Download or read book Anodized Titania Processing and Characterization to Improve Cell materials Interactions for Load Bearing Implants written by Kakoli Das and published by . This book was released on 2007 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this study is to investigate in vitro cell-materials interactions using human osteoblast cells on anodized titanium. Titanium is a bioinert material and, therefore, gets encapsulated after implantation into the living body by a fibrous tissue that isolates them from the surrounding tissues. In this work, bioactive nonporous and nanoporous TiO2 layers were grown on commercially pure titanium substrate by anodization process using different electrolyte solutions namely (1) H3PO 4, (2) HF and (3) H2SO4, (4) aqueous solution of citric acid, sodium fluoride and sulfuric acid. The first three electrolytes produced bioactive TiO2 films with a nonporous structure showing three distinctive surface morphologies. Nanoporous morphology was obtained on Ti-surfaces from the fourth electrolyte at 20V for 4h. Cross-sectional view of the nanoporous surface reveals titania nanotubes of length 600 nm. It was found that increasing anodization time initially increased the height of the nanotubes while maintaining the tubular array structure, but beyond 4h, growth of nanotubes decreased with a collapsed array structure. Human osteoblast (HOB) cell attachment and growth behavior were studied using an osteoprecursor cell line (OPC 1) for 3, 7 and 11 days. Colonization of the cells was noticed with distinctive cell-to-cell attachment on HF anodized surfaces. TiO2 layer grown in H2SO4 electrolyte did not show significant cell growth on the surface, and some cell death was also noticed. Good cellular adherence with extracellular matrix extensions in between the cells was noticed for samples anodized with H3PO 4 electrolyte and nanotube surface. Cell proliferation was excellent on anodized nanotube surfaces. An abundant amount of extracellular matrix (ECM) between the neighboring cells was also noticed on nanotube surfaces with filopodia extensions coming out from cells to grasp the nanoporous surface for anchorage. To better understand and compare cell-materials interactions, anodized nanoporous sample surfaces were etched with different patterns. Preferential cell attachment was noticed on nanotube surfaces compared to no cells on etched patterned surface. Cell adhesions and differentiation were more pronounced with vinculin protein and alkaline phosphatase, respectively, on anodized surfaces. MTT assays showed increase in living cell density and higher proliferation on H3PO4, HF and nanotube surfaces. When anodized surfaces were compared for cell materials interaction, it was noticed that each of the surfaces has different surface properties that led to variations in cell-materials interactions. It was clear that rough surface morphology, high surface energy, and low value of the contact angles were important factors for better cell materials interaction. Mineralization study was done in simulated body fluid (SBF) with ion concentration nearly equal to human blood plasma to further understand biomimetic apatite deposition behavior. Similar to cell-materials interaction, variation in mineral deposition behavior was also noticed for films grown with different electrolytes. These results clearly show that nonporous titania in H3PO4, HF electrolytes and nanotubes can significantly increase biocompatibility of Ti implants, which has the potential to reduce the healing time and increase in vivo lifetime for these implants.
Download or read book Processing Microstructure Characterization and Biological Performance of Hierarchical Surface Coatings for Titanium Implants written by Ellen Elizabeth Sauter and published by . This book was released on 2013 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, the lifetime of a typical orthopaedic implant is only 15-20 years, a lifetime that many patients are outliving. Therefore, implants with superior longevity need to be engineered. To improve implant longevity, much research has been focused on creating micro-scale porosity/roughness to enhance osseointegration by mechanical interlocking of bone and implant. These structures have improved osseointegration to the current 15-20 year lifespan. It has also been shown that nano-scale structures enhance osteoblast (bone cell) function. The combination of micro-scale and nano-scale structures into one hierarchical structure may further improve the osseointegrative properties of implants. A hierarchical surface modification consisting of titanium dioxide [(TiO2)] nanotubes produced by anodic oxidation of titanium in an electrolyte containing fluoride ions, [F], on a commercially pure (cp) titanium, micro-scale grid structure produced by laser powder deposition was successfully developed. [TiO2] nanotubes were characterized using field emission scanning electron microscopy (FE-SEM), while laser deposited grid structures were characterized with both FE-SEM and optical microscopy. Mouse preosteoblasts were used to evaluate the in vitro biological effects, including cell morphology and cell viability, on the four experimental groups: unanodized flat, anodized flat, unanodized laser deposition, and anodized laser deposition. All treatment groups showed good cell attachment and spreading; however, it was observed that on the samples with [TiO2] nanotubes there was a much greater density of adhesion proteins. The presence of these proteins provides a surface that cells can more readily attach to which can lead to greater cell proliferation and differentiation. Also, viability of cells on samples with nanotubes was higher than samples without nanotubes. However, viability was highest on the anodized flat surface, suggesting that the micro-scale grid on the surface of laser deposition samples did not positively affect the osteoblasts. Optimization of the micro-scale surface features, along with anodization of the micro-scale structures, could possibly further improve the bone/implant interaction and further study is needed on this topic.
Download or read book Handbook of Nanophysics written by Klaus D. Sattler and published by CRC Press. This book was released on 2010-09-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nanophysics: Functional Nanomaterials illustrates the importance of tailoring nanomaterials to achieve desired functions in applications. Each peer-reviewed chapter contains a broad-based introduction and enhances understanding of the state-of-the-art scientific content through fundamental equations and illustrations, some in color.This
Download or read book Application of Titanium Dioxide written by Magdalena Janus and published by BoD – Books on Demand. This book was released on 2017-07-26 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium dioxide is mainly used as a pigment and photocatalyst. It is possible to find it in food, cosmetics, building materials, electric devices, and others. This book contains chapters about application of titanium dioxide in different branches of economy such as the agriculture, the food industry, the medicine, the cosmetics, the water treatment technologies, and the semiconductors.
Download or read book Titanium Dioxide written by Dongfang Yang and published by BoD – Books on Demand. This book was released on 2018-06-27 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium dioxide is currently being used in many industrial products. It provides unique photocatalytic properties for water splitting and purification, bacterial inactivation, and organics degradation. It has also been widely used as the photoanode for dye-sensitized solar cells and coatings for self-cleaning surfaces, biomedical implants, and nanomedicine. This book covers various aspects of titanium dioxide nanomaterials including their unique one-dimensional, two-dimensional, mesoporous, and hierarchical nanostructures and their synthetic methods such as sol-gel, hydrothermal, anodic oxidation, and electrophoretic deposition, as well as its key applications in environmental and energy sectors. Through these 24 chapters written by experts from the international scientific community, readers will have access to a comprehensive overview of the recent research and development findings on the titanium dioxide nanomaterials.
Download or read book Engineered Nanostructures for Therapeutics and Biomedical Applications written by Ajeet Kumar Kaushik and published by Woodhead Publishing. This book was released on 2022-08-31 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineered Nanostructures for Therapeutics and Biomedical Applications offers a single reference for a diverse biomedical readership to learn about the application of nanotechnology in biomedicine and biomedical engineering, from past developments to current research and future prospects. This book sets out a broad selection of biomedical and therapeutic applications for nanostructures, including bioimaging, nanorobotics, orthopedics, and tissue engineering, offering a useful, multidisciplinary approach. Each chapter discusses challenges faced in each discipline, including limiting factors, biocompatibility, and toxicity, thus enabling the reader to make informed decisions in their research.This book is a comprehensive, broad overview of the role and significance of nanomaterials and their composites that also includes discussions of key aspects in the field of biomedicine. It will be of significant interest to academics and researchers in materials science and engineering, biomedicine and biomedical engineering, chemical engineering, pharmaceutics, bioimaging, and nanorobotics. Provides a broad overview of the many applications of nanomaterials and nanotechnology in biomedicine and engineering Offers a multidisciplinary approach that will appeal to a diverse readership, including those in biomedical engineering, materials science, biomedicine, and pharmaceutics Includes challenges faced and limiting factors for each application, allowing readers to make an informed decision when using nanomaterials in their research
Download or read book TiO2 Nanoparticles written by Aiguo Wu and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique book that summarizes the properties, toxicology, and biomedical applications of TiO2-based nanoparticles Nanotechnology is becoming increasingly important for products used in our daily lives. Nanometer-sized titanium dioxide (TiO2) are widely used in industry for different purposes, such as painting, sunscreen, printing, cosmetics, biomedicine, and so on. This book summarizes the advances of TiO2 based nanobiotechnology and nanomedicine, covering materials properties, toxicological research, and biomedical application, such as antibacter, biosensing, and cancer theranostics. It uniquely integrates the TiO2 applications from physical properties, toxicology to various biomedical applications, and includes black TiO2 based cancer theranostics. Beginning with a comprehensive introduction to the properties and applications of nanoparticles, TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine offers chapters on: Toxicity of TiO2 Nanoparticles; Antibacterial Applications of TiO2 Nanoparticles; Surface Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate); TiO2 as Inorganic Photosensitizer for Photodynamic Therapy; Cancer Theranostics of Black TiO2 Nanoparticles; and Neurodegenerative Disease Diagnostics and Therapy of TiO2-Based Nanoparticles. This title: -Blends the physical properties, toxicology of TiO2 nanoparticles to the many biomedical applications -Includes black TiO2 based cancer theranostics in its coverage -Appeals to a broad audience of researchers in academia and industry working on nanomaterials-based biosensing, drug delivery, nanomedicine TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine is an ideal book for medicinal chemists, analytical chemists, biochemists, materials scientists, toxicologists, and those in the pharmaceutical industry.
Download or read book Titanate and Titania Nanotubes written by Dmitry V. Bavykin and published by Royal Society of Chemistry. This book was released on 2010 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exciting new book is a unique compilation of data from a wide range of chemical and spectroscopic instrumentation and the integration of nanostructure characterisation drawn from physical, chemical, electrochemical, spectroscopic and electron microscopic measurements. It fills a gap in the current nanomaterials literature by documenting the latest research from scientific journals and patent literature to provide a concise yet balanced and integrated treatment of an interesting topic: titanium oxide nanostructures within the emerging fashionable area of nanomaterials. Of particular interest are the following key chapters: * Modification and Coating Techniques - provides a unique summary and discussion of available techniques to coat surfaces with nanostructured materials * Chemical Properties - relates structure to surface chemistry and hence applications * Structural and Physical Properties - reviews the relationship between nanostructure and physical properties providing a basis for the rationalisation of applications The book, a valuable reference point, is aimed at professionals, postgraduates and industrial research workers in nanomaterials. Readers will gain a knowledge of the methods for synthesising nanomaterials as well as an understanding of their structure and resulting physical characteristics and a knowledge of their (existing and potential) applications.
Download or read book Cell Growth Processes written by Daiki Kimura and published by Nova Publishers. This book was released on 2008 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basis for cell proliferation entails the control of key signalling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This book presents research in the field.
Download or read book Bioceramic Coatings for Medical Implants written by Robert B. Heimann and published by John Wiley & Sons. This book was released on 2015-05-26 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the progress in recent years, this book provides in-depth information on the preparation, chemistry, and engineering of bioceramic coatings for medical implants. It is authored by two renowned experts with over 30 years of experience in industry and academia, who know the potentials and pitfalls of the techniques concerned. Following an introduction to the principles of biocompatibility, they present the structures and properties of various bioceramics from alumina to zirconia. The main part of the work focuses on coating technologies, such as chemical vapor deposition, sol-gel deposition and thermal spraying. There then follows a discussion of the major interactions of bioceramics with bone or tissue cells, complemented by an overview of the in-vitro testing methods of the biomineralization properties of bioceramics. The text is rounded off by chapters on the functionalization of bioceramic coatings and a look at future trends. As a result, the authors bring together all aspects of the latest techniques for designing, depositing, testing, and implementing improved and novel bioceramic coating compositions, providing a full yet concise overview for beginners and professionals.
Download or read book Plasma Electrolytic Oxidation PEO Coatings written by Marta Mohedano and published by MDPI. This book was released on 2021-06-02 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma electrolytic oxidation (PEO), also known as micro-arc oxidation (MAO), functionalizes surfaces, improving the mechanical, thermal, and corrosion performance of metallic substrates, along with other tailored properties (e.g., biocompatibility, catalysis, antibacterial response, self-lubrication, etc.). The extensive field of applications of this technique ranges from structural components, in particular, in the transport sector, to more advanced fields, such as bioengineering. The present Special Issue covers the latest advances in PEO‐coated light alloys for structural (Al, Mg) and biomedical applications (Ti, Mg), with 10 research papers and 1 review from leading research groups around the world.
Download or read book Mechanotransduction written by and published by Academic Press. This book was released on 2014-07-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds
Download or read book Titanium in Medical and Dental Applications written by Francis Froes and published by Woodhead Publishing. This book was released on 2018-05-09 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium in Medical and Dental Applications is an essential reference book for those involved in biomedical materials and advanced metals. Written by well-known experts in the field, it covers a broad array of titanium uses, including implants, instruments, devices, the manufacturing processes used to create them, their properties, corrosion resistance and various fabrication approaches. Biomedical titanium materials are a critically important part of biomaterials, especially in cases where non-metallic biomedical materials are not suited to applications, such as the case of load-bearing implants. The book also covers the use of titanium for implants in the medical and dental fields and reviews the use of titanium for medical instruments and devices. Provides an understanding of the essential and broad applications of Titanium in both the medical and dental industries Discusses the pathways to manufacturing titanium into critical biomedical and dental devices Includes insights into further applications within the industry
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2676 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomaterials in Translational Medicine written by Lei Yang and published by Academic Press. This book was released on 2018-11-30 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
Download or read book Characterization of Biomaterials written by Susmita Bose and published by Elsevier Inc. Chapters. This book was released on 2013-03-12 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief introductory chapter provides a broad overview of materials, biomaterials and the need to understand different techniques to characterize biomaterials. From this chapter, the reader can gain a perspective on how the rest of the topics in different chapters are divided to fully comprehend this inherently multidisciplinary field. Application of appropriate characterization tools can not only save time to fully evaluate different biomaterials, it can also make commercial biomedical devices safer. In the long run, safer biomedical devices can only reduce the pain and suffering of mankind, a dream that resonates with every biomedical researcher.
Download or read book Nanoscience and Nanotechnology for Human Health written by Bert Müller and published by John Wiley & Sons. This book was released on 2017-04-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.
