Download or read book Structure and Functions of Amine Oxidases written by Mondovi and published by CRC Press. This book was released on 2018-01-10 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: A good portion of this book has been devoted to the copper-dependent enzymes, these being the more numerous. The chapter dealing with serum amine oxidases also focuses attention on their catalytic mechanism, as these enzymes have been studied in greater depth.As the presentation of topics whose experimental basis is rapidly developing is likely to stimulate the reader‘s interest, many bibliographic references have been included.Readers could find this book poor, as far as many topics are dealt with in a relatively little space, but we believe it essential to trace the background of our present knowledge in the field of amine oxidases, stressing the future outlook of research on these enzymes, for they are becoming more and more important in general and medical biochemistry.
Download or read book Amine Oxidases and Methods for Their Study written by R. Kapeller-Adler and published by . This book was released on 1970 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Amine Oxidases in Clinical Research written by V. Z. Gorkin and published by Elsevier. This book was released on 2013-10-22 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amine Oxidases in Clinical Research discusses the functions of amine oxidases in the rapid development of medical and biological research. Composed of 13 chapters, the book focuses on amine oxidases, including their key role in the metabolism of biogenic amines and other nitrogenous compounds in diseases and human health. The book considers primarily the enzymes denoted as EC 1.4.3.4 (flavin amine oxidases or monoamine oxidases) and EC 1.4.3.6 (copper-containing amine oxidase or diamine oxidases). To measure the estimates of amine oxidase activity, several methods and a number of requirements are presented. A description of the distribution and intracellular localization of amine oxidase follows. The methods of isolation and purification of amine oxides from different sources and the results of these various methods are explained. The text also considers the properties of the purified amine oxidases: the different methods of isolation and purification; storage conditions; and analytical techniques. Care is given when examining amine oxidases, because these may exhibit considerable differences in substrate specificity even if their physicochemical properties are similar. Inhibition of amine oxidase activity by unspecific and specific inhibitions is further discussed, including the biological functions and known effects of hormones on the biosynthesis and catabolism of the amine oxidase. Finally, the possible pathogenetic and/or diagnostic significance of the amine oxidases, as well as the corrective approaches seen in pathological conditions and in clinical medicine, are explained. Written as a handbook for the medically oriented investigators, biologists, and medical and chemical researchers, this book will prove a handy reference.
Download or read book Copper Amine Oxidases written by Giovanni Floris and published by CRC Press. This book was released on 2009-06-01 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual co
Download or read book Amine Oxidases Function and Dysfunction written by K.F. Tipton and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoamine oxidase plays a major role in the pathogenesis of neuropsychiatric disorders including depressive illness, Parkinson ́s disease and Alzheimer ́s disease. The new generation of selective monoamine oxidase inhibitors, devoid of major side effects, has found a prominent place in the treatment of these diseases. Some of these drugs may have neuroprotective activity with prospects for treating progressive neurodegenerative diseases. The volume presents a collection of research papers on monoamine oxidase and its inhibitors. The topic is treated from the point of view of chemistry, biochemistry, pharmacology, physiology, neurology and psychiatry. The book serves as a quick and comprehensive reference source for obtaining the most up to date information.
Download or read book Monoamine Oxidase Enzymes written by Lars Oreland and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume are the invited lectures at the Second Workshop on Amine Oxidases held at the Biomedical Center, Uppsala University, 2 to 4 August 1986. It was a great pleasure for the organizers to see, in Uppsala, so many old and new friends, all brought together by our common interest in the fascinating field of Amine Oxidases. The Workshop was the successor of a long row of successful predecessors to start with the 1972 meeting in Cagliari, Sardinia, and recently preceded by the first meeting of Workshop design, held in Cambridge 1984. Several of the previous meetings have been dedicated to distinguished senior research workers within the field. To start this Workshop a memorial lecture was given. This lecture, given by Prof. T. P. Singer, was dedicated to the late Prof. K. Kamijo, who was one of the pioneers of what is now worldwide interest in Amine Oxidases and who organized the superb meeting in Hakone 1981. To the great honour of all the participants the family of the late Prof. Kamijo visited the Workshop. Abstracts of all the presentations have been published as a Supplement of Acta Pharmacologica et Toxicologica (Copenhagen).
Download or read book Amine Oxidases and Their Impact on Neurobiology written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Amine Oxidase Workshop was the brain child of Brian Callingham and Keith Tipton. The present book is the proceedings of the fourth in the series and in the past we have dedicated our meeting to individuals who have made significant fundamental contributions to the biochemistry, physiology and pharmacology of this interesting group of enzymes. The present meeting is not an exception because we have gathered here in Wtirzburg to honour an individual whose outstanding work on the autonomic pharmacology has span ned more than 30 years and whose contribution has made a vast impact in our understanding of the kinetic relationship between amine metabolism (that uptake and enzymatic inactivation) and adrenergic neurotransmission. We speak of course of Professor Ullrich Trendelenburg, or Ulli as he likes to be known. Like the amine oxidases, he has a unique place in Pharmacology. Professor Trendelenburg was born on the eve of the new year of 1922 in the city of Rostock in northern Germany, where his father was Professor of Pharmacology at the Faculty of Medicine of Rostock. His father accepted the offer to take over the corresponding chair in Freiburg im Breisgrau (in Southern Germany). As the youngest of four children, Ulli grew up mainly in the garden of the department, in the animal quarters and in the workshop. Of the various coworkers of his father, one he liked especially was Otto Krayer, the young pharmacologist.
Download or read book Structure and Functions of Amine Oxidases written by Mondovi and published by CRC Press. This book was released on 2017-12-08 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: A good portion of this book has been devoted to the copper-dependent enzymes, these being the more numerous. The chapter dealing with serum amine oxidases also focuses attention on their catalytic mechanism, as these enzymes have been studied in greater depth.As the presentation of topics whose experimental basis is rapidly developing is likely to stimulate the reader�s interest, many bibliographic references have been included.Readers could find this book poor, as far as many topics are dealt with in a relatively little space, but we believe it essential to trace the background of our present knowledge in the field of amine oxidases, stressing the future outlook of research on these enzymes, for they are becoming more and more important in general and medical biochemistry.
Download or read book Flavin Dependent Enzymes Mechanisms Structures and Applications written by and published by Academic Press. This book was released on 2020-09-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes, Volume 47, highlights new advances in the field, with this new volume presenting interesting chapters on The Multipurpose Family of Oxidases, Vanillyl alcohol oxidase, Choline oxidases, Aryl alcohol oxidase, D- and L-amino acid oxidases, Sugar oxidases, Phenolic Compounds hydroxylases, Baeyer-Villiger Monooxygenases, Flavin-dependent halogenases, Flavin-dependent dehalogenases, Styrene Monooxygenases, Bacterial luciferases, Cellobiose Dehydrogenases, Prenylated flavoenzymes, Ene-reductases, Flavoenzymes in Biocatalysis. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Download or read book MAO The Mother of all Amine Oxidases written by John P.M. Finberg and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinson’s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors.
Download or read book Monoamine Oxidase Enzymes written by Lars Oreland and published by Springer Verlag. This book was released on 1987 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanistic Characterization of Amine Oxidases from Hansenula Polymorpha by X ray Crystallographic Structural Studies written by Bryan Jonas Johnson and published by . This book was released on 2007 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Production of Novel Amine Oxidases from Microorganisms written by Ioannis Voulgaris and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of molecular biology and genetic transformation the production of high value proteins in recombinant host cells has become an everyday reality. However, the establishment of the optimum conditions for every target protein requires to take into account the nature of the product, and needs experimentation. In this study the over-expression of an industrially important monoamine oxidase was attempted using different expression systems, both homologous and heterologous, and the optimum conditions for the industrial production were established. Amine oxidases exhibit stereoselectivity, and, therefore, can potentially be used for the deracemisation of non-optically pure mixtures of amines leading to optically pure amines of high value in the fine chemical and pharmaceutical areas. Initially, different strains of A.niger were evaluated regarding their ability to produce the industrially important monoamine oxidase (MAO-N), while later optimisation of the culture conditions took place. These were achieved by the use of the appropriate nitrogen source, incorporation of an amine oxidase inhibitor to reduce inducer's breakdown and consequently boost amine oxidase expression, and the induction of the culture at the appropriate time. Over-expression of the genetically modified MAO-5N in E.coli was studied under different experimental set ups with the aim of improving both the activity of the produced enzyme leading to relatively low-cost scalable processes. Towards this aim, substitution of the expensive inducer IPTG with the less expensive lactose took place, while changes in the feed profile were implemented. Moreover, the examination of the combined effects of induction biomass levels and oxygen availability, through the use of air and oxygen enriched air, in the culture led to significant increase of the enzyme activity and gave important insights about the sensitivity of this enzyme under highly oxidative conditions. Undoubtedly, E.coli remains the main workhorse for the production of recombinant proteins, nevertheless, the use of methylotrophic yeasts is gaining significant ground and for that reason a P.pastoris system intracellularly expressing the MAO-5N was investigated. Appropriate monitoring and control of the bioprocess along with optimisation of the carbon flux led to significantly higher volumetric MAO activities and better biotransformation capacity of the whole cells than the previously used E.coli systems.The aforementioned improvements result in more efficient processes, where both the overall productivity is increased with a simultaneous reduction of the cost which ultimately leads to production of cheaper valuable compounds. Moreover, the present study extends our knowledge on the nature and physiology of monoamine oxidase production by microbial organisms and suggest a solution which can be implemented for the industrial manufacture of other oxidase type enzymes.
Download or read book Monoamine Oxidase written by Claudia Binda and published by Springer Nature. This book was released on 2022-09-28 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function of MAOs, either in cell lines or in animal models, as well as computational methods applied to rational drug design approaches that are used to develop new MAO inhibitors. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoamine Oxidase: Methods and Protocols serves as a vital resource for scientists who are interested in studying MAOs and other similar amine oxidase enzymes.
Download or read book Behavior and Intracellular Localization of Amine Oxidases in Various Sources written by Elaine Ruth Berman and published by . This book was released on 1955 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Functions of Amine Oxidases written by Mondovi and published by CRC Press. This book was released on 2018-01-10 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: A good portion of this book has been devoted to the copper-dependent enzymes, these being the more numerous. The chapter dealing with serum amine oxidases also focuses attention on their catalytic mechanism, as these enzymes have been studied in greater depth.As the presentation of topics whose experimental basis is rapidly developing is likely to stimulate the reader‘s interest, many bibliographic references have been included.Readers could find this book poor, as far as many topics are dealt with in a relatively little space, but we believe it essential to trace the background of our present knowledge in the field of amine oxidases, stressing the future outlook of research on these enzymes, for they are becoming more and more important in general and medical biochemistry.
Download or read book Amine Oxidases in Dental Pulp written by Astrid Norqvist-Sjöberg and published by . This book was released on 1988 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
