Download or read book Acetylcholinesterase Old Questions and New Developments written by Karl Tsim and published by Frontiers E-books. This book was released on with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acetylcholinesterase (AChE) is a primary regulator of cholinergic signaling within and out of the central nervous system. It has been studied extensively for several decades, yet many basic questions about its regulation, composition and functions remain open. Thus, neither the full impact of AChE’s activities on neuronal development, maintenance and functioning nor the reasons for why and how different AChE molecular forms are being synthesized and degraded are fully known yet, although recent evidence suggests the involvement of micro-RNA regulators in both of these aspects. The identification of the anchoring proteins, PRiMA and ColQ, stimulates studies on AChE’s assembly and its specific localization in the brain and muscle. Additionally, non-cholinergic function(s) of AChE has been proposed as relevant both for neuronal differentiation and cognitive functioning, whereas transgenic engineering, recombinant production and structure-function analyses of this enzyme’s variants with various inhibitors paved new avenues for the development of novel Alzheimer’s disease therapeutics, agricultural pesticides and prophylactics in anticipation of warfare agent exposure. The aims of this Research Topic is to provide a forum for experts in the field to critically discuss recent developments in AChE studies, initiate global critiques of the current views for resolving the fundamental questions in AChE research and promote the development of novel versions and uses of AChE-targeted agents. Topics of interest include but are not limited to: (i) post-transcriptional regulation of AChE; (ii) the non-cholinergic functions of AChE; and (iii) anti-AChE inhibitors and diseases.
Download or read book Advances in Cancer Research written by and published by Academic Press. This book was released on 2021-08-03 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 152, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike
Download or read book Marine Carotenoids written by Tatsuya Sugawara and published by MDPI. This book was released on 2021-01-22 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carotenoids represent a large group of isoprenoid structures with many different structural characteristics and biological activities. They are the most important of the naturally occurring pigments and are responsible for the various colors of different fruits, vegetables, and plant parts. Marine carotenoids and their unique structures are responsible for the color of many fish, shellfish, and algae. However, while there have been many papers and reviews on carotenoids of terrestrial origin, there has been relatively little research conducted on the impact of marine carotenoids on human health. Recent research efforts have revealed that marine carotenoids have strong biological activity affecting human health and are candidates for nutraceuticals. This Topical Collection of Marine Drugs is dedicated to marine carotenoids, and will focus on the benefits of carotenoids for human beings. For a better understanding of the physiological effects of marine carotenoids, this collection should include the most recent developments in the presence, analysis, chemistry, and biochemistry of marine carotenoids.
Download or read book Cholinergic Mechanisms written by Israel Silman and published by CRC Press. This book was released on 2004-09-20 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.
Download or read book Reviews in Environmental Health 1999 written by and published by . This book was released on 1999 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Evolution of Invertebrate Nervous Systems written by Andreas Schmidt-Rhaesa and published by Oxford University Press. This book was released on 2015-12-17 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nervous system is particularly fascinating for many biologists because it controls animal characteristics such as movement, behavior, and coordinated thinking. Invertebrate neurobiology has traditionally been studied in specific model organisms, whilst knowledge of the broad diversity of nervous system architecture and its evolution among metazoan animals has received less attention. This is the first major reference work in the field for 50 years, bringing together many leading evolutionary neurobiologists to review the most recent research on the structure of invertebrate nervous systems and provide a comprehensive and authoritative overview for a new generation of researchers. Presented in full colour throughout, Structure and Evolution of Invertebrate Nervous Systems synthesizes and illustrates the numerous new findings that have been made possible with light and electron microscopy. These include the recent introduction of new molecular and optical techniques such as immunohistochemical staining of neuron-specific antigens and fluorescence in-situ-hybridization, combined with visualization by confocal laser scanning microscopy. New approaches to analysing the structure of the nervous system are also included such as micro-computational tomography, cryo-soft X-ray tomography, and various 3-D visualization techniques. The book follows a systematic and phylogenetic structure, covering a broad range of taxa, interspersed with chapters focusing on selected topics in nervous system functioning which are presented as research highlights and perspectives. This comprehensive reference work will be an essential companion for graduate students and researchers alike in the fields of metazoan neurobiology, morphology, zoology, phylogeny and evolution.
Download or read book Connecting Expertise Multidisciplinary Development For The Future written by Seven Publicações and published by Seven Editora. This book was released on with total page 2526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1983 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acetylcholine in the Cerebral Cortex written by L. Descarries and published by Elsevier. This book was released on 2004 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive exposé, by leading neuroscientists, of current knowledge on the neurotransmitter acetylcholine in the cerebral cortex. All aspects of the subject are covered, from its most elementary, at the molecular and cellular levels, to its systemic and holistic implications, including its role in cognition and involvement in human diseases and therapeutics. The twenty-two chapters are grouped under four main headings : I. Functional Morphology of the Acetylcholine Innervation in Cerebral Cortex (Including Hippocampus); II. Modes of Action of Acetylcholine in the Cerebral Cortex; III. Cortical Properties and Functions Modulated by Acetylcholine, and IV. Clinical, Pathological and Therapeutic Implications. This broad perspective updates the reader on recent advances and future trends in the study of a major neuromodulatory system in brain.
Download or read book Nicotinic Acetylcholine Receptor written by Alfred Maelicke and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Research Workshop on Mechanism of Action of the Nicotinic Acetylcholine Receptors held on the Island of Santorini, Greece, May 19-23, 1986
Download or read book Advances in Research and Treatment for Alzheimer s Disease written by Samuel Barrack and published by iMedPub. This book was released on 2012-01-30 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD), is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. The cause and progression of Alzheimer's disease are not well understood. Research indicates that the disease is associated with plaques and tangles in the brain. Current treatments only help with the symptoms of the disease. There are no available treatments that stop or reverse the progression of the disease. As of 2012, more than 1000 clinical trials have been or are being conducted to find ways to treat the disease, but it is unknown if any of the tested treatments will work. Because AD cannot be cured and is degenerative, the sufferer relies on others for assistance. The role of the main caregiver is often taken by the spouse or a close relative. Alzheimer's disease is known for placing a great burden on caregivers; the pressures can be wide-ranging, involving social, psychological, physical, and economic elements of the caregiver's life. In developed countries, AD is one of the most costly diseases to society. Research is the only hope to present and future patients and families suffering from this devastating disorder. This book compiles some of the most interesting articles on Alzheimer's disease published by PLoS journals lately: from epidemiology and prevention to management and treatment.
Download or read book Developments in Aging written by United States. Congress. Senate. Special Committee on Aging and published by . This book was released on 1987 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Summaries of Projects Completed written by National Science Foundation (U.S.) and published by . This book was released on with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Summaries of Projects Completed in Fiscal Year written by and published by . This book was released on with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Summaries of Projects Completed in Fiscal Year written by National Science Foundation (U.S.) and published by . This book was released on 1979 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Linking Environmental Agents to Autoimmune Diseases written by and published by . This book was released on 1993 with total page 1022 pages. Available in PDF, EPUB and Kindle. Book excerpt:
