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Book Agave negatively regulates YAP and TAZ transcriptionally and post translationally in osteosarcoma cell lines

Download or read book Agave negatively regulates YAP and TAZ transcriptionally and post translationally in osteosarcoma cell lines written by Maria Ferraiuolo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Previously published works indicate that Agave exhibits anticancer properties. In the present study, anticancer effects of Agave leaf extract were investigated in the OS cells, discovering that Agave inhibits cell growth and cell migration, and sensitizes OS cells to cisplatin (CDDP), to overcome chemoresistance. Agave’s mechanisms of action include an initial process in which Agave induces YAP/TAZ oncogenic protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription through NF-κB p65:p50 heterodimers deregulation. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS Directed Therapies

Download or read book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS Directed Therapies written by Ludovica Monti and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

Book Multi drug resistant Klebsiella pneumoniae strains circulating in hospital setting

Download or read book Multi drug resistant Klebsiella pneumoniae strains circulating in hospital setting written by Eleonora Cella and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings. In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Book Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades

Download or read book Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades written by Danilo Quartullo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LIU program at CERN is of paramount importance at international level. The program foresees a significant upgrade of the LHC injector chain to increase the luminosity of the LHC beam by a factor of ten after 2024, when the HL-LHC era will start. This thesis deals with longitudinal beam dynamics studies for two LHC injectors (PSB and SPS), the main goal being the analysis of beam instabilities in the HL-LHC scenario.

Book Towards Recognizing New Semantic Concepts in New Visual Domains

Download or read book Towards Recognizing New Semantic Concepts in New Visual Domains written by Massimiliano Mancini and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being the leading paradigm in computer vision, deep neural networks are inherently limited by the visual and semantic information contained in their training set. In this thesis, we aim to design deep models operating with previously unseen visual domains and semantic concepts. We first describe different solutions for generalizing to new visual domains, applying variants of normalization layers to multiple challenging settings e.g. where new domain data is not available but arrives online or is described by metadata. In the second part, we incorporate new semantic concepts into pretrained deep models. We propose specific solutions for different problems such as multi-task/incremental learning and open-world recognition. Finally, we merge the two challenges: given images of multiple domains and categories, can we recognize unseen concepts in unseen domains? We propose an approach that is the first, promising step, towards solving this problem. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Book Trauma Narratives in Italian and Transnational Women   s Writing

Download or read book Trauma Narratives in Italian and Transnational Women s Writing written by Tiziana de Rogatis and published by Sapienza Università Editrice. This book was released on 2022-12-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is the first to propose new readings of Italian and transnational female-authored texts through the lens of Trauma Studies. Illuminating a space that has so far been left in the shadows, Trauma Narratives in Italian and Transnational Women’s Writing provides new insights into how the trope of trauma shapes the narrative, temporal and linguistic dimension of these works. The various contributions delineate a landscape of female-authored Italian and transnational trauma narratives and their complex textual negotiation of suffering and pathos, from the twentieth century to the present day. These zones of trauma engender a new aesthetics and a new reading of history and cultural memory as an articulation of female creativity and resistance against a dominant cultural and social order.

Book NASH and Systemic Complications

Download or read book NASH and Systemic Complications written by Ronit Shiri-Sverdlov and published by Mdpi AG. This book was released on 2022-01-28 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). NASH is a chronic inflammatory condition of the liver that can further progress to fibrosis and cirrhosis, which may eventually lead to liver failure and death. While we have increased our mechanistic knowledge regarding the pathogenesis of NASH within the last decade, treatment options are still limited and liver biopsies have remained the gold standard for diagnosis. To achieve major clinical breakthroughs for NASH patients, it is not sufficient to use a single animal model, since each model has specific limitations. Furthermore, we should rely more on alternative models such as organ-on-a-chip, which will enable us to explore unknown aspects of disease pathogenesis much faster and serve as clinically relevant surrogates for murine models. Another important direction for the improvement of patient health is to pay more attention to extrahepatic, organ-specific and systemic effects, which are associated with NASH. The articles in this Special Issue include an up-to-date overview of the rapidly developing technologies, novel targets for intervention and insights in the field in NASH. Additionally, these articles describe the major challenges in the field, strategies to overcome them and suggestions for future directions. To improve patient's outcome, clinicians, as well as scientists with biomedical, nutrition, physics and mathematics backgrounds, should join forces. Although challenges remain, the future of the field seems promising as these novel technologies and developments are expected to lead to progress in NASH.

Book Structural and Functional Analysis of Extracts in Plants

Download or read book Structural and Functional Analysis of Extracts in Plants written by Stefania Lamponi and published by . This book was released on 2021 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural and Functional Analysis of Extracts in Plants collects 1 editorial, 3 reviews, and 26 research articles reporting recent research findings which cover several aspects of plant-derived bioactive compounds, to correlate extraction techniques with the chemical composition of extracts and their bioactivity for identifying molecules that might be used as active substances in a wide variety of areas.This book is a valuable resource for members of the scientific community wishing to further explore plants and the therapeutic applications of their bioactive compounds. It will appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Book Atlas of Musculoskeletal Tumors and Tumorlike Lesions

Download or read book Atlas of Musculoskeletal Tumors and Tumorlike Lesions written by Piero Picci and published by Springer Science & Business Media. This book was released on 2014-01-18 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reflects the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment of musculoskeletal tumor and tumorlike lesions. It presents a wide range of lesions from a multidisciplinary perspective, highlighting pertinent clinical, radiological, and histological correlations. Treatment is briefly reported for each entity. In addition, the more recent biomolecular findings of use for diagnosis, prognosis, and treatment are carefully analyzed. The Rizzoli case archive spans more than a century, the first treated case dating back to 28 September 1900, and contains the original material – clinical charts, imaging, paraffin blocks, and histological slides – of more than 40,000 cases, including about 29,000 bone lesions and 11,000 soft tissue lesions. This book reports the most relevant entities and reflects the improvements in knowledge of musculoskeletal tumors as presented during the yearly international course held at the Rizzoli Institute.​

Book Antifascisms

    Book Details:
  • Author : David Ward
  • Publisher : Fairleigh Dickinson Univ Press
  • Release : 1996
  • ISBN : 9780838636763
  • Pages : 260 pages

Download or read book Antifascisms written by David Ward and published by Fairleigh Dickinson Univ Press. This book was released on 1996 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an in-depth analysis of three of the most crucial years in twentieth-century Italian history, the years 1943-46. After more than two decades of a Fascist regime and a disastrous war experience during which Italy changed sides, these years saw the laying of the political and cultural foundations for what has since become known as Italy's First Republic. Drawing on texts from the literature, film, journalism, and political debate of the period, Antifascisms offers a thorough survey of the personalities and positions that informed the decisions taken in this crucial phase of modern Italian history.

Book Tile   Till

    Book Details:
  • Author :
  • Publisher :
  • Release : 1915
  • ISBN :
  • Pages : 536 pages

Download or read book Tile Till written by and published by . This book was released on 1915 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Type   Typo

    Book Details:
  • Author :
  • Publisher : Omair Nazir
  • Release :
  • ISBN :
  • Pages : 18 pages

Download or read book Type Typo written by and published by Omair Nazir. This book was released on with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Squamous cell Carcinoma

    Book Details:
  • Author : Saman Warnakulasuriya
  • Publisher : Springer
  • Release : 2018-07-25
  • ISBN : 9789402414851
  • Pages : 0 pages

Download or read book Squamous cell Carcinoma written by Saman Warnakulasuriya and published by Springer. This book was released on 2018-07-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

Book Alphaherpesviruses

    Book Details:
  • Author : Sandra Knowles Weller
  • Publisher : Caister Academic Press Limited
  • Release : 2011
  • ISBN : 9781904455769
  • Pages : 0 pages

Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

Book Yvain

    Book Details:
  • Author : Chretien de Troyes
  • Publisher : Yale University Press
  • Release : 1987-09-10
  • ISBN : 0300038380
  • Pages : 244 pages

Download or read book Yvain written by Chretien de Troyes and published by Yale University Press. This book was released on 1987-09-10 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A twelfth-century poem by the creator of the Arthurian romance describes the courageous exploits and triumphs of a brave lord who tries to win back his deserted wife's love

Book Bibliophily

    Book Details:
  • Author : University of London. Department of Extra-Mural Studies
  • Publisher : Cambridge [Cambridgeshire] ; Alexandria, VA : Chadwyck-Healey
  • Release : 1986
  • ISBN :
  • Pages : 192 pages

Download or read book Bibliophily written by University of London. Department of Extra-Mural Studies and published by Cambridge [Cambridgeshire] ; Alexandria, VA : Chadwyck-Healey. This book was released on 1986 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book MicroRNA in Solid Tumor and Hematological Diseases

Download or read book MicroRNA in Solid Tumor and Hematological Diseases written by Francesca Lovat and published by . This book was released on 2022 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs), which are a type of short non-coding RNA, are involved in number of processes, such as differentiation, development, inflammation, immune response, and cancer. miRNAs, which act as oncogenes or tumor suppressor genes, can control and regulate the translation and stability of target messenger RNA, contributing to cancer pathogenesis. Despite the progress that has been made in discovering the mechanisms of how miRNAs function in tumors, many questions and aspects of miRNA biology and processing still remain to be determined. This Special Issue, titled “MicroRNA in Solid Tumor and Hematological Diseases”, provides a panorama of the existing knowledge gaps and potential uses of microRNAs to predict clinical outcome or response to therapies and provides evidence to explain their role as biomarkers to modulate the biological pathways that are critical for cancer development and progression. It includes eleven peer-reviewed papers that cover the role of microRNAs in different tumor types and their potential applications in diagnosis and clinical approaches.