Download or read book Anti Cancer N Heterocyclic Carbene Complexes of Gold III Gold I and Platinum II written by Taotao Zou and published by Springer. This book was released on 2016-02-19 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
Download or read book Anti cancer N heterocyclic Carbene Complexes of Platinum II and Gold III written by 馮善琪 and published by . This book was released on 2017 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anti Cancer N Heterocyclic Carbene Complexes of Gold iii Gold i and Platinum ii written by Taotao Zou and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Anti-cancer N-heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol "switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents" by Taotao, Zou, 邹滔滔, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents" Submitted by ZOU TAOTAO for the degree of Doctor of Philosophy at The University of Hong Kong in Feb 2015 Despite the success of cisplatin in combating various cancers, the problems of resistance and side effects have limited its wide application in cancer treatment. Gold complexes have recently emerged as promising candidates for cancer treatment. Unlike cisplatin, gold complexes do not favor DNA binding, but instead preferentially bind SH/SeH-containing proteins/enzymes in cancer cells, giving hope that these compounds may overcome cisplatin's resistance problems. Since the side effects of cisplatin are, at least partially, caused by instability-associated, off-target binding interactions, the incorporation of N-heterocyclic carbene (NHC) ligands may be a useful strategy to improve the stability of metal-based chemotherapeutics due to the strong donating ability of NHC to form strong M-C(NHC) bonds. Meanwhile, the ease of modification and steric effects of NHC ligands provide favorable lipophilicity, reactivity and binding specificity of metal complexes. Indeed, some Pt(II)-NHC complexes have been reported to specifically target proteins/organelles rather than DNA. 3+ + The reduction of 4-coordinated Au to 2-coordinated Au by thiols has been 3+ demonstrated. Meanwhile, owing to the low energy d 2 2 orbital of Au, most gold(III) x -y complexes are non-emissive in solutions. In Chapter 3, by taking advantage of these unique properties, the synthesis of a class of non-emissive Au(III) complexes containing highly fluorescent N DEGREESN DEGREESN ligands and NHC ligands is described. In these compounds, the NHC ligand prevented further reduction of Au(III) to Au(0) and increased the III + solubility of the Au(III) complexes. The [Au (N DEGREESN DEGREESN)(NHC)] complex was readily reduced by GSH to form [Au (NHC)(GS)], accompanied by the release of the fluorescent H N DEGREESN DEGREESN ligand, therefore acting as a fluorescent "switch-on" probe for thiols. In addition, the anti-cancer activity of Au(I) is owed to its ability to inhibit thiol-enzymes; thus, the Au(III) complexes could also serve as precursors/prodrugs, activated by metal reduction, to deliver anti-cancer active Au(I) species. The major problem of most Au(I) anti-cancer agents is the lack of in vivo anti-tumor activity due to their high thiol-reactivity which leads to many off-target binding interactions with blood thiols. In Chapter 4, the synthesis of a dinuclear gold(I) complex bearing a mixed diphosphine and bis(NHC) ligand is described. This dinuclear Au(I) complex displayed a favorable stability that conveys potent thioredoxin reductase inhibition without being attacked by blood thiols. This complex significantly inhibited tumor growth in two independent mouse models with no observable side effects. The dinuclear Au(I) complex also exhibited anti-angiogenesis activity in a tumor model and inhibited sphere formation of cancer stem cells in vitro. In toxicology studies, neither systemic anaphylaxis in guinea pigs nor localized irritation in rabbits was observed
Download or read book Anti cancer N heterocyclic Carbene Complexes of Gold III Gold I and Platinum II written by 邹滔滔 and published by . This book was released on 2015 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anti cancer Gold Phosphine Palladium N heterocyclic Carbene and Platinum Acetylide Complexes written by 方祉謙 and published by . This book was released on 2015 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal based Anticancer Agents written by Angela Casini and published by Royal Society of Chemistry. This book was released on 2019-04-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.
Download or read book Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells written by Kenneth Kam-Wing Lo and published by Academic Press. This book was released on 2016-12-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells Foscuses on the fundamentals and their potential therapeutic and diagnostic applications Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents
Download or read book N Heterocyclic Carbene Complexes written by Edith Chardon and published by . This book was released on 2011 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the existing anticancer agents, cisplatin or cis-diamminedichloroplatinum(II), represents the most known and commonly used chemotherapeutic drug worldwide highlighting the potential of metals in medicinal chemistry. However, its clinical effectiveness is also accompanied by severe side toxicities and cell-resistance mechanisms. These therapeutic limitations have encouraged the development of substitutes to cisplatin and have led to the discovery of N-heterocyclic carbene (NHC) complexes of several late transition metals as new anticancer agents with similar to higher in vitro activities than cisplatin. In this context, the present project dealt with the synthesis and the study of novel cytotoxic NHC complexes of some transition metals (mainly platinum). Two simple, reproducible and modular synthetic routes were developed for the easy functionalization post-complexation of NHC derivatives using (a) ruthenium-catalyzed alkyne-azide cycloaddition and (b) ligand substitution. In order to improve the efficacy and selectivity of the NHC complexes, we have extended these strategies of functionalization to the attachment of biologically interesting moieties such as targeting agents, hydrosoluble groups and fluorescent dyes. In vitro cytotoxic activities of these newly synthesized complexes were measured against a wide variety of cancerous cells. The majority of the compounds demonstrated higher activities than the benchmark cisplatin and some were selective toward tumoral cells. These promising early-stage results offer new perspectives in cancer therapy while giving alternatives to the biomedical limitations of cisplatin.
Download or read book Gold and its Complexes in Anticancer Chemotherapy written by Mohmmad Younus Wani and published by Springer Nature. This book was released on 2021-02-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.
Download or read book Gold I N heterocyclic Carbene Complexes written by and published by . This book was released on 2012 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metallo Drugs Development and Action of Anticancer Agents written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-02-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Download or read book Synthesis of N heterocyclic Carbene Gold I Complexes written by Luca Boselli and published by . This book was released on 2014 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical applications of gold complexes based on N-heterocyclic carbenes (NHCs) are beginning to unfold. Some cationic gold(I) NHCs complexes show antimitochondrial activities, a very promising action mode in the fight against cancer; due to their positive charge these complexes target preferentially tumor cells, leading to cell death. In this work of thesis, three groups of new NHC-based gold and heterobimetallic complexes involving aliphatic or aromatic amino-functionalized NHCs with interesting potential in biomedical research have been synthesized and characterized. The first group is formed by three luminescent heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-NHC ligands. These compounds have been biologically investigated by in vitro tests for their antitumoral, antileishmanial and antimalarial activities. Finally, imaging studies in cancer cells have been performed exploiting the luminescent properties of the most active compound. The second group of molecules is concerned by cationic gold(I) complexes containing two 1-[2-(diethylamino)ethyl]imidazolydene ligands. First the complexes have been tested for their antiproliferative activity in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells demonstrating a potent action and selectivity for cancer cells. In addition, antileishmanial and antimalarial activities of these compounds have been investigated showing interesting results. The third group is formed by a hetero-dinuclear gold(I)-silver(I) and a trinuclear gold(I)-copper(II) complexes containing phenanthroline-NHC ligands. The compounds are formed by two different organometallic units potentially able to act as multi-targeting anticancer drug.
Download or read book The Synthesis Characterization and Antitumor Properties of Ag I Cu II and Rh III Metal Complexes written by Douglas Allen Medvetz and published by . This book was released on 2008 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: The anticancer drug cisplatin, which has been approved to treat ovarian, testicular, head and neck, certain types of lung, and metastatic breast cancers, has been a major advancement in cancer therapy. However, severe side effects including nausea, ear damage, vomiting, sensation loss in the extremities, and liver and kidney toxicity are usually experienced leading to the discontinuation of therapy. Along with the toxic side effects, resistance to this drug has become a major disadvantage. Due to these factors various other platinum derivatives have been explored leading to the discovery of carboplatin. Though carboplatin is quite active it still carries many of the same limitations as cisplatin, leading to the conclusion that the use of non-platinum metal complexes is essential. To date complexes of silver, rhodium, ruthenium, iron, copper, rhenium, titanium, and gold have shown promising results which may lead to the divergence from platinum based drugs. This dissertation describes the synthesis, characterization, and anticancer properties of a variety of metal complexes. These include Ag(I) metal complexes along with a Cu(II) and a Rh(III) metal complex. Chapter 1 of this dissertation discusses a vast majority of the work that has been previously explored using non-platinum metal complexes as anticancer agents. Chapter 2 is devoted to the anticancer properties of three N-Heterocyclic carbene Ag(I) complexes. These complexes have shown anticancer properties in vitro against ovarian, breast, melanoma, colon carcinoma, and renal carcinoma cell lines with one of the complexes possessing preliminary in vivo anticancer properties against an ovarian cancer xenograft model. Chapter 3 is devoted to the synthesis, characterization, and in vitro anticancer properties of a Cu(II) thiaether complex and a Rh(III) thiaether complex against ovarian, breast, and lung cancer cell lines. Both complexes are active, however, the Cu(II) complex is more efficacious. Chapter 4 describes the synthesis and characterization of a variety of new imidazolium salts, which are the precursors to N-Heterocyclic carbenes, and some of their respective N-Heterocyclic carbene Ag(I) metal complexes that may have future use as anticancer agents.
Download or read book Medicinal Chemistry written by and published by Academic Press. This book was released on 2020-02-10 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers that empowers readers to pursue new developments in each field. Users will find this to be a comprehensive overview of recent findings and trends from the last decade that covers various kinds of inorganic topics, from theoretical oriented supramolecular chemistry, to the quest for accurate calculations of spin states in transition metals. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Inorganic Chemistry series Includes the latest information on medicinal chemistry
Download or read book N Heterocyclic Carbenes in Synthesis written by Steven P. Nolan and published by John Wiley & Sons. This book was released on 2006-10-27 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first handbook to focus solely on the application of N-heterocyclic carbenes in synthesis covers metathesis, organocatalysis, oxidation and asymmetric reactions, along with experimental procedures. Written by leading international experts this is a valuable and practical source for every organic chemist.
Download or read book Anti cancer Organoplatinum II N heterocyclic Carbene Complexes and Anti amyloidogenic Timosaponins written by 溫佩琪 and published by . This book was released on 2018 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Frontiers in Anti Cancer Drug Discovery Volume 1 written by Atta-ur- Rahman and published by Bentham Science Publishers. This book was released on 2011-02-14 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Frontiers in Anti-Cancer Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug di