Download or read book Streptomyces in Nature and Medicine written by D. A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
Download or read book Genetic Manipulation of Streptomyces written by D. A. Hopwood and published by . This book was released on 1985 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Actinobacteria written by Dharumadurai Dhanasekaran and published by BoD – Books on Demand. This book was released on 2016-02-11 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.
Download or read book Actinomycetes written by Evi Stegmann and published by . This book was released on 2020-09-04 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Download or read book Perspectives in Biotechnology and Applied Microbiology written by Daham I. Alani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon an invitation from Arab Bureau of Education for the Gulf States "ABEGS"; an International Conference on Biotechnology and Applied Microbiol ogy was held in Riyadh, Saudi Arabia, 12-15 November 1984. The Conference was sponsored by ABEGS and organized through coopera tion with Saudi Biological Society "SBS". ABEGS was established in 1976 with the aim of coordinating, unifying and developing all aspects of Education, Culture and Science in the Gulf States. In the field of publications, ABEGS is publishing various books, pamphlets and two scientific journals, one in Arabic and the other in English entitled: the Arab Gulf Journal of Scientific Research. This volume contains topics presented by the invited speakers and selected papers from among those submitted by participants. Selection was done on basis of some of the invited talks. Main topics of the conference were grouped into sections representing seven themes of Biotechnology and Applied Microbiology: - production of microbial proteins - utilization of microorganisms for the production of chemicals - microbial treatment and utilization of waste - continuous culture - application of biotechnology in plant science - applied microbiology and environment and - applied microbiology and biotechnology: international cooperation - tween developed and developing countries. Some of the topics in this volume present surveys of recent developments in several important areas of biotechnology and applied microbiology, while the remaining papers carry detailed research contributions.
Download or read book The Search for Bioactive Compounds from Microorganisms written by Satoshi Omura and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.
Download or read book The Actinomycetes written by Selman Abraham Waksman and published by . This book was released on 1959 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
Download or read book Current Developments in Solid state Fermentation written by Ashok Pandey and published by Springer Science & Business Media. This book was released on 2008-09-16 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the period of last two decades, there has been significant resurgence in solid-state fermentation due to the numerous benefits it offers, especially in the engineering and environmental aspects. SSF has shown much promise in the development of several bioprocesses and products. This resurgence gained further momentum during the last 5-6 years with the developments in fundamental and applied aspects. A good deal of information has been generated in published literature and patented information. Several commercial ventures have come up based on SSF in different parts of the world. The contents are organized into four parts: Part 1 deals with the General and Fundamentals aspects of SSF; Part 2 deals with the production of bulk chemicals and products such as enzymes, organic acids, spores and mushrooms in SSF; Part 3 is on the use of SSF for specialty chemicals such as gibberellic acid, antibiotics and other pharmaceutically valuable secondary metabolites, pigments, and aroma compounds; Part 4 deals with the use of SSF miscellaneous application such as SSF for food and feed applications, agro-industrial residues as substrates in SSF and the production of silage and vermicompost.
Download or read book Basic Biology and Applications of Actinobacteria written by Shymaa Enany and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actinobacteria have an extensive bioactive secondary metabolism and produce a huge amount of naturally derived antibiotics, as well as many anticancer, anthelmintic, and antifungal compounds. These bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects.
Download or read book Microbial Biodegradation and Bioremediation written by Surajit Das and published by Elsevier. This book was released on 2014-07-01 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Biodegradation and Bioremediation brings together experts in relevant fields to describe the successful application of microbes and their derivatives for bioremediation of potentially toxic and relatively novel compounds. This single-source reference encompasses all categories of pollutants and their applications in a convenient, comprehensive package. Our natural biodiversity and environment is in danger due to the release of continuously emerging potential pollutants by anthropogenic activities. Though many attempts have been made to eradicate and remediate these noxious elements, every day thousands of xenobiotics of relatively new entities emerge, thus worsening the situation. Primitive microorganisms are highly adaptable to toxic environments, and can reduce the load of toxic elements by their successful transformation and remediation. - Describes many novel approaches of microbial bioremediation including genetic engineering, metagenomics, microbial fuel cell technology, biosurfactants and biofilm-based bioremediation - Introduces relatively new hazardous elements and their bioremediation practices including oil spills, military waste water, greenhouse gases, polythene wastes, and more - Provides the most advanced techniques in the field of bioremediation, including insilico approach, microbes as pollution indicators, use of bioreactors, techniques of pollution monitoring, and more
Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Download or read book Natural Product Biosynthesis by Microorganisms and Plants written by D. A. Hopwood and published by Academic Press. This book was released on 2012 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This volume of 'Methods in Enzymology' continues the legacy of this premier serial by containing quality chapters authored by leaders in the field.
Download or read book Insect Symbiosis Volume 3 written by Kostas Bourtzis and published by CRC Press. This book was released on 2008-10-28 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The associations between insects and microorganisms, while pervasive and of paramount ecological importance, have been relatively poorly understood. The third book in this set, Insect Symbiosis, Volume 3, complements the previous volumes in exploring this somewhat uncharted territory. Like its predecessors, Volume 3 illustrates how symbiosis resear
Download or read book Mechanism of Action of Antimicrobial and Antitumor Agents written by J. F. Snell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.
Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Download or read book Actinomycetes in Biotechnology written by Bozzano G Luisa and published by Elsevier. This book was released on 2012-12-02 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The actinomycetes are a group of bacteria well known as producers of antibiotics. With the advent of molecular biology they have become important to biotechnologists in the search for new antibiotics, vitamins, enzyme inhibitors, etc. They also play an important role in the biodegradation of wastes, and their wide (natural) distribution in soil, composts, water and elsewhere in the environment makes them important to the agricultural and waste industries. This research book presents a broad view of the current interest in actinomycetes, ranging from isolation/screening of actinomycetes, discovery of new antibiotics, a substantial contribution on genetic manipulation to actinomycetes in agriculture, forestry, and the threat of actinomycetes as pollutants in the environment.The chapters, which have been written by experts, are intended to provide a balanced view of the opportunities and problems in an expanding field of interest.
