Download or read book Animal Models of Ophthalmic Diseases written by Chi-Chao Chan and published by Springer. This book was released on 2015-12-01 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience and the text is supported by numerous photos and diagrams. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents and medical students.
Download or read book Animal Models in Eye Research written by and published by Academic Press. This book was released on 2011-04-28 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. - Presents information on the major animal models used in eye research including invertebrates and vertebrates - Provides researchers with information needed to choose between model organisms - Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery
Download or read book Animal Models for Retinal Diseases written by Iok-Hou Pang and published by Humana. This book was released on 2016-08-23 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. In Animal Models for Retinal Diseases, recognized experts in the field highlight valuable techniques as well as animal models for the prominent retinal diseases in order to aid in the evaluation, development, and improvement of therapeutic strategies. Beginning with an overview of the morphology of the retina, visual behavior, and genetics and genomics approaches for retinal research, the book continues by covering animal models for the research of specific human retinal diseases, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal inflammation. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used approaches in the field. Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study.
Download or read book Animal Models of Ocular Diseases written by Khalid F. Tabbara and published by Charles C. Thomas Publisher. This book was released on 1984 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Myopia Animal Models To Clinical Trials written by Donald Tiang Hwee Tan and published by World Scientific. This book was released on 2010-04-23 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myopia is the most common optical disorder in the world, and is on the rise in many countries, particularly in East Asia. The impact of myopia is evident as the driving force in the development of refractive surgery and of the spectacle and contact lens industries. While myopia is often seen as a childhood disease that involves complex genetic-environmental factors, it is also a major cause of adult blindness. In Singapore (where myopia has reached one of the highest rates in the world) as well as in Taiwan, Japan and Hong Kong, affected patients have greater severity of myopia, leading to additional secondary complications such as glaucoma.This book provides a comprehensive coverage of all aspects of myopia. It is aimed at ophthalmologists, optometrists, opticians, scientists and pharmaceutical companies. The topics are uniquely treated in that they cover research at the laboratory bench as well as clinical applications and population-based approaches in epidemiology.
Download or read book Sourcebook of Models for Biomedical Research written by P. Michael Conn and published by Springer Science & Business Media. This book was released on 2008 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.
Download or read book Animal Models in Vision Research written by Bahram Bodaghi and published by S. Karger AG (Switzerland). This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multidisciplinary and translational approach Doubtless, inflammatory processes are involved in the pathogenesis of various ocular diseases. Autoimmunity, inflammation and infection may initiate a large spectrum of pathologic processes or contribute to their progression. In light of the recent introduction of novel therapeutic interventions in ophthalmic disorders, it is necessary to revisit experimental models of ocular inflammation and discuss the relevance of each of them to human diseases. This publication presents the contributions made during the workshop on animal models of ocular inflammation held by the International Ocular Inflammation Society in Paris in 2007. The presence of expert immunologists, molecular biologists, geneticists and physicians, dealing with specific aspects of diseases, was a major step towards a multidisciplinary and translational approach. This special issue provides validated animal models addressing pathogenesis which are the starting point of developing novel therapies based on immune mechanisms learned from these models. Ophthalmologists, immunologists, pathologists and pharmacologists interested in drug delivery for intraocular disorders will find it valuable reading.
Download or read book OCT and Imaging in Central Nervous System Diseases written by and published by . This book was released on 2020 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson's disease, Alzheimer's disease, intracranial hypertension, Friedreich's ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the "window to the brain".
Download or read book Retinal Degenerative Diseases written by Matthew M. LaVail and published by Springer Science & Business Media. This book was released on 2011-12-21 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
Download or read book Animal Models for the Study of Human Disease written by Caroline J. Zeiss and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt: Age-related macular degeneration (AMD) is a degenerative condition that begins in Bruch’s membrane and progresses to involve the retinal pigment epithelium and ultimately, overlying photoreceptors. The only required etiologic factor is age, and AMD is regarded as the leading cause of blindness in individuals over 65 years. AMD results from variable contributions of age, environment, and genetic predisposition. Many loci are linked to AMD—in the vast majority of cases, the disease is associated with polymorphisms within these genes, rather than mutations that ablate gene function. The etiologic complexity of AMD is reflected by the paucity of animal models that entirely replicate the human disease. In this review, we compare the salient anatomy of the primate and rodent retina, particularly in the light of AMD pathology. Next, prevailing hypotheses explaining how AMD may develop are discussed. These include the role of complement activation and macrophage chemotaxis in AMD, molecular mechanisms of choroidal neovascularization, and the roles of oxidative damage and lipid metabolism. An overview of spontaneous and induced non-human primate models is given, and relevant mouse models are described in the context of each pathogenetic mechanism.
Download or read book New Mouse Models of Inherited Eye Diseases and Evaluation of Vision Testing Methods written by Caroline Thaung and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinal Degenerations written by Joyce Tombran-Tink and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new and noteworthy research into retinal diseases. It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.
Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 2021-05-17 with total page 1890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.
Download or read book Ocular Allergy written by Leonard Bielory and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics include: Introduction- Immunopathophysiology and Classification of Ocular Allergy", "OcularMast CDermatologicdisorders of the Eyelidsells and Mediators","SeasonalAllergic Conjunctivitis&Perennial Allergic Conjunctivitis","VernalKeratoconjunctivitis","GiantPapillary Conjunctivitis","Dermatologicdisorders of the Eyelids","ContactDermatitis of the Eyelids","AutoimmuneDisorders of the Anterior Surface","PediatricConcerns of Ocular Inflammation","ContactLens","OcularAllergy Treatment","Adverse(Allergic) Effects of GlaucomaMedications"
Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.
Download or read book New Mouse Models of Inherited Eye Disease and Evaluation of Vision Testing Methods written by Caroline May Thaung and published by . This book was released on 2001 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Myopia and the Control of Eye Growth written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myopia, the most common disorder of the eye, affects 80% of the population of some countries. Although its basis remains uncertain, recent development of animal models have permitted tests of hypothesis as to myopia's origins. The symposium proceedings cover normal growth of the eye including the roles of peptide factors, metabolism and accomodation, investigation of the deficiencies that lead to myopia and other refractive disorders.
