radically transformed many fields, spanning biology, anthropology, agriculture, and medicine. Examples include understanding evolutionary relationships of extinct species known only from fossils, the domestication of plants and animals, and the evolution and geographical spread of certain pathogens. This pioneering book presents a snapshot view of the history, current status, and future prospects of paleogenomics, taking a broad viewpoint that covers a range of topics and organisms to provide an up-to-date status of the applications, challenges, and promise of the field. This book is intended for a variety of readerships, including upper-level undergraduate and graduate students, professionals and experts in the field, as well as anyone excited by the extraordinary insights that paleogenomics offers.
Download or read book How to Clone a Mammoth written by Beth Shapiro and published by Princeton University Press. This book was released on 2020-09-08 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: An insider's view on bringing extinct species back to life Could extinct species, like mammoths and passenger pigeons, be brought back to life? In How to Clone a Mammoth, Beth Shapiro, an evolutionary biologist and pioneer in ancient DNA research, addresses this intriguing question by walking readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used to resurrect the past. Considering de-extinction's practical benefits and ethical challenges, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.
Download or read book Evolutionary Patterns and Processes written by D. R. Lees and published by Academic Press. This book was released on 1993 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolution is the central theme of all biology. Researcarcch in the many branches of evolutionary study continues to flourish. This book, based on a symposium of the Linnean Society, discusses the diversity in currentevolutionary research. It approaches the subject ambitiously and from several angles, bringing ttogether eminent authors from a variety of disciplines paleontologists traditionally with a macroevolutionary bias, neontologists concentrating on microevolutionary processes, and those studying the very essence ofsses and those studying the very essence of evolution the process of speciation in living organisms. Evolutionary Patterns and Processes will appeal to a broad spectrum of professional biologistsworking in such fields as paleontology, population biology, and evolutionary genetics. Biologists will enjoy chapters by Stephen J. Gould, discovering in the much earlier work of Hugo de Vries parallels with his ideas on punctuational evolution; Guy Bush,considering why there are so many small animals; Peter Sheldon, examining detailed fossil trilobite sequences for evidence of microevolutionary processes and considering models of speciation; as well as others dealing with cytological, ecological, and behavioral processes leading to the evolution of new species. None
Download or read book Who We Are and How We Got Here written by David Reich and published by Vintage. This book was released on 2019-02-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking book about how ancient DNA has profoundly changed our understanding of human history. Geneticists like David Reich have made astounding advances in the field of genomics, which is proving to be as important as archeology, linguistics, and written records as a means to understand our ancestry. In Who We Are and How We Got Here, Reich allows readers to discover how the human genome provides not only all the information a human embryo needs to develop but also the hidden story of our species. Reich delves into how the genomic revolution is transforming our understanding of modern humans and how DNA studies reveal deep inequalities among different populations, between the sexes, and among individuals. Provocatively, Reich’s book suggests that there might very well be biological differences among human populations but that these differences are unlikely to conform to common stereotypes. Drawing upon revolutionary findings and unparalleled scientific studies, Who We Are and How We Got Here is a captivating glimpse into humankind—where we came from and what that says about our lives today.
Download or read book Archaeogenetics written by Colin Renfrew and published by . This book was released on 2000 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: MtDNA.
Download or read book The Handbook of Mummy Studies written by Dong Hoon Shin and published by Springer. This book was released on 2021-10-26 with total page 1171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Owing to their unique state of preservation, mummies provide us with significant historical and scientific knowledge of humankind’s past. This handbook, written by prominent international experts in mummy studies, offers readers a comprehensive guide to new understandings of the field’s most recent trends and developments. It provides invaluable information on the health states and pathologies of historic populations and civilizations, as well as their socio-cultural and religious characteristics. Addressing the developments in mummy studies that have taken place over the past two decades – which have been neglected for as long a time – the authors excavate the ground-breaking research that has transformed scientific and cultural knowledge of our ancient predecessors. The handbook investigates the many new biotechnological tools that are routinely applied in mummy studies, ranging from morphological inspection and endoscopy to minimally invasive radiological techniques that are used to assess states of preservation. It also looks at the paleoparasitological and pathological approaches that have been employed to reconstruct the lifestyles and pathologic conditions of ancient populations, and considers the techniques that have been applied to enhance biomedical knowledge, such as craniofacial reconstruction, chemical analysis, stable isotope analysis and ancient DNA analysis. This interdisciplinary handbook will appeal to academics in historical, anthropological, archaeological and biological sciences, and will serve as an indispensable companion to researchers and students interested in worldwide mummy studies.
Download or read book DNA written by Torsten Krude and published by Cambridge University Press. This book was released on 2004 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1953 witnessed a breakthrough in biological science, the revelation of the double helical structure of DNA. Since the original revelation by James Watson and Francis Crick, knowledge of the structure and function of DNA has dramatically changed science and society. This volume explores the dramatic impact that this discovery has had on our lives. Beginning with the story of the discovery of the double helix, the collection looks at DNA fingerprinting and its impact on forensic and legal medicine; the extraction of ancient DNA from archaeological and palaeontological remains; the ethical implications arising from the genetic knowledge encoded in our DNA; the complex role of DNA in the cause, detection and treatment of cancer; the debates surrounding the potential commercialisation of genetically modified crops; the emotive field of reproductive medicine; and finally how the genetic basis of developmental language disorders is teaching us more about how humans communicate.
