Download or read book Antibody Responses to and the Structure of Plasmodium Falciparum Merozoite Surface Protein 1 written by Jose Alejandro Guevara-Patino and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Murine and Human Antibody Responses to Plasmodium Falciparum Merozoite Surface Protein 1 written by and published by . This book was released on 2004 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Antibody Responses to Plasmodium Falciparum Merozoite Rhoptry Associated Protein 1 RAP1 written by Peter Nkong Fonjungo and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Antibody Responses to Plasmodium Falciparum Merozoite Rhoptry Associated Protein 1 RAP1 written by Peter Nkong Fonjungo and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies of Naturally Acquired Antibody Responses to Plasmodium Falciparum Merozoite Surface Proteins in Malaria Endemic Populations written by Simon Weisman and published by . This book was released on 2003 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book T cell Responses to Plasmodium Falciparum Merozoite Surface Protein 1 written by Edwin A. M. Lee and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Download or read book Advances in Malaria Research written by Deepak Gaur and published by John Wiley & Sons. This book was released on 2016-12-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders

Download or read book Plasmodium Falciparum Merozoite Surface Protein 1 written by Chairat Uthaipibull and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Age dependent Antibody Response to Plasmodium Falciparum Merozoite Surface Protein 2 MSP 2 written by Afra Khosravi and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functional Antibody Responses to the Plasmodium Falciparum Merozoite written by and published by . This book was released on 2014 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell Mediated Immune Responses to the Plasmodium Falciparum Asexual Stage Vaccine Candidate Merozoite Surface Protein 1 MSP1 written by Anne Ellizabeth Smillie and published by . This book was released on 2002 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bead based Chemistries to Quantitate Antibody Responses to Multiple Plasmodium Falciparum and Plasmodium Vivax Antigens written by Sonam Kaur Ghag and published by . This book was released on 2019 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year malaria impacts approximately 219 million people and causes over 400,000 deaths. The worldwide parasite burden remains high, even with the availability of efficacious antimalarial drugs and vector control tools such as insecticides and bed nets. Despite large investments in malaria vaccine development, there is currently no deployable vaccine for malaria. However, individuals who live in malaria endemic regions develop naturally acquired immunity (NAI). Thus, good vaccine candidates may be identified by studying serum antibody responses in malaria patients who live in endemic areas. Protein arrays, which interrogate patient serum antibody binding to many proteins simultaneously, are the primary method of antigen prioritization. However, protein arrays are fabricated by generating unpurified malaria antigens in bacteria and directly spotting lysates onto slides without validation of correct antigen folding or purification. Results from protein arrays can be affected by the sample impurity where positive binding events may be masked by background protein interactions or unrecognizable epitope presentation. Thus, technical improvements are needed to control protein production and protein exposure to patient sera. More recently, multiplexing bead-based assays have been applied to investigate malaria patient immune responses where spectrally distinct bead sets are coated with unique antigens of interest. For such assays, antigens traditionally are individually purified before coupling onto beads. To produce a more high-throughput method of patient immune response dissection using a large panel of antigens, bead-based chemistries were developed to modify multiplexing beads with a small linker molecule or with antigen capturing antibody. These modified beads capture malaria antigens directly from translation lysates, essentially purifying antigens in a single step. Both chemistries utilized the capture of recombinant antigens via a highly specific protein tag, HaloTag or C-tag. Although both systems successfully capture tagged antigens from translation lysates, the C-tag capture system proved to be more reliable and reproducible. Using recombinant malaria antigen merozoite surface protein 1 (MSP1)-coated beads and standard anti-MSP1 detecting antibodies, a 105-fold signal increase was observed in comparison to green fluorescence protein (GFP)-coated beads. Malaria patient sera responses to recombinant MSP1 were also measured. When assessed against MSP1-coated beads, serum from a high immune responsive patient gave an 8.5-fold increase in comparison to GFP-coated beads, while a low immune responsive patient gave a 2-fold increase. These results agree with previously reported protein microarray dissection of the same patient serum samples. The bead chemistries developed here make it possible to interrogate multiple malaria antigens simultaneously without demanding timely antigen purification. Furthermore, the multiplexing assay present antigen epitopes in a more accessible configuration while utilizing small amount of precious patient sera. The platform developed here will provide a high-throughput method of identifying specific patient antibody-antigen binding events and has the potential to customize bead arrays to model populations with high antigenic variation.

Download or read book Analysis of the Human Immune Response Against the Merozoite Surface Protein MSP 1 from Plasmodium Falciparum a Malaria Vaccine Candidate written by Anja Jäschke and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.

Download or read book Proteolytic Processing of the Merozoite Surface Protein 1 from Plasmodium Falciparum Implications on Its Structure and Function During Invasion written by Nadine Hertrich and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Malaria Immunology written by Peter Perlmann and published by Karger Medical and Scientific Publishers. This book was released on 2002-01-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.