Download or read book Adenosinergic Modulation of Hippocampal Gamma Oscillations from Single Cell to Whole Animal written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Gamma oscillations, synchronous network activity between 30 and 100 Hz, have been linked to higher cognitive functions. Adenosine receptor modulation has been shown to alter cognitive function in animals and humans. In this thesis the effects of adenosine receptor modulation on in vitro and in vivo hippocampal gamma oscillations were investigated as well as the underlying mechanisms. \(A_1\)-receptor activation selectively decreased gamma oscillations while blocking \(A_1\)-receptors and activating \(A_{2A}\)-receptors increased gamma oscillations. Increasing endogenous adenosine levels suppressed gamma oscillations while decreasing endogenous adenosine levels facilitated gamma oscillations in vitro. Sharp electrode current clamp and whole-cell voltage clamp experiments showed that \(A_1\)-receptor activation hyperpolarised resting membrane potential, reduced firing rate and EPSP amplitude and shifted the IPSC reversal potential to more negative potentials. Blocking \(A_1\)-receptors increased pyramidal cell excitability and increased excitatory synaptic transmission. The results in vivo were more ambiguous but \(A_1\)-receptor activation decreased power in all frequency bands indicating that adenosine receptors can modulate hippocampal gamma oscillations in vivo. \(A_1\)-receptor blockage had no consistent effect on in vivo hippocampal gamma oscillations. Adenosine receptors modulate gamma oscillations in rodent hippocampal slices but are difficult targets for developing treatments that have cognitive benefits because of their ambiguous effects in vivo.
Download or read book Modulation of Hippocampal Gamma Oscillations by Dopamine and Serotonin Receptor Subtypes written by and published by . This book was released on 2014 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modulation of Hippocampal Gamma Oscillations by Acetycholine written by Ruth Traer Betterton and published by . This book was released on 2016 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Leitmotifs written by Roger Traub and published by Springer Nature. This book was released on with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Foundations of Psychiatric Sleep Medicine written by John W. Winkelman and published by Cambridge University Press. This book was released on 2010-12-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.
Download or read book Sleep and Mental Illness written by S. R. Pandi-Perumal and published by Cambridge University Press. This book was released on 2010-04-01 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.
Download or read book Purinergic pharmacology volume II written by Francisco Ciruela and published by Frontiers Media SA. This book was released on 2023-06-07 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Neurochemistry written by Abel Lajtha and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sleep Wake Neurobiology and Pharmacology written by Hans-Peter Landolt and published by Springer Nature. This book was released on 2019-09-03 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com
Download or read book Adenosine Receptors in Health and Disease written by Constance N. Wilson and published by Springer Science & Business Media. This book was released on 2009-07-28 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
Download or read book The Adenosine Receptors written by Pier Andrea Borea and published by Humana Press. This book was released on 2018-07-28 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Download or read book Neurochemistry of Sleep and Wakefulness written by Jaime Monti and published by Cambridge University Press. This book was released on 2008-01-17 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.
Download or read book Neural Circuits of Innate Behaviors written by Hao Wang and published by Springer Nature. This book was released on 2020-08-27 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation. For decades, humans have been fascinated by wild animals’ instincts, like the annual two-thousand-mile migration of the monarch butterfly in North American, and the “imprint” behavior of newborn birds. Since these instincts are always displayed in stereotypical patterns in most individuals of a given species, the neural circuits processing such behaviors must be genetically hard-wired in the brain. Recently, with the development of modern techniques, including optogenetics, retrograde and anterograde virus tracing, and in vivo calcium imaging, researchers have been able to determine and dissect the specific neural circuits for many innate behaviors by selectively manipulating well-defined cell types in the brain. This book discusses recent advances in the investigation of the neural-circuit mechanisms underlying innate behaviors.
Download or read book Mechanisms and Mediators of Neuropathic Pain written by Annika B. Malmberg and published by Springer Science & Business Media. This book was released on 2002-04-01 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences. This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.
Download or read book Receptor Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Mechanisms of Sleep written by Dennis J. McGinty and published by . This book was released on 1985 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nicotinic Receptors in the CNS written by and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
