Download or read book Applications of Quantitative Whole Body Autoradiographic Technique in Radiopharmaceutical Research written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The routine evaluation of radiopharmaceuticals involves dissecting tissue distribution studies (DTDS) and gamma or positron imaging. DTDS have the following disadvantages: since not all tissues can always be sampled, sites of radiopharmaceutical uptake may be missed and because the procedure involves weighing of dissected tissue samples, the spatial resolution of this method is low and determined by the smallest amount that can be weighed accurately. Gamma camera imaging and positron emission tomography though more comprehensive in evaluating the global distribution of a compound, have relative low spatial resolution. Whole body autoradiography of small animals has a much higher spatial resolution as compared to the above and depicts the global distribution of radiopharmaceuticals. A computer-assisted quantification method of WBARG applied to positron, beta, and gamma emitters will complement the method by producing quantitative values comparable to those obtained by dissection and direct tissue counting, with the advantages of depicting the global distribution at high spatial resolution.
Download or read book Applications of Quantitative Whole body Autoradiographic Technique in Radiopharmaceutical Research written by and published by . This book was released on 1982 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Whole body Autoradiography written by C. G. Curtis and published by . This book was released on 1981 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Energy Research Abstracts written by and published by . This book was released on 1982 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Directions in Radiopharmaceutical Research and Development written by Steven J. Mather and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.
Download or read book Energy Research Abstracts written by and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Xenobiotic Metabolism and Disposition written by Harry P.A. Illing and published by CRC Press. This book was released on 2019-11-11 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.
Download or read book Advanced Techniques and Future Trends in Laboratory Science Part 1 written by Dr. Ashwini Sarang Pande and published by Shashwat Publication. This book was released on 2023-11-01 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is designed to provide step- by step approach to all techniques currently used in medical laboratories. This book contains useful information and detailed protocol related to Clinical Biochemistry, Microbiology, Immunology and Serology, Clinical Pathology, Hematology and Molecular Biology. All methods are explained with easy readability, each chapter written in simple language and practical based. It is intended to benefit the Undergraduate, Postgraduate, Medical Laboratory Technologist, MBBS, Medical Biochemistry students of Medical, Pharmacy, Physiotherapy, Nursing, Medical Laboratory Sciences and other allied courses. This book will be helpful to the students, teachers and also useful to the paper setters in setting question papers. The author has done rigorous work for explaining different advanced techniques in medical laboratory sciences.
Download or read book INIS Atomindex written by and published by . This book was released on 1985 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Medicine and Biology Advances written by Claude Raynaud and published by Pergamon. This book was released on 1983 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Imaging in Drug Discovery Development and Approval written by BURNS and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is the purpose and business of the pharmaceutical industry to dis cover, develop, and make available drugs for the care of the sick. The purpose of universities and national laboratories is to provide people and scientific knowledge that can help in the process. This book presents the combined efforts of scientists from the drug in dustry, academic laboratories and national laboratories to describe advances in radiotracer technology in studies on experimental ani mals and living human beings. The authors believe that the technol ogy is now ready for widespread application in the pharmaceutical industry. The goal of this book is to help bring this about. The field of Nuclear Medicine is based on the concept that, if treatment of disease is chemical, the patient's diagnosis should be chemical. Anatomy and histopathology have been the principle ba sis for making a diagnosis. Histopathologic data suffer from being descriptive, subjective, not quantifiable, and based on the study of dead tissue. The era of histopathology as the dominant concept in medical practice is coming to an end. Histopathologic findings are often heterogeneous and a single biopsy will at times not reveal the true nature of the disease, such as the grading of malignancy. Far greater accuracy of staging of disease and in the planning of treat ment is possible through chemistry, as well as by making possible a more suitable selection of a histological biopsy site.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1987 with total page 1176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Models of Lung Disease written by Joan Gil and published by CRC Press. This book was released on 2020-08-11 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research-level reference provides a review of the morphological techniques that have become a primary method of anatomical study correlating structure and function in lung physiology and pathology. Detailing the evolution of anatomy as a research discipline, it explores general structural techn
Download or read book ERDA Energy Research Abstracts written by and published by . This book was released on 1983 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Production Quality Control and Clinical Applications of Radiosynovectomy Agents written by International Atomic Energy Agency and published by . This book was released on 2021-08-31 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic radiopharmaceuticals play a major role in today's nuclear medicine with a positive impact on the diagnosis and treatment of diseases. One area of application is radiation synovectomy (RSV).
Download or read book Journal of Pharmacological Methods written by and published by . This book was released on 1990 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development and Perspectives of Other Applications of Nuclear Energy written by and published by . This book was released on 1987 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
