Download or read book Anatomical Basis and Physiological Role of Cerebrospinal Fluid Transport Through the Murine Cribriform Plate written by Jordan Norwood and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebrospinal fluid (CSF) flows through the brain, transporting chemical signals and removing waste. CSF production in the brain is balanced by a constant outflow of CSF, the anatomical basis of which is poorly understood. Here, I developed a novel histological method to characterize the anatomy of the CSF outflow pathway along the olfactory sensory nerves through the cribriform plate, and into the nasal epithelia. The physiological function of this clearance pathway was studied utilizing dye injections, intracranial pressure (ICP) measurements, ablation of the olfactory nerves, and intranasal administration of soot compounds. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate. The reduction in CSF outflow did not cause an increase in ICP, consistent with an alteration in the pattern of CSF drainage or production. Intranasal administration of an oxidized soot compound significantly reduced the number of olfactory sensory neuron progenitor cells in the neuroepithelium. My results suggest that damage to olfactory sensory neurons (such as from air pollution) could contribute to altered CSF turnover and flow, providing a potential mechanism for neurological diseases.
Download or read book Pediatric Hydrocephalus written by G. Cinalli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last ten years the pediatric neurosurgeon has witnessed a real revolution in the diagnosis and treatment of pediatric hydrocephalus, the most frequently encountered condition in everyday clinical practice. The evolution of MRI and the advent of neuroendoscopic surgery have resuscitated the interest in the classification, etiology and pathophysiology of hydrocephalus. The book offers an updated overview on the recent progress in this field, and a new approach to hydrocephalus: the reader will find in it a modern and new presentation of an old disease, where genetics, endoscopy, cost-effectiveness analyses and many other aspects of the various therapies are extensively discussed. The volume will be useful not only for neurosurgeons, but for all specialists interested in the various aspects of hydrocephalus: pediatricians, radiologists, endocrinologists, pathologists and geneticists.
Download or read book The Neurology of AIDS written by Howard E. Gendelman, MD and published by Oxford University Press. This book was released on 2011-11-29 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Download or read book Adult Hydrocephalus written by Daniele Rigamonti and published by Cambridge University Press. This book was released on 2014-02-06 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides guidelines for managing this grossly underdiagnosed and undertreated condition, focusing on early detection and timely, effective interventions.
Download or read book Synopsis of Pathophysiology in Nuclear Medicine written by Abdelhamid H. Elgazzar and published by Springer Nature. This book was released on 2023-06-27 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in its second edition, will serve as a quick reference that will help the reader to understand different diagnostic scintigraphic patterns and to select appropriate treatment modalities based on functional imaging. The book concisely describes relevant anatomic and physiologic considerations for each organ system and the pathophysiologic features of different relevant diseases and relates them to the scintigraphy of each system. It thereby provides an informative synopsis of the pathophysiologic basis of nuclear medicine and molecular imaging. The volume is divided into 13 chapters that feature basic pathophysiology, cell biology and biologic effects of ionizing radiation, radiopharmaceutical uptake and relevant anatomic and physiologic considerations for each organ system and the pathophysiologic features of different relevant diseases. The objective of this volume is to provide a brief, easy to-use but nonetheless comprehensive companion guide to “The Pathophysiology Basis of Nuclear Medicine” that will prove useful to undergraduates and postgraduates as well as to practitioners in clinical and research fields.
Download or read book Physiology and Pharmacology of the Blood Brain Barrier written by Michael W.B. Bradbury and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain barrier? What are the known therapeutic and toxic agents? How are they transported across cerebral microvessels? The discussion of these and other questions with far-reaching consequences for all neuroscientists can be found in this volume. This authoritative and up-to-date review of the blood-brain barrier gives a proper understanding of the topic. The experimental principles, the results of very recent research, as well as the implications that experimental research has for clinical treatment are thoroughly covered. Information is given on: - new findings based on classical physiological and pharmacological techniques, - results obtained from brain capillaries in vitro and in culture, - results obtained from the new scanning techniques (PET and MRI), - the immunology of the blood-brain barrier, - trace metal transport, - the pathological breakdown of the barrier and - the modification of drugs to increase their entry into the brain. Here is a source of information that is invaluable to specialists concerned with basic research in the neurosciences, with the design of neuropharmacological agents, with the radiological diagnosis of cerebral pathology or with the treatment of cerebral lesions!
Download or read book Cardiovascular Mathematics written by Luca Formaggia and published by Springer Science & Business Media. This book was released on 2010-06-27 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.
Download or read book Cerebrospinal fluid dynamics and intracranial pressure elevation novel insights on molecular and physiological mechanisms and implications for neurological disease written by Adjanie Patabendige and published by Frontiers Media SA. This book was released on 2023-02-02 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Delivery to the Brain written by Elizabeth C.M. de Lange and published by Springer Nature. This book was released on 2022-05-24 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.
Download or read book Neuro AIDS written by Alireza Minagar and published by Nova Publishers. This book was released on 2006 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past two decades, the world scientific community has witnessed major achievements in our understanding of the pathogenesis of HIV infection of the nervous system and HIV-Associated Dementia (HAD). Despite these giant gains, nervous system involvement during AIDS remains a relentlessly progressive disease with a deadly fate in many cases. This book on NeuroAIDS provides a unique resource for both general neurologists as well as basic neuroscientists with profound interests for research on NeuroAIDS. This book has special emphasis on the mechanisms of disease development and progression of HIV-infected patients with NeuroAIDS. The contributors have provided the readers with comprehensive reviews on clinical manifestations of HAD, mechanisms of HIV entry into the central nervous system, the role of cytokines and chemokines in pathogenesis of NeuroAIDS, drug abuse and NeuroAIDS, virus load in HAD, allostasis in HIV and AIDS, stroke in AIDS patients, and neuroimaging of HIV infection of the central nervous system. In addition, there are chapters on Varicella Zoster virus infection of HIV-seropositive and AIDS patients, as well as the molecular basis for opioids and AIDS virus interactions.
Download or read book Sensory Processing in Vision and Olfaction Common Features of Key Players written by Thor Eysteinsson and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diseases of the Sinuses written by Christopher C. Chang and published by Springer. This book was released on 2014-06-06 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
Download or read book Textbook of Pediatric Neurosurgery written by Concezio Di Rocco and published by Springer. This book was released on 2020-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.
Download or read book Paniker s Textbook of Medical Parasitology written by C. K. Jayaram Paniker and published by JP Medical Ltd. This book was released on 2017-09-14 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this textbook is a complete guide to parasitology for undergraduate medical students. Divided into 23 chapters, each topic has been thoroughly updated and expanded to cover the most recent advances and latest knowledge in the field. The book begins with an overview of parasitology, then discusses numerous different types of parasite, concluding with a chapter on diagnosis methods. Many chapters have been rewritten and the eighth edition of the book features many new tables, flow charts and photographs. Each chapter concludes with a ‘key points’ box to assist with revision. Key points Eighth edition providing undergraduates with a complete guide to parasitology Fully revised text with many new topics, tables and photographs Each chapter concludes with ‘key points’ box to assist revision Previous edition (9789350905340) published in 2013
Download or read book Clinical Neuroanatomy written by Hans J. ten Donkelaar and published by Springer Nature. This book was released on 2020-06-18 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain. The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.
Download or read book Peritoneal Tumors and Metastases written by Beate Rau and published by Springer Nature. This book was released on 2021-05-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides surgeons and oncologists with a well-founded and detailed overview of the available treatment options for peritoneal malignancy and differential selection of the appropriate forms of therapy. Systemic chemotherapy options are also considered, as are surgical cytoreduction (CRS) and all forms of intraperitoneal chemotherapy (IPC) especially hyperthermic IPC (HIPEC), and immunotherapy, including specific procedures such as PIPAC. Subsequent chapters address perioperative care, complications and recurrences, as well as psycho-oncological, palliative medical and nursing care. The process of parietal and visceral peritonectomy in the large and small intestine is additionally illustrated by three video clips accessible online. Covering a broad range of aspects, including peritoneal metastasis and intraperitoneal chemotherapy, the book offers a valuable tool for surgeons, oncologists and anesthesiologists alike.
Download or read book Equine Pharmacology written by Cynthia Cole and published by John Wiley & Sons. This book was released on 2014-11-17 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Equine Pharmacology combines highly practical therapeutic guidance with reliable scientific background information to provide a clinically relevant resource. Taking a body systems approach to the subject, the book offers the equine clinician fast access to drug options for a given disease, with additional information available for reference as needed. Logically organized to lead the reader through the clinical decision-making process, Equine Pharmacology is a user-friendly reference for pharmacological information on the horse. The book begins with a general review section presenting the principles of antimicrobials, anesthesia, analgesics, anti-parasitics, foals, fluid therapy, and drug and medication control programs. The remainder of the book is devoted to a body systems approach to therapeutics, allowing the reader to search by affected system or specific disease to find detailed advice on drug therapy. Equine Pharmacology is an invaluable addition to the practice library for any clinician treating equine patients.
