Download or read book A Study of the Effects of Middle T and Small T Proteins on the Induction of Polyomavirus DNA Replication written by Cedric O. Buckley and published by . This book was released on 2000 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enhancer and Middle T Control of Age and Organ specific Polyomavirus Replication in the Mouse written by Larry Gregory Martin and published by . This book was released on 1994 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Polyomavirus HR T Mutants Induce a G2 M Cell Cycle Arrest and Show Preferential Gene Expression and Replication in Competition with A2 derived Viruses written by Kathryn Marie Spink and published by . This book was released on 2000 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Middle T Antigen Mediated Enhancer Activity in Polyoma Viral DNA Replication and Neoplastic Transformation written by Ming Chu Chen and published by . This book was released on 1991 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2001 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small DNA Tumour Viruses written by Kevin Gaston and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this timely book leading scientists from around the world review current hot-topics in this area providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. Topics covered include: HPV infections and the production of HPV virion stocks; viral oncoproteins and their functions; the replication and maintenance of viral genomes; virus induced alterations in cellular miRNAs; viral deregulation of DNA damage responses; the initiation of viral DNA replication; induction of genomic instability by viral oncoproteins; targeting of PML proteins and.
Download or read book Cellular Transforming Genes written by and published by . This book was released on 1986 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Polyomaviruses written by Ugo Moens and published by Nova Science Pub Incorporated. This book was released on 2009 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human polyomaviruses are non-enveloped viruses with a circular double-stranded DNA genome of approximately 5,000 base pairs. The members BK virus and JC virus were first isolated in 1971 and are very common in the human population. Simian virus 40 (SV40), although originally isolated from rhesus macaques and accidentally introduced in the human population during massive poliovirus vaccination, may represent a third member of the polyomaviruses that can have man as a natural host. Primary infection with BK or/and JC virus occurs during early childhood. Subsequently, these viruses establish a seemingly life-long harmless latent infection. However, virus reactivation can occur especially in immunocompromised individuals and JC virus has been recognised as the cause of progressive multifocal leukoencephalopathy, while BK virus-associated interstitial nephritis has become an emerging complication in renal transplant patients. The genomes of human polyomaviruses encode two functional classes of proteins: the regulatory proteins large T-antigen, small t-antigen, and agnoprotein, and the structural proteins VP1, VP2 and VP3 that form the capsid. The regulatory proteins can modulate the expression and/or activity of cellular proteins involved in signal transduction, cell cycle regulation, and chromosomal functions. Therefore, they all possess oncogenic potential. Consistent with this, human polyomaviruses are capable of transforming human cells and inducing tumours in rodents, and are implicated in human malignancies. This book focuses on the etiological role of human polyomaviruses in cancer and highlights the mechanisms by which the viral regulatory proteins may contribute to neoplastic transformation of the infected host cells. Possible therapeutic strategies against these viruses will also be discussed.
Download or read book The Role of Polyomavirus Middle T Tyrosines in Viral Infection written by Xiaoyu Wang and published by . This book was released on 2004 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Insight Into Merkel Cell Polyomavirus Replication Through the Study of the Viral Early Proteins written by Sabrina H. Tsang and published by . This book was released on 2015 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The association of Merkel cell polyomavirus (MCPyV) and Merkel cell carcinoma (MCC) established in 2008 has opened doors for the study of virus-induced oncogenesis. Much of what is known about polyomaviruses (PyVs) stems from decades of studies on SV40. However, recent research has shown differences among PyVs that might help explain the uniqueness of MCPyV that makes it the only PyV discovered to date that is associated with a human cancer. Therefore, it is important to understand the biology of this virus and its oncogenic potential. My study focuses on two of the early proteins of MCPyV, namely the large tumor antigen (LT) and the small tumor antigen (sT). Both proteins are multi-functional, contributing to viral replication and the stimulation of cellular proliferation. MCPyV LT is the viral helicase that binds to the viral origin (Ori) to initiate unwinding and the replication of the double-stranded DNA genome. Like other PyVs, MCPyV requires numerous cellular proteins to replicate its genome. In my research, I show that, in the presence of the viral Ori, the binding of LT to the Ori forms replication factories in the nucleus. A number of cellular factors involved in the host DNA damage response (DDR) re-localize to the sites of MCPyV LT-mediated replication. Inhibition of the DNA damage response by either drug treatment or siRNA knockdown decreases MCPyV replication, suggesting that an intact host DDR pathway is essential for the optimal replication of MCPyV. Previous research has shown that MCPyV sT indirectly enhances viral replication by stabilizing LT. In my study, I discover that sT is a metalloprotein that coordinates two iron-sulfur clusters. Mutations in the highly conserved cysteines found in MCPyV sTs abolishes its ability to stimulate LT-mediated viral DNA replication, and that sT can enhance LT-mediated replication in a manner that is independent of LT stabilization. Moreover, I show that sT translocates to the nuclear replication factories formed in the presence of LT and Ori, suggesting a more direct role of sT in promoting viral DNA replication. Interestingly, upon treatment with the potent antiviral agent cidofovir, sT-mediated enhancement of MCPyV replication is robustly inhibited, while replication driven by LT alone was not affected much. This finding supports the use of cidofovir in controlling PyV infection and offers MCPyV sT as a potential drug target to dampen viral growth. In summary, my work elucidates various aspects of MCPyV replication, including the involvement of the host DDR machinery and the role of sT that could potentially be targeted by drug treatment. This study contributes to the understanding of the virology of MCPyV and opens avenues for further research.
Download or read book Molecular Virology of Human Pathogenic Viruses written by Wang-Shick Ryu and published by Academic Press. This book was released on 2016-03-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author's more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. - Presents viruses within their family structure - Contains recommended journal articles with perspectives to put primary literature in context - Includes integrated recommended reading references within each chapter - Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor's manual, study guide, and test bank
Download or read book Polyoma Virus Middle T Effects on Elements of Signal Transduction written by Alexander T. Young and published by . This book was released on 1991 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Mouse in Biomedical Research written by and published by Elsevier. This book was released on 2006-11-30 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases, the second volume in the four volume set, The Mouse in Biomedical Research, departs from the first edition, by discussing specific disease causing microorganisms, rather than the format used in the first edition which discussed infectious diseases affecting specific organs and tissues. As such, the volume consists of 26 chapters subdivided into RNA viruses and DNA viruses, as well as bacterial, mycotic, and parasitic infections. These chapters not only provide updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens, but also include information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter spp. A separate category, consisting of 3 chapters, discusses zoonoses, tumor pathology of genetically engineered mice, and spontaneous diseases in commonly used mouse strains.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1988 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2098 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Construction and Analysis of Mutations of the Polyoma Virus Medium T Antigen written by Dennis Templeton and published by . This book was released on 1983 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
