Download or read book Agave negatively regulates YAP and TAZ transcriptionally and post translationally in osteosarcoma cell lines written by Maria Ferraiuolo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Previously published works indicate that Agave exhibits anticancer properties. In the present study, anticancer effects of Agave leaf extract were investigated in the OS cells, discovering that Agave inhibits cell growth and cell migration, and sensitizes OS cells to cisplatin (CDDP), to overcome chemoresistance. Agave’s mechanisms of action include an initial process in which Agave induces YAP/TAZ oncogenic protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription through NF-κB p65:p50 heterodimers deregulation. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.
Download or read book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS Directed Therapies written by Ludovica Monti and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.
Download or read book Multi drug resistant Klebsiella pneumoniae strains circulating in hospital setting written by Eleonora Cella and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings. In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.
Download or read book Simulations of RF Beam Manipulations Including Intensity Effects for CERN PSB and SPS Upgrades written by Danilo Quartullo and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LIU program at CERN is of paramount importance at international level. The program foresees a significant upgrade of the LHC injector chain to increase the luminosity of the LHC beam by a factor of ten after 2024, when the HL-LHC era will start. This thesis deals with longitudinal beam dynamics studies for two LHC injectors (PSB and SPS), the main goal being the analysis of beam instabilities in the HL-LHC scenario.
Download or read book Towards Recognizing New Semantic Concepts in New Visual Domains written by Massimiliano Mancini and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being the leading paradigm in computer vision, deep neural networks are inherently limited by the visual and semantic information contained in their training set. In this thesis, we aim to design deep models operating with previously unseen visual domains and semantic concepts. We first describe different solutions for generalizing to new visual domains, applying variants of normalization layers to multiple challenging settings e.g. where new domain data is not available but arrives online or is described by metadata. In the second part, we incorporate new semantic concepts into pretrained deep models. We propose specific solutions for different problems such as multi-task/incremental learning and open-world recognition. Finally, we merge the two challenges: given images of multiple domains and categories, can we recognize unseen concepts in unseen domains? We propose an approach that is the first, promising step, towards solving this problem. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.
Download or read book Trauma Narratives in Italian and Transnational Women s Writing written by Tiziana de Rogatis and published by Sapienza Università Editrice. This book was released on 2022-12-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is the first to propose new readings of Italian and transnational female-authored texts through the lens of Trauma Studies. Illuminating a space that has so far been left in the shadows, Trauma Narratives in Italian and Transnational Women’s Writing provides new insights into how the trope of trauma shapes the narrative, temporal and linguistic dimension of these works. The various contributions delineate a landscape of female-authored Italian and transnational trauma narratives and their complex textual negotiation of suffering and pathos, from the twentieth century to the present day. These zones of trauma engender a new aesthetics and a new reading of history and cultural memory as an articulation of female creativity and resistance against a dominant cultural and social order.
Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Download or read book Antifascisms written by David Ward and published by Fairleigh Dickinson Univ Press. This book was released on 1996 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an in-depth analysis of three of the most crucial years in twentieth-century Italian history, the years 1943-46. After more than two decades of a Fascist regime and a disastrous war experience during which Italy changed sides, these years saw the laying of the political and cultural foundations for what has since become known as Italy's First Republic. Drawing on texts from the literature, film, journalism, and political debate of the period, Antifascisms offers a thorough survey of the personalities and positions that informed the decisions taken in this crucial phase of modern Italian history.
Download or read book Type Typo written by and published by Omair Nazir. This book was released on with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Yvain written by Chretien de Troyes and published by Yale University Press. This book was released on 1987-09-10 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A twelfth-century poem by the creator of the Arthurian romance describes the courageous exploits and triumphs of a brave lord who tries to win back his deserted wife's love
Download or read book The Boob Book written by and published by Chronicle Books. This book was released on 2020-01-07 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring 30 types of breasts, The Boob Book is an illustrated celebration of womanhood and the boobs that come with it. Scattered throughout are boob miscellany: a boob personality flow chart, boob facts, boob self-care tips, a roundup of bras, types of nipples, a boob doodle, and illustrated ways we show off the goods. This joyful book features breasts of all colors and sizes—from "The Handful" to "The Mom-To-Be" to "The Small but Mighty"—showing women that every boob type is weird, beautiful, and natural. • An illustrated love letter to a girl's breast friend • Filled with fun and interactive boob-related miscellany, like a boob personality test (are you a "Chillaxer" or a "Handful"?), boob facts, and breast self-care tips • Light, celebratory, and a little cheeky—but ultimately sincere Let's hear it for our bosom buddies. Our mammary mamas. Our breasts-in-arms. From small and mighty to large and in charge to long, short, hairy, bumpy, or any boobs in between, this book uplifts them all. • A perfect book for women of all generations—from friends to mothers and daughters—or anyone who wants to send some extra support and love to their ladies • Ideal for anyone who needs a boob-size boost • Great for those who enjoyed Feminist Activity Book by Gemma Correll, Celebrating You: (And the Beautiful Person You Are) by M. H. Clark, and Gross Anatomy: Dispatches from the Front (and Back) by Mara Altman
Download or read book Functional Nanoporous Materials written by Christian Weinberger and published by . This book was released on 2020 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: With pore sizes up to 100 nm, the term "nanoporous" covers a wide range of material classes. A broad field of applications has arisen from the diversity of unique structures and properties of nanoporous materials. Recent research spans the range from fundamental studies of the behavior of atoms and molecules in confined space, creative synthetic pathways for novel materials, to applications in high-performance technologies. This Special Issue collects current studies about the progress in the development, characterization, and application of nanoporous materials, including (but not restricted to) mesoporous silica, carbon and metal oxides, porous coordination polymers, metal organic frameworks (MOFs), and covalent organic frameworks (COFs), as well as materials exhibiting hierarchical porosity. Their functionalities show promise for fields such as energy storage/conversion (e.g., photocatalysis and battery electrodes), sensing, catalysis, and their sorption properties for N2, CO2, NOx, or H2O, to name just a few.
Download or read book Charles Pettigrew First Bishop elect of the North Carolina Episcopal Church written by Bennett H Wall and published by Hassell Street Press. This book was released on 2021-09-10 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
