Download or read book Ap4a and Other Dinucleoside Polyphosphates written by Alexander G. McLennan and published by CRC Press. This book was released on 2020-11-25 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ap4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
Download or read book Ap4a and Other Dinucleoside Polyphosphates written by Alexander G. McLennan and published by CRC Press. This book was released on 2020-11-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ap4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
Download or read book Ap4A Analogues written by Michael James Lee Wright and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Microbial Physiology written by and published by Academic Press. This book was released on 1994-03-10 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Reviews of Previous Volumes"This series has consistently presented a well-balanced account of progress in microbial physiology...Invaluable for teaching purposes."-AMERICAN SCIENTIST
Download or read book P2 Purinoceptors written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
Download or read book Cardiovascular Hormone Systems written by Michael Bader and published by John Wiley & Sons. This book was released on 2008-10-20 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a renowned scientist in the field with more than 200 high profile scientific publications to his name, this is the first book to provide a comprehensive overview of all cardiovascular hormone systems. Clearly structured, the text covers steroid and peptide hormones, amines, and arachidonic acid metabolites, as well as such others as nucleotides, nitric oxide, and acetylcholine. An essential reference for researchers working on the cardiovascular system and related diseases.
Download or read book Cell Signal Transduction Second Messengers and Protein Phosphorylation in Health and Disease written by A.M. Municio and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is the great glory as it is also the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute. Peter Medawar, "The Threat and the Glory" An international symposium on "Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease" was held at EI Escorial (Spain) from July 5-9, 1993 as a summer course of the Complutense University in Madrid. The lectures were delivered by renowned scientists from Europe, America, and Asia and attended by a large number of young scientists and graduate students from many countries. During evolution multicellular organisms have developed the most sophisticated and heterogeneous signals to maintain in harmony their multiple functions. The latest and most controversial aspects and developments in signal transduction were the main focus of this course. The communication among participants was extremely fluid, alive, and warm. This allowed the understanding of the key steps in cellular communication, from their original and historical sources to the main present hypothesis in the borderline of the latest scientific discoveries in this field. Without any doubt, the special atmosphere of the place, the monuments and the old granite stones, the "patio" with the fountain and the rose garden were responsible for the cordial meeting. This book comprises the manuscripts of the participants and we hope it will contribute to our knowledge of cellular signal transduction and be of value to a wider scientific community.
Download or read book Uremic Toxins written by Toshimitsu Niwa and published by John Wiley & Sons. This book was released on 2012-09-04 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs Section Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent All chapters are based on the authors' thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field. Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.
Download or read book Acta Biochimica Polonica written by and published by . This book was released on 2003 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Dinucleoside Tetraphosphates and Their Analogs written by and published by . This book was released on 2007 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dinucleoside polyphosphates, NpnN' (n = 2 - 7), are observed in many biological processes and are recognized as playing important regulatory functions. Ap4A is a particularly important signaling molecule. AZTp4A is the product of excision of AZT by HIV-1 RT from a growing chain of viral DNA, and can be used to study details of the excision process. Its hydrolysis-resistant analogs can be used to study the inhibition of AZT excision. Current methods to prepare dinucleoside tetraphosphates, enzymatic or chemical, are not satisfactory. A convenient and high-yield method was developed to prepare dinucleoside tetra- and pentaphosphates. The method was based on a mixture of P(III) and P(V) chemistry and involved a trimetaphosphate intermediate. Six dinucleoside tetraphosphates and two pentaphosphates were prepared. In addition, the method was modified to prepare thio, seleno, borano, methylene and difluoromethylene analogs of Ap4A and AZTp4A. These analogs are good model compounds for their unmodified versions. Ap4A analogs can be used to study the mechanisms of its molecular signaling processes. The AZTp4A analogs are currently being used in HIV-1 RT drug resistance studies. The configurations of the diastereomers of the thio, seleno and borano analogs were assigned based on the elution order on reverse-phase HPLC. Enzymatic degradation of the Ap4A analogs was done with snake venom phosphodiesterase in order to confirm the configuration assignments. Furthermore, this method was extended to prepare multimodified hydrolysis-resistant AZTpSpCX2ppSA and AZTpSpCX2ppSAZT (X = H or F) as potential inhibitors of the AZT excision reaction by HIV-1 RT. The reactions were carried out by the coupling of adenosine or AZT H-phosphonate with trimetaphosphate analogs, taking advantage of the differential power of elemental sulfur to sulfurize H-phosphonate diesters but not monoesters. Enzymatic degradation was performed in order to assign configurations of the diastereomers and compare their enzymatic stabilities.
Download or read book Calcium and Phosphate Metabolism Management in Chronic Renal Disease written by Chen H. Hsu and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the kidney fails its intended mission to manage the body’s waste products, physicians must perform multi-level and simultaneous adjustments to replicate kidney function. The management of the body’s absorption, reabsorption, utilization and excretion of calcium and phosphate requires constant fine tuning. This book provides an overview of the state-of-the-art clinical and basic science aspects of abnormal calcium and phosphate metabolism and its management.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemistry and Cell Biology of Artemia written by Thomas H. MacRae and published by CRC Press. This book was released on 2018-01-18 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The unusual life history of the brine shrimp, Artemia, and the relative ease with which it can be experimentally manipulated have long made his crustacean a favorite system for biological studies. Over the years, descriptive morphological work has given way to a rigorous analysis of biochemical and cellular aspects of the organism. The underlying theme of the work is often been developmental in nature.This book brings together a wide spectrum of topics under study in the shrimp. Analyses of gene structure and protein synthesis are combined with descriptions of protein interactions characteristic of functional cells.
Download or read book Aminoacyl tRNA Synthetases in Biology and Medicine written by Sunghoon Kim and published by Springer. This book was released on 2014-04-28 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 1998-04-09 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis and colleagues, discusses the effect of MAP kinase cascades as examples of signal transduction mechanisms in signaling pathways. In Chapter 4, Sozi et al. Review the frequent abnormalities found in the FHIT gene in a variety of cancer-derived cell lines. Volume 74 concludes with an overview by J.J. Hsuan and co-workers of the cellular functions of PtdlnsP2 and the regulation of its biosynthesis.
Download or read book Heart Physiology and Pathophysiology written by Yoshihisa Kurachi and published by Elsevier. This book was released on 2000-10-09 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Download or read book Botanica Acta written by and published by . This book was released on 1987 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
