Download or read book Altered Intraerythrocytic Development Phenotypes Of Artemisinin Resistant Plasmodium Falciparum Confer A Fitness Advantage written by Amanda Hott and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to artemisinin combination therapies (ACTs) has emerged in southeast Asia threatening the most widely used treatment against antimalarial-resistant Plasmodium falciparum worldwide. Artemisinin resistance has been associated with a reduced rate of parasite clearance following treatment with an ACT and is attributed to increased survival of ring-stage parasites. Single nucleotide polymorphisms (SNPs) in kelch gene (K13) has been associated with delayed in vivo clearance half-life of artemisinin-resistant P. falciparum and is the only known molecular marker of resistance. The absence of reliable in vitro phenotypes for artemisinin resistance has limited our understanding of the resistance mechanism(s) and fitness costs, therefore we have culture adapted and cloned patient isolates from Thailand and Cambodia that had clinical resistant phenotypes. Stable reduced susceptibility to artemisinin derivatives and mefloquine was observed using a modified [3H]hypoxanthine drug susceptibility assay. In addition we devised an in vitro phenotype assay of artemisinin resistance, known as the delayed clearance assay (DCA), that was positively correlated with the in vivo delayed clearance and presence of K13 SNPs of artemisinin resistance. Remarkably we discovered for the first time altered patterns of intraerythrocytic development in artemisinin-resistant P. falciparum. In the absence of drug pressure most artemisinin-resistant clones have a prolonged ring phenotype with temporally compressed trophozoite stage, yet with the normal overall asexual life cycle period. Parasites remain in ring-stage up to 14 hours longer than wild-type, whereas time spent in trophozoite-stage is dramatically reduced. One parasite, PL08-09 (5C), exhibited an accelerated 36-hour life cycle in the absence of drug pressure and progressed through asexual development in equal time spent at each intraerythrocytic stage.
Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Download or read book Handbook of Antimicrobial Resistance written by Matthias Gotte and published by Springer. This book was released on 2018-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
Download or read book Resistance of Malaria Parasites to Drugs written by World Health Organization. Scientific Group on Resistance of Malaria Parasites to Drugs and published by . This book was released on 1965 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards Malaria Elimination written by Sylvie Manguin and published by BoD – Books on Demand. This book was released on 2018-07-18 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.
Download or read book The Thalassaemia Syndromes written by David J. Weatherall and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.
Download or read book Global Report on Antimalarial Drug Efficacy and Drug Resistance written by and published by . This book was released on 2010 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides a comprehensive, global overview of antimalarial drug efficacy and the resistance of malaria parasites to the antimalarial medicines used between 2000 and June 2010. Policy-makers in national ministries of health will benefit from this document, as it provides both a global and a regional picture of the efficacy of the antimalarial medicines currently used in national treatment programmes. In addition, the report will be a reference for scientists, enhancing their understanding of the complexity of antimalarial drug resistance.
Download or read book Parasitic Protozoa of Farm Animals and Pets written by Monica Florin-Christensen and published by Springer. This book was released on 2018-04-17 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth yet concise overview of the most common and emerging protozoa that cause diseases in both farm animals and companion animals. As outlined in the concise introduction, pathogenic protozoans represent an evolutionary highly diverse and little understood group of disease-causing microorganisms. For each of the featured parasitic unicellular eukaryotes, it discusses the morphology, lifecycle, epidemiology and host-pathogen interactions. In addition, the book highlights the latest developments in diagnostic methods, as well as prevention and treatment strategies. Thorough information on genomes and genetic manipulation strategies for some of the protozoa covered in this book is also included. Infections involving parasitic protozoa can cause productivity losses and/or reduce the quality of life of infected animals. Some infections are zoonotic, posing an on-going public health threat. In most cases, prevention and treatment are either non-existent or need considerable improvement. On the other hand, a great deal of research has recently been conducted on these organisms, yielding valuable new information on their global distribution and revealing the mechanisms of host-pathogen interactions at the molecular level – and essential insights that can be used for the development of new control tools. This book includes extensive information on both basic aspects and recent scientific discoveries on these protozoa and thus constitutes a unique resource for students, veterinarians, and researchers alike.
Download or read book World Malaria Report 2008 written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Curious kids will delight in the joy of scientific discovery through the fifty fun activities in The Budding Scientist! This book is filled with great ways for you and your child to learn about how our world works. Create memories together as you make invisible ink, explore ice crystals, and investigate magnets. Perfect for children ages three to six, this fun-filled introduction to science features easy-to-follow instructions and easy-to-find materials that will help you satisfy your child’s natural curiosity.
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2009-08-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the definitive reference on disorders of hemoglobin.
Download or read book Evolution Of Life Histories written by Derek Roff and published by Springer Science & Business Media. This book was released on 1993-04-30 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many different types of organisms in the world: they differ in size, physiology, appearance, and life history. The challenge for evolutionary biology is to explain how such diversity arises. The Evolution of Life Histories does this by showing that natural selection is the principal underlying force molding life history variation. The book describes in particular the ways in which variation can be analyzed and predicted. It covers both the genetic and optimization approaches to life history analysis and gives an overview of the general framework of life history theory and the mathematical tools by which predictions can be made and tested. Factors affecting the age schedule of birth and death and the costs of reproduction are discussed. The Evolution of Life Histories concentrates on those theoretical developments that have been tested experimentally. It will interest both students and professionals in evolution, evolutionary ecology, mathematical and theoretical biology, and zoology and entomology.
Download or read book Drug Resistance in Bacteria Fungi Malaria and Cancer written by Gunjan Arora and published by Springer. This book was released on 2017-03-21 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.
Download or read book World Malaria Report 2010 written by and published by . This book was released on 2011-04-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report summarizes information received from 106 malaria-endemic countries and from malaria control partners. It highlights continued progress made towards meeting international targets for malaria control to be achieved by 2010 and by 2015. International funds disbursed for malaria control increased from $200 million in 2004 to $1.5 billion in 2009. Since 2008, more than 289 million insecticide-treated mosquito nets have been delivered to sub-Saharan Africa, enough to protect three quarters of the 765 million persons at risk of the disease. Over the last decade, 11 countries in the Africa Region and 32 countries in other regions showed reductions of 50% or greater in either confirmed malaria cases or malaria admissions and deaths. Malaria control is making a major contribution to reducing mortality in children less than 5 years old and to attaining the health-related Millennium Development Goals.
Download or read book Biology Controls and Models of Tree Volatile Organic Compound Emissions written by Ülo Niinemets and published by Springer Science & Business Media. This book was released on 2013-07-08 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant-driven volatile organic compound (BVOC) emissions play a major role in atmospheric chemistry, including ozone and photochemical smog formation in the troposphere, and they extend the atmospheric lifetime of the key greenhouse gas, methane. Furthermore, condensation of photo-oxidation products of BVOCs leads to formation of secondary organic aerosols with profound implications for the earth's solar radiation budget and climate. Trees represent the plant life form that most contributes to BVOC emissions, which gives global forests a unique role in regulating atmospheric chemistry. Written by leading experts in the field, the focus is on recent advancements in understanding the controls on plant-driven BVOC emissions, including efforts to quantitatively predict emissions using computer models, particularly on elicitation of emissions under biotic and abiotic stresses, molecular mechanisms of volatile synthesis and emission and the role of emissions in plant stress tolerance.
Download or read book World Malaria Report 2019 written by World Health Organization and published by . This book was released on 2019-08-28 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2019 provides a comprehensive update on global and regional malaria data and trends. The report tracks investments in malaria programs and research as well as progress across all intervention areas: prevention, diagnosis, treatment, elimination, and surveillance. It also includes dedicated chapters on the consequences of malaria on maternal infant and child health the "High Burden to High Impact" approach as well as biological threats to the fight against malaria. The 2019 report is based on information received from more than 80 countries and areas with ongoing malaria transmission. This information is supplemented by data from national household surveys and databases held by other organizations.
Download or read book Malaria Parasites and Other Haemosporidia written by Percy Cyril Claude Garnham and published by . This book was released on 1966 with total page 1234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parasites and Parasitic Diseases written by Gilberto Antonio Bastidas Pacheco and published by BoD – Books on Demand. This book was released on 2019-04-24 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitic diseases are considered nowadays as an important public health problem due to the high morbidity and mortality rates registered in the world. These diseases result in more severe consequences for the social order of tropical and subtropical countries because many of them have low economic income that makes it even more difficult to design and implement health control programs. This situation opens the door to the emergence and reemergence of these diseases; therefore, it is convenient, necessary, and essential to study and update the epidemiological behavior of tropical diseases with the objective of offering official health professionals and institutions current information for decision-making in this area to ensure social welfare.
