Download or read book Practical Considerations for Adaptive Trial Design and Implementation written by Weili He and published by Springer. This book was released on 2014-10-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.
Download or read book Adaptive Implementation written by Ryoko Yamaguchi and published by Rowman & Littlefield. This book was released on 2017-07-21 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: After decades spent pondering basic questions about adopting or implementing ‘best practices’ in education, educators have assembled a canon of evidence-based strategies and programs that should consistently produce good outcomes. So why is the work of educating students still such challenging work for so many? The best, most skilled educators adapt programs every day to meet the changing needs of their students. One size does not fit all, and one textbook, teaching strategy, or program will never meet the needs of all teachers and learners. Adaptive Implementation: Navigating the School Improvement Landscape focuses on how practitioners and researchers together continue to improve their craft by systematically collecting data on adaptations, testing them out, and figuring out what works. We provide a framework for building an adaptive implementation process in education, with tools and templates for practitioners to use. In the end, we hope that this book sparks a dialogue among educators as they continue to create adaptive implementation processes that work for their context.
Download or read book Adaptive Design Theory and Implementation Using SAS and R written by Mark Chang and published by CRC Press. This book was released on 2014-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the
Download or read book Adaptive Design Theory and Implementation Using SAS and R Second Edition written by Mark Chang and published by CRC Press. This book was released on 2014-12-01 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. New to the Second Edition Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winners design, biomarker-informed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival modeling, and adaptive treatment switching New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive dose-escalation trials Twenty new SAS macros and R functions Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.
Download or read book Adaptive Design Theory and Implementation Using SAS and R written by Mark Chang and published by CRC Press. This book was released on 2012-10-09 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase the probability of success, reduce costs and the t
Download or read book Adaptive Regulation written by Vladimir Nikiforov and published by Springer Nature. This book was released on 2022-08-18 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph is focused on control law design methods for asymptotic tracking and disturbance rejection in the presence of uncertainties. The methods are based on adaptive implementation of the Internal Model Principle (IMP). The monograph shows how this principle can be applied to the problems of asymptotic rejection/tracking of a priori uncertain exogenous signals for linear and nonlinear plants with known and unknown parameters. The book begins by introducing the problems of adaptive control, the challenges that are faced, modern methods and an overview of the IMP. It then introduces special observers for uncertain exogeneous signals affecting linear and nonlinear systems with known and unknown parameters. The basic algorithms of adaptation applied to the canonical closed-loop error models are presented. The authors then address the systematic design of adaptive systems for asymptotic rejection/tracking of a priori uncertain exosignals. The monograph also discusses the adaptive rejection/tracking of a priori uncertain exogenous signals in systems with input delay, the problems of performance improvement in disturbance rejection and reference tracking and the issue of robustness of closed-loop systems. Adaptive Regulation provides a systematic discussion of the IMP applied to a variety of control problems, making it of interest to researchers and industrial practitioners.
Download or read book An Adaptive Random search Algorithm for Implementation of the Maximum Principle written by Elwood C. Stewart and published by . This book was released on 1970 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Subband Adaptive Filtering written by Kong-Aik Lee and published by John Wiley & Sons. This book was released on 2009-07-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Subband adaptive filtering is rapidly becoming one of the most effective techniques for reducing computational complexity and improving the convergence rate of algorithms in adaptive signal processing applications. This book provides an introductory, yet extensive guide on the theory of various subband adaptive filtering techniques. For beginners, the authors discuss the basic principles that underlie the design and implementation of subband adaptive filters. For advanced readers, a comprehensive coverage of recent developments, such as multiband tap–weight adaptation, delayless architectures, and filter–bank design methods for reducing band–edge effects are included. Several analysis techniques and complexity evaluation are also introduced in this book to provide better understanding of subband adaptive filtering. This book bridges the gaps between the mixed–domain natures of subband adaptive filtering techniques and provides enough depth to the material augmented by many MATLAB® functions and examples. Key Features: Acts as a timely introduction for researchers, graduate students and engineers who want to design and deploy subband adaptive filters in their research and applications. Bridges the gaps between two distinct domains: adaptive filter theory and multirate signal processing. Uses a practical approach through MATLAB®-based source programs on the accompanying CD. Includes more than 100 M-files, allowing readers to modify the code for different algorithms and applications and to gain more insight into the theory and concepts of subband adaptive filters. Subband Adaptive Filtering is aimed primarily at practicing engineers, as well as senior undergraduate and graduate students. It will also be of interest to researchers, technical managers, and computer scientists.
Download or read book Adaptive Control written by Ioan Doré Landau and published by Springer Science & Business Media. This book was released on 2011-06-06 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive Control (second edition) shows how a desired level of system performance can be maintained automatically and in real time, even when process or disturbance parameters are unknown and variable. It is a coherent exposition of the many aspects of this field, setting out the problems to be addressed and moving on to solutions, their practical significance and their application. Discrete-time aspects of adaptive control are emphasized to reflect the importance of digital computers in the application of the ideas presented. The second edition is thoroughly revised to throw light on recent developments in theory and applications with new chapters on: multimodel adaptive control with switching, direct and indirect adaptive regulation and adaptive feedforward disturbance compensation. Many algorithms are newly presented in MATLAB® m-file format to facilitate their employment in real systems. Classroom-tested slides for instructors to use in teaching this material are also now provided. All of this supplementary electronic material can be downloaded from fill in URL. The core material is also up-dated and re-edited to keep its perspective in line with modern ideas and more closely to associate algorithms with their applications giving the reader a solid grounding in: synthesis and analysis of parameter adaptation algorithms, recursive plant model identification in open and closed loop, robust digital control for adaptive control; • robust parameter adaptation algorithms, practical considerations and applications, including flexible transmission systems, active vibration control and broadband disturbance rejection and a supplementary introduction on hot dip galvanizing and a phosphate drying furnace. Control researchers and applied mathematicians will find Adaptive Control of significant and enduring interest and its use of example and application will appeal to practitioners working with unknown- and variable-parameter plant. Praise for the first edition: ...well written, interesting and easy to follow, so that it constitutes a valuable addition to the monographies in adaptive control for discrete-time linear systems... suitable (at least in part) for use in graduate courses in adaptive control.
Download or read book Simplified Robust Adaptive Detection and Beamforming for Wireless Communications written by Ayman ElNashar and published by John Wiley & Sons. This book was released on 2018-08-20 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an alternative and simplified approaches for the robust adaptive detection and beamforming in wireless communications. It adopts several systems models including DS/CDMA, OFDM/MIMO with antenna array, and general antenna arrays beamforming model. It presents and analyzes recently developed detection and beamforming algorithms with an emphasis on robustness. In addition, simplified and efficient robust adaptive detection and beamforming techniques are presented and compared with exiting techniques. Practical examples based on the above systems models are provided to exemplify the developed detectors and beamforming algorithms. Moreover, the developed techniques are implemented using MATLAB—and the relevant MATLAB scripts are provided to help the readers to develop and analyze the presented algorithms. em style="mso-bidi-font-style: normal;"Simplified Robust Adaptive Detection and Beamforming for Wireless Communications starts by introducing readers to adaptive signal processing and robust adaptive detection. It then goes on to cover Wireless Systems Models. The robust adaptive detectors and beamformers are implemented using the well-known algorithms including LMS, RLS, IQRD-RLS, RSD, BSCMA, CG, and SD. The robust detection and beamforming are derived based on the existing detectors/beamformers including MOE, PLIC, LCCMA, LCMV, MVDR, BSCMA, and MBER. The adopted cost functions include MSE, BER, CM, MV, and SINR/SNR.
Download or read book Optimal and Adaptive Signal Processing written by Peter M. Clarkson and published by Routledge. This book was released on 2017-11-01 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal and Adaptive Signal Processing covers the theory of optimal and adaptive signal processing using examples and computer simulations drawn from a wide range of applications, including speech and audio, communications, reflection seismology and sonar systems. The material is presented without a heavy reliance on mathematics and focuses on one-dimensional and array processing results, as well as a wide range of adaptive filter algorithms and implementations. Topics discussed include random signals and optimal processing, adaptive signal processing with the LMS algorithm, applications of adaptive filtering, algorithms and structures for adaptive filtering, spectral analysis, and array signal processing. Optimal and Adaptive Signal Processing is a valuable guide for scientists and engineers, as well as an excellent text for senior undergraduate/graduate level students in electrical engineering.
Download or read book Climate Change 2014 Impacts Adaptation and Vulnerability Global and Sectoral Aspects written by Christopher B. Field and published by Cambridge University Press. This book was released on 2014-12-29 with total page 1149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) will again form the standard reference for all those concerned with climate change and its consequences, including students, researchers and policy makers in environmental science, meteorology, climatology, biology, ecology, atmospheric chemistry and environmental policy.
Download or read book PROMOTING ADAPTIVE SYSTEM TO THE CURRENT TURBULENCE WITHIN CRISIS ENVIRONMENTS written by Sulikah Asmorowati and published by Airlangga University Press. This book was released on 2023-01-09 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary works and contributions of writers with different backgrounds ranging from academics to bureaucrats make this book rich in treasures to see how far the scientific development of public administration is dealing with global conditions which are currently starting to show signs of revival. At the same time, we can learn from when local to national governments have to work hard to provide public policies in the form of a stimulus to help the country get out of the problems caused by disease outbreaks. This book is contained of 38 selected writings that can be an excellent literature for for those who seek for reference on public policy. In addition, this book is expected to ignite further discussions within the scientific scope. Apart from the various shortcomings, we apologize profusely and hopefully this book can provide benefits to the wider community. We thank the authors and editors who have contributed their best energy, thoughts, and works.
Download or read book Architectures for Adaptive Software Systems written by Raffaela Mirandola and published by Springer Science & Business Media. This book was released on 2009-06-08 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of a software architect’s life is spent designing software systems to meet a set of quality requirements. General software quality attributes include scalability, security, performance or reliability. Quality attribute requirements are part of an application’s non-functional requirements, which capture the many facets of how the functional - quirements of an application are achieved. Understanding, modeling and continually evaluating quality attributes throughout a project lifecycle are all complex engineering tasks whichcontinuetochallengethe softwareengineeringscienti ccommunity. While we search for improved approaches, methods, formalisms and tools that are usable in practice and can scale to large systems, the complexity of the applications that the so- ware industry is challenged to build is ever increasing. Thus, as a research community, there is little opportunity for us to rest on our laurels, as our innovations that address new aspects of system complexity must be deployed and validated. To this end the 5th International Conference on the Quality of Software Archit- tures (QoSA) 2009 focused on architectures for adaptive software systems. Modern software systems must often recon guretheir structure and behavior to respond to c- tinuous changes in requirements and in their execution environment. In these settings, quality models are helpful at an architectural level to guide systematic model-driven software development strategies by evaluating the impact of competing architectural choices.
Download or read book Engineering Adaptive Software Systems written by Yijun Yu and published by Springer. This book was released on 2019-01-14 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the problems and challenges in the interdisciplinary research field of self-adaptive software systems. Modern society is increasingly filled with software-intensive systems, which are required to operate in more and more dynamic and uncertain environments. These systems must monitor and control their environment while adapting to meet the requirements at runtime. This book provides promising approaches and research methods in software engineering, system engineering, and related fields to address the challenges in engineering the next-generation adaptive software systems. The contents of the book range from design and engineering principles (Chap. 1) to control–theoretic solutions (Chap. 2) and bidirectional transformations (Chap. 3), which can be seen as promising ways to implement the functional requirements of self-adaptive systems. Important quality requirements are also dealt with by these approaches: parallel adaptation for performance (Chap. 4), self-adaptive authorization infrastructure for security (Chap. 5), and self-adaptive risk assessment for self-protection (Chap. 6). Finally, Chap. 7 provides a concrete self-adaptive robotics operating system as a testbed for self-adaptive systems. The book grew out of a series of the Shonan Meetings on this ambitious topic held in 2012, 2013, and 2015. The authors were active participants in the meetings and have brought in interesting points of view. After several years of reflection, they now have been able to crystalize the ideas contained herein and collaboratively pave the way for solving some aspects of the research problems. As a result, the book stands as a milestone to initiate further progress in this promising interdisciplinary research field.
Download or read book Intelligent Adaptive Systems written by Ming Hou and published by CRC Press. This book was released on 2018-10-30 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: As ubiquitous as the atmosphere, intelligent adaptive systems (IASs) surround us in our daily lives. When designed well, these systems sense users and their environments so that they can provide support in a manner that is not only responsive to the evolving situation, but unnoticed by the user. A synthesis of recent research and developments on IASs from the human factors (HF) and human–computer interaction (HCI) domains, Intelligent Adaptive Systems: An Interaction-Centered Design Perspective provides integrated design guidance and recommendations for researchers and system developers. The book explores a recognized lack of integration between the HF and HCI research communities, which has led to inconsistencies between the research approaches adopted, and a lack of exploitation of research from one field by the other. The authors integrate theories and methodologies from these domains to provide design recommendations for human–machine developers. They then establish design guidance through the review of conceptual frameworks, analytical methodologies, and design processes for intelligent adaptive systems. The book draws on case studies from the military, medical, and distance learning domains to illustrate intelligent system design to examine lessons learned. Outlining an interaction-centered perspective for designing an IAS, the book details methodologies for understanding human work in complex environments and offers understanding about why and how optimizing human–machine interaction should be central to the design of IASs. The authors present an analytical and design methodology as well as an implementation strategy that helps you choose the proper design framework for your needs.
Download or read book Terminal evaluation of the project Reducing vulnerability and increasing adaptive capacity to respond to impacts of climate change and variability for sustainable livelihoods in agriculture sector in Nepal written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2020-04-01 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: The project’s goal was to support Nepal’s agriculture sector to become climate resilient by promoting urgent and immediate adaptation measures and integration of adaptation priorities outlined in the National Adaptation Programme of Action (NAPA) into agriculture sectorial policies, plans, programmes and local actions. The final evaluation found that the relevant institutional structures in Nepal are now technically capable of incorporating climate change adaptation in agriculture sector decision-making. However, project districts could not benefit from strengthened staff capacity due to scattering of institutional memory caused by staff transfers and relocation in federal, provincial and local governments. Evidence of climate change adaptation related awareness raising and knowledge management activities were apparent in project districts. However, wider dissemination of knowledge and awareness raising products for replication and up-scaling of the project remains yet to be achieved adequately. The project has contributed in economic and social empowerment of most vulnerable Farmer’s Field School group members and specifically the women. However, a robust agriculture sector support mechanism will be required to sustain the impact in future.