Download or read book Analysis of Accessory Genes of Feline Immunodeficiency Virus FIV written by Barbara Lynn Shacklett and published by . This book was released on 1994 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pathogenic Determinants of Feline Immunodeficiency Virus Accessory Gene Orf A written by Benjamin Wang and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Feline immunodeficiency virus (FIV) is a member of the lentivirus subfamily of retroviruses and naturally infects domestic cats resulting in an immunodeficiency similar to that induced by human immunodeficiency virus (HIV) in humans. Previous research examining an accessory protein (Orf-A) encoded by FIV revealed a critical importance for this viral protein in virus replication under natural infection. Additional studies characterizing specific functions of Orf-A established that this viral protein shares similar functional characteristics as previously described for HIV-1 Vpr. To explain the disparity between the number of regulatory and accessory proteins encoded by FIV in comparison to HIV-1, we investigated Orf-A as a functional analog to HIV-1 accessory proteins Vpr as well as other HIV-1 accessory proteins. Previous studies identified a putative nuclear localization signal (NLS) and demonstrated Orf-A as a nuclear protein. To further assess the importance of residues within the putative NLS, amino acid substitutions were introduced as point mutations within the Orf-A NLS to examine their impact on nuclear localization. Results from these studies confirmed that basic residues within the putative NLS are necessary for nuclear localization. Examination of a FIV Orf-A NLS mutant provirus revealed that nuclear localization is critical function for efficient productive virus replication. Additional studies were conducted to further examine the role of Orf-A in the induction of arrest at gap 2 (G2) phase of the cell cycle and a possible role in apoptosis. Orf-A deletion mutant analysis revealed that amino residues 1-54 are critical for induction of G2 cell cycle arrest and induction of apoptosis comparable in magnitude to wild type (WT) Orf-A. Preliminary studies assessing a potential mechanism for Orf-A induction of apoptosis revealed a possible co-localization of Orf-A with the mitochondria compartment of host cells suggesting that further examination of this phenomenon is warranted. Additional assays of a feline lymphoid cell line experimentally infected with FIV revealed that FIV infection as well as transient Orf-A expression was capable of inducing G2 arrest. Furthermore, down-regulation of FIV primary receptor CD134 was also demonstrated for experimental FIV infection. Lastly, down-regulation of CD134, a recently described function of Orf-A, was confirmed by transient expression of Orf-A in a feline lymphoid cell line and shown to require the N-terminus of Orf-A of Orf-A. Mapping of Orf-A determinants for previously described Orf-A functions and discovery of new functions supports Orf-A as a multi-faceted accessory protein encoding functions described for HIV-1 accessory proteins including Vpr, Vpu, and Nef.

Download or read book Preparation of an Infectious Molecular Clone and Analysis of the Vif Gene of a Feline Immunodeficiency Virus FIV Oma written by Fan Long and published by . This book was released on 1997 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of Orf A of Feline Immunodeficiency Virus written by Maria Lourdes Charmaine Gemeniano and published by . This book was released on 2002 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Viruses and Human Disease written by Ellen G. Strauss and published by Elsevier. This book was released on 2007-09-21 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text

Download or read book Immunopathogenesis of HIV Infection written by Anthony S. Fauci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.

Download or read book Feline Lentiviruses Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Feline Lentiviruses—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Feline Lentiviruses in a concise format. The editors have built Feline Lentiviruses—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Feline Lentiviruses in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Feline Lentiviruses—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Lentivirus Gene Engineering Protocols written by Maurizio Federico and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell gene engineering is emerging as a field with outstanding impact, not only in medicine/biology, but also, and perhaps most importantly, in agriculture and in all those food sciences involved in the fight against world hunger. Lentivirus vector-based technologies represent the last frontier in the development of powerful and reliable methods for both in vitro and in vivo gene transfer in eukaryotic animal cells. Although the design of lentivirus vectors is closely reminiscent of those already successfully applied to the construction of oncoretroviral vectors, some unique features, e.g., the ef- ciency in transducing both postmitotic and stem cells, render the use of lentivirus vectors invaluable. It has been a great pleasure to edit Lentivirus Gene Engineering Pro- cols, owing in part to the high level of enthusiasm that the authors dem- strated in contributing to this book. The fact that so many outstanding scientists engaged in lentivirus vector research have provided articles renders it so- thing more than a technical handbook. In addition to detailed descriptions of the most innovative methodologies, the reader may find very informative ov- views concerning both theoretical and practical aspects of the origin and the development of diverse lentivirus vector types. This, in my opinion, rep- sents a unique added value of this volume, which should help our work resist the passage of time, to which books such as this are particularly sensitive.

Download or read book Animal Models of HIV and Other Retroviral Infections written by Paul Racz and published by S. Karger AG (Switzerland). This book was released on 1993 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aquaculture Virology written by Frederick S.B. Kibenge and published by Elsevier. This book was released on 2024-07-16 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture Virology, Second Edition covers all the known virus families, and specific diseases that affect each aquatic organism. Descriptions of each disease includes disease name, structure and composition of virus, classification and virus replication, epidemiology, pathology and immunity, diagnostic methods (gross pathology, histopathology, cell culture, PCR, sequencing, ELISA, etc.) and prevention and control. This is an excellent reference of updated foundational and practical knowledge from experts in both academia and research.Those interested in fish viral diseases will find the book an excellent source for high quality illustrations of viral structure, diagrams of pathogenesis of diseases, and many images of gross pathology and histopathology lesions, using the same format in all chapters to facilitate the reading and studying. This second edition of the book will cover all virus families and the specific diseases relevant to aquaculture with current information delivered in a systematic and succinct way to the researcher, teacher, student, diagnostic laboratory staff, clinical veterinarian, aquaculture disease practitioner, farmer, and all people that are interested in viruses in general. Provides unique, comprehensive information on animal pathogens and viruses found in aquaculture and fisheries Presents high-quality illustrations of viral structure, diagrams of viral disease processes, gross pathology, and histopathology lesions to aid in understanding Incorporates all updated changes in taxonomy since the first edition Includes a new chapter on the impact of climate change on the manifestations of different aquatic animal viral diseases Describes aquatic viruses of the major aquatic animals, fish, crustaceans, and mollusks

Download or read book Emerging and Re emerging Infectious Diseases of Livestock written by Jagadeesh Bayry and published by Springer. This book was released on 2017-02-07 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive knowledge on diseases in livestock that are caused by viruses, parasites and bacteria. Emerging and re-emerging pathogens are presented in detail for various animal groups and in-depth insights into pathogenesis and epidemiology will be provided for each of them. In addition, state-of-the-art treatment possibilities, control measures as well as vaccination strategies are discussed. The recent years have witnessed a sharp increase in the number of emerging and re-emerging infectious diseases of livestock and many of these, including Influenza, Corona and Hanta are of public health importance. The reasons for this development are manifold:changes in the climate, life cycle of vectors and increased global travel. Also, due to extensive deforestation, livestock are increasingly coming in direct contact with wild animals that are reservoirs of many emerging pathogens. Recent progress in diagnosis and management of emerging infectious diseases are also topic of this book.

Download or read book Infectious Diseases of the Dog and Cat E Book written by Jane E. Sykes and published by Elsevier Health Sciences. This book was released on 2013-09-27 with total page 1376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive reference for the diagnosis, treatment, and prevention of small animal infections, Infectious Diseases of the Dog and Cat, 4th Edition delivers current, comprehensive information essential to the management of infectious diseases caused by viruses, rickettsiae, chlamydiae, mycoplasmas, bacteria, fungi, algae, protozoa, and unknown agents. Each section guides you through diagnostic testing for specific microorganisms, from sample collection to laboratory submission to interpretation of results, then details appropriate treatment measures and pharmacologic considerations for the various related infections. Full-color illustrations and hundreds of tables provide quick, convenient access to diagnostic and therapeutic guidelines, and thoroughly updated drug information helps you confidently administer appropriate dosages for the most effective treatment and prevention. The most comprehensive infectious disease coverage available helps you confidently address clinical problems related to infectious diseases in dogs and cats, and includes: Immunization strategies and environmental control of infections Immunodeficiency disorders Prevention of infection in multi-pet and shelter settings Immunocompromised people and their pets Vibrant full-color illustrations clarify disease features and modes of disease transmission for enhanced diagnostic accuracy and disease prevention. Convenient tables deliver therapeutic recommendations and drug dosages at a glance. Complete antimicrobial drug formulary provides fast, easy access to indications, recommended dosages, and pharmacologic considerations essential for all relevant pharmaceuticals. State-of-the-art diagnostic testing procedures help you ensure accurate diagnoses for all clinically relevant pathogens. Content reflects the expert insight and vast clinical experience of a panel of trusted authorities on small animal infectious diseases. Easy-to-use companion website provides convenient online access to additional images, tables, boxes, appendices, and references linked directly to original PubMed abstracts. Expanded coverage of zoonoses, zoonotic potential, and precautions helps you effectively monitor and treat zoonotic infections. Fully updated drug formulary reflects the most current pharmacokinetics, indications, contraindications, handling and administration guidelines, and dosage recommendations available. Updated content throughout the text details current diagnostic testing regimens and therapeutic and preventive considerations for all pathogens you're likely to encounter in the clinical setting. Special focus on disease incidence and susceptibility in traveling animals helps you alert animal owners to potential risks associated with pet travel.

Download or read book Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents written by National Research Council and published by National Academies Press. This book was released on 2006-09-07 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies-including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)-be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.

Download or read book AIDS Bibliography written by and published by . This book was released on 1994-11 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Models of Protection Against HIV SIV written by Gianfranco Pancino and published by Academic Press. This book was released on 2011-12-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Download or read book In Vivo Models of HIV Disease and Control written by Herman Friedman and published by Springer Science & Business Media. This book was released on 2006 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

Download or read book Gene Vaccines written by Josef Thalhamer and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.