Download or read book Protein Misfolding Aggregation and Conformational Diseases written by Vladimir N. Uversky and published by Springer Science & Business Media. This book was released on 2007-11-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
Download or read book Aggregation Functions written by Michel Grabisch and published by Cambridge University Press. This book was released on 2009-07-09 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rigorous and self-contained exposition of aggregation functions and their properties.
Download or read book Judgment Aggregation written by Davide Grossi and published by Morgan & Claypool Publishers. This book was released on 2014-03-01 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Judgment aggregation is a mathematical theory of collective decision-making. It concerns the methods whereby individual opinions about logically interconnected issues of interest can, or cannot, be aggregated into one collective stance. Aggregation problems have traditionally been of interest for disciplines like economics and the political sciences, as well as philosophy, where judgment aggregation itself originates from, but have recently captured the attention of disciplines like computer science, artificial intelligence and multi-agent systems. Judgment aggregation has emerged in the last decade as a unifying paradigm for the formalization and understanding of aggregation problems. Still, no comprehensive presentation of the theory is available to date. This Synthesis Lecture aims at filling this gap presenting the key motivations, results, abstractions and techniques underpinning it.
Download or read book Microbial Aggregation written by Calleja and published by CRC Press. This book was released on 2018-05-04 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers in detail bacteria and yeasts, including an overall perspective of microbial aggregation as fundamental form and function, which is presented here to include systems still to be treated in detail.
Download or read book Red Blood Cell Aggregation written by Oguz Baskurt and published by CRC Press. This book was released on 2011-09-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
Download or read book Aggregation Functions in Theory and in Practise written by Humberto Bustince Sola and published by Springer Science & Business Media. This book was released on 2013-06-20 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects the extended abstracts of 45 contributions of participants to the Seventh International Summer School on Aggregation Operators (AGOP 2013), held at Pamplona in July, 16-20, 2013. These contributions cover a very broad range, from the purely theoretical ones to those with a more applied focus. Moreover, the summaries of the plenary talks and tutorials given at the same workshop are included. Together they provide a good overview of recent trends in research in aggregation functions which can be of interest to both researchers in Physics or Mathematics working on the theoretical basis of aggregation functions, and to engineers who require them for applications.
Download or read book Biophysics And Biochemistry Of Protein Aggregation Experimental And Theoretical Studies On Folding Misfolding And Self assembly Of Amyloidogenic Peptides written by Yuan Jian-min and published by World Scientific. This book was released on 2017-06-02 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.
Download or read book Folding and Aggregation Studies in the Acylphosphatase like Family written by Francesco Bemporad and published by Firenze University Press. This book was released on 2009 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases.
Download or read book Aggregation Operators for Various Extensions of Fuzzy Set and Its Applications in Transportation Problems written by Akansha Mishra and published by Springer Nature. This book was released on 2020-08-19 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the fundamentals of transportation problems under the fuzzy environment and its extensions. It also discusses the limitations and drawbacks of (1) recently proposed aggregation operators under the fuzzy environment and its various extensions; (2) recently proposed methods for solving transportation problems under the fuzzy environment; and (3) recently proposed methods for solving transportation problems under the intuitionistic fuzzy environment. In turn, the book proposes simplified methods to overcome these limitations.
Download or read book Power Aggregation Operators of Simpli ed Neutrosophic Sets and Their Use in Multi attribute Group Decision Making written by Chunfang Liu and published by Infinite Study. This book was released on with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The simplified neutrosophic set (SNS) is a useful generalization of the fuzzy set that is designed for some practical situations in which each element has different truth membership function, indeterminacy membership function and falsity membership function.
Download or read book Collected Works of W M Gorman Separability and aggregation written by William Moore Gorman and published by Oxford University Press. This book was released on 1995 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together for the first time the important work of W.M. (Terence) Gorman, a major figure in the development of economics during the past 40 years. His publications on separability, aggregation, duality and demand are recongized as fundamental contributions to economic theory.
Download or read book Handbook of Aggregation Induced Emission Volume 2 written by Youhong Tang and published by John Wiley & Sons. This book was released on 2022-03-28 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the ultimate reference on the science and applications of aggregation-induced emission The Handbook of Aggregation-Induced Emission explores foundational and advanced topics in aggregation-induced emission, as well as cutting-edge developments in the field, celebrating twenty years of progress and achievement in this important and interdisciplinary field. The three volumes combine to offer readers a comprehensive and insightful interpretation accessible to both new and experienced researchers working on aggregation-induced emission. In Volume 2: Typical AIEgens Design, the editors address the design and synthesis of typical AIEgens that have made significant contributions to aggregation-induced emission research. Recent advances in the development of aggregation-induced emission systems are discussed and the book covers novel aggregation-induced emission systems in small molecule organogels, polymersomes, metal-organic coordination complexes and metal nanoclusters. Readers will also discover: A thorough introduction to the synthesis and applications of tetraphenylpyrazine-based AIEgens, AIEgens based on 9,10-distyrylanthracene , and the Salicylaldehyde Schiff base Practical discussions of aggregation-induced emission from the sixth main group and fluorescence detection of dynamic aggregation processes using AIEgens Coverage of cyclic triimidazole derivatives and the synthesis of multi-phenyl-substituted pyrrole based materials and their applications Perfect for academic researchers working on aggregation-induced emission, this set of volumes is also ideal for professionals and students in the fields of photophysics, photochemistry, materials science, optoelectronic materials, synthetic organic chemistry, macromolecular chemistry, polymer science, and biological sciences.
Download or read book Analysis of Aggregates and Particles in Protein Pharmaceuticals written by Hanns-Christian Mahler and published by John Wiley & Sons. This book was released on 2012-01-24 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Download or read book Aggregation Operators written by Tomasa Calvo and published by Physica. This book was released on 2012-12-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. The increasing number of research papers appeared in the last years that either make use of aggregation functions or contribute to its theoretieal study asses its growing importance in the field of Fuzzy Logie and in others where uncertainty and imprecision play a relevant role. Since these papers are pub lished in many journals, few books and several proceedings of conferences, books on aggregation are partieularly welcome. To my knowledge, "Agrega tion Operators. New Trends and Applications" is the first book aiming at generality , and I take it as a honour to write this Foreword in response to the gentle demand of its editors, Radko Mesiar, Tomasa Calvo and Gaspar Mayor. My pleasure also derives from the fact that twenty years aga I was one of the first Spaniards interested in the study of aggregation functions, and this book includes work by several Spanish authors. The book contains nice and relevant original papers, authored by some of the most outstanding researchers in the field, and since it can serve, as the editors point out in the Preface, as a small handbook on aggregation, the book is very useful for those entering the subject for the first time. The book also contains apart dealing with potential areas of application, so it can be helpful in gaining insight on the future developments.
Download or read book Suspensions of Colloidal Particles and Aggregates written by Frank Babick and published by Springer. This book was released on 2016-04-04 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the properties of particles in colloidal suspensions. It has a focus on particle aggregates and the dependency of their physical behaviour on morphological parameters. For this purpose, relevant theories and methodological tools are reviewed and applied to selected examples. The book is divided into four main chapters. The first of them introduces important measurement techniques for the determination of particle size and interfacial properties in colloidal suspensions. A further chapter is devoted to the physico-chemical properties of colloidal particles—highlighting the interfacial phenomena and the corresponding interactions between particles. The book’s central chapter examines the structure-property relations of colloidal aggregates. This comprises concepts to quantify size and structure of aggregates, models and numerical tools for calculating the (light) scattering and hydrodynamic properties of aggregates, and a discussion on van-der-Waals and double layer interactions between aggregates. It is illustrated how such knowledge may significantly enhance the characterisation of colloidal suspensions. The final part of the book refers to the information, ideas and concepts already presented in order to address technical aspects of the preparation of colloidal suspensions—in particular the performance of relevant dispersion techniques and the stability of colloidal suspensions.
Download or read book Reef Fish Spawning Aggregations Biology Research and Management written by Yvonne Sadovy de Mitcheson and published by Springer Science & Business Media. This book was released on 2011-12-10 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reef fish spawning aggregations, ranging from small groups to many tens of thousands of individuals, are spectacular but poorly known natural phenomena whereby fish assemble at specific times and locations to spawn. For some species these large groups may be the only form of reproduction, the high fish numbers briefly giving a false impression of stability and abundance—an ‘illusion of plenty’. They are often a focus for intensive seasonal fishing because of their predictability and because many important commercial fishes form them. Highly vulnerable to overexploitation, many aggregations and their associated fisheries, have disappeared or are in decline. Few are effectively managed or incorporated into protected areas. Aggregations are not well understood by fishery scientists, managers and conservationists and their significance little appreciated by fishers or the wider public. To ensure their persistence to replenish important fisheries in coral ecosystems, maintain their ecosystem function and continue to delight divers, a significant change in perspective is needed to foster protection and management. This book provides comprehensive and practical coverage of the biology, study and management of reef fish aggregations, exploring their how, when, where, and why. It explores ways to better protect, study, manage and conserve them, while identifying key data gaps and questions. The text is extensively illustrated with many unique, never before published, photographs and graphics. Case studies on over 20 interesting and important fishes are included, outlining their biology and fisheries and highlighting major concerns and challenges.
Download or read book Aggregation Functions A Guide for Practitioners written by Gleb Beliakov and published by Springer. This book was released on 2007-09-09 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: A broad introduction to the topic of aggregation functions is to be found in this book. It also provides a concise account of the properties and the main classes of such functions. Some state-of-the-art techniques are presented, along with many graphical illustrations and new interpolatory aggregation functions. Particular attention is paid to identification and construction of aggregation functions from application specific requirements and empirical data.
