Download or read book Advances in the Management of Peritoneal Carcinomatosis written by Jesus Esquivel and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, we review some of the historical aspects of peritoneal carcinomatosis, describe the advances in understanding the biological behavior of the different types of cancers that can develop peritoneal carcinomatosis, and how these differences impact the mode of presentation, their radiological findings and their clinical outcome

Download or read book Peritoneal Carcinomatosis Principles of Management written by Paul H. Sugarbaker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paul Sugarbaker and his colleagues have persevered in the study and treat ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and incompletely appreciated properties. These properties, coupled with the biologic behavior of many cancers, results in the seeding and growth of these cancers on the peritoneum. Many of these cancers remain localized to the peritoneum only, never metastasizing to other sites. One possible reason for this may be the obstruction of the afferent lymphatics on the undersurface of the diaphragm. The mucopolysaccharides produced by many of these neoplasma are probably viscous enough to obstruct these lymphatics, leading to the syndrome of pseudomyxoma peritonei. Many of the neoplasms taking residence on the peritoneum have extremely long cell-cycle times and are resistant to radiotherapy and many chemotherapeutic agents. How ever, much can be done for these patients - resection of primary cancers, omentectomies to reduce ascites formation, management of recurrent ascites, management of intestinal obstruction, nutritional care, and, hopefully, intraperitoneal chemotherapy. We have reviewed many of these problems in the past [1-7]. Dr. Sugarbaker and his colleagues have organized the current state of knowledge and technology for continuing use. The book provides a basis for thoughtful, prospective research planning. John S. Spratt, M. D. , F. A. C. S. Professor of Surgery The James Graham Brown Cancer Center University of Louisville Louisville, Kentucky References 1. Long RTL, Spratt JS, Dowling E.

Download or read book Management of Peritoneal Metastases Cytoreductive Surgery HIPEC and Beyond written by Aditi Bhatt and published by Springer. This book was released on 2018-04-02 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: The widespread acceptance among the oncology community at large of cytoreductive surgery and HIPEC as a potentially curative treatment for peritoneal metastases has paved the way for innovative new therapies that could benefit a larger proportion of patients. Much has been and continues to be published on this subject. This book provides comprehensive reviews on the various aspects of managing peritoneal metastases. The authors highlight essential practical issues that surgical oncologists encounter in their day-to-day practice, and try to before provide evidence based answers to address them. All chapters were written and/or reviewed by leading experts in this field.

Download or read book Peritoneal Carcinomatosis A Multidisciplinary Approach written by wim ceelen and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume to provide a multidisciplinary approach to peritoneal carcinomatosis encompassing molecular mechanisms, histopathology, regional and systemic cytotoxic therapy, and surgical options. Illustrations aid the reader throughout in the many facets of this disease. The book will be of particular interest for medical, surgical and gynecological oncologists faced with the complexities of decision making in patients suffering from PC.

Download or read book Surgical Management of Advanced Pelvic Cancer written by Desmond C. Winter and published by John Wiley & Sons. This book was released on 2021-11-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: An innovative guide to the practice of pelvic exenterative surgery for the management of advanced pelvic neoplasms Exenterative surgery plays an important role in the management of advanced pelvic cancer. However, while a large body of evidence regarding outcomes following pelvic exenteration now exists, practical strategies and management options remain unclear. Surgical Management of Advanced Pelvic Cancer addresses this problem by assembling world-leaders in the field to provide insights into the latest techniques and best practices. It includes detailed coverage of: Surgical anatomy Operative approaches and exenterative techniques Reconstruction options Current evidence on survival and quality of life outcomes Featuring essential information for those managing patients with advanced pelvic neoplasms, Surgical Management of Advanced Pelvic Cancer consolidates the latest data and practical advice in one indispensable guide.

Download or read book Peritoneal Surface Malignancies written by Emel Canbay and published by Springer. This book was released on 2015-07-09 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been designed to provide the full description of the comprehensive management of peritoneal surface malignancies as a new emerging specialty. Combined treatment of cytoreductive surgery (CRS) and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) introduced by our leader Paul H. Sugarbaker are performed to treat peritoneal metastases by surgeons all around the world. Therefore this book is focused on detailed surgical anatomy of the peritoneum, preoperative clinical assessment of the peritoneal surface malignancy, patient preparation and operation room equipments, different surgical procedures for CRS and reconstruction, intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and neoadjuvant intraperitoneal chemotherapy, early postoperative intraperitoneal chemotherapy (EPIC) and molecular basis of peritoneal surface malignancies. The chapter on molecular mechanisms of the formation of peritoneal carcinomatosis provides insight into a rapidly expanding knowledge within this speciality. This book should be valuable for surgical oncologists who deal with multimodal treatment for peritoneal surface malignancies, as well as for the trained peritonectomy surgeons. For the senior surgeons, it will also introduce new techniques and approaches in this field such as dealing with the omental cakes and massive organ involvement that requires multi-organ resection.

Download or read book Treatment of Peritoneal Surface Malignancies written by Angelo Di Giorgio and published by Springer. This book was released on 2015-02-14 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authors’ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.

Download or read book Advances in Peritoneal Surface Oncology written by S. González-Moreno and published by Springer Science & Business Media. This book was released on 2010-05-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current research in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the latest clinical trials. The book covers the essentials of perioperative intraperitoneal chemotherapy and modern histopathological assessment of peritoneal surface malignancy. The book’s historical perspective on the unfolding of new knowledge points the way for future research. Contributors include leading experts, among them the pioneers who gave birth to this new era in oncology.

Download or read book Perioperative Chemotherapy written by U. Metzger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.

Download or read book Management of Peritoneal Surface Malignancies Cytoreductive Surgery HIPEC PIPAC and Beyond written by Amine Souadka and published by Frontiers Media SA. This book was released on 2024-04-05 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peritoneal surface malignancies (PSM) include a heterogeneous group of primary tumors, like peritoneal mesothelioma, and peritoneal metastases from various origins such as ovarian, gastric, colorectal, or appendicular cancers. Their pathophysiology is complex and still not fully elucidated. Historically, due to their dismal prognosis, peritoneal surface malignancies were considered a terminal condition and treated as such in palliative intent.. Surgery has become pivotal in the treatment of PSM and the development of specific techniques of cytoreductive surgery (peritonectomies, “en-bloc” resection) open up a new era of curative intent treatments.

Download or read book Peritoneal Carcinomatosis Principles and management written by Paul H. Sugarbaker and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Peritoneal Carcinomatosis Drugs and Diseases written by Paul H. Sugarbaker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peritoneal carcinomatosis dominates the clinical picture of many patients with gastrointestinal, gynecological and urological cancers. For many of them its dev astating effects contribute directly to their death. Most clinicians consider peritoneal carcinomatosis an incurable metastatic disease and give palliative treatment, re stricted to limited surgery and systemic chemotherapy. Contrary to this view, Paul Sugarbaker and his collegues base their approach on the concept that peritoneal carcinomatosis represents regional tumor spread, similar in its impact on treatment and prognosis to that of lymph node metastases in other malignancies. This concept emphasises the value of regional tumor control, as a potentially curative measure. In this book the combination of aggressive cytoreduction and intraperitoneal chemotherapy to control peritoneal carcinomatosis is extensively explored. Basic to this approach is the observation that most cancer cells show only relative resistence against commonly available drugs, which can be overcome by a sufficient increase of drug concentrations in tumor tissue. After intraperitoneal delivery, drugs will reach high tissue concentrations in the superficial few cell layers, while plasma concentrations will remain below toxic levels. Patients with only limited residual tumor at the peritoneal surface after cytoreduction may therefore benefit from intraperitoneal chemotherapy.

Download or read book Peritoneal Tumors and Metastases written by Beate Rau and published by Springer Nature. This book was released on 2021-05-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides surgeons and oncologists with a well-founded and detailed overview of the available treatment options for peritoneal malignancy and differential selection of the appropriate forms of therapy. Systemic chemotherapy options are also considered, as are surgical cytoreduction (CRS) and all forms of intraperitoneal chemotherapy (IPC) especially hyperthermic IPC (HIPEC), and immunotherapy, including specific procedures such as PIPAC. Subsequent chapters address perioperative care, complications and recurrences, as well as psycho-oncological, palliative medical and nursing care. The process of parietal and visceral peritonectomy in the large and small intestine is additionally illustrated by three video clips accessible online. Covering a broad range of aspects, including peritoneal metastasis and intraperitoneal chemotherapy, the book offers a valuable tool for surgeons, oncologists and anesthesiologists alike.

Download or read book Intraperitoneal Cancer Therapy written by Wim P. Ceelen and published by CRC Press. This book was released on 2015-10-22 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraperitoneal Cancer Therapy: Principles and Practice is one of the first books to combine the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy. The book covers basic concepts such as anatomy, physiology, pharmacology

Download or read book Peritoneal Carcinomatosis from Ovarian Cancer written by Konstantinos N. Chatzigeorgiou and published by Nova Science Publishers. This book was released on 2005 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ovarian cancer is the most common cause of death among all gynecological neoplasms. Ovarian epithelial cancer represents approximately 90% of all ovarian malignant tumours. The most usual pattern of spread and probably the earliest kind of metastasis of ovarian cancer is intraperitoneal spread, caused by apoptosis of viable cancer cells, even in cases where the ovarian surface has no visible rupture. Approximately 70% to 75% of all ovarian cancers are being diagnosed with peritoneal carcinomatosis and ascites in advanced stages III and IV. Peritoneal carcinomatosis from ovarian cancer may occur either concomitantly with the primary tumour or as a recurrence pattern of spread. Standard treatment consists of surgical debulking and postoperative systemic chemotherapy. Response rates to first-line chemotherapy with platinum/taxane combinations are high, about 70-80%, but the vast majority of patients will relapse. Peritoneal seeding is a major cause of surgical treatment failure among those patients, even after optimal debulking. However, progressing ovarian cancer tends to remain within the peritoneal cavity or, better-expressed, ovarian cancer is a cancer of the peritoneum. The administration of cytotoxic agents directly into the peritoneal cavity as treatment for malignancy was initially evaluated more than 40 years ago. Over the past two decades regional therapy of ovarian cancer has evolved from just an interesting pharmacokinetic concept into a viable management option for women with advanced disease. Several authors, and among them some of the world's leading experts on this field present the current knowledge and their experience on peritoneal carcinomatosis from ovarian cancer.

Download or read book Staging Laparoscopy written by P. Hohenberger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included here is a discussion of the pathophysiological aspects and risks of laparoscopic staging (such as trocar metastases) on the basis of international experience.

Download or read book Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for the Management of Peritoneal Carcinomatosis from Ovarian Cancer A Preliminary Single Center Experience from Saudi Arabia written by osama alomar and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Ovarian cancer is regarded as the leading cause of cancer-related death among all types of gynecologic malignancy. Unfortunately, around two thirds of patients present to clinical attention with advanced disease stage in the form of peritoneal carcinomatosis (PC) or distant metastasis, and the associated five-year survival is very poor. Aim: To report our pilot single-center experience with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for management of peritoneal carcinomatosis (PC) from ovarian cancer. Methods. Twenty seven patients (n=27) were retrospectively analyzed for perioperative details. Results. The mean age was 53 years, whereas the mean body mass index (BMI) was 33.1 kg/m2. The vast majority of patients had serous adenocarcinoma (92.6%), stage III disease (77.8%) and primary advanced disease presentation (59.3%). Cytoreduction completeness (CC-0) and (CC-1) were achieved in 556% and 44.6%, respectively. The median peritoneal cancer index (PCI) was 11. Combination cisplatin + doxorubicin HIPEC chemotherapy was used in the vast majority of patients (70.4%). The median operative time, estimated blood loss, and hospital stay were 8 hours, 1100 mL and 12 days, respectively. Major postoperative Clavien-Dindo grade III/IV complications occurred in 5 patients (18.5%) and none developed HIPEC chemotherapy-related toxicities. The median follow-up time was 16 months. A total of 8 patients (29.6%) experienced recurrence. A total of 18 patients were alive either with disease (n=9, 33.3%) or without disease (n=17, 63%); only one patient died. Patients with CC-0 and PCI10 had higher statistically significant disease-free survival (DFS) than patients with CC-1 and PCI10. Conclusion: CRS plus HIPEC is feasible, safe and offers favorable therapeutic benefits in patients with PC arising from ovarian cancer.